PT2411507T - Expansão de células nk - Google Patents

Expansão de células nk

Info

Publication number
PT2411507T
PT2411507T PT107564304T PT10756430T PT2411507T PT 2411507 T PT2411507 T PT 2411507T PT 107564304 T PT107564304 T PT 107564304T PT 10756430 T PT10756430 T PT 10756430T PT 2411507 T PT2411507 T PT 2411507T
Authority
PT
Portugal
Prior art keywords
expansion
cells
Prior art date
Application number
PT107564304T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Cellprotect Nordic Pharmaceuticals Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellprotect Nordic Pharmaceuticals Ab filed Critical Cellprotect Nordic Pharmaceuticals Ab
Publication of PT2411507T publication Critical patent/PT2411507T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1164—NK cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
PT107564304T 2009-03-26 2010-03-25 Expansão de células nk PT2411507T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16359009P 2009-03-26 2009-03-26

Publications (1)

Publication Number Publication Date
PT2411507T true PT2411507T (pt) 2020-01-09

Family

ID=42781254

Family Applications (1)

Application Number Title Priority Date Filing Date
PT107564304T PT2411507T (pt) 2009-03-26 2010-03-25 Expansão de células nk

Country Status (10)

Country Link
US (1) US8877182B2 (enExample)
EP (1) EP2411507B1 (enExample)
JP (3) JP2012521215A (enExample)
KR (1) KR101881520B1 (enExample)
CN (1) CN102428173B (enExample)
DK (1) DK2411507T3 (enExample)
ES (1) ES2763169T3 (enExample)
PL (1) PL2411507T3 (enExample)
PT (1) PT2411507T (enExample)
WO (1) WO2010110734A1 (enExample)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS53841B1 (sr) 2007-09-28 2015-06-30 Anthrogenesis Corporation Supresija tumora korišćenjem humanog placentalnog perfuzata i intermedijernih ćelija ubica poreklom iz humane placente
CN103097520B (zh) 2010-07-13 2017-12-05 人类起源公司 产生自然杀伤细胞的方法
JP5572863B2 (ja) * 2011-06-24 2014-08-20 国立大学法人九州大学 Ｎｋ細胞の増幅方法
NO2794859T3 (enExample) * 2011-12-22 2018-02-17
US10066207B2 (en) 2012-04-18 2018-09-04 Board Of Trustees Of Michigan State University Natural killer cells with enhanced immune response
KR101525199B1 (ko) * 2012-09-13 2015-06-04 (주)케이셀바이오 100㎖ 이하 말초혈액으로부터 ｎｋ세포의 대량 증식 방법
CN102994449A (zh) * 2012-12-13 2013-03-27 上海柯莱逊生物技术有限公司 一种体外扩增nk细胞的方法
SG11201505858VA (en) 2013-01-28 2015-09-29 St Jude Childrens Res Hospital A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
US9763983B2 (en) 2013-02-05 2017-09-19 Anthrogenesis Corporation Natural killer cells from placenta
WO2014155572A1 (ja) * 2013-03-27 2014-10-02 株式会社日本バイオセラピー研究所 Nk細胞強化型血液製剤の製造方法
AU2014262469B2 (en) 2013-05-10 2019-11-14 Whitehead Institute For Biomedical Research Protein modification of living cells using sortase
WO2015125113A1 (en) * 2014-02-21 2015-08-27 Dr. Reddy's Laboratories Limited Method of culturing high cell density pbmc's
CN105002139B (zh) * 2014-04-25 2019-02-01 中国医学科学院肿瘤医院 一种cd3+cd8+cd56+t细胞亚型促进nk细胞增殖的方法
EP3805371A1 (en) 2014-05-15 2021-04-14 National University of Singapore Modified natural killer cells and uses thereof
CN104357390B (zh) * 2014-10-15 2017-07-07 恒瑞源正（深圳）生物科技有限公司 同时扩增cd3+cd56+cik细胞和cd3‑cd56+nk细胞的方法
KR101697473B1 (ko) 2014-11-26 2017-01-18 주식회사 녹십자랩셀 T 세포를 이용한 자연살해세포의 배양방법
WO2017070237A1 (en) * 2015-10-19 2017-04-27 University Of Maryland, Baltimore Methods for generating engineered human primary blood dendritic cell lines
CN105624109B (zh) * 2016-02-26 2019-07-12 广州赛莱拉干细胞科技股份有限公司 一种使用生物反应器培养nkt细胞的方法
CN107779434A (zh) * 2016-08-30 2018-03-09 天津市康婷生物工程有限公司 高效扩增人外周血nk细胞的实验方法
EP3580341A4 (en) 2017-02-09 2020-11-04 Indapta Therapeutics, Inc. Engineered natural killer (nk) cells and compositions and methods thereof
CA3056439A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy
SG11201908337VA (en) 2017-03-27 2019-10-30 Nat Univ Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
KR102460173B1 (ko) 2017-05-26 2022-10-31 주식회사 지씨셀 형질전환된 t세포를 이용한 자연살해세포의 배양방법
CN107541491A (zh) * 2017-10-12 2018-01-05 广州金晟生物科技有限公司 一种nk细胞体外培养方法
KR102265437B1 (ko) 2017-11-24 2021-06-15 의료법인 성광의료재단 Nk 배양용 조성물 및 이를 이용하여 nk 세포를 배양하는 방법
CN108060130B (zh) * 2017-12-29 2018-12-07 广州沙艾生物科技有限公司 控制培养箱适于免疫细胞的诱导扩增的方法
CN108192868B (zh) * 2017-12-29 2018-12-07 广州沙艾生物科技有限公司 免疫细胞的诱导扩增方法
NZ766453A (en) 2018-02-01 2022-02-25 Nkmax Co Ltd Method of producing natural killer cells and composition for treating cancer
SG11202007156QA (en) 2018-02-09 2020-08-28 Nat Univ Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
WO2019175802A1 (en) * 2018-03-13 2019-09-19 Fundación Para La Investigación Biomédica Del Hospital Universitario La Paz Anti-cxcr4 antibody combined with activated and expanded natural killer cells for cancer immunotherapy
KR102232321B1 (ko) * 2018-03-23 2021-03-26 주식회사 녹십자랩셀 자연살해세포의 제조방법
WO2019182392A1 (ko) * 2018-03-23 2019-09-26 주식회사 녹십자랩셀 자연살해세포의 제조방법
SG11202008976YA (en) 2018-04-02 2020-10-29 Nat Univ Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
GB201807050D0 (en) 2018-04-30 2018-06-13 Cellprotect Nordic Pharmaceuticals Ab Medical uses
KR102069704B1 (ko) * 2018-05-16 2020-01-23 고려대학교 산학협력단 Hdac 억제제를 이용한 사람 유래 자연살해세포의 확장 배양법
EP3822341A4 (en) * 2018-05-31 2022-03-09 Korea University Research and Business Foundation EXPANSION AND CULTURE OF HUMAN-DERIVED NATURAL KILLER CELLS USING IGFBP2
CN110628715B (zh) * 2018-06-21 2022-11-25 精准生技股份有限公司 体外扩增自然杀手细胞及自然杀手t细胞的方法及其医药组成物
KR102839381B1 (ko) 2018-08-29 2025-07-28 내셔널 유니버시티 오브 싱가포르 유전적으로 변형된 면역 세포의 생존 및 확장을 특이적으로 자극하는 방법
JP7179986B2 (ja) 2018-11-14 2022-11-29 グリーン クロス ラボ セル コーポレーション 形質転換されたｔ細胞を用いた臍帯血由来のナチュラルキラー細胞の培養方法
US12410402B2 (en) 2018-11-21 2025-09-09 Indapta Therapeutics, Inc. Methods for expansion of natural killer (NK) cell subset and related compositions and methods
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
WO2020188573A1 (en) * 2019-03-21 2020-09-24 Gamida-Cell Ltd. Expanded nk cell fractions for transplantation in combination therapy
SG11202104339WA (en) * 2019-07-08 2021-05-28 Nantkwest Inc Mononuclear cell derived nk cells
US11453862B2 (en) 2019-07-08 2022-09-27 Immunitybio, Inc. Mononuclear cell derived NK cells
EP4096688A1 (en) 2020-01-28 2022-12-07 Sorrento Therapeutics, Inc. Natural killer cells for treatment of coronavirus infection
WO2022133169A1 (en) 2020-12-18 2022-06-23 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
EP4277638A4 (en) * 2021-01-12 2024-12-04 Hadasit Medical Research Services&Development Ltd. ENHANCED ADOPTIVE CELL TRANSFER THERAPY FOR CANCER
GB202115389D0 (en) 2021-10-26 2021-12-08 XNK Therapeutics AB Methods
WO2023081813A1 (en) 2021-11-05 2023-05-11 St. Jude Children's Research Hospital, Inc. Zip cytokine receptors
WO2023240182A1 (en) 2022-06-08 2023-12-14 St. Jude Children's Research Hospital, Inc. Disruption of kdm4a in t cells to enhance immunotherapy
WO2024059787A1 (en) 2022-09-16 2024-03-21 St. Jude Children's Research Hospital, Inc. Disruption of asxl1 in t cells to enhance immunotherapy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2383418T3 (es) * 1999-11-24 2012-06-21 Red Cliff Holding Agente celular antiangiogénico para la terapia del cáncer.
US20030119185A1 (en) * 2000-02-24 2003-06-26 Xcyte Therapies, Inc. Activation and expansion of cells
KR20030032961A (ko) * 2000-06-06 2003-04-26 기린 비루 가부시키가이샤 내츄럴 킬러 ｔ 세포의 증폭 방법
US20030068306A1 (en) 2001-09-14 2003-04-10 Dilber Mehmet Sirac Medium
EP1786456A1 (en) * 2004-06-18 2007-05-23 Genentech, Inc. Use of apo2l receptor agonists and nk cells or nk cell activators
US20090196850A1 (en) * 2005-01-06 2009-08-06 Novo Nordisk A/S Anti-Kir Combination Treatments and Methods
JP4953403B2 (ja) 2007-11-05 2012-06-13 恒雄 倉持 がん免疫療法用細胞の製造方法
US20090123442A1 (en) * 2007-11-09 2009-05-14 Avaris Ab Expanded nk cells
KR20090127974A (ko) 2008-06-10 2009-12-15 주식회사 엔케이바이오 자기활성화 림프구 배양용 배지 조성물

Also Published As

Publication number Publication date
PL2411507T3 (pl) 2020-07-13
US20120258085A1 (en) 2012-10-11
JP2012521215A (ja) 2012-09-13
KR20110132618A (ko) 2011-12-08
HK1170258A1 (en) 2013-02-22
JP2016105713A (ja) 2016-06-16
EP2411507A4 (en) 2013-06-19
ES2763169T3 (es) 2020-05-27
DK2411507T3 (da) 2020-01-06
US8877182B2 (en) 2014-11-04
EP2411507B1 (en) 2019-09-25
EP2411507A1 (en) 2012-02-01
KR101881520B1 (ko) 2018-07-24
JP6574823B2 (ja) 2019-09-11
WO2010110734A1 (en) 2010-09-30
JP2018046840A (ja) 2018-03-29
CN102428173B (zh) 2014-07-30
CN102428173A (zh) 2012-04-25

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