JP2013227339A5 - - Google Patents
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- JP2013227339A5 JP2013227339A5 JP2013153626A JP2013153626A JP2013227339A5 JP 2013227339 A5 JP2013227339 A5 JP 2013227339A5 JP 2013153626 A JP2013153626 A JP 2013153626A JP 2013153626 A JP2013153626 A JP 2013153626A JP 2013227339 A5 JP2013227339 A5 JP 2013227339A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- variable region
- monoclonal antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 79
- 230000004048 modification Effects 0.000 claims 36
- 238000012986 modification Methods 0.000 claims 36
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 28
- 210000004027 cell Anatomy 0.000 claims 22
- 102000053523 human CXCR4 Human genes 0.000 claims 17
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims 13
- 101710088580 Stromal cell-derived factor 1 Proteins 0.000 claims 13
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 6
- 210000004881 tumor cell Anatomy 0.000 claims 6
- 230000006907 apoptotic process Effects 0.000 claims 4
- 230000003185 calcium uptake Effects 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 210000004602 germ cell Anatomy 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 230000005012 migration Effects 0.000 claims 4
- 238000013508 migration Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 206010027476 Metastases Diseases 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 230000009401 metastasis Effects 0.000 claims 3
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 2
- 210000002889 endothelial cell Anatomy 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 210000005259 peripheral blood Anatomy 0.000 claims 2
- 239000011886 peripheral blood Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 230000004565 tumor cell growth Effects 0.000 claims 2
- 210000003606 umbilical vein Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102000012000 CXCR4 Receptors Human genes 0.000 claims 1
- 108010061299 CXCR4 Receptors Proteins 0.000 claims 1
- 101710112752 Cytotoxin Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010050017 Lung cancer metastatic Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000002619 cytotoxin Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 229940127121 immunoconjugate Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000009545 invasion Effects 0.000 claims 1
- 230000017066 negative regulation of growth Effects 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82785106P | 2006-10-02 | 2006-10-02 | |
| US60/827,851 | 2006-10-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009531416A Division JP5417175B2 (ja) | 2006-10-02 | 2007-10-01 | Ｃｘｃｒ４に結合するヒト抗体およびその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016014621A Division JP6496673B2 (ja) | 2006-10-02 | 2016-01-28 | Ｃｘｃｒ４に結合するヒト抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013227339A JP2013227339A (ja) | 2013-11-07 |
| JP2013227339A5 true JP2013227339A5 (OSRAM) | 2014-07-31 |
| JP6097650B2 JP6097650B2 (ja) | 2017-03-15 |
Family
ID=39402166
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009531416A Expired - Fee Related JP5417175B2 (ja) | 2006-10-02 | 2007-10-01 | Ｃｘｃｒ４に結合するヒト抗体およびその使用 |
| JP2013153626A Expired - Fee Related JP6097650B2 (ja) | 2006-10-02 | 2013-07-24 | Ｃｘｃｒ４に結合するヒト抗体およびその使用 |
| JP2016014621A Expired - Fee Related JP6496673B2 (ja) | 2006-10-02 | 2016-01-28 | Ｃｘｃｒ４に結合するヒト抗体およびその使用 |
| JP2018207100A Withdrawn JP2019054798A (ja) | 2006-10-02 | 2018-11-02 | Ｃｘｃｒ４に結合するヒト抗体およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009531416A Expired - Fee Related JP5417175B2 (ja) | 2006-10-02 | 2007-10-01 | Ｃｘｃｒ４に結合するヒト抗体およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016014621A Expired - Fee Related JP6496673B2 (ja) | 2006-10-02 | 2016-01-28 | Ｃｘｃｒ４に結合するヒト抗体およびその使用 |
| JP2018207100A Withdrawn JP2019054798A (ja) | 2006-10-02 | 2018-11-02 | Ｃｘｃｒ４に結合するヒト抗体およびその使用 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US8450464B2 (OSRAM) |
| EP (2) | EP2066351B1 (OSRAM) |
| JP (4) | JP5417175B2 (OSRAM) |
| KR (3) | KR101722261B1 (OSRAM) |
| CN (2) | CN103897058B (OSRAM) |
| AR (2) | AR063086A1 (OSRAM) |
| AU (1) | AU2007320024B2 (OSRAM) |
| BR (1) | BRPI0718197A2 (OSRAM) |
| CA (1) | CA2665239A1 (OSRAM) |
| CL (1) | CL2007002835A1 (OSRAM) |
| CY (2) | CY1117036T1 (OSRAM) |
| DK (2) | DK2486941T3 (OSRAM) |
| EA (1) | EA018836B1 (OSRAM) |
| ES (2) | ES2625798T3 (OSRAM) |
| HU (2) | HUE027165T2 (OSRAM) |
| IL (1) | IL197831A (OSRAM) |
| LT (1) | LT2486941T (OSRAM) |
| ME (1) | ME02269B (OSRAM) |
| MX (1) | MX2009003306A (OSRAM) |
| NO (1) | NO345287B1 (OSRAM) |
| NZ (1) | NZ575924A (OSRAM) |
| PL (2) | PL2066351T3 (OSRAM) |
| PT (2) | PT2486941T (OSRAM) |
| RS (2) | RS54424B1 (OSRAM) |
| SG (2) | SG10201608268RA (OSRAM) |
| SI (2) | SI2066351T1 (OSRAM) |
| TW (2) | TWI592425B (OSRAM) |
| WO (1) | WO2008060367A2 (OSRAM) |
| ZA (1) | ZA200902256B (OSRAM) |
Families Citing this family (68)
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| AR061929A1 (es) | 2006-07-18 | 2008-10-01 | Noxxon Pharma Ag | Acidos nucleicos de union al factor derivado de celulas estomales sdf-1 |
| ME02269B (me) * | 2006-10-02 | 2016-04-28 | Medarex Inc | Humana antitela koja se vezuju za cxcr4 i njihove upotrebe |
| FR2915102B1 (fr) * | 2007-04-23 | 2014-05-16 | Pf Medicament | Utilisation d'un anticorps anti-cxcr4 pour le traitement du cancer |
| JP5815945B2 (ja) | 2007-08-06 | 2015-11-17 | ノクソン・ファルマ・アクチエンゲゼルシャフト | Ｓｄｆ−１結合核酸およびその使用 |
| CN102027015A (zh) * | 2008-05-14 | 2011-04-20 | 伊莱利利公司 | 抗cxcr4抗体 |
| US7892546B2 (en) | 2008-05-14 | 2011-02-22 | Eli Lilly And Company | Anti-CXCR4 antibodies |
| KR101813464B1 (ko) | 2009-06-05 | 2018-01-30 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | Ｔ 세포 및 조혈 세포의 재프로그래밍 |
| WO2011042398A1 (en) * | 2009-10-09 | 2011-04-14 | Ablynx Nv | Immunoglobulin single variable domain directed against human cxcr4 and other cell associated proteins and methods to generate them |
| SG10202110692WA (en) * | 2009-11-11 | 2021-12-30 | Ganymed Pharmaceuticals Gmbh | Antibodies specific for claudin 6 (cldn6) |
| WO2011083141A2 (en) * | 2010-01-08 | 2011-07-14 | Ablynx Nv | Method for generation of immunoglobulin sequences by using lipoprotein particles |
| GB201002238D0 (en) | 2010-02-10 | 2010-03-31 | Affitech As | Antibodies |
| EP2371863A1 (en) * | 2010-03-30 | 2011-10-05 | Pierre Fabre Médicament | Humanized anti CXCR4 antibodies for the treatment of cancer |
| WO2011161266A1 (en) * | 2010-06-25 | 2011-12-29 | Ablynx Nv | Improved immunoglobulin single variable domains and constructs thereof directed against cxcr4 |
| US20140120555A1 (en) * | 2011-06-20 | 2014-05-01 | Pierre Fabre Medicament | Anti-cxcr4 antibody with effector functions and its use for the treatment of cancer |
| EP3626739A1 (en) | 2011-06-24 | 2020-03-25 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
| US10465247B2 (en) | 2011-07-01 | 2019-11-05 | Dana-Farber Cancer Institute, Inc. | Discovery of a somatic mutation in MYD88 gene in lymphoplasmacytic lymphoma |
| CA2842169A1 (en) * | 2011-07-20 | 2013-01-24 | Medimmune Limited | Anti-cxcr4 antibodies and methods of use |
| AR087363A1 (es) * | 2011-07-29 | 2014-03-19 | Pf Medicament | Uso del anticuerpo i-3859 para la deteccion y diagnostico de los canceres |
| AR087364A1 (es) * | 2011-07-29 | 2014-03-19 | Pf Medicament | Anticuerpo anti-cxcr4 y su uso para la deteccion y dianostico de canceres |
| KR102024957B1 (ko) * | 2011-11-09 | 2019-09-24 | 브리스톨-마이어스 스큅 컴퍼니 | 항-cxcr4 항체를 이용한 혈액 악성종양의 치료 |
| KR20180023035A (ko) * | 2013-02-26 | 2018-03-06 | 로슈 글리카트 아게 | 이중특이적 t 세포 활성화 항원 결합 분자 |
| SG10201806428YA (en) | 2013-06-28 | 2018-08-30 | X Body Inc | Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes |
| SG11201600171SA (en) * | 2013-08-02 | 2016-02-26 | Pfizer | Anti-cxcr4 antibodies and antibody-drug conjugates |
| JP2016527303A (ja) * | 2013-08-05 | 2016-09-08 | ケンブリッジ エンタープライズ リミテッド | がん免疫療法におけるｃｘｃｒ４シグナル伝達の阻害 |
| EP3044338B1 (en) * | 2013-09-12 | 2021-11-24 | Dana-Farber Cancer Institute, Inc. | Methods for evaluating and treating waldenstrom's macroglobulinemia |
| ES2827281T3 (es) * | 2013-09-23 | 2021-05-20 | X Body Inc | Métodos y composiciones para la generación de agentes de unión contra antígenos de superficie celular |
| EP3599248A1 (en) | 2013-11-06 | 2020-01-29 | Bristol-Myers Squibb Company | Treatment of c1013g/cxcr4-associated waldenström's macroglobulinemia with an anti-cxcr4 antibody |
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| BR112017026189A2 (pt) | 2015-06-12 | 2018-08-14 | Bristol Myers Squibb Co | tratamento de câncer através do bloqueio combinado das vias de sinalização de pd-1 e cxcr4 |
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| CN112661845B (zh) * | 2020-12-25 | 2022-06-21 | 暨南大学 | 与cxcr4结合的亲和力成熟结合蛋白及其应用 |
| CN112521500B (zh) * | 2020-12-25 | 2022-06-24 | 暨南大学 | 与cxcr4结合的亲和力成熟结合蛋白及应用 |
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| CN118255888A (zh) * | 2023-08-31 | 2024-06-28 | 恺佧生物科技(上海)有限公司 | 一种Anti-CXCR4膜蛋白抗体及其制备方法和应用 |
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