GB1479544A - 1,2,3,4-tetrahydro-1-naphthylurea derivatives their preparation and their use - Google Patents

1,2,3,4-tetrahydro-1-naphthylurea derivatives their preparation and their use

Info

Publication number
GB1479544A
GB1479544A GB4621/75A GB462175A GB1479544A GB 1479544 A GB1479544 A GB 1479544A GB 4621/75 A GB4621/75 A GB 4621/75A GB 462175 A GB462175 A GB 462175A GB 1479544 A GB1479544 A GB 1479544A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
alkyl
alkoxy
hydroxy
chlorine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4621/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/440,625 external-priority patent/US3953506A/en
Priority claimed from US05/440,626 external-priority patent/US3953606A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB1479544A publication Critical patent/GB1479544A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/32—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing >N—CO—N< or >N—CS—N< groups directly attached to a cycloaliphatic ring
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

1479544 Animal feed compositions AMERICAN CYANAMID CO 3 Feb 1975 [7 Feb 1974 (2)] 4621/75 Heading A5B [Also in Divisions A2 and C2] An animal feed composition for enhancing the growth rate of ruminant livestock, poultry and fur-bearing lanimals contains 25 ppm to 800 ppm of a compound of the formula wherein X is sulfur or oxygen; R, is hydrogen, C 1 -C 12 alkyl, C 1 -C 4 alkoxy, allyl, benzyloxy, (C 1 -C 4 alkoxy) carbonylmethyl, (C 1 -C 4 alkoxy) methyl, C 3 -C 7 cycloalkyl, benzyl, hydroxy, C 1 -C 4 hydroxyalkyl, monohalophenyl, mono (C 1 -C 4 alkoxy)-phenyl, 2-thiazolyl, 2-thiazolin- 2-yl, 2-pyridyl, dihalo-2-pyrimidinyl, pyridylmethyl, acetyl, benzoyl, amino, di(C 1 -C 4 alkyl) amino, (C 1 -C 4 alkyl) carbamoyl, anilino, (C 1 -C 4 alkyl) phenylsulfonyl, phenylsulfonyl, 1, 2, 3, 4-tetrahydro-1-naphthyl, or 2-[3-(1, 2, 3, 4- tetrahydro-l-naphthyl)ureido]ethyl; R 2 is hydrogen or C 1 -C 12 akyl; R 3 is hydrogen, C 1 -C 4 alkyl or hydroxy; R 4 is hydrogen or methyl; R 5 is hydrogen or iodine; R 6 and R' 6 are both hydrogen or both methyl; R 7 is hydrogen, amino, chlorine, cyano, C 1 -C 4 alkyl or C 1 -C 4 alkoxy; R 8 is hydrogen, chlorine, C 1 -C 4 alkyl or C 1 -C 4 alkoxy; R 9 is hydrogen, chlorine, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, acetamido or -NH-CO-NHR 11 where R 11 is allyl, C 1 -C 12 alkyl or hydrogen; R 10 is hydrogen, C 1 -C 4 alkoxy or C 1 -C 4 alkyl; with the following provisos; (a) that when R 1 is H, R 2 and R 3 may be a C 2-4 alkylene group joined together to form with the intervening atoms a 5-7 membered saturated ring; (b) that when R 3 is hydroxy, then R 1 is other than hydroxy, benzyloxy or C 2-4 alkoxy; and (c) that at least four of R groups R, to R 10 are hydrogen; in a nutritionally balanced diet.
GB4621/75A 1974-02-07 1975-02-03 1,2,3,4-tetrahydro-1-naphthylurea derivatives their preparation and their use Expired GB1479544A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/440,625 US3953506A (en) 1974-02-07 1974-02-07 Ureidotetralin compounds
US05/440,626 US3953606A (en) 1974-02-07 1974-02-07 Compositions and method of using ureidotetralin compounds or derivatives thereof

Publications (1)

Publication Number Publication Date
GB1479544A true GB1479544A (en) 1977-07-13

Family

ID=27032485

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4621/75A Expired GB1479544A (en) 1974-02-07 1975-02-03 1,2,3,4-tetrahydro-1-naphthylurea derivatives their preparation and their use

Country Status (7)

Country Link
JP (1) JPS50108250A (en)
DE (1) DE2505301A1 (en)
ES (1) ES434544A1 (en)
FR (1) FR2260339B1 (en)
GB (1) GB1479544A (en)
LU (1) LU71799A1 (en)
NL (1) NL7501474A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0399422A1 (en) * 1989-05-25 1990-11-28 Takeda Chemical Industries, Ltd. Benzocycloalkane derivatives and production thereof
WO1999037607A1 (en) * 1998-01-27 1999-07-29 Icagen, Inc. Potassium channel inhibitors
WO2000068230A1 (en) * 1999-05-05 2000-11-16 Darwin Discovery Limited 9-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,9-dihydropurin-6-one derivatives as pde7 inhibitors
US9388147B2 (en) 2009-11-13 2016-07-12 Celgene International II Sárl Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
US9394264B2 (en) 2009-11-13 2016-07-19 Receptos, Inc. Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
US9481659B2 (en) 2011-05-13 2016-11-01 Celgene International Ii Sàrl Selective heterocyclic sphingosine 1 phosphate receptor modulators
CN110831926A (en) * 2017-04-27 2020-02-21 持田制药株式会社 Novel tetralinyl urea derivatives

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8414987D0 (en) * 1984-06-12 1984-07-18 Beecham Group Plc Active compounds
WO1991014674A2 (en) * 1990-03-27 1991-10-03 Smithkline Beecham Corporation 5-lipoxygenase inhibitors
DE10207037A1 (en) 2002-02-20 2003-08-28 Bayer Cropscience Gmbh New 2-amino-4-(bicyclic substituted amino)-1,3,5-triazine derivatives, useful as pre- or post-emergence, total or selective herbicides or as plant growth regulators
PE20070797A1 (en) * 2005-11-25 2007-09-27 Basf Ag INDANIL- AND TETRAHIDRONAFTIL-AMINO-THIOUREA COMPOUNDS TO FIGHT ANIMAL PESTS
US8173675B2 (en) * 2007-05-24 2012-05-08 Basf Se Substituted amino-thiourea compounds for combating animal pests
GB2561540A (en) * 2017-03-13 2018-10-24 Nodthera Ltd Chemical compounds
KR20200052938A (en) * 2017-09-15 2020-05-15 모찌다 세이야쿠 가부시끼가이샤 Determination of tetrahydronaphthylurea derivatives
JPWO2021065893A1 (en) * 2019-09-30 2021-04-08

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0399422A1 (en) * 1989-05-25 1990-11-28 Takeda Chemical Industries, Ltd. Benzocycloalkane derivatives and production thereof
AU632809B2 (en) * 1989-05-25 1993-01-14 Takeda Chemical Industries Ltd. Benzocycloalkane benzopyran and benzothiopyran urea derivatives and production thereof
WO1999037607A1 (en) * 1998-01-27 1999-07-29 Icagen, Inc. Potassium channel inhibitors
US6333337B1 (en) 1998-01-27 2001-12-25 Icagen, Inc. Potassium channel inhibitors
AU745845B2 (en) * 1998-01-27 2002-04-11 Icagen, Inc. Potassium channel inhibitors
WO2000068230A1 (en) * 1999-05-05 2000-11-16 Darwin Discovery Limited 9-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,9-dihydropurin-6-one derivatives as pde7 inhibitors
US9388147B2 (en) 2009-11-13 2016-07-12 Celgene International II Sárl Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
US9394264B2 (en) 2009-11-13 2016-07-19 Receptos, Inc. Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
US10239846B2 (en) 2009-11-13 2019-03-26 Celgene International Ii Sàrl Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
US9481659B2 (en) 2011-05-13 2016-11-01 Celgene International Ii Sàrl Selective heterocyclic sphingosine 1 phosphate receptor modulators
CN110831926A (en) * 2017-04-27 2020-02-21 持田制药株式会社 Novel tetralinyl urea derivatives
CN110831926B (en) * 2017-04-27 2023-11-21 持田制药株式会社 Tetrahydronaphtyl urea derivatives

Also Published As

Publication number Publication date
ES434544A1 (en) 1977-03-16
DE2505301A1 (en) 1975-08-14
JPS50108250A (en) 1975-08-26
FR2260339A1 (en) 1975-09-05
NL7501474A (en) 1975-08-11
FR2260339B1 (en) 1978-07-21
LU71799A1 (en) 1975-06-24

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee