JP6059985B2 - 抗ｎｏｔｃｈ−１抗体 - Google Patents

抗ｎｏｔｃｈ−１抗体 Download PDF

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Publication number
JP6059985B2
JP6059985B2 JP2012515616A JP2012515616A JP6059985B2 JP 6059985 B2 JP6059985 B2 JP 6059985B2 JP 2012515616 A JP2012515616 A JP 2012515616A JP 2012515616 A JP2012515616 A JP 2012515616A JP 6059985 B2 JP6059985 B2 JP 6059985B2
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JP
Japan
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antibody
antigen
human
binding
binding portion
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Expired - Fee Related
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JP2012515616A
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Japanese (ja)
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JP2012530487A5 (https=
JP2012530487A (ja
Inventor
ホストムスキー ズデネック
ホストムスキー ズデネック
リ カング
リ カング
アンドリュー リッピンコット ジョン
アンドリュー リッピンコット ジョン
ペング キングハイ
ペング キングハイ
マリー ストーン ドナ
マリー ストーン ドナ
ウェイ ピング
ウェイ ピング
Original Assignee
ファイザー・インク
ライナット ニューロサイエンス コーポレイション
ライナット ニューロサイエンス コーポレイション
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42575817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP6059985(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ファイザー・インク, ライナット ニューロサイエンス コーポレイション, ライナット ニューロサイエンス コーポレイション filed Critical ファイザー・インク
Publication of JP2012530487A publication Critical patent/JP2012530487A/ja
Publication of JP2012530487A5 publication Critical patent/JP2012530487A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2012515616A 2009-06-18 2010-06-16 抗ｎｏｔｃｈ−１抗体 Expired - Fee Related JP6059985B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21819309P 2009-06-18 2009-06-18
US61/218,193 2009-06-18
PCT/IB2010/052711 WO2010146550A1 (en) 2009-06-18 2010-06-16 Anti notch-1 antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016004952A Division JP2016121162A (ja) 2009-06-18 2016-01-14 抗ｎｏｔｃｈ−１抗体

Publications (3)

Publication Number Publication Date
JP2012530487A JP2012530487A (ja) 2012-12-06
JP2012530487A5 JP2012530487A5 (https=) 2013-08-01
JP6059985B2 true JP6059985B2 (ja) 2017-01-11

Family

ID=42575817

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012515616A Expired - Fee Related JP6059985B2 (ja) 2009-06-18 2010-06-16 抗ｎｏｔｃｈ−１抗体
JP2016004952A Pending JP2016121162A (ja) 2009-06-18 2016-01-14 抗ｎｏｔｃｈ−１抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016004952A Pending JP2016121162A (ja) 2009-06-18 2016-01-14 抗ｎｏｔｃｈ−１抗体

Country Status (18)

Country Link
US (1) US9090690B2 (https=)
EP (2) EP3431501A1 (https=)
JP (2) JP6059985B2 (https=)
KR (1) KR101570898B1 (https=)
CN (1) CN102686610A (https=)
AU (1) AU2010261364B2 (https=)
BR (1) BRPI1011805A2 (https=)
CA (1) CA2765989C (https=)
CO (1) CO6480924A2 (https=)
IL (1) IL217066A0 (https=)
MX (1) MX337468B (https=)
NZ (1) NZ597611A (https=)
PE (1) PE20121494A1 (https=)
PH (1) PH12011502609B1 (https=)
RU (1) RU2011151287A (https=)
SG (1) SG176731A1 (https=)
WO (1) WO2010146550A1 (https=)
ZA (1) ZA201109282B (https=)

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* Cited by examiner, † Cited by third party
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AR073717A1 (es) * 2008-10-01 2010-11-24 Genentech Inc Anticuerpos anti-notch2 de murino y humano, y metodos de uso
EP3431501A1 (en) * 2009-06-18 2019-01-23 Pfizer Inc Anti notch-1 antibodies
MX342250B (es) * 2009-09-30 2016-09-22 Genentech Inc Tratamiento de cánceres resistentes a antagonistas notch1, mediante el uso de antagonistas notch3.
AU2011342799B2 (en) 2010-12-15 2016-06-09 Wyeth Llc Anti-Notch1 antibodies
WO2012080891A1 (en) * 2010-12-15 2012-06-21 Rinat Neuroscience Corp. Anti-notch-1 antibodies
CA2890571A1 (en) 2012-11-07 2014-05-15 Kenneth G. Geles Anti-notch3 antibodies and antibody-drug conjugates
AU2015227247A1 (en) * 2014-03-07 2016-09-15 Oncomed Pharmaceuticals, Inc. Methods for treating cancer with Notch 1 antibodies
CN106488775A (zh) 2014-07-11 2017-03-08 基因泰克公司 Notch途径抑制
WO2017205651A1 (en) * 2016-05-25 2017-11-30 The Trustees Of Columbia University In The City Of New York Human notch1 based fusion proteins as decoy inhibitors of jagged-notch signaling and dll-notch signaling
WO2018081648A2 (en) 2016-10-29 2018-05-03 Genentech, Inc. Anti-mic antibidies and methods of use
JP7525160B2 (ja) 2018-08-31 2024-07-30 Ｂｌｏｏｍ Ｔｅｃｈｎｏｌｏｇｙ 株式会社 終末糖化産物に対する抗体およびその使用
EP4585226A1 (en) 2022-09-09 2025-07-16 Institute Of Science Tokyo Therapeutic agent for coronavirus infection
CN121270710B (zh) * 2025-04-14 2026-03-31 北京光辉天成生物科技有限公司 一种高亲和力padi2抗体及其制备方法

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Also Published As

Publication number Publication date
MX337468B (es) 2016-03-02
CN102686610A (zh) 2012-09-19
AU2010261364B2 (en) 2015-05-07
SG176731A1 (en) 2012-01-30
KR101570898B1 (ko) 2015-11-23
CO6480924A2 (es) 2012-07-16
NZ597611A (en) 2014-03-28
KR20120071379A (ko) 2012-07-02
MX2011013717A (es) 2012-05-29
JP2016121162A (ja) 2016-07-07
US9090690B2 (en) 2015-07-28
PH12011502609B1 (en) 2018-11-07
JP2012530487A (ja) 2012-12-06
EP2443151A1 (en) 2012-04-25
PE20121494A1 (es) 2012-11-01
EP3431501A1 (en) 2019-01-23
BRPI1011805A2 (pt) 2016-10-11
AU2010261364A1 (en) 2012-01-19
ZA201109282B (en) 2012-08-29
CA2765989A1 (en) 2010-12-23
RU2011151287A (ru) 2013-07-27
CA2765989C (en) 2016-11-29
IL217066A0 (en) 2012-02-29
US20120093813A1 (en) 2012-04-19
PH12011502609A1 (en) 2012-11-12
WO2010146550A1 (en) 2010-12-23

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