CN102482715A - 用于癌症治疗的诊断方法和组合物 - Google Patents

用于癌症治疗的诊断方法和组合物 Download PDF

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Publication number
CN102482715A
CN102482715A CN2010800365602A CN201080036560A CN102482715A CN 102482715 A CN102482715 A CN 102482715A CN 2010800365602 A CN2010800365602 A CN 2010800365602A CN 201080036560 A CN201080036560 A CN 201080036560A CN 102482715 A CN102482715 A CN 102482715A
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patient
antagonist
vegf
expression level
treatment
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Chinese (zh)
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M.施米特
L.桑德斯
R.拉贾
R.D.帕特尔
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Priority to CN201610767315.8A priority Critical patent/CN106148547A/zh
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN2010800365602A 2009-07-13 2010-07-12 用于癌症治疗的诊断方法和组合物 Pending CN102482715A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610767315.8A CN106148547A (zh) 2009-07-13 2010-07-12 用于癌症治疗的诊断方法和组合物

Applications Claiming Priority (5)

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US22512009P 2009-07-13 2009-07-13
US61/225,120 2009-07-13
US35173310P 2010-06-04 2010-06-04
US61/351,733 2010-06-04
PCT/US2010/041706 WO2011008696A2 (en) 2009-07-13 2010-07-12 Diagnostic methods and compositions for treatment of cancer

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US (2) US20110076271A1 (enExample)
EP (1) EP2454380A2 (enExample)
JP (2) JP6095367B2 (enExample)
KR (1) KR20120106935A (enExample)
CN (2) CN102482715A (enExample)
AU (1) AU2010273585B2 (enExample)
BR (1) BR112012000735A2 (enExample)
CA (1) CA2766403A1 (enExample)
HK (1) HK1226108A1 (enExample)
IL (1) IL216926A0 (enExample)
MX (1) MX2012000620A (enExample)
SG (2) SG177640A1 (enExample)
WO (1) WO2011008696A2 (enExample)

Cited By (11)

* Cited by examiner, † Cited by third party
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CN103911451A (zh) * 2014-04-11 2014-07-09 蒋晓东 筛选抗血管生成靶向药物治疗肺癌目标人群的方法
CN104364655A (zh) * 2012-06-26 2015-02-18 霍夫曼-拉罗奇有限公司 贝伐单抗组合疗法用于治疗乳腺癌的血浆生物标志物
CN105377310A (zh) * 2013-07-23 2016-03-02 豪夫迈·罗氏有限公司 结直肠癌的模型
CN106282376A (zh) * 2016-09-27 2017-01-04 上海交通大学医学院附属第九人民医院 一种用于检测bmp9基因表达的反义rna探针
CN107108743A (zh) * 2014-12-03 2017-08-29 社会福祉法人三星生命公益财团 针对神经毡蛋白1的抗体及其用途
CN109154027A (zh) * 2016-04-15 2019-01-04 豪夫迈·罗氏有限公司 用于监测和治疗癌症的方法
CN109416363A (zh) * 2016-06-03 2019-03-01 社会福祉法人三星生命公益财团 抗nrp1抗体筛选方法
CN109828114A (zh) * 2017-11-23 2019-05-31 复旦大学附属肿瘤医院 MFAP5蛋白作为筛选α干扰素治疗肝癌敏感人群的试剂盒中的方法及应用
CN110087676A (zh) * 2016-03-29 2019-08-02 巴黎大学迪德罗特第七分校 用于治疗癌症的包含表达nfatc4的细胞的分泌性胞外囊泡的组合物
CN110893238A (zh) * 2018-09-13 2020-03-20 常州大学 抑制血管内皮生长因子活性和表达量的物质在制备抑制淋巴结转移的产品中的应用
US11402382B2 (en) 2017-03-01 2022-08-02 Genentech, Inc. Diagnostic and therapeutic methods for cancer

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WO2013101758A1 (en) * 2011-12-29 2013-07-04 Baylor Research Institute Biomarkers for kawasaki disease
MX356802B (es) 2012-01-13 2018-06-13 Genentech Inc Marcadores biologicos para identificar pacientes para tratamiento con antagonistas de vegf.
SG11201406184XA (en) * 2012-03-30 2014-10-30 Genentech Inc Diagnostic methods and compositions for treatment of cancer
WO2014058915A2 (en) 2012-10-08 2014-04-17 St. Jude Children's Research Hospital Therapies based on control of regulatory t cell stability and function via a neuropilin-1:semaphorin axis
PT3170005T (pt) * 2014-07-18 2019-07-16 Sanofi Sa Método para a previsão do resultado de um tratamento com aflibercept de um paciente suspeito de sofrer de um cancro
US10801068B2 (en) 2015-10-16 2020-10-13 The Trustees Of Columbia University In The City Of New York JAG1 expression predicts therapeutic response in NASH
WO2017201166A1 (en) 2016-05-17 2017-11-23 Duke University Methods of predicting responsiveness of a cancer to a vegf targeting agent and methods of prognosing and treating cancer
WO2018127599A1 (en) * 2017-01-09 2018-07-12 Secarna Pharmaceuticals Gmbh & Co Kg Oligonucleotides inhibiting the expression of nrp1
CN109828111A (zh) * 2017-11-23 2019-05-31 复旦大学附属肿瘤医院 MFAP5在制备筛选α干扰素干预肝癌敏感人群标志物的制剂中的用途
KR20210044257A (ko) * 2018-08-17 2021-04-22 에프. 호프만-라 로슈 아게 심방 세동의 평가에서의 순환 bmp10 (골형성 단백질 10)
KR20210082207A (ko) * 2018-10-23 2021-07-02 리제너론 파아마슈티컬스, 인크. 항-npr1 항체 및 이의 용도
CN112213495B (zh) * 2020-09-18 2022-10-28 广州中医药大学第三附属医院(广州中医药大学第三临床医学院、广州中医药大学附属骨伤科医院、广州中医药大学骨伤科研究所) 一种辅助诊断或诊断股骨头坏死的标志物

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