JP2012521215A5 - - Google Patents
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- JP2012521215A5 JP2012521215A5 JP2012501965A JP2012501965A JP2012521215A5 JP 2012521215 A5 JP2012521215 A5 JP 2012521215A5 JP 2012501965 A JP2012501965 A JP 2012501965A JP 2012501965 A JP2012501965 A JP 2012501965A JP 2012521215 A5 JP2012521215 A5 JP 2012521215A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- phenotype
- cell
- suspension
- nkt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000822 natural killer cell Anatomy 0.000 claims description 16
- 210000004027 cell Anatomy 0.000 claims description 15
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 14
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 12
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 12
- 210000000581 natural killer T-cell Anatomy 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 5
- 239000000725 suspension Substances 0.000 claims 4
- 102000000588 Interleukin-2 Human genes 0.000 claims 3
- 108010002350 Interleukin-2 Proteins 0.000 claims 3
- 239000006285 cell suspension Substances 0.000 claims 3
- 239000001963 growth medium Substances 0.000 claims 3
- 101000589305 Homo sapiens Natural cytotoxicity triggering receptor 2 Proteins 0.000 claims 2
- 102100032851 Natural cytotoxicity triggering receptor 2 Human genes 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 231100000135 cytotoxicity Toxicity 0.000 claims 2
- 230000003013 cytotoxicity Effects 0.000 claims 2
- 231100000263 cytotoxicity test Toxicity 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 210000004976 peripheral blood cell Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000012467 final product Substances 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16359009P | 2009-03-26 | 2009-03-26 | |
| US61/163,590 | 2009-03-26 | ||
| PCT/SE2010/050333 WO2010110734A1 (en) | 2009-03-26 | 2010-03-25 | Expansion of nk cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015254493A Division JP2016105713A (ja) | 2009-03-26 | 2015-12-25 | Ｎｋ細胞の増殖 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012521215A JP2012521215A (ja) | 2012-09-13 |
| JP2012521215A5 true JP2012521215A5 (enExample) | 2013-04-25 |
Family
ID=42781254
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012501965A Pending JP2012521215A (ja) | 2009-03-26 | 2010-03-25 | Ｎｋ細胞の増殖 |
| JP2015254493A Pending JP2016105713A (ja) | 2009-03-26 | 2015-12-25 | Ｎｋ細胞の増殖 |
| JP2017208238A Active JP6574823B2 (ja) | 2009-03-26 | 2017-10-27 | Ｎｋ細胞の増殖 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015254493A Pending JP2016105713A (ja) | 2009-03-26 | 2015-12-25 | Ｎｋ細胞の増殖 |
| JP2017208238A Active JP6574823B2 (ja) | 2009-03-26 | 2017-10-27 | Ｎｋ細胞の増殖 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8877182B2 (enExample) |
| EP (1) | EP2411507B1 (enExample) |
| JP (3) | JP2012521215A (enExample) |
| KR (1) | KR101881520B1 (enExample) |
| CN (1) | CN102428173B (enExample) |
| DK (1) | DK2411507T3 (enExample) |
| ES (1) | ES2763169T3 (enExample) |
| PL (1) | PL2411507T3 (enExample) |
| PT (1) | PT2411507T (enExample) |
| WO (1) | WO2010110734A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2203176B1 (en) | 2007-09-28 | 2014-11-26 | Anthrogenesis Corporation | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| MX342995B (es) | 2010-07-13 | 2016-10-21 | Anthrogenesis Corp | Métodos de generar células asesinas naturales. |
| JP5572863B2 (ja) | 2011-06-24 | 2014-08-20 | 国立大学法人九州大学 | Ｎｋ細胞の増幅方法 |
| CN104204194B (zh) * | 2011-12-22 | 2018-08-03 | 财团法人牧岩生命工学研究所 | 生产自然杀伤细胞的方法、由该方法生产的自然杀伤细胞以及包含该自然杀伤细胞的用于治疗癌症和感染性疾病的组合物 |
| US10066207B2 (en) | 2012-04-18 | 2018-09-04 | Board Of Trustees Of Michigan State University | Natural killer cells with enhanced immune response |
| KR101520534B1 (ko) | 2012-05-07 | 2015-05-21 | 고려대학교 산학협력단 | 말초혈액단핵구 유래 자연 살해세포의 유도 및 증식 방법 |
| KR101525199B1 (ko) * | 2012-09-13 | 2015-06-04 | (주)케이셀바이오 | 100㎖ 이하 말초혈액으로부터 ｎｋ세포의 대량 증식 방법 |
| CN102994449A (zh) * | 2012-12-13 | 2013-03-27 | 上海柯莱逊生物技术有限公司 | 一种体外扩增nk细胞的方法 |
| SG11201505858VA (en) | 2013-01-28 | 2015-09-29 | St Jude Childrens Res Hospital | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| EP3622960A1 (en) | 2013-02-05 | 2020-03-18 | Celularity, Inc. | Natural killer cells from placenta |
| US20160075996A1 (en) * | 2013-03-27 | 2016-03-17 | Biotherapy Institute Of Japan | Method for producing nk cell-enriched blood preparation |
| US10260038B2 (en) | 2013-05-10 | 2019-04-16 | Whitehead Institute For Biomedical Research | Protein modification of living cells using sortase |
| WO2015125113A1 (en) * | 2014-02-21 | 2015-08-27 | Dr. Reddy's Laboratories Limited | Method of culturing high cell density pbmc's |
| CN105002139B (zh) * | 2014-04-25 | 2019-02-01 | 中国医学科学院肿瘤医院 | 一种cd3+cd8+cd56+t细胞亚型促进nk细胞增殖的方法 |
| EP3805371A1 (en) | 2014-05-15 | 2021-04-14 | National University of Singapore | Modified natural killer cells and uses thereof |
| CN104357390B (zh) * | 2014-10-15 | 2017-07-07 | 恒瑞源正（深圳）生物科技有限公司 | 同时扩增cd3+cd56+cik细胞和cd3‑cd56+nk细胞的方法 |
| KR101697473B1 (ko) | 2014-11-26 | 2017-01-18 | 주식회사 녹십자랩셀 | T 세포를 이용한 자연살해세포의 배양방법 |
| US12098387B2 (en) | 2015-10-19 | 2024-09-24 | University Of Maryland, Baltimore | Methods for generating engineered human primary blood dendritic cell lines |
| CN105624109B (zh) * | 2016-02-26 | 2019-07-12 | 广州赛莱拉干细胞科技股份有限公司 | 一种使用生物反应器培养nkt细胞的方法 |
| CN107779434A (zh) * | 2016-08-30 | 2018-03-09 | 天津市康婷生物工程有限公司 | 高效扩增人外周血nk细胞的实验方法 |
| AU2018219895C1 (en) | 2017-02-09 | 2024-10-03 | Indapta Therapeutics, Inc. | Engineered Natural Killer (NK) cells and compositions and methods thereof |
| MX2019011570A (es) | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
| CN117363636A (zh) | 2017-03-27 | 2024-01-09 | 新加坡国立大学 | 一种编码嵌合受体的多核苷酸 |
| EP3633029A4 (en) | 2017-05-26 | 2021-06-09 | Green Cross Lab Cell Corporation | METHOD OF DEVELOPING A NATURAL KILLER CELL USING A T-CELL |
| CN107541491A (zh) * | 2017-10-12 | 2018-01-05 | 广州金晟生物科技有限公司 | 一种nk细胞体外培养方法 |
| KR102265437B1 (ko) | 2017-11-24 | 2021-06-15 | 의료법인 성광의료재단 | Nk 배양용 조성물 및 이를 이용하여 nk 세포를 배양하는 방법 |
| CN108060130B (zh) * | 2017-12-29 | 2018-12-07 | 广州沙艾生物科技有限公司 | 控制培养箱适于免疫细胞的诱导扩增的方法 |
| CN108192868B (zh) * | 2017-12-29 | 2018-12-07 | 广州沙艾生物科技有限公司 | 免疫细胞的诱导扩增方法 |
| CN115710576A (zh) | 2018-02-01 | 2023-02-24 | Nkmax有限公司 | 产生天然杀伤细胞的方法和用于治疗癌症的组合物 |
| JP7360174B2 (ja) | 2018-02-09 | 2023-10-12 | ナショナル ユニヴァーシティー オブ シンガポール | ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用 |
| CN112513079A (zh) * | 2018-03-13 | 2021-03-16 | 拉巴斯大学医院生物医学研究基金会 | 用于癌症免疫疗法的联合激活和扩增的自然杀伤细胞的抗cxcr4抗体 |
| WO2019182392A1 (ko) * | 2018-03-23 | 2019-09-26 | 주식회사 녹십자랩셀 | 자연살해세포의 제조방법 |
| KR102232321B1 (ko) * | 2018-03-23 | 2021-03-26 | 주식회사 녹십자랩셀 | 자연살해세포의 제조방법 |
| US12441787B2 (en) | 2018-04-02 | 2025-10-14 | National University Of Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| GB201807050D0 (en) * | 2018-04-30 | 2018-06-13 | Cellprotect Nordic Pharmaceuticals Ab | Medical uses |
| KR102069704B1 (ko) * | 2018-05-16 | 2020-01-23 | 고려대학교 산학협력단 | Hdac 억제제를 이용한 사람 유래 자연살해세포의 확장 배양법 |
| EP3822341A4 (en) * | 2018-05-31 | 2022-03-09 | Korea University Research and Business Foundation | EXPANSION AND CULTURE OF HUMAN-DERIVED NATURAL KILLER CELLS USING IGFBP2 |
| CN110628715B (zh) * | 2018-06-21 | 2022-11-25 | 精准生技股份有限公司 | 体外扩增自然杀手细胞及自然杀手t细胞的方法及其医药组成物 |
| WO2020044239A1 (en) | 2018-08-29 | 2020-03-05 | National University Of Singapore | A method to specifically stimulate survival and expansion of genetically-modified immune cells |
| JP7179986B2 (ja) | 2018-11-14 | 2022-11-29 | グリーン クロス ラボ セル コーポレーション | 形質転換されたｔ細胞を用いた臍帯血由来のナチュラルキラー細胞の培養方法 |
| EP3884041A2 (en) | 2018-11-21 | 2021-09-29 | Indapta Therapeutics, Inc. | Methods for expansion of natural killer (nk) cell subset and related compositions and methods |
| CN113226340A (zh) | 2018-11-26 | 2021-08-06 | 恩卡尔塔公司 | 同时扩增多种免疫细胞类型的方法、相关组合物及其在癌症免疫疗法中的用途 |
| KR20210137085A (ko) | 2019-03-05 | 2021-11-17 | 엔카르타, 인크. | Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도 |
| JP2022525928A (ja) * | 2019-03-21 | 2022-05-20 | ガミダ セル リミテッド | 併用療法における移植に適したｎｋ細胞画分の増殖及び増殖ｎｋ細胞画分の使用 |
| CN113166726A (zh) * | 2019-07-08 | 2021-07-23 | 南克维斯特公司 | 单核细胞源性nk细胞 |
| US11453862B2 (en) | 2019-07-08 | 2022-09-27 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| WO2021154886A1 (en) | 2020-01-28 | 2021-08-05 | Sorrento Therapeutics, Inc. | Natural killer cells for treatment of coronavirus infection |
| TW202241935A (zh) | 2020-12-18 | 2022-11-01 | 美商世紀治療股份有限公司 | 具有可調適受體專一性之嵌合抗原受體系統 |
| WO2022153295A1 (en) * | 2021-01-12 | 2022-07-21 | Hadasit Medical Research Services & Development Ltd. | Improved adoptive cell transfer therapy for cancer |
| GB202115389D0 (en) | 2021-10-26 | 2021-12-08 | XNK Therapeutics AB | Methods |
| WO2023081813A1 (en) | 2021-11-05 | 2023-05-11 | St. Jude Children's Research Hospital, Inc. | Zip cytokine receptors |
| EP4536687A1 (en) | 2022-06-08 | 2025-04-16 | St. Jude Children's Research Hospital, Inc. | Disruption of kdm4a in t cells to enhance immunotherapy |
| WO2024059787A1 (en) | 2022-09-16 | 2024-03-21 | St. Jude Children's Research Hospital, Inc. | Disruption of asxl1 in t cells to enhance immunotherapy |
| WO2026156062A2 (en) | 2025-01-15 | 2026-07-23 | St. Jude Children's Research Hospital, Inc. | Chimeric antigen receptors targeting cluster of differentiation 19 (cd19) and cluster of differentiation 22 (cd22) |
| WO2026165423A2 (en) | 2025-01-31 | 2026-08-06 | St. Jude Children's Research Hospital, Inc. | Methods for enhancing immune effector cell activity leveraging biophysical modulation in adoptive cellular therapies |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2383418T3 (es) * | 1999-11-24 | 2012-06-21 | Red Cliff Holding | Agente celular antiangiogénico para la terapia del cáncer. |
| US20030119185A1 (en) * | 2000-02-24 | 2003-06-26 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| CN1444648A (zh) * | 2000-06-06 | 2003-09-24 | 麒麟麦酒株式会社 | 扩增自然杀伤t细胞的方法 |
| US20030068306A1 (en) * | 2001-09-14 | 2003-04-10 | Dilber Mehmet Sirac | Medium |
| US20080199423A1 (en) * | 2004-06-18 | 2008-08-21 | Genentech, Inc. | Methods of Using Apo2l Receptor Agonists and Ink Cell Activators |
| US20090196850A1 (en) * | 2005-01-06 | 2009-08-06 | Novo Nordisk A/S | Anti-Kir Combination Treatments and Methods |
| KR101299299B1 (ko) * | 2007-11-05 | 2013-08-26 | 츠네오 쿠라모치 | 암면역 요법용 세포의 제조방법 |
| US20090123442A1 (en) * | 2007-11-09 | 2009-05-14 | Avaris Ab | Expanded nk cells |
| KR20090127974A (ko) * | 2008-06-10 | 2009-12-15 | 주식회사 엔케이바이오 | 자기활성화 림프구 배양용 배지 조성물 |
-
2010
- 2010-03-25 JP JP2012501965A patent/JP2012521215A/ja active Pending
- 2010-03-25 US US13/260,004 patent/US8877182B2/en active Active
- 2010-03-25 EP EP10756430.4A patent/EP2411507B1/en active Active
- 2010-03-25 CN CN201080021237.8A patent/CN102428173B/zh active Active
- 2010-03-25 DK DK10756430.4T patent/DK2411507T3/da active
- 2010-03-25 KR KR1020117025234A patent/KR101881520B1/ko active Active
- 2010-03-25 PT PT107564304T patent/PT2411507T/pt unknown
- 2010-03-25 PL PL10756430T patent/PL2411507T3/pl unknown
- 2010-03-25 ES ES10756430T patent/ES2763169T3/es active Active
- 2010-03-25 WO PCT/SE2010/050333 patent/WO2010110734A1/en not_active Ceased
-
2015
- 2015-12-25 JP JP2015254493A patent/JP2016105713A/ja active Pending
-
2017
- 2017-10-27 JP JP2017208238A patent/JP6574823B2/ja active Active
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