JP2015163068A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015163068A5 JP2015163068A5 JP2015042824A JP2015042824A JP2015163068A5 JP 2015163068 A5 JP2015163068 A5 JP 2015163068A5 JP 2015042824 A JP2015042824 A JP 2015042824A JP 2015042824 A JP2015042824 A JP 2015042824A JP 2015163068 A5 JP2015163068 A5 JP 2015163068A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- fragment
- human
- kir
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101000945371 Homo sapiens Killer cell immunoglobulin-like receptor 2DL2 Proteins 0.000 claims description 8
- 101001027081 Homo sapiens Killer cell immunoglobulin-like receptor 2DL1 Proteins 0.000 claims description 6
- 102100037363 Killer cell immunoglobulin-like receptor 2DL1 Human genes 0.000 claims description 4
- 102100033599 Killer cell immunoglobulin-like receptor 2DL2 Human genes 0.000 claims description 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 12
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 9
- 101000945333 Homo sapiens Killer cell immunoglobulin-like receptor 2DL3 Proteins 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 102000058207 human KIR2DL2 Human genes 0.000 claims 4
- 102000058208 human KIR2DL3 Human genes 0.000 claims 4
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 102100033634 Killer cell immunoglobulin-like receptor 2DL3 Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 102000047041 human KIR2DL1 Human genes 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 2
- 239000002872 contrast media Substances 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108010043610 KIR Receptors Proteins 0.000 description 1
- 102100033627 Killer cell immunoglobulin-like receptor 3DL1 Human genes 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 230000007910 cell fusion Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48389403P | 2003-07-02 | 2003-07-02 | |
| US60/483,894 | 2003-07-02 | ||
| US54547104P | 2004-02-19 | 2004-02-19 | |
| US60/545,471 | 2004-02-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012087648A Division JP5826697B2 (ja) | 2003-07-02 | 2012-04-06 | Ｎｋ細胞活性を制御するための組成物及び方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018078329A Division JP2018153185A (ja) | 2003-07-02 | 2018-04-16 | Ｎｋ細胞活性を制御するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015163068A JP2015163068A (ja) | 2015-09-10 |
| JP2015163068A5 true JP2015163068A5 (OSRAM) | 2017-11-16 |
| JP6556465B2 JP6556465B2 (ja) | 2019-08-07 |
Family
ID=33567703
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006516606A Expired - Lifetime JP4871125B2 (ja) | 2003-07-02 | 2004-07-01 | Ｎｋ細胞活性を調節するための組成物および方法 |
| JP2006515738A Expired - Lifetime JP5015592B2 (ja) | 2003-07-02 | 2004-07-01 | Ｎｋ細胞活性を制御するための組成物及び方法 |
| JP2012087648A Expired - Lifetime JP5826697B2 (ja) | 2003-07-02 | 2012-04-06 | Ｎｋ細胞活性を制御するための組成物及び方法 |
| JP2015042824A Expired - Lifetime JP6556465B2 (ja) | 2003-07-02 | 2015-03-04 | Ｎｋ細胞活性を制御するための組成物及び方法 |
| JP2018078329A Pending JP2018153185A (ja) | 2003-07-02 | 2018-04-16 | Ｎｋ細胞活性を制御するための組成物及び方法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006516606A Expired - Lifetime JP4871125B2 (ja) | 2003-07-02 | 2004-07-01 | Ｎｋ細胞活性を調節するための組成物および方法 |
| JP2006515738A Expired - Lifetime JP5015592B2 (ja) | 2003-07-02 | 2004-07-01 | Ｎｋ細胞活性を制御するための組成物及び方法 |
| JP2012087648A Expired - Lifetime JP5826697B2 (ja) | 2003-07-02 | 2012-04-06 | Ｎｋ細胞活性を制御するための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018078329A Pending JP2018153185A (ja) | 2003-07-02 | 2018-04-16 | Ｎｋ細胞活性を制御するための組成物及び方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9902936B2 (OSRAM) |
| EP (3) | EP2289939B1 (OSRAM) |
| JP (5) | JP4871125B2 (OSRAM) |
| KR (5) | KR20060079180A (OSRAM) |
| CN (2) | CN103467602B (OSRAM) |
| AT (1) | ATE490984T1 (OSRAM) |
| AU (2) | AU2004253630B2 (OSRAM) |
| BR (2) | BRPI0412138B8 (OSRAM) |
| CA (2) | CA2530272C (OSRAM) |
| CY (1) | CY1113394T1 (OSRAM) |
| DE (1) | DE602004030464D1 (OSRAM) |
| DK (2) | DK1639013T3 (OSRAM) |
| ES (2) | ES2725526T3 (OSRAM) |
| HR (1) | HRP20120845T1 (OSRAM) |
| IL (3) | IL172613A (OSRAM) |
| MX (1) | MXPA05013923A (OSRAM) |
| NO (4) | NO338818B1 (OSRAM) |
| PL (1) | PL1639013T3 (OSRAM) |
| PT (1) | PT1639013E (OSRAM) |
| RU (2) | RU2376315C2 (OSRAM) |
| WO (2) | WO2005003172A2 (OSRAM) |
Families Citing this family (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090191213A9 (en) * | 2003-07-02 | 2009-07-30 | Novo Nordisk A/S | Compositions and methods for regulating NK cell activity |
| US7803376B2 (en) | 2003-07-24 | 2010-09-28 | Innate Pharma S.A. | Methods and compositions for increasing the efficiency of therapeutic antibodies using NK cell potentiating compounds |
| AU2005238300A1 (en) * | 2004-04-30 | 2005-11-10 | Innate Pharma | Compositions and methods for treating proliferative disorders such as NK-type LDGL |
| LT2287195T (lt) * | 2004-07-01 | 2019-07-25 | Novo Nordisk A/S | Antikūnai, atpažįstantys pan-kir2dl nk receptorius, ir jų panaudojimas diagnostikoje bei terapijoje |
| WO2006003179A2 (en) * | 2004-07-01 | 2006-01-12 | Novo Nordisk A/S | Antibodies binding to receptors kir2dl1, -2, 3 but not kir2ds4 and their therapeutic use |
| DK2112162T3 (da) | 2004-07-10 | 2015-02-23 | Fox Chase Cancer Ct | Genetisk modificerede humane naturlige dræbercellelinjer |
| US20090104170A1 (en) * | 2004-11-02 | 2009-04-23 | Richard William Wyatt Childs | Compositions and methods for treating hyperproliferative disorders |
| JP5154949B2 (ja) | 2005-01-06 | 2013-02-27 | ノヴォ ノルディスク アー／エス | ウイルス感染を治療するための組成物および方法 |
| US20090196850A1 (en) | 2005-01-06 | 2009-08-06 | Novo Nordisk A/S | Anti-Kir Combination Treatments and Methods |
| EP1836225B1 (en) | 2005-01-06 | 2011-11-02 | Novo Nordisk A/S | Kir-binding agents and methods of use thereof |
| GT200600148A (es) * | 2005-04-14 | 2006-11-22 | Metodos para el tratamiento y la prevencion de fibrosis | |
| US9447185B2 (en) | 2005-10-14 | 2016-09-20 | Innate Pharma, S.A. | Compositions and methods for treating proliferative disorders |
| ES2579768T3 (es) * | 2007-01-11 | 2016-08-16 | Novo Nordisk A/S | Anticuerpos anti-KIR, formulaciones y usos de los mismos |
| EP2367553B1 (en) | 2008-12-05 | 2017-05-03 | Novo Nordisk A/S | Combination therapy to enhance nk cell mediated cytotoxicity |
| EP2376653A2 (en) * | 2008-12-29 | 2011-10-19 | Yissum Research Development Company of The Hebrew University of Jerusalem | Methods of predicting responsiveness to interferon treatment and treating hepatitis c infection |
| KR20130033354A (ko) * | 2010-02-08 | 2013-04-03 | 가부시키가이샤 니혼 바이오세라피 켄큐쇼 | Ｎｋ세포 강화형 혈액제제의 제조 방법 |
| BR112013012138B1 (pt) | 2010-11-22 | 2022-02-22 | Innate Pharma Sa | Uso de um composto que inibe um receptor inibidor de célula natural killer (nkcir) |
| EA036545B1 (ru) * | 2011-05-25 | 2020-11-20 | Иннейт Фарма, С.А. | Анти-kir антитела для лечения воспалительных заболеваний |
| EP2723362A1 (en) | 2011-06-21 | 2014-04-30 | Innate Pharma | NKp46-MEDIATED NK CELL TUNING |
| JO3370B1 (ar) * | 2011-11-10 | 2019-03-13 | Regeneron Pharma | طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6 |
| ES2617488T3 (es) * | 2011-11-23 | 2017-06-19 | F. Hoffmann-La Roche Ag | Células de mamífero que expresan CD40L y su uso |
| WO2014044686A1 (en) * | 2012-09-19 | 2014-03-27 | Innate Pharma | Kir3dl2 binding agents |
| US20150290316A1 (en) | 2012-10-02 | 2015-10-15 | Bristol-Myers Squibb Company | Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer |
| EP3066128B1 (en) | 2013-11-06 | 2018-10-31 | Bristol-Myers Squibb Company | Combination of anti-kir and anti-cs1 antibodies to treat multiple myeloma |
| WO2016031936A1 (ja) * | 2014-08-29 | 2016-03-03 | 国立大学法人北海道大学 | Ｋｉｒ２ｄｓ１に対するモノクローナル抗体 |
| US11639384B2 (en) | 2014-10-28 | 2023-05-02 | University Children's Hospital Tübingen | Treatment of pediatric BCP-ALL patients with an anti-KIR antibody |
| SG11201706236SA (en) | 2015-02-06 | 2017-08-30 | Nat Univ Singapore | Methods for enhancing efficacy of therapeutic immune cells |
| ES2813580T3 (es) | 2015-04-17 | 2021-03-24 | Bristol Myers Squibb Co | Composiciones que comprenden una combinación de ipilimumab y nivolumab |
| EP3461337A1 (en) | 2015-05-06 | 2019-04-03 | Snipr Technologies Limited | Altering microbial populations & modifying microbiota |
| CN107849148B (zh) | 2015-05-21 | 2023-09-19 | 哈普恩治疗公司 | 三特异性结合蛋白质及使用方法 |
| CN111375066B (zh) | 2015-07-16 | 2023-04-25 | 百欧肯治疗有限公司 | 治疗癌症的组合物及方法 |
| BR112018008891A8 (pt) | 2015-11-03 | 2019-02-26 | Janssen Biotech Inc | anticorpos que se ligam especificamente a pd-1 e tim-3 e seus usos |
| CA3004530A1 (en) | 2015-11-07 | 2017-05-11 | Multivir Inc. | Methods and compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| PL3458053T3 (pl) | 2016-05-20 | 2022-04-25 | Biohaven Therapeutics Ltd. | Stosowanie riluzolu, proleków riluzolu lub analogów riluzolu z immunoterapiami w leczeniu nowotworów |
| GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
| AU2017297603A1 (en) | 2016-07-14 | 2019-02-14 | Fred Hutchinson Cancer Research Center | Multiple bi-specific binding domain constructs with different epitope binding to treat cancer |
| GB201616365D0 (en) * | 2016-09-27 | 2016-11-09 | Helsingin Yliopisto | Non-genetic modification of enveloped viruses |
| JP7542946B2 (ja) | 2016-09-27 | 2024-09-02 | ボード オブ リージェンツ， ザ ユニヴァーシティー オブ テキサス システム | マイクロバイオームをモジュレートすることにより、免疫チェックポイント遮断療法を増強するための方法 |
| IL322445A (en) | 2016-10-12 | 2025-09-01 | Univ Texas | Methods and compounds for tusc2 immunotherapy |
| KR20230173745A (ko) | 2016-10-21 | 2023-12-27 | 이나뜨 파르마 에스.에이. | 항-kir3dl2 작용제에 의한 치료 |
| CN110381997A (zh) | 2016-12-12 | 2019-10-25 | 茂体外尔公司 | 用于治疗和预防癌症和感染性疾病的包含病毒基因治疗和免疫检查点抑制剂的方法和组合物 |
| SG10202110594UA (en) | 2017-03-31 | 2021-11-29 | Bristol Myers Squibb Co | Methods of treating tumor |
| KR102009040B1 (ko) | 2017-04-05 | 2019-08-08 | 한국생명공학연구원 | Nk 세포 활성화 융합 단백질, nk 세포 및 이들을 포함하는 약제학적 조성물 |
| CN113896792B (zh) | 2017-05-12 | 2025-08-22 | 哈普恩治疗公司 | 间皮素结合蛋白质 |
| US12116406B2 (en) | 2017-05-26 | 2024-10-15 | Fred Hutchinson Cancer Center | Anti-CD33 antibodies and uses thereof |
| CN107261304A (zh) * | 2017-06-05 | 2017-10-20 | 中国兽医药品监察所 | 一种奶牛的布鲁氏菌病免疫试剂盒及其应用 |
| AU2018313939A1 (en) | 2017-08-10 | 2020-02-06 | National University Of Singapore | T cell receptor-deficient chimeric antigen receptor T-cells and methods of use thereof |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| KR102425983B1 (ko) | 2017-10-13 | 2022-07-29 | 하푼 테라퓨틱스, 인크. | 삼중특이적 단백질 및 사용 방법 |
| EP3694884A1 (en) | 2017-10-15 | 2020-08-19 | Bristol-Myers Squibb Company | Methods of treating tumor |
| CN108060137B (zh) * | 2017-12-26 | 2021-07-02 | 博生吉医药科技(苏州)有限公司 | Il7和il21修饰的nk92细胞、制备方法及其应用 |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| MX2020008336A (es) | 2018-02-08 | 2020-09-21 | Dragonfly Therapeutics Inc | Dominios variables de anticuerpos que se dirigen al receptor nkg2d. |
| BR112020015994A2 (pt) | 2018-02-08 | 2020-12-15 | Dragonfly Therapeutics, Inc. | Terapia de combinação do câncer que envolve proteínas de ligação multiespecíficas que ativam células natural killer |
| JP7353576B2 (ja) | 2018-02-20 | 2023-10-02 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｃｄ３３、ｎｋｇ２ｄ、及びｃｄ１６に結合する多重特異性結合タンパク質、ならびにその使用方法 |
| AU2019322487B2 (en) | 2018-03-19 | 2024-04-18 | Multivir Inc. | Methods and compositions comprising tumor suppressor gene therapy and CD122/CD132 agonists for the treatment of cancer |
| JP7351845B2 (ja) | 2018-03-23 | 2023-09-27 | ブリストル－マイヤーズ スクイブ カンパニー | Ｍｉｃａおよび／またはｍｉｃｂに対する抗体ならびにそれらの使用 |
| US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
| EP3773685A1 (en) | 2018-03-25 | 2021-02-17 | SNIPR Biome ApS. | Treating & preventing microbial infections |
| WO2019191676A1 (en) | 2018-03-30 | 2019-10-03 | Bristol-Myers Squibb Company | Methods of treating tumor |
| AU2019275076B2 (en) | 2018-05-23 | 2024-12-19 | National University Of Singapore | Blockade of CD2 surface expression and expression of chimeric antigen receptors for immunotherapy of T-cell malignancies |
| EA202190468A1 (ru) | 2018-08-08 | 2021-07-06 | Драгонфлай Терапьютикс, Инк. | Мультиспецифические связывающие белки, которые связывают bcma, nkg2d и cd16, и способы их применения |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| SG11202101298XA (en) | 2018-08-08 | 2021-03-30 | Dragonfly Therapeutics Inc | Proteins binding nkg2d, cd16 and a tumor-associated antigen |
| EP3849565A4 (en) | 2018-09-12 | 2022-12-28 | Fred Hutchinson Cancer Research Center | REDUCTION OF CD33 EXPRESSION TO SELECTIVELY PROTECT THERAPEUTIC CELLS |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| IL281683B2 (en) | 2018-09-25 | 2023-04-01 | Harpoon Therapeutics Inc | dll3 binding proteins and methods of use |
| MX2021007271A (es) | 2018-12-21 | 2021-07-15 | Onxeo | Nuevas moleculas de acido nucleico conjugado y sus usos. |
| KR20220016157A (ko) | 2019-05-30 | 2022-02-08 | 브리스톨-마이어스 스큅 컴퍼니 | 세포 국재화 시그너쳐 및 조합 요법 |
| US20220363760A1 (en) | 2019-05-30 | 2022-11-17 | Bristol-Myers Squibb Company | Multi-tumor gene signature for suitability to immuno-oncology therapy |
| WO2020243568A1 (en) | 2019-05-30 | 2020-12-03 | Bristol-Myers Squibb Company | Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy |
| WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
| CN111424012A (zh) * | 2020-03-30 | 2020-07-17 | 威海市中心医院 | 一种nk细胞培养用的饲养细胞去增殖能力的处理方法 |
| AR122018A1 (es) | 2020-05-06 | 2022-08-03 | Dragonfly Therapeutics Inc | Proteínas que se unen a nkg2d, cd16 y clec12a |
| TW202214857A (zh) | 2020-06-19 | 2022-04-16 | 法商昂席歐公司 | 新型結合核酸分子及其用途 |
| CA3182579A1 (en) | 2020-07-07 | 2022-01-13 | Ugur Sahin | Therapeutic rna for hpv-positive cancer |
| WO2022047412A1 (en) | 2020-08-31 | 2022-03-03 | Bristol-Myers Squibb Company | Cell localization signature and immunotherapy |
| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
| WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
| WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
| TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性ｒｎａ |
| WO2022140755A1 (en) * | 2020-12-23 | 2022-06-30 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Inhibition of kir2dl2 for the enhancement of adoptive immunotherapies |
| WO2022146948A1 (en) | 2020-12-28 | 2022-07-07 | Bristol-Myers Squibb Company | Subcutaneous administration of pd1/pd-l1 antibodies |
| US20220233693A1 (en) | 2020-12-28 | 2022-07-28 | Bristol-Myers Squibb Company | Antibody Compositions and Methods of Use Thereof |
| WO2022169825A1 (en) | 2021-02-03 | 2022-08-11 | Mozart Therapeutics, Inc. | Binding agents and methods of using the same |
| CN117222663A (zh) | 2021-03-03 | 2023-12-12 | 蜻蜓疗法股份有限公司 | 使用结合nkg2d、cd16和肿瘤相关抗原的多特异性结合蛋白治疗癌症的方法 |
| US20240376224A1 (en) | 2021-04-02 | 2024-11-14 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
| JP2024525758A (ja) | 2021-07-13 | 2024-07-12 | ビオンテック・ソシエタス・エウロパエア | がんのための併用療法におけるｃｄ４０およびｃｄ１３７に対する多重特異性結合剤 |
| EP4412814A1 (en) | 2021-10-08 | 2024-08-14 | 3M Innovative Properties Company | Slot die assembly with tuned stiffness, reduced draw zone, and force budget |
| TW202333802A (zh) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | 用於肺癌之治療性rna(二) |
| US20250051440A1 (en) | 2021-12-14 | 2025-02-13 | Institut National de la Santé et de la Recherche Médicale | Depletion of nk cells for the treatment of adverse post-ischemic cardiac remodeling |
| CN118660964A (zh) | 2021-12-16 | 2024-09-17 | 瓦莱里奥治疗公司 | 新型缀合核酸分子及其用途 |
| JP2025509749A (ja) | 2022-03-18 | 2025-04-11 | ブリストル－マイヤーズ スクイブ カンパニー | ポリペプチドの単離方法 |
| JP2025518785A (ja) | 2022-06-02 | 2025-06-19 | ブリストル－マイヤーズ スクイブ カンパニー | 抗体組成物及びその使用方法 |
| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
| WO2024026385A1 (en) * | 2022-07-28 | 2024-02-01 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Inhibition of kir2dl2 and/or kir2dl3 for the enhancement of adoptive immunotherapies |
| WO2024090458A1 (ja) * | 2022-10-25 | 2024-05-02 | 第一三共株式会社 | 抑制型ｋｉｒに対するアゴニストを用いた免疫拒絶の回避方法 |
| WO2024126457A1 (en) | 2022-12-14 | 2024-06-20 | Astellas Pharma Europe Bv | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and immune checkpoint inhibitors |
| WO2025038763A1 (en) | 2023-08-15 | 2025-02-20 | Bristol-Myers Squibb Company | Ceramic hydroxyapatite chromatography flow through method |
| WO2025121445A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| WO2025120867A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies |
| WO2025120866A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| US20250215087A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg depleting agent |
| CN117883553B (zh) * | 2024-01-12 | 2024-08-27 | 成都医学院 | Pml-1蛋白在制备抑制细胞因子风暴的药物中的应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5660827A (en) | 1992-03-05 | 1997-08-26 | Board Of Regents, The University Of Texas System | Antibodies that bind to endoglin |
| US5539094A (en) | 1993-11-12 | 1996-07-23 | La Jolla Cancer Research Foundation | DNA encoding Bcl-2-associated proteins |
| IL108501A (en) * | 1994-01-31 | 1998-10-30 | Mor Research Applic Ltd | Antibodies and pharmaceutical compositions containing them |
| US5583034A (en) | 1994-02-22 | 1996-12-10 | La Jolla Institute For Allergy And Immunology | Enhancement of adoptosis using antisense oligonucleotides |
| US5808028A (en) | 1994-05-24 | 1998-09-15 | The United States Of America As Represented By The Department Of Health And Human Services | Molecular clone of a P58 receptor protein and uses thereof |
| NZ298145A (en) | 1994-12-29 | 1998-08-26 | Yamanouchi Pharma Co Ltd | Monoclonal antibodies having inhibitory effect on type ii phospholipase a2, proteins forming part thereof, cells producing them, dna encoding them, recombinant vector comprising the dna and medicament |
| US6750044B1 (en) | 1996-10-17 | 2004-06-15 | Genentech, Inc. | Variants of vascular endothelial cell growth factor having antagonistic properties, nucleic acids encoding the same and host cells comprising those nucleic acids |
| ES2270638T3 (es) | 1998-10-29 | 2007-04-01 | Dakocytomation Denmark A/S | Deteccion de microorganismos acido-resistentes en las heces. |
| MXPA01010891A (es) | 1999-04-28 | 2002-11-07 | Univ Texas | Composiciones y metodos para el tratamiento contra el cancer mediante la inhibicion selectiva del factor de crecimiento endotelial vascular (vegf). |
| KR100419555B1 (ko) | 2000-05-29 | 2004-02-19 | 주식회사유한양행 | 비형간염바이러스의 에스-표면항원을 인식하는단일클론항체의 가변영역 및 이를 코딩하는 유전자 |
| US7803376B2 (en) * | 2003-07-24 | 2010-09-28 | Innate Pharma S.A. | Methods and compositions for increasing the efficiency of therapeutic antibodies using NK cell potentiating compounds |
| WO2006003179A2 (en) * | 2004-07-01 | 2006-01-12 | Novo Nordisk A/S | Antibodies binding to receptors kir2dl1, -2, 3 but not kir2ds4 and their therapeutic use |
| MX2007007935A (es) | 2004-12-28 | 2007-12-06 | Innate Pharma Sa | Anticuerpos monoclonales contra nkg2a. |
| JP5154949B2 (ja) * | 2005-01-06 | 2013-02-27 | ノヴォ ノルディスク アー／エス | ウイルス感染を治療するための組成物および方法 |
| US20090196850A1 (en) | 2005-01-06 | 2009-08-06 | Novo Nordisk A/S | Anti-Kir Combination Treatments and Methods |
| EP1836225B1 (en) | 2005-01-06 | 2011-11-02 | Novo Nordisk A/S | Kir-binding agents and methods of use thereof |
| US9447185B2 (en) | 2005-10-14 | 2016-09-20 | Innate Pharma, S.A. | Compositions and methods for treating proliferative disorders |
| ES2579768T3 (es) | 2007-01-11 | 2016-08-16 | Novo Nordisk A/S | Anticuerpos anti-KIR, formulaciones y usos de los mismos |
| EA036545B1 (ru) * | 2011-05-25 | 2020-11-20 | Иннейт Фарма, С.А. | Анти-kir антитела для лечения воспалительных заболеваний |
| WO2014066532A1 (en) * | 2012-10-23 | 2014-05-01 | Bristol-Myers Squibb Company | Combination of anti-kir and anti-ctla-4 antibodies to treat cancer |
| EP3066128B1 (en) * | 2013-11-06 | 2018-10-31 | Bristol-Myers Squibb Company | Combination of anti-kir and anti-cs1 antibodies to treat multiple myeloma |
| US9884593B2 (en) * | 2015-02-12 | 2018-02-06 | Pro-Gard Products, Llc | Weapon mounting system |
-
2004
- 2004-07-01 KR KR1020067000025A patent/KR20060079180A/ko not_active Ceased
- 2004-07-01 KR KR1020127013323A patent/KR101420344B1/ko not_active Expired - Lifetime
- 2004-07-01 EP EP10178580.6A patent/EP2289939B1/en not_active Expired - Lifetime
- 2004-07-01 EP EP04744115A patent/EP1639013B1/en not_active Expired - Lifetime
- 2004-07-01 KR KR1020137013482A patent/KR101444717B1/ko not_active Expired - Lifetime
- 2004-07-01 ES ES10178580T patent/ES2725526T3/es not_active Expired - Lifetime
- 2004-07-01 DE DE602004030464T patent/DE602004030464D1/de not_active Expired - Lifetime
- 2004-07-01 RU RU2005140152/13A patent/RU2376315C2/ru active
- 2004-07-01 US US10/563,045 patent/US9902936B2/en active Active
- 2004-07-01 CA CA2530272A patent/CA2530272C/en not_active Expired - Lifetime
- 2004-07-01 ES ES04744115T patent/ES2393485T3/es not_active Expired - Lifetime
- 2004-07-01 DK DK04744115.9T patent/DK1639013T3/da active
- 2004-07-01 MX MXPA05013923A patent/MXPA05013923A/es active IP Right Grant
- 2004-07-01 AT AT04738967T patent/ATE490984T1/de not_active IP Right Cessation
- 2004-07-01 AU AU2004253630A patent/AU2004253630B2/en not_active Expired
- 2004-07-01 DK DK04738967.1T patent/DK1673397T3/da active
- 2004-07-01 JP JP2006516606A patent/JP4871125B2/ja not_active Expired - Lifetime
- 2004-07-01 BR BRPI0412138A patent/BRPI0412138B8/pt not_active IP Right Cessation
- 2004-07-01 HR HRP20120845TT patent/HRP20120845T1/hr unknown
- 2004-07-01 BR BRPI0412153A patent/BRPI0412153B8/pt not_active IP Right Cessation
- 2004-07-01 JP JP2006515738A patent/JP5015592B2/ja not_active Expired - Lifetime
- 2004-07-01 CN CN201310392765.XA patent/CN103467602B/zh not_active Expired - Lifetime
- 2004-07-01 KR KR1020067000109A patent/KR101375153B1/ko not_active Expired - Lifetime
- 2004-07-01 WO PCT/IB2004/002464 patent/WO2005003172A2/en not_active Ceased
- 2004-07-01 KR KR1020127002275A patent/KR101325023B1/ko not_active Expired - Lifetime
- 2004-07-01 EP EP04738967A patent/EP1673397B1/en not_active Expired - Lifetime
- 2004-07-01 PT PT47441159T patent/PT1639013E/pt unknown
- 2004-07-01 AU AU2004253770A patent/AU2004253770C1/en not_active Expired
- 2004-07-01 CA CA002530591A patent/CA2530591A1/en not_active Abandoned
- 2004-07-01 CN CN201310057089.0A patent/CN103588880B/zh not_active Expired - Lifetime
- 2004-07-01 WO PCT/DK2004/000470 patent/WO2005003168A2/en not_active Ceased
- 2004-07-01 PL PL04744115T patent/PL1639013T3/pl unknown
- 2004-07-01 RU RU2006102960/10A patent/RU2404993C2/ru active
-
2005
- 2005-12-15 IL IL172613A patent/IL172613A/en active IP Right Grant
- 2005-12-19 NO NO20056048A patent/NO338818B1/no unknown
- 2005-12-20 IL IL172700A patent/IL172700A/en active IP Right Grant
-
2006
- 2006-02-01 NO NO20060528A patent/NO338255B1/no unknown
-
2012
- 2012-04-06 JP JP2012087648A patent/JP5826697B2/ja not_active Expired - Lifetime
- 2012-11-28 CY CY20121101151T patent/CY1113394T1/el unknown
-
2015
- 2015-03-04 JP JP2015042824A patent/JP6556465B2/ja not_active Expired - Lifetime
- 2015-04-28 IL IL238490A patent/IL238490A0/en unknown
-
2016
- 2016-02-16 NO NO20160264A patent/NO342318B1/no unknown
- 2016-03-10 NO NO20160411A patent/NO343342B1/no unknown
-
2018
- 2018-01-22 US US15/876,839 patent/US11365393B2/en active Active
- 2018-04-16 JP JP2018078329A patent/JP2018153185A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015163068A5 (OSRAM) | ||
| US10836829B2 (en) | Anti-WT1/HLA-specific antibodies | |
| JP2018510636A5 (OSRAM) | ||
| JP2017535257A5 (OSRAM) | ||
| JP2012176953A5 (OSRAM) | ||
| JP2006502699A5 (OSRAM) | ||
| JP2020525032A5 (OSRAM) | ||
| JP2013198490A5 (OSRAM) | ||
| CN112969476B (zh) | 多特异性蛋白分子 | |
| JP2020504076A5 (OSRAM) | ||
| RU2016100892A (ru) | Антитела против tweakr и их применение | |
| JP2017149720A5 (OSRAM) | ||
| JP2016533763A5 (ja) | ヒトｐｄ−１に特異的に結合する抗体抗原結合ドメインおよびそれを含む医薬組成物 | |
| JP2018517431A5 (OSRAM) | ||
| KR20140014064A (ko) | 신규한 조절 인자 및 사용 방법 | |
| JP2018506961A5 (OSRAM) | ||
| RU2018107658A (ru) | Новые антитела против pd-l1 | |
| HRP20241381T1 (hr) | Nova anti-pd-1 protutijela | |
| CN107405397A (zh) | 抗tim‑3抗体 | |
| JP2018500014A5 (OSRAM) | ||
| JP2020514277A5 (OSRAM) | ||
| JP2015533853A5 (OSRAM) | ||
| JP2017500057A5 (OSRAM) | ||
| JP2021502984A5 (OSRAM) | ||
| JP2018528776A5 (OSRAM) |