|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
DE3572982D1
(en)
|
1984-03-06 |
1989-10-19 |
Takeda Chemical Industries Ltd |
Chemically modified lymphokine and production thereof
|
|
GB8421551D0
(en)
|
1984-08-24 |
1984-09-26 |
Ici Plc |
Water-soluble dye
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US4754065A
(en)
|
1984-12-18 |
1988-06-28 |
Cetus Corporation |
Precursor to nucleic acid probe
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US4800159A
(en)
|
1986-02-07 |
1989-01-24 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・２・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
US5047335A
(en)
|
1988-12-21 |
1991-09-10 |
The Regents Of The University Of Calif. |
Process for controlling intracellular glycosylation of proteins
|
|
WO1990006952A1
(fr)
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Facteur de stimulation de colonies de granulocytes modifies chimiquement
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
US5278299A
(en)
|
1991-03-18 |
1994-01-11 |
Scripps Clinic And Research Foundation |
Method and composition for synthesizing sialylated glycosyl compounds
|
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
GB9115364D0
(en)
|
1991-07-16 |
1991-08-28 |
Wellcome Found |
Antibody
|
|
AU669124B2
(en)
|
1991-09-18 |
1996-05-30 |
Kyowa Hakko Kirin Co., Ltd. |
Process for producing humanized chimera antibody
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
EP0605522B1
(en)
|
1991-09-23 |
1999-06-23 |
Medical Research Council |
Methods for the production of humanized antibodies
|
|
WO1993010260A1
(en)
|
1991-11-21 |
1993-05-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Controlling degradation of glycoprotein oligosaccharides by extracellular glycosisases
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
CA2118508A1
(en)
|
1992-04-24 |
1993-11-11 |
Elizabeth S. Ward |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
US5786158A
(en)
|
1992-04-30 |
1998-07-28 |
Yale University |
Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
|
|
US6210671B1
(en)
|
1992-12-01 |
2001-04-03 |
Protein Design Labs, Inc. |
Humanized antibodies reactive with L-selectin
|
|
JP2698529B2
(ja)
|
1993-04-06 |
1998-01-19 |
浜松ホトニクス株式会社 |
イメージインテンシファイア装置
|
|
US6180377B1
(en)
|
1993-06-16 |
2001-01-30 |
Celltech Therapeutics Limited |
Humanized antibodies
|
|
AU691811B2
(en)
|
1993-06-16 |
1998-05-28 |
Celltech Therapeutics Limited |
Antibodies
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US6265150B1
(en)
|
1995-06-07 |
2001-07-24 |
Becton Dickinson & Company |
Phage antibodies
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
DK1071700T3
(da)
|
1998-04-20 |
2010-06-07 |
Glycart Biotechnology Ag |
Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
EP1117778A2
(en)
|
1998-10-02 |
2001-07-25 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Methods and compositions for inducing differentiation and apoptosis in cells that overexpress the notch protein
|
|
US20030035798A1
(en)
|
2000-08-16 |
2003-02-20 |
Fang Fang |
Humanized antibodies
|
|
PL209392B1
(pl)
|
1999-01-15 |
2011-08-31 |
Genentech Inc |
Przeciwciało, komórka gospodarza, sposób wytwarzania przeciwciała oraz zastosowanie przeciwciała
|
|
CA2704600C
(en)
|
1999-04-09 |
2016-10-25 |
Kyowa Kirin Co., Ltd. |
A method for producing antibodies with increased adcc activity
|
|
US6849425B1
(en)
|
1999-10-14 |
2005-02-01 |
Ixsys, Inc. |
Methods of optimizing antibody variable region binding affinity
|
|
WO2002059285A1
(en)
*
|
2000-10-27 |
2002-08-01 |
Fred Hutchinson Cancer Research Center |
Methods for immortalizing cells
|
|
CA2463879C
(en)
|
2001-10-25 |
2012-12-04 |
Genentech, Inc. |
Glycoprotein compositions
|
|
US20030148954A1
(en)
*
|
2001-11-02 |
2003-08-07 |
Wisconsin Alumni Research Foundation |
Agents and methods for modulating activator protein-1-mediated cellular processes
|
|
WO2003042246A2
(en)
|
2001-11-14 |
2003-05-22 |
Lorantis Limited |
Inhibitors of the notch signalling pathway for use in the treatment of cancer
|
|
BR0309145A
(pt)
|
2002-04-09 |
2005-02-01 |
Kyowa Hakko Kogyo Kk |
Células das quais o genoma é modificado
|
|
EP1544210A4
(en)
|
2002-07-18 |
2006-01-25 |
Masayasu Okochi |
NEW NOTCH ORIGIN POLYPEPTIDES AND BIOMARKERS AND REAGENTS FOR WHICH THEY ARE USED
|
|
DK2270048T3
(en)
|
2002-12-24 |
2016-01-18 |
Rinat Neuroscience Corp |
Anti-NGF antibodies and methods for their use
|
|
JP2007512348A
(ja)
|
2003-11-26 |
2007-05-17 |
ヘルス リサーチ インコーポレイテッド |
形質細胞の治療のためのノッチ経路干渉剤の使用
|
|
US20080220416A1
(en)
|
2004-05-20 |
2008-09-11 |
The Board Of Trustees Of The University Of Illinoi |
Compositions for Inhibiting Cell Growth and Inducing Apoptosis in Cancer Cells and Methods of Use Thereof
|
|
US20070077245A1
(en)
|
2004-08-04 |
2007-04-05 |
The Brigham And Women's Hospital, Inc. |
NOTCH mutations leading to increased receptor signaling
|
|
WO2006053063A2
(en)
|
2004-11-05 |
2006-05-18 |
The Regents Of The University Of California |
Notch-1 assay to detect neurodegenerative diseases
|
|
ZA200705695B
(en)
|
2004-12-21 |
2009-02-25 |
Astrazeneca Ab |
Antibodies directed to angiopoietin-2 and uses thereof
|
|
WO2006092062A1
(en)
|
2005-03-04 |
2006-09-08 |
The Hospital For Sick Children |
Methods for cancer prognosis
|
|
US7100777B1
(en)
*
|
2005-07-07 |
2006-09-05 |
Jui-Chien Kao |
Hanger rack for hand tools
|
|
US20070072222A1
(en)
|
2005-09-23 |
2007-03-29 |
Franziska Boess |
FABP4 as biomarker for toxic effect
|
|
US20090305310A1
(en)
|
2005-11-22 |
2009-12-10 |
University Of Vermont And State Agricultural College |
Methods for Determining Notch Signaling and Uses Thereof
|
|
US20080241150A1
(en)
|
2006-05-15 |
2008-10-02 |
The Brigham And Women's Hospital, Inc. |
Functional negative regulatory domain sequences from human NOTCH1 and 2 and isolated LNR domains from human NOTCH1
|
|
ES2413087T3
(es)
|
2006-06-13 |
2013-07-15 |
Oncomed Pharmaceuticals, Inc. |
Composiciones y métodos para el diagnóstico y tratamiento del cáncer
|
|
JP2010520280A
(ja)
|
2007-03-05 |
2010-06-10 |
ボード オブ リージェンツ， ザ ユニバーシティ オブ テキサス システム |
ＮｏｔｃｈまたはＮｕｍｂ特異的免疫療法との相乗効果を有する、癌細胞の再生のネガティブな遺伝的制御
|
|
PE20090321A1
(es)
|
2007-06-04 |
2009-04-20 |
Genentech Inc |
Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
|
|
US8119366B2
(en)
|
2007-10-05 |
2012-02-21 |
Trojan Technologies, Ltd. |
Antennapedia-dominant negative mastermind-like construct
|
|
JO3076B1
(ar)
|
2007-10-17 |
2017-03-15 |
Janssen Alzheimer Immunotherap |
نظم العلاج المناعي المعتمد على حالة apoe
|
|
CN102112490B
(zh)
|
2008-07-08 |
2014-10-22 |
昂考梅德药品有限公司 |
Notch1受体结合剂和其使用方法
|
|
US20110286916A1
(en)
|
2008-11-20 |
2011-11-24 |
Jose Miguel Aste-Amezaga |
Generation and characterization of anti-notch antibodies for therapeutic and diagnostic use
|
|
EP3431501A1
(en)
|
2009-06-18 |
2019-01-23 |
Pfizer Inc |
Anti notch-1 antibodies
|
|
MX342250B
(es)
|
2009-09-30 |
2016-09-22 |
Genentech Inc |
Tratamiento de cánceres resistentes a antagonistas notch1, mediante el uso de antagonistas notch3.
|
|
MX2012008085A
(es)
|
2010-01-13 |
2012-09-12 |
Oncomed Pharm Inc |
Agentes de union notch1 y metodos de uso de los mismos.
|
|
AU2011342799B2
(en)
|
2010-12-15 |
2016-06-09 |
Wyeth Llc |
Anti-Notch1 antibodies
|
|
WO2012080891A1
(en)
|
2010-12-15 |
2012-06-21 |
Rinat Neuroscience Corp. |
Anti-notch-1 antibodies
|