JP2012532628A5 - - Google Patents
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- JP2012532628A5 JP2012532628A5 JP2012520702A JP2012520702A JP2012532628A5 JP 2012532628 A5 JP2012532628 A5 JP 2012532628A5 JP 2012520702 A JP2012520702 A JP 2012520702A JP 2012520702 A JP2012520702 A JP 2012520702A JP 2012532628 A5 JP2012532628 A5 JP 2012532628A5
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- JP
- Japan
- Prior art keywords
- patient
- antagonist
- expression level
- vegf
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000014509 gene expression Effects 0.000 claims description 450
- 239000005557 antagonist Substances 0.000 claims description 411
- 239000000523 sample Substances 0.000 claims description 361
- 238000000034 method Methods 0.000 claims description 305
- 238000011282 treatment Methods 0.000 claims description 295
- 108090000623 proteins and genes Proteins 0.000 claims description 206
- 239000013074 reference sample Substances 0.000 claims description 203
- 108010073923 Vascular Endothelial Growth Factor C Proteins 0.000 claims description 135
- 102100038232 Vascular endothelial growth factor C Human genes 0.000 claims description 135
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 97
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 claims description 97
- 206010028980 Neoplasm Diseases 0.000 claims description 86
- 201000011510 cancer Diseases 0.000 claims description 86
- 210000004027 cell Anatomy 0.000 claims description 72
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 72
- 230000002062 proliferating effect Effects 0.000 claims description 72
- 229940121695 NRP 1 antagonist Drugs 0.000 claims description 58
- -1 cMet Proteins 0.000 claims description 56
- 238000011319 anticancer therapy Methods 0.000 claims description 55
- 102000009123 Fibrin Human genes 0.000 claims description 50
- 108010073385 Fibrin Proteins 0.000 claims description 50
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 50
- 229950003499 fibrin Drugs 0.000 claims description 50
- 102100035290 Fibroblast growth factor 13 Human genes 0.000 claims description 43
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims description 43
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims description 43
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 claims description 43
- 102100037421 Regulator of G-protein signaling 5 Human genes 0.000 claims description 43
- 101710140403 Regulator of G-protein signaling 5 Proteins 0.000 claims description 43
- FOCAHLGSDWHSAH-UHFFFAOYSA-N difluoromethanethione Chemical compound FC(F)=S FOCAHLGSDWHSAH-UHFFFAOYSA-N 0.000 claims description 43
- 108090000772 Neuropilin-1 Proteins 0.000 claims description 42
- 230000001225 therapeutic effect Effects 0.000 claims description 41
- 102100040681 Platelet-derived growth factor C Human genes 0.000 claims description 40
- 108010017992 platelet-derived growth factor C Proteins 0.000 claims description 40
- 102100039398 C-X-C motif chemokine 2 Human genes 0.000 claims description 34
- 102100021866 Hepatocyte growth factor Human genes 0.000 claims description 34
- 101000889128 Homo sapiens C-X-C motif chemokine 2 Proteins 0.000 claims description 34
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims description 25
- 102100037665 Fibroblast growth factor 9 Human genes 0.000 claims description 25
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims description 25
- 101001027380 Homo sapiens Fibroblast growth factor 9 Proteins 0.000 claims description 25
- 101000947695 Homo sapiens Microfibrillar-associated protein 5 Proteins 0.000 claims description 25
- 102100036203 Microfibrillar-associated protein 5 Human genes 0.000 claims description 25
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 25
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 25
- 101710183446 C-type lectin domain family 4 member E Proteins 0.000 claims description 16
- 101000898034 Homo sapiens Hepatocyte growth factor Proteins 0.000 claims description 16
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 claims description 16
- 101000610543 Homo sapiens Prokineticin-2 Proteins 0.000 claims description 16
- 101000868152 Homo sapiens Son of sevenless homolog 1 Proteins 0.000 claims description 16
- 102100040125 Prokineticin-2 Human genes 0.000 claims description 16
- 102000004169 proteins and genes Human genes 0.000 claims description 15
- 102100028067 EGF-containing fibulin-like extracellular matrix protein 2 Human genes 0.000 claims description 10
- 101001060248 Homo sapiens EGF-containing fibulin-like extracellular matrix protein 2 Proteins 0.000 claims description 10
- 210000004369 blood Anatomy 0.000 claims description 10
- 239000008280 blood Substances 0.000 claims description 10
- 229960000397 bevacizumab Drugs 0.000 claims description 9
- 229940124650 anti-cancer therapies Drugs 0.000 claims description 8
- 108020004999 messenger RNA Proteins 0.000 claims description 5
- 210000004180 plasmocyte Anatomy 0.000 claims description 5
- 210000002966 serum Anatomy 0.000 claims description 5
- 102000012545 EGF-like domains Human genes 0.000 claims description 2
- 108050002150 EGF-like domains Proteins 0.000 claims description 2
- 108020004459 Small interfering RNA Proteins 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 150000003384 small molecules Chemical class 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 14
- 239000002246 antineoplastic agent Substances 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 102100023068 Protein kinase C-binding protein NELL1 Human genes 0.000 claims 3
- 229940126585 therapeutic drug Drugs 0.000 claims 2
- 208000035475 disorder Diseases 0.000 description 69
- 150000001875 compounds Chemical class 0.000 description 53
- 230000004043 responsiveness Effects 0.000 description 47
- 102000004207 Neuropilin-1 Human genes 0.000 description 39
- 108010082093 Placenta Growth Factor Proteins 0.000 description 36
- 102100035194 Placenta growth factor Human genes 0.000 description 36
- 108091033319 polynucleotide Proteins 0.000 description 20
- 102000040430 polynucleotide Human genes 0.000 description 20
- 239000002157 polynucleotide Substances 0.000 description 20
- 101000851030 Homo sapiens Vascular endothelial growth factor receptor 3 Proteins 0.000 description 18
- 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 description 18
- 101150042788 PROK2 gene Proteins 0.000 description 18
- 102000013008 Semaphorin-3A Human genes 0.000 description 18
- 108010090319 Semaphorin-3A Proteins 0.000 description 18
- 108010073919 Vascular Endothelial Growth Factor D Proteins 0.000 description 18
- 102100038234 Vascular endothelial growth factor D Human genes 0.000 description 18
- 102100033179 Vascular endothelial growth factor receptor 3 Human genes 0.000 description 18
- 102100021943 C-C motif chemokine 2 Human genes 0.000 description 9
- 102100036150 C-X-C motif chemokine 5 Human genes 0.000 description 9
- 101150066399 COL4A1 gene Proteins 0.000 description 9
- 102100029761 Cadherin-5 Human genes 0.000 description 9
- 102100021860 Endothelial cell-specific molecule 1 Human genes 0.000 description 9
- 102100037680 Fibroblast growth factor 8 Human genes 0.000 description 9
- 108010001498 Galectin 1 Proteins 0.000 description 9
- 102000000795 Galectin 1 Human genes 0.000 description 9
- 102100039555 Galectin-7 Human genes 0.000 description 9
- 102100034221 Growth-regulated alpha protein Human genes 0.000 description 9
- 101000897480 Homo sapiens C-C motif chemokine 2 Proteins 0.000 description 9
- 101000947186 Homo sapiens C-X-C motif chemokine 5 Proteins 0.000 description 9
- 101000794587 Homo sapiens Cadherin-5 Proteins 0.000 description 9
- 101000897959 Homo sapiens Endothelial cell-specific molecule 1 Proteins 0.000 description 9
- 101001027382 Homo sapiens Fibroblast growth factor 8 Proteins 0.000 description 9
- 101000608772 Homo sapiens Galectin-7 Proteins 0.000 description 9
- 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 description 9
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 description 9
- 101000659879 Homo sapiens Thrombospondin-1 Proteins 0.000 description 9
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 9
- 102000004890 Interleukin-8 Human genes 0.000 description 9
- 108090001007 Interleukin-8 Proteins 0.000 description 9
- 102100036034 Thrombospondin-1 Human genes 0.000 description 9
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 9
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 9
- 102000013127 Vimentin Human genes 0.000 description 9
- 108010065472 Vimentin Proteins 0.000 description 9
- 210000005048 vimentin Anatomy 0.000 description 9
- 101150097704 HHEX gene Proteins 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 3
- 101001082391 Aspergillus oryzae Beta-hexosaminidase Proteins 0.000 description 1
- 101600105505 Mus musculus Vascular endothelial growth factor C (isoform 1) Proteins 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 230000004044 response Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22512009P | 2009-07-13 | 2009-07-13 | |
| US61/225,120 | 2009-07-13 | ||
| US35173310P | 2010-06-04 | 2010-06-04 | |
| US61/351,733 | 2010-06-04 | ||
| PCT/US2010/041706 WO2011008696A2 (en) | 2009-07-13 | 2010-07-12 | Diagnostic methods and compositions for treatment of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016255038A Division JP2017099389A (ja) | 2009-07-13 | 2016-12-28 | 癌治療のための診断方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012532628A JP2012532628A (ja) | 2012-12-20 |
| JP2012532628A5 true JP2012532628A5 (enExample) | 2013-08-22 |
| JP6095367B2 JP6095367B2 (ja) | 2017-03-15 |
Family
ID=43227992
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012520702A Expired - Fee Related JP6095367B2 (ja) | 2009-07-13 | 2010-07-12 | 癌治療のための診断方法および組成物 |
| JP2016255038A Pending JP2017099389A (ja) | 2009-07-13 | 2016-12-28 | 癌治療のための診断方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016255038A Pending JP2017099389A (ja) | 2009-07-13 | 2016-12-28 | 癌治療のための診断方法および組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20110076271A1 (enExample) |
| EP (1) | EP2454380A2 (enExample) |
| JP (2) | JP6095367B2 (enExample) |
| KR (1) | KR20120106935A (enExample) |
| CN (2) | CN102482715A (enExample) |
| AU (1) | AU2010273585B2 (enExample) |
| BR (1) | BR112012000735A2 (enExample) |
| CA (1) | CA2766403A1 (enExample) |
| HK (1) | HK1226108A1 (enExample) |
| IL (1) | IL216926A0 (enExample) |
| MX (1) | MX2012000620A (enExample) |
| SG (2) | SG177640A1 (enExample) |
| WO (1) | WO2011008696A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011153224A2 (en) * | 2010-06-02 | 2011-12-08 | Genentech, Inc. | Diagnostic methods and compositions for treatment of cancer |
| US9255927B2 (en) | 2011-05-05 | 2016-02-09 | Duke University | Methods of developing a prognosis for pancreatic cancer and predicting responsiveness to cancer therapeutics |
| KR20140108718A (ko) * | 2011-12-29 | 2014-09-12 | 베일러 리서치 인스티튜트 | 가와사키 질환용 바이오마커 |
| EP2802346B1 (en) | 2012-01-13 | 2018-09-12 | F.Hoffmann-La Roche Ag | Biological markers for identifying patients for treatment with vegf antagonists |
| US20150056190A1 (en) * | 2012-03-30 | 2015-02-26 | Genentech, Inc. | Diagnostic methods and compositions for treatment of cancer |
| KR20150024342A (ko) * | 2012-06-26 | 2015-03-06 | 에프. 호프만-라 로슈 아게 | 유방암을 치료하기 위한 베바시주맙 조합 요법에 대한 혈장 바이오마커 |
| ES2776029T3 (es) | 2012-10-08 | 2020-07-28 | St Jude Childrens Res Hospital | Terapias basadas en el control de la estabilidad y función de las células T reguladoras por medio de un eje neuropilina-1:semaforina |
| JP2016525358A (ja) * | 2013-07-23 | 2016-08-25 | ジェネンテック， インコーポレイテッド | 結腸直腸がんのモデル |
| CN103911451A (zh) * | 2014-04-11 | 2014-07-09 | 蒋晓东 | 筛选抗血管生成靶向药物治疗肺癌目标人群的方法 |
| SI3170005T1 (sl) * | 2014-07-18 | 2019-08-30 | Sanofi | Postopek napovedovanja izida zdravljenja z afliberceptom, pacienta, pri katerem obstaja sum, da je zbolel za rakom |
| CA2969402C (en) * | 2014-12-03 | 2019-06-11 | Samsung Life Public Welfare Foundation | Antibody binding to neuropilin 1 and use thereof |
| US10801068B2 (en) | 2015-10-16 | 2020-10-13 | The Trustees Of Columbia University In The City Of New York | JAG1 expression predicts therapeutic response in NASH |
| CA3019412A1 (en) * | 2016-03-29 | 2017-10-05 | Universite Paris 7-Denis Diderot | Compositions comprising secreted extracellular vesicles of cells expressing nfatc4 useful for the treatment of cancer |
| CN109154027A (zh) * | 2016-04-15 | 2019-01-04 | 豪夫迈·罗氏有限公司 | 用于监测和治疗癌症的方法 |
| WO2017201166A1 (en) | 2016-05-17 | 2017-11-23 | Duke University | Methods of predicting responsiveness of a cancer to a vegf targeting agent and methods of prognosing and treating cancer |
| SG11201810775SA (en) * | 2016-06-03 | 2019-01-30 | Samsung Life Public Welfare Foundation | Anti-nrp1 antibody screening method |
| CN106282376A (zh) * | 2016-09-27 | 2017-01-04 | 上海交通大学医学院附属第九人民医院 | 一种用于检测bmp9基因表达的反义rna探针 |
| JP2020503872A (ja) * | 2017-01-09 | 2020-02-06 | セカルナ・ファーマシューティカルズ・ゲーエムベーハー・ウント・コ・カーゲー | Ｎｒｐ１の発現を阻害するオリゴヌクレオチド |
| CN110546277B (zh) | 2017-03-01 | 2024-06-11 | 豪夫迈·罗氏有限公司 | 用于癌症的诊断和治疗方法 |
| CN109828111A (zh) * | 2017-11-23 | 2019-05-31 | 复旦大学附属肿瘤医院 | MFAP5在制备筛选α干扰素干预肝癌敏感人群标志物的制剂中的用途 |
| CN109828114A (zh) * | 2017-11-23 | 2019-05-31 | 复旦大学附属肿瘤医院 | MFAP5蛋白作为筛选α干扰素治疗肝癌敏感人群的试剂盒中的方法及应用 |
| EP3837550A1 (en) * | 2018-08-17 | 2021-06-23 | Roche Diagnostics GmbH | Circulating bmp10 (bone morphogenic protein 10) in the assessment of atrial fibrillation |
| CN110893238A (zh) * | 2018-09-13 | 2020-03-20 | 常州大学 | 抑制血管内皮生长因子活性和表达量的物质在制备抑制淋巴结转移的产品中的应用 |
| MY205168A (en) * | 2018-10-23 | 2024-10-04 | Regeneron Pharma | Anti-npr1 antibodies and uses thereof |
| CN112213495B (zh) * | 2020-09-18 | 2022-10-28 | 广州中医药大学第三附属医院(广州中医药大学第三临床医学院、广州中医药大学附属骨伤科医院、广州中医药大学骨伤科研究所) | 一种辅助诊断或诊断股骨头坏死的标志物 |
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2010
- 2010-07-12 CA CA2766403A patent/CA2766403A1/en not_active Abandoned
- 2010-07-12 CN CN2010800365602A patent/CN102482715A/zh active Pending
- 2010-07-12 SG SG2012002432A patent/SG177640A1/en unknown
- 2010-07-12 JP JP2012520702A patent/JP6095367B2/ja not_active Expired - Fee Related
- 2010-07-12 US US12/834,523 patent/US20110076271A1/en not_active Abandoned
- 2010-07-12 BR BR112012000735A patent/BR112012000735A2/pt not_active IP Right Cessation
- 2010-07-12 KR KR1020127003607A patent/KR20120106935A/ko not_active Ceased
- 2010-07-12 WO PCT/US2010/041706 patent/WO2011008696A2/en not_active Ceased
- 2010-07-12 MX MX2012000620A patent/MX2012000620A/es unknown
- 2010-07-12 SG SG10201510152RA patent/SG10201510152RA/en unknown
- 2010-07-12 AU AU2010273585A patent/AU2010273585B2/en not_active Ceased
- 2010-07-12 CN CN201610767315.8A patent/CN106148547A/zh active Pending
- 2010-07-12 EP EP10731915A patent/EP2454380A2/en not_active Withdrawn
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2011
- 2011-12-13 IL IL216926A patent/IL216926A0/en unknown
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2012
- 2012-08-18 HK HK16114547.1A patent/HK1226108A1/zh unknown
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2013
- 2013-07-10 US US13/938,535 patent/US20140302056A2/en not_active Abandoned
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2016
- 2016-12-28 JP JP2016255038A patent/JP2017099389A/ja active Pending
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