|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
|
RU2601892C2
(ru)
*
|
2008-03-06 |
2016-11-10 |
Дженентек, Инк. |
Комбинированная терапия антагонистами с-мет и egfr
|
|
PE20120591A1
(es)
|
2009-04-02 |
2012-05-23 |
Roche Glycart Ag |
Anticuerpos multiespecificos que comprenden anticuerpos de longitud completa y fragmentos fab de cadena sencilla
|
|
JP5616428B2
(ja)
|
2009-04-07 |
2014-10-29 |
ロシュ グリクアート アクチェンゲゼルシャフト |
三価の二重特異性抗体
|
|
US9676845B2
(en)
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
|
US9493578B2
(en)
|
2009-09-02 |
2016-11-15 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
KR20120108967A
(ko)
|
2009-09-16 |
2012-10-05 |
제넨테크, 인크. |
코일드 코일 및/또는 테더 함유 단백질 복합체 및 그의 용도
|
|
TW201138821A
(en)
|
2010-03-26 |
2011-11-16 |
Roche Glycart Ag |
Bispecific antibodies
|
|
EP3029066B1
(en)
|
2010-07-29 |
2019-02-20 |
Xencor, Inc. |
Antibodies with modified isoelectric points
|
|
SG10201912639SA
(en)
*
|
2010-08-02 |
2020-02-27 |
Regeneron Pharma |
Mice that make binding proteins comprising vl domains
|
|
WO2012025530A1
(en)
|
2010-08-24 |
2012-03-01 |
F. Hoffmann-La Roche Ag |
Bispecific antibodies comprising a disulfide stabilized - fv fragment
|
|
KR20130103734A
(ko)
|
2010-08-31 |
2013-09-24 |
제넨테크, 인크. |
바이오마커 및 치료 방법
|
|
KR20140019284A
(ko)
|
2010-09-03 |
2014-02-14 |
아카데미아 시니카 |
항-C-Met 항체 및 이의 이용 방법들
|
|
PL2635607T3
(pl)
*
|
2010-11-05 |
2020-05-18 |
Zymeworks Inc. |
Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC
|
|
JP5766296B2
(ja)
|
2010-12-23 |
2015-08-19 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
|
|
JP5768147B2
(ja)
*
|
2011-02-28 |
2015-08-26 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
一価抗原結合タンパク質
|
|
WO2012116926A1
(en)
|
2011-02-28 |
2012-09-07 |
F. Hoffmann-La Roche Ag |
Antigen binding proteins
|
|
IN2013MN01438A
(https=)
*
|
2011-03-17 |
2015-06-12 |
Univ Ramot |
|
|
EP2694972B8
(en)
*
|
2011-04-04 |
2017-08-16 |
Pierian Holdings, Inc. |
Methods for predicting and improving the survival of gastric cancer patients
|
|
WO2013026835A1
(en)
*
|
2011-08-23 |
2013-02-28 |
Roche Glycart Ag |
Fc-free antibodies comprising two fab fragments and methods of use
|
|
MY169358A
(en)
*
|
2011-08-23 |
2019-03-26 |
Roche Glycart Ag |
Bispecific t cell activating antigen binding molecules
|
|
BR112014004168A2
(pt)
|
2011-08-23 |
2017-12-12 |
Roche Glycart Ag |
anticorpo biespecífico, composição farmacêutica, uso do anticorpo biespecífico, célula hospedeira procariótica ou eucariótica, método de produção de anticorpo e invenção
|
|
WO2013026837A1
(en)
*
|
2011-08-23 |
2013-02-28 |
Roche Glycart Ag |
Bispecific t cell activating antigen binding molecules
|
|
MX349095B
(es)
*
|
2011-08-23 |
2017-07-11 |
Roche Glycart Ag |
Moleculas biespecificas de union a antigeno.
|
|
EP2748197A2
(en)
*
|
2011-08-26 |
2014-07-02 |
Merrimack Pharmaceuticals, Inc. |
Tandem fc bispecific antibodies
|
|
KR20130037153A
(ko)
*
|
2011-10-05 |
2013-04-15 |
삼성전자주식회사 |
항 ｃ-Ｍｅｔ 항체 및 그의 용도
|
|
US12466897B2
(en)
|
2011-10-10 |
2025-11-11 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
GB2504139B
(en)
|
2012-07-20 |
2014-12-31 |
Argen X Bv |
Antibodies to highly conserved targets produced by the immunisation of Camelidae species
|
|
CA2854233C
(en)
|
2011-11-04 |
2020-05-12 |
Zymeworks Inc. |
Stable heterodimeric antibody design with mutations in the fc domain
|
|
KR101963230B1
(ko)
|
2011-12-26 |
2019-03-29 |
삼성전자주식회사 |
복수개의 단일 항체를 포함하는 단백질 복합체
|
|
WO2013119966A2
(en)
|
2012-02-10 |
2013-08-15 |
Genentech, Inc. |
Single-chain antibodies and other heteromultimers
|
|
US9062120B2
(en)
|
2012-05-02 |
2015-06-23 |
Janssen Biotech, Inc. |
Binding proteins having tethered light chains
|
|
WO2014004586A1
(en)
|
2012-06-25 |
2014-01-03 |
Zymeworks Inc. |
Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
|
|
TWI641619B
(zh)
*
|
2012-06-25 |
2018-11-21 |
美商再生元醫藥公司 |
抗－ｅｇｆｒ抗體及其用途
|
|
MX354862B
(es)
|
2012-06-27 |
2018-03-23 |
Hoffmann La Roche |
Método para la producción de entidades dirigidas altamente selectivas hechas a la medida y biespecíficas que contienen dos entidades de unión diferentes.
|
|
WO2014001325A1
(en)
|
2012-06-27 |
2014-01-03 |
F. Hoffmann-La Roche Ag |
Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
|
|
CN105121630B
(zh)
|
2012-10-03 |
2018-09-25 |
酵活有限公司 |
定量重链和轻链多肽对的方法
|
|
KR101911438B1
(ko)
|
2012-10-31 |
2018-10-24 |
삼성전자주식회사 |
이중 특이 항원 결합 단백질 복합체 및 이중 특이 항체의 제조 방법
|
|
JP6694712B2
(ja)
|
2012-11-01 |
2020-05-20 |
マックス−デルブルック−セントラム フアー モレキュラーレ メデジン |
Ｃｄ２６９（ｂｃｍａ）に対する抗体
|
|
EP2727941A1
(en)
|
2012-11-05 |
2014-05-07 |
MAB Discovery GmbH |
Method for the production of multispecific antibodies
|
|
US20150259430A1
(en)
|
2012-11-05 |
2015-09-17 |
Mab Discovery Gmbh |
Method for the production of multispecific antibodies
|
|
CN113201073A
(zh)
|
2012-11-21 |
2021-08-03 |
詹森生物科技公司 |
双特异性EGFR/c-Met抗体
|
|
US9695228B2
(en)
*
|
2012-11-21 |
2017-07-04 |
Janssen Biotech, Inc. |
EGFR and c-Met fibronectin type III domain binding molecules
|
|
US20170275367A1
(en)
|
2012-11-21 |
2017-09-28 |
Janssen Biotech, Inc. |
Bispecific EGFR/C-Met Antibodies
|
|
US9914785B2
(en)
|
2012-11-28 |
2018-03-13 |
Zymeworks Inc. |
Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
|
|
EP2925785A4
(en)
|
2012-11-28 |
2016-11-16 |
Zymeworks Inc |
MANIPULATED IMMUNOGLOBULIN HEAVY CHAIN LIGHT CHAIN COUPLES AND USES THEREOF
|
|
US10487155B2
(en)
|
2013-01-14 |
2019-11-26 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10131710B2
(en)
|
2013-01-14 |
2018-11-20 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US9605084B2
(en)
|
2013-03-15 |
2017-03-28 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10968276B2
(en)
|
2013-03-12 |
2021-04-06 |
Xencor, Inc. |
Optimized anti-CD3 variable regions
|
|
US11053316B2
(en)
|
2013-01-14 |
2021-07-06 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
|
CA2898100C
(en)
|
2013-01-14 |
2023-10-10 |
Xencor, Inc. |
Novel heterodimeric proteins
|
|
US9738722B2
(en)
|
2013-01-15 |
2017-08-22 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
|
CN105143270B
(zh)
*
|
2013-02-26 |
2019-11-12 |
罗切格利卡特公司 |
双特异性t细胞活化抗原结合分子
|
|
TW201444872A
(zh)
|
2013-03-06 |
2014-12-01 |
Merrimack Pharmaceuticals Inc |
抗Ｃ－ＭＥＴ串聯Ｆｃ雙特異性抗體
|
|
EP2970486B1
(en)
|
2013-03-15 |
2018-05-16 |
Xencor, Inc. |
Modulation of t cells with bispecific antibodies and fc fusions
|
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10106624B2
(en)
|
2013-03-15 |
2018-10-23 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10519242B2
(en)
|
2013-03-15 |
2019-12-31 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
|
KR102067613B1
(ko)
*
|
2013-03-28 |
2020-01-20 |
삼성전자주식회사 |
항 c-Met 항체 및 항 her2 항체를 포함하는 병용 투여용 조성물
|
|
KR102049991B1
(ko)
*
|
2013-03-28 |
2019-12-02 |
삼성전자주식회사 |
항 c-Met/항 Her2 이중 특이 항체
|
|
KR102049990B1
(ko)
*
|
2013-03-28 |
2019-12-03 |
삼성전자주식회사 |
c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질
|
|
KR102074421B1
(ko)
*
|
2013-03-29 |
2020-02-10 |
삼성전자주식회사 |
항 c-Met/항 EGFR 이중 특이 항체
|
|
CN104211814A
(zh)
|
2013-05-29 |
2014-12-17 |
三星电子株式会社 |
用于消耗靶膜蛋白的组合物
|
|
KR102190220B1
(ko)
*
|
2013-05-29 |
2020-12-14 |
삼성전자주식회사 |
타겟 특이적 세포막 단백질 제거용 조성물
|
|
US9879081B2
(en)
*
|
2013-06-25 |
2018-01-30 |
Samsung Electronics Co., Ltd. |
Protein complex, bispecific antibody including the protein complex, and method of preparation thereof
|
|
KR102236367B1
(ko)
*
|
2013-07-26 |
2021-04-05 |
삼성전자주식회사 |
DARPin을 포함하는 이중 특이 키메라 단백질
|
|
KR102089591B1
(ko)
|
2013-07-29 |
2020-03-18 |
삼성전자주식회사 |
항 EGFR scFv 단편 및 이를 포함하는 항 c-Met/항 EGFR 이중 특이 항체
|
|
KR20160044060A
(ko)
|
2013-10-11 |
2016-04-22 |
에프. 호프만-라 로슈 아게 |
다중특이적 도메인 교환된 통상의 가변 경쇄 항체
|
|
CN105899226B
(zh)
|
2013-10-14 |
2020-05-12 |
詹森生物科技公司 |
半胱氨酸工程化iii型纤连蛋白域结合分子
|
|
EA039356B1
(ru)
*
|
2013-10-18 |
2022-01-18 |
Янссен Байотек, Инк. |
БИСПЕЦИФИЧЕСКИЕ К EGFR/c-Met АНТИТЕЛА
|
|
US9717715B2
(en)
|
2013-11-15 |
2017-08-01 |
Samsung Electronics Co., Ltd. |
Method of combination therapy using an anti-C-Met antibody
|
|
CA2924268C
(en)
*
|
2013-11-21 |
2021-05-18 |
F. Hoffmann-La Roche Ag |
Anti-alpha-synuclein antibodies and methods of use
|
|
HRP20250551T1
(hr)
|
2013-11-27 |
2025-06-20 |
Zymeworks Bc Inc. |
Bispecifični antigen-vezujući konstrukti koji ciljaju her2
|
|
KR102178323B1
(ko)
|
2013-11-29 |
2020-11-13 |
삼성전자주식회사 |
항 c-Met/항 Ang2 이중 특이 항체
|
|
JP6618912B2
(ja)
|
2013-12-20 |
2019-12-11 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
改良された、組換えポリペプチド作製方法
|
|
TW201609805A
(zh)
|
2013-12-23 |
2016-03-16 |
美國禮來大藥廠 |
結合ｅｇｆｒ及ｍｅｔ之多功能抗體
|
|
CA2932547C
(en)
*
|
2014-01-06 |
2023-05-23 |
F. Hoffmann-La Roche Ag |
Monovalent blood brain barrier shuttle modules
|
|
KR102194142B1
(ko)
*
|
2014-01-20 |
2020-12-23 |
삼성전자주식회사 |
항 c-Met/항 EGFR 이중 특이 항체 및 c-Src 저해제를 포함하는 병용 투여용 약학 조성물
|
|
MX2016011228A
(es)
*
|
2014-02-28 |
2016-11-30 |
Astellas Pharma Inc |
Anticuerpos biespecificos novedosos de union a tlr2 humano y tlr4 humano.
|
|
ES2800674T3
(es)
*
|
2014-03-21 |
2021-01-04 |
X Body Inc |
Polipéptidos biespecíficos de unión a antígeno
|
|
WO2015143406A2
(en)
|
2014-03-21 |
2015-09-24 |
Regeneron Pharmaceuticals, Inc. |
Vl antigen binding proteins exhibiting distinct binding characteristics
|
|
KR102276752B1
(ko)
|
2014-03-21 |
2021-07-13 |
리제너론 파마슈티칼스 인코포레이티드 |
단일 도메인 결합 단백질을 생산하는 비-인간 동물
|
|
EP3122900A1
(en)
|
2014-03-24 |
2017-02-01 |
F. Hoffmann-La Roche AG |
Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
|
|
JP6775422B2
(ja)
|
2014-03-28 |
2020-10-28 |
ゼンコー・インコーポレイテッドＸｅｎｃｏｒ、 Ｉｎｃ． |
Ｃｄ３８及びｃｄ３に結合する二重特異性抗体
|
|
KR102632731B1
(ko)
|
2014-04-30 |
2024-02-01 |
막스-델부뤽-센트럼 퓌어 몰레쿨라레 메디친 인 데어 헬름홀츠-게마인샤프트 |
Ｃｄ269에 대한 인간화 항체
|
|
KR102223502B1
(ko)
|
2014-05-09 |
2021-03-05 |
삼성전자주식회사 |
항 c-Met/항 EGFR/항 Her3 다중 특이 항체 및 이의 이용
|
|
KR102401595B1
(ko)
*
|
2014-05-09 |
2022-05-24 |
삼성전자주식회사 |
항 HER2 scFv 단편 및 이를 포함하는 항 c-Met/항 HER2 이중 특이 항체
|
|
US9975960B2
(en)
*
|
2014-05-09 |
2018-05-22 |
Samsung Electronics Co., Ltd. |
Anti-HER2 antibody and anti-c-Met/anti-HER2 bispecific antibodies comprising the same
|
|
US20170233489A1
(en)
*
|
2014-05-26 |
2017-08-17 |
Samsung Electronics Co., Ltd. |
Composition for combination therapy comprising anti-her2 antibody and anti-c-met antibody
|
|
RU2729467C2
(ru)
|
2014-05-28 |
2020-08-06 |
Займворкс Инк. |
Модифицированные антигенсвязывающие полипептидные конструкции и их применение
|
|
KR102259232B1
(ko)
*
|
2014-08-25 |
2021-05-31 |
삼성전자주식회사 |
항 c-Met/항 Ang2 이중 특이 항체
|
|
CN105888672B
(zh)
*
|
2014-09-02 |
2018-07-27 |
北京中煤矿山工程有限公司 |
一种斜冻结孔用外夹式下冻结管装置
|
|
BR112017006591A2
(pt)
|
2014-11-06 |
2018-01-16 |
Hoffmann La Roche |
polipeptídeo heterodimérico, formulação farmacêutica e uso de um polipeptídeo heterodimérico
|
|
DK3221355T3
(da)
|
2014-11-20 |
2020-12-07 |
Hoffmann La Roche |
Kombinationsbehandling med T-celleaktiverende bispecifikke antigenbindende molekyler CD3 og folatreceptor 1 (FolR1) samt PD-1-aksebindende antagonister
|
|
SI3221357T1
(sl)
|
2014-11-20 |
2020-09-30 |
F. Hoffmann-La Roche Ag |
Pogoste lahke verige in načini uporabe
|
|
RS61010B1
(sr)
*
|
2014-11-20 |
2020-11-30 |
Hoffmann La Roche |
Bispecifični antigen vezujući molekuli koji aktiviraju t ćelije protiv folr1 i cd3
|
|
US10259887B2
(en)
|
2014-11-26 |
2019-04-16 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
|
CN110894240B
(zh)
|
2014-11-26 |
2022-04-15 |
森科股份有限公司 |
结合cd3和肿瘤抗原的异二聚体抗体
|
|
BR112017011166A2
(pt)
|
2014-11-26 |
2018-02-27 |
Xencor, Inc. |
anticorpos heterodiméricos que se ligam a cd3 e cd38
|
|
CN107001482B
(zh)
|
2014-12-03 |
2021-06-15 |
豪夫迈·罗氏有限公司 |
多特异性抗体
|
|
WO2016105450A2
(en)
|
2014-12-22 |
2016-06-30 |
Xencor, Inc. |
Trispecific antibodies
|
|
WO2016141387A1
(en)
|
2015-03-05 |
2016-09-09 |
Xencor, Inc. |
Modulation of t cells with bispecific antibodies and fc fusions
|
|
EP3271403A1
(en)
|
2015-03-19 |
2018-01-24 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals that select for light chain variable regions that bind antigen
|
|
MX391086B
(es)
|
2015-06-24 |
2025-03-21 |
Hoffmann La Roche |
Anticuerpos anti-receptor de transferrina con afinidad diseñada.
|
|
EP3356410B1
(en)
*
|
2015-10-02 |
2021-10-20 |
F. Hoffmann-La Roche AG |
Bispecific anti-ceaxcd3 t cell activating antigen binding molecules
|
|
NZ741067A
(en)
|
2015-10-02 |
2023-07-28 |
Hoffmann La Roche |
Bispecific anti-human cd20/human transferrin receptor antibodies and methods of use
|
|
AR106189A1
(es)
|
2015-10-02 |
2017-12-20 |
Hoffmann La Roche |
ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
|
|
AU2016334063B2
(en)
|
2015-10-08 |
2023-05-25 |
Zymeworks Bc Inc. |
Antigen-binding polypeptide constructs comprising kappa and lambda light chains and uses thereof
|
|
CN108350078A
(zh)
|
2015-11-03 |
2018-07-31 |
默克专利股份公司 |
用于提高肿瘤选择性和抑制的双特异性抗体及其用途
|
|
JP7058219B2
(ja)
|
2015-12-07 |
2022-04-21 |
ゼンコア インコーポレイテッド |
Ｃｄ３及びｐｓｍａに結合するヘテロ二量体抗体
|
|
CR20180365A
(es)
|
2015-12-16 |
2018-09-28 |
Amgen Inc |
PROTEÍNAS DE UNIÓN AL ANTÍGENO BISPECÍFICO DE ANTI-TL1A/ANTI-TNF-a Y SUS USOS
|
|
SI3468586T1
(sl)
|
2016-06-14 |
2025-01-31 |
Xencor, Inc. |
Bispecifična protitelesa za zaviralce kontrolnih točk
|
|
JP2019527540A
(ja)
|
2016-06-21 |
2019-10-03 |
ヤンセン バイオテツク，インコーポレーテツド |
システイン操作フィブロネクチンｉｉｉ型ドメイン結合分子
|
|
WO2018005706A1
(en)
|
2016-06-28 |
2018-01-04 |
Xencor, Inc. |
Heterodimeric antibodies that bind somatostatin receptor 2
|
|
US10793632B2
(en)
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
CN110214147A
(zh)
|
2016-10-14 |
2019-09-06 |
Xencor股份有限公司 |
IL15/IL15Rα异源二聚体FC-融合蛋白
|
|
TWI782930B
(zh)
|
2016-11-16 |
2022-11-11 |
美商再生元醫藥公司 |
抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法
|
|
WO2018111976A1
(en)
|
2016-12-14 |
2018-06-21 |
Janssen Biotech, Inc. |
Pd-l1 binding fibronectin type iii domains
|
|
US10611823B2
(en)
|
2016-12-14 |
2020-04-07 |
Hanssen Biotech, Inc |
CD137 binding fibronectin type III domains
|
|
NZ754187A
(en)
|
2016-12-14 |
2026-02-27 |
Janssen Biotech Inc |
Cd8a-binding fibronectin type iii domains
|
|
EP3559048A1
(en)
*
|
2016-12-22 |
2019-10-30 |
Eli Lilly and Company |
Methods for producing fabs and igg bispecific antibodies
|
|
AU2018250641B2
(en)
|
2017-04-11 |
2025-03-13 |
Inhibrx Biosciences, Inc. |
Multispecific polypeptide constructs having constrained CD3 binding and methods of using the same
|
|
NZ758605A
(en)
|
2017-05-30 |
2022-07-29 |
Chong Kun Dang Pharmaceutical Corp |
A novel anti-c-met antibody and use thereof
|
|
US11084863B2
(en)
|
2017-06-30 |
2021-08-10 |
Xencor, Inc. |
Targeted heterodimeric Fc fusion proteins containing IL-15 IL-15alpha and antigen binding domains
|
|
JP2021502100A
(ja)
|
2017-11-08 |
2021-01-28 |
ゼンコア インコーポレイテッド |
新規抗ｐｄ−１配列を用いた二重特異性および単一特異性抗体
|
|
US10981992B2
(en)
|
2017-11-08 |
2021-04-20 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
US11319355B2
(en)
|
2017-12-19 |
2022-05-03 |
Xencor, Inc. |
Engineered IL-2 Fc fusion proteins
|
|
DK3728328T5
(da)
|
2017-12-22 |
2025-02-17 |
Argenx Bvba |
Bispecifik antigenbindende konstruktion
|
|
GB201802487D0
(en)
|
2018-02-15 |
2018-04-04 |
Argenx Bvba |
Cytokine combination therapy
|
|
WO2019179627A1
(en)
*
|
2018-03-22 |
2019-09-26 |
Universität Stuttgart |
Multivalent binding molecules
|
|
WO2019195623A2
(en)
|
2018-04-04 |
2019-10-10 |
Xencor, Inc. |
Heterodimeric antibodies that bind fibroblast activation protein
|
|
BR112020020604A2
(pt)
*
|
2018-04-11 |
2021-01-12 |
Inhibrx, Inc. |
Construções de polipeptídeo multiespecífico tendo ligação restrita de cd3 e métodos e usos relacionados
|
|
US11505595B2
(en)
|
2018-04-18 |
2022-11-22 |
Xencor, Inc. |
TIM-3 targeted heterodimeric fusion proteins containing IL-15/IL-15RA Fc-fusion proteins and TIM-3 antigen binding domains
|
|
SG11202010163QA
(en)
|
2018-04-18 |
2020-11-27 |
Xencor Inc |
Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof
|
|
WO2020023553A1
(en)
|
2018-07-24 |
2020-01-30 |
Inhibrx, Inc. |
Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same
|
|
EP3861016A2
(en)
|
2018-10-03 |
2021-08-11 |
Xencor, Inc. |
Il-12 heterodimeric fc-fusion proteins
|
|
EP3864045A2
(en)
|
2018-10-11 |
2021-08-18 |
Inhibrx, Inc. |
Dll3 single domain antibodies and therapeutic compositions thereof
|
|
WO2020076992A1
(en)
|
2018-10-11 |
2020-04-16 |
Inhibrx, Inc. |
5t4 single domain antibodies and therapeutic compositions thereof
|
|
UA128825C2
(uk)
|
2019-03-01 |
2024-10-30 |
Ксенкор, Інк. |
Гетеродимерні антитіла, що зв'язують enpp3 та cd3
|
|
KR102239781B1
(ko)
*
|
2019-04-08 |
2021-04-13 |
주식회사 녹십자 |
Gpnmb 및 cd3에 특이적으로 결합하는 이중특이적 항체 및 이의 용도
|
|
BR112021019959A2
(pt)
*
|
2019-04-17 |
2022-02-08 |
Novo Nordisk As |
Anticorpo biespecífico, e, formulação farmacêutica
|
|
US11896682B2
(en)
|
2019-09-16 |
2024-02-13 |
Regeneron Pharmaceuticals, Inc. |
Radiolabeled MET binding proteins for immuno-PET imaging and methods of use thereof
|
|
CN114786682B
(zh)
|
2019-10-14 |
2024-07-16 |
Aro生物疗法公司 |
结合cd71的纤维粘连蛋白iii型结构域
|
|
WO2021076543A1
(en)
|
2019-10-14 |
2021-04-22 |
Aro Biotherapeutics Company |
Epcam binding fibronectin type iii domains
|
|
WO2021076574A2
(en)
|
2019-10-14 |
2021-04-22 |
Aro Biotherapeutics Company |
Fn3 domain-sirna conjugates and uses thereof
|
|
CN115380047A
(zh)
|
2020-01-29 |
2022-11-22 |
印希比股份有限公司 |
Cd28单结构域抗体及其多价和多特异性构建体
|
|
WO2021231976A1
(en)
|
2020-05-14 |
2021-11-18 |
Xencor, Inc. |
Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
|
|
CA3192204A1
(en)
|
2020-08-19 |
2022-02-24 |
Xencor, Inc. |
Anti-cd28 and/or anti-b7h3 compositions
|
|
JP2024511319A
(ja)
|
2021-03-09 |
2024-03-13 |
ゼンコア インコーポレイテッド |
Ｃｄ３及びｃｌｄｎ６に結合するヘテロ二量体抗体
|
|
JP2024509274A
(ja)
|
2021-03-10 |
2024-02-29 |
ゼンコア インコーポレイテッド |
Ｃｄ３及びｇｐｃ３に結合するヘテロ二量体抗体
|
|
BR112023021318A2
(pt)
|
2021-04-14 |
2023-12-19 |
Aro Biotherapeutics Company |
Conjugados de domínio fn3-sirna e usos dos mesmos
|
|
CA3214552A1
(en)
|
2021-04-14 |
2022-10-20 |
Russell C. Addis |
Cd71 binding fibronectin type iii domains
|
|
JP2024538148A
(ja)
|
2021-10-18 |
2024-10-18 |
タボテック バイオセラピューティクス（ホンコン）リミティド |
抗ＥＧＦＲ抗体、抗ｃＭＥＴ抗体、抗ＶＥＧＦ抗体、多重特異性抗体及びそれらの使用
|
|
WO2023142996A1
(zh)
|
2022-01-28 |
2023-08-03 |
上海岸阔医药科技有限公司 |
预防或治疗与抗肿瘤剂相关的疾病或病症的方法
|
|
WO2023155905A1
(zh)
|
2022-02-21 |
2023-08-24 |
上海岸阔医药科技有限公司 |
化合物及其用途
|
|
US20240209100A1
(en)
|
2022-10-21 |
2024-06-27 |
Diagonal Therapeutics Inc. |
Heteromeric agonistic antibodies to il-18 receptor
|
|
CN120035608A
(zh)
*
|
2022-11-24 |
2025-05-23 |
江苏恒瑞医药股份有限公司 |
一种包含特异性结合hgfr和egfr的双特异性抗体的药物组合物
|
|
US20250002588A1
(en)
|
2023-04-07 |
2025-01-02 |
Diagonal Therapeutics Inc. |
Bispecific agonistic antibodies to activin a receptor like type 1 (alk1)
|
|
US20240383990A1
(en)
|
2023-04-07 |
2024-11-21 |
Diagonal Therapeutics Inc. |
Hinge-modified bispecific antibodies
|
|
CN121219320A
(zh)
|
2023-05-19 |
2025-12-26 |
达科纳治疗有限公司 |
针对il12受体的双特异性激动性抗体
|
|
AU2024287954A1
(en)
*
|
2023-07-07 |
2026-01-22 |
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. |
Egfr/c-met bispecific binding protein and use thereof
|
|
CN121443647A
(zh)
*
|
2023-07-07 |
2026-01-30 |
四川科伦博泰生物医药股份有限公司 |
EGFR/c-MET双特异性结合蛋白及其用途
|
|
WO2025025434A1
(zh)
*
|
2023-08-02 |
2025-02-06 |
百泰生物药业有限公司 |
EGFR/c-Met双特异性抗体及其应用
|
|
AU2024366926A1
(en)
|
2023-10-23 |
2026-03-12 |
Diagonal Therapeutics Inc. |
Heteromeric agonistic antibodies to il-18 receptor
|
|
TW202527997A
(zh)
*
|
2023-11-15 |
2025-07-16 |
大陸商四川科倫博泰生物醫藥股份有限公司 |
靶向ｅｇｆｒ／ｃ—ｍｅｔ之抗體—藥物結合物以及其製備方法及用途
|
|
US20250388688A1
(en)
|
2024-04-04 |
2025-12-25 |
Ethyreal Bio, Inc. |
Anti-tshr antibodies and uses thereof
|
|
WO2026044000A1
(en)
|
2024-08-20 |
2026-02-26 |
Ethyreal Bio, Inc. |
Multispecific antibodies and methods of use thereof
|
|
WO2026080757A2
(en)
|
2024-10-09 |
2026-04-16 |
Diagonal Therapeutics Inc. |
Activin receptor type ii a/b (actriia/b) antibodies
|
|
WO2026080748A2
(en)
|
2024-10-09 |
2026-04-16 |
Diagonal Therapeutics Inc. |
Bone morphogenetic protein receptor type 2 (bmprii) antibodies
|
|
WO2026080752A2
(en)
|
2024-10-09 |
2026-04-16 |
Diagonal Therapeutics Inc. |
De novo antibodies to activin a receptor like type 1 (alk1)
|