PT2411507T - Expansão de células nk - Google Patents
Expansão de células nkInfo
- Publication number
- PT2411507T PT2411507T PT107564304T PT10756430T PT2411507T PT 2411507 T PT2411507 T PT 2411507T PT 107564304 T PT107564304 T PT 107564304T PT 10756430 T PT10756430 T PT 10756430T PT 2411507 T PT2411507 T PT 2411507T
- Authority
- PT
- Portugal
- Prior art keywords
- expansion
- cells
- Prior art date
Links
- 210000000822 natural killer cell Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1164—NK cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16359009P | 2009-03-26 | 2009-03-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2411507T true PT2411507T (pt) | 2020-01-09 |
Family
ID=42781254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT107564304T PT2411507T (pt) | 2009-03-26 | 2010-03-25 | Expansão de células nk |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8877182B2 (pt) |
| EP (1) | EP2411507B1 (pt) |
| JP (3) | JP2012521215A (pt) |
| KR (1) | KR101881520B1 (pt) |
| CN (1) | CN102428173B (pt) |
| DK (1) | DK2411507T3 (pt) |
| ES (1) | ES2763169T3 (pt) |
| HK (1) | HK1170258A1 (pt) |
| PL (1) | PL2411507T3 (pt) |
| PT (1) | PT2411507T (pt) |
| WO (1) | WO2010110734A1 (pt) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2203176T1 (sl) | 2007-09-28 | 2015-04-30 | Anthrogenesis Corporation | Tumorska supresija z uporabo humanega perfuzata placente in intermediarnih naravnih celic ubijalk, pridobljenih iz humane placente |
| KR20200077613A (ko) | 2010-07-13 | 2020-06-30 | 안트로제네시스 코포레이션 | 천연 킬러 세포의 생성 방법 |
| JP5572863B2 (ja) * | 2011-06-24 | 2014-08-20 | 国立大学法人九州大学 | Ｎｋ細胞の増幅方法 |
| NO2794859T3 (pt) * | 2011-12-22 | 2018-02-17 | ||
| KR101525199B1 (ko) * | 2012-09-13 | 2015-06-04 | (주)케이셀바이오 | 100㎖ 이하 말초혈액으로부터 ｎｋ세포의 대량 증식 방법 |
| CN102994449A (zh) * | 2012-12-13 | 2013-03-27 | 上海柯莱逊生物技术有限公司 | 一种体外扩增nk细胞的方法 |
| WO2014117121A1 (en) | 2013-01-28 | 2014-07-31 | St. Jude Children's Research Hospital, Inc. | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| CN105142651A (zh) | 2013-02-05 | 2015-12-09 | 人类起源公司 | 来自胎盘的自然杀伤细胞 |
| WO2014155572A1 (ja) * | 2013-03-27 | 2014-10-02 | 株式会社日本バイオセラピー研究所 | Nk細胞強化型血液製剤の製造方法 |
| JP6603209B2 (ja) | 2013-05-10 | 2019-11-06 | ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ | ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾 |
| WO2015125113A1 (en) * | 2014-02-21 | 2015-08-27 | Dr. Reddy's Laboratories Limited | Method of culturing high cell density pbmc's |
| CN105002139B (zh) * | 2014-04-25 | 2019-02-01 | 中国医学科学院肿瘤医院 | 一种cd3+cd8+cd56+t细胞亚型促进nk细胞增殖的方法 |
| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| CN104357390B (zh) * | 2014-10-15 | 2017-07-07 | 恒瑞源正（深圳）生物科技有限公司 | 同时扩增cd3+cd56+cik细胞和cd3‑cd56+nk细胞的方法 |
| KR101697473B1 (ko) | 2014-11-26 | 2017-01-18 | 주식회사 녹십자랩셀 | T 세포를 이용한 자연살해세포의 배양방법 |
| CN108289909A (zh) | 2015-10-19 | 2018-07-17 | 巴尔的摩马里兰大学 | 用于产生工程改造的人原代血液树突细胞系的方法 |
| CN105624109B (zh) * | 2016-02-26 | 2019-07-12 | 广州赛莱拉干细胞科技股份有限公司 | 一种使用生物反应器培养nkt细胞的方法 |
| CN107779434A (zh) * | 2016-08-30 | 2018-03-09 | 天津市康婷生物工程有限公司 | 高效扩增人外周血nk细胞的实验方法 |
| CA3052473A1 (en) | 2017-02-09 | 2018-08-16 | Indapta Therapeutics, Inc. | Engineered natural killer (nk) cells and compositions and methods thereof |
| CN117384929A (zh) | 2017-03-27 | 2024-01-12 | 新加坡国立大学 | 一种编码由细胞表达的嵌合受体的多核苷酸 |
| MX2019011570A (es) | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
| CN107541491A (zh) * | 2017-10-12 | 2018-01-05 | 广州金晟生物科技有限公司 | 一种nk细胞体外培养方法 |
| KR102265437B1 (ko) | 2017-11-24 | 2021-06-15 | 의료법인 성광의료재단 | Nk 배양용 조성물 및 이를 이용하여 nk 세포를 배양하는 방법 |
| CN108192868B (zh) * | 2017-12-29 | 2018-12-07 | 广州沙艾生物科技有限公司 | 免疫细胞的诱导扩增方法 |
| CN108060130B (zh) * | 2017-12-29 | 2018-12-07 | 广州沙艾生物科技有限公司 | 控制培养箱适于免疫细胞的诱导扩增的方法 |
| IL276365B2 (en) | 2018-02-01 | 2023-10-01 | Nkmax Co Ltd | A method for the production of natural killer cells and a preparation for cancer treatment |
| JP7561631B2 (ja) * | 2018-03-13 | 2024-10-04 | フンダシオン・パラ・ラ・インベスティガシオン・ビオメディカ・デル・オスピタル・ウニベルシタリオ・ラ・パス | 癌免疫療法のための活性化および拡張ナチュラルキラー細胞と組み合わせた抗ｃｘｃｒ４抗体 |
| KR102232321B1 (ko) * | 2018-03-23 | 2021-03-26 | 주식회사 녹십자랩셀 | 자연살해세포의 제조방법 |
| WO2019182392A1 (ko) * | 2018-03-23 | 2019-09-26 | 주식회사 녹십자랩셀 | 자연살해세포의 제조방법 |
| GB201807050D0 (en) | 2018-04-30 | 2018-06-13 | Cellprotect Nordic Pharmaceuticals Ab | Medical uses |
| KR102069704B1 (ko) * | 2018-05-16 | 2020-01-23 | 고려대학교 산학협력단 | Hdac 억제제를 이용한 사람 유래 자연살해세포의 확장 배양법 |
| KR102213108B1 (ko) * | 2018-05-31 | 2021-02-05 | 고려대학교 산학협력단 | Igfbp2를 이용한 사람 유래 자연살해세포의 확장배양 |
| CN110628715B (zh) * | 2018-06-21 | 2022-11-25 | 精准生技股份有限公司 | 体外扩增自然杀手细胞及自然杀手t细胞的方法及其医药组成物 |
| WO2020107002A2 (en) * | 2018-11-21 | 2020-05-28 | Indapta Therapeutics, Inc. | Methods for expansion of natural killer (nk) cell subset and related compositions and methods |
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY |
| EP3941489A4 (en) * | 2019-03-21 | 2022-12-28 | Gamida-Cell Ltd. | EXTENDED NK CELL FRACTIONS SUITABLE FOR POLYTHERAPY TRANSPLANTATION |
| US11453862B2 (en) | 2019-07-08 | 2022-09-27 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| SG11202104339WA (en) * | 2019-07-08 | 2021-05-28 | Nantkwest Inc | Mononuclear cell derived nk cells |
| US20230071405A1 (en) | 2020-01-28 | 2023-03-09 | Sorrento Therapeutics, Inc. | Natural Killer Cells for Treatment of Coronavirus Infection |
| TW202241935A (zh) | 2020-12-18 | 2022-11-01 | 美商世紀治療股份有限公司 | 具有可調適受體專一性之嵌合抗原受體系統 |
| JP2024502170A (ja) * | 2021-01-12 | 2024-01-17 | ハダシット メディカル リサーチ サービシーズ アンド ディベロップメント リミテッド | 癌のための改良された養子細胞移植療法 |
| GB202115389D0 (en) | 2021-10-26 | 2021-12-08 | XNK Therapeutics AB | Methods |
| WO2023081813A1 (en) | 2021-11-05 | 2023-05-11 | St. Jude Children's Research Hospital, Inc. | Zip cytokine receptors |
| WO2023240182A1 (en) | 2022-06-08 | 2023-12-14 | St. Jude Children's Research Hospital, Inc. | Disruption of kdm4a in t cells to enhance immunotherapy |
| WO2024059787A1 (en) | 2022-09-16 | 2024-03-21 | St. Jude Children's Research Hospital, Inc. | Disruption of asxl1 in t cells to enhance immunotherapy |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2425801A (en) | 1999-11-24 | 2001-06-04 | Ernest G. Hope | Anti-angiogenic cellular agent for cancer therapy |
| US20030119185A1 (en) * | 2000-02-24 | 2003-06-26 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| WO2001094553A1 (fr) * | 2000-06-06 | 2001-12-13 | Kirin Beer Kabushiki Kaisha | Methode d'amplification de lymphocytes t tueurs naturels |
| US20030068306A1 (en) | 2001-09-14 | 2003-04-10 | Dilber Mehmet Sirac | Medium |
| CN101005850A (zh) * | 2004-06-18 | 2007-07-25 | 健泰科生物技术公司 | 使用apo2l受体激动剂和nk细胞活化剂的方法 |
| JP5855326B2 (ja) * | 2005-01-06 | 2016-02-09 | ノヴォ ノルディスク アー／エス | 抗ｋｉｒ組み合わせ治療および方法 |
| JP4953403B2 (ja) * | 2007-11-05 | 2012-06-13 | 恒雄 倉持 | がん免疫療法用細胞の製造方法 |
| US20090123442A1 (en) * | 2007-11-09 | 2009-05-14 | Avaris Ab | Expanded nk cells |
| KR20090127974A (ko) * | 2008-06-10 | 2009-12-15 | 주식회사 엔케이바이오 | 자기활성화 림프구 배양용 배지 조성물 |
-
2010
- 2010-03-25 KR KR1020117025234A patent/KR101881520B1/ko active IP Right Grant
- 2010-03-25 CN CN201080021237.8A patent/CN102428173B/zh active Active
- 2010-03-25 PL PL10756430T patent/PL2411507T3/pl unknown
- 2010-03-25 DK DK10756430.4T patent/DK2411507T3/da active
- 2010-03-25 EP EP10756430.4A patent/EP2411507B1/en active Active
- 2010-03-25 ES ES10756430T patent/ES2763169T3/es active Active
- 2010-03-25 PT PT107564304T patent/PT2411507T/pt unknown
- 2010-03-25 US US13/260,004 patent/US8877182B2/en active Active
- 2010-03-25 JP JP2012501965A patent/JP2012521215A/ja active Pending
- 2010-03-25 WO PCT/SE2010/050333 patent/WO2010110734A1/en active Application Filing
-
2012
- 2012-10-25 HK HK12110647.2A patent/HK1170258A1/xx unknown
-
2015
- 2015-12-25 JP JP2015254493A patent/JP2016105713A/ja active Pending
-
2017
- 2017-10-27 JP JP2017208238A patent/JP6574823B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN102428173A (zh) | 2012-04-25 |
| JP2016105713A (ja) | 2016-06-16 |
| HK1170258A1 (en) | 2013-02-22 |
| ES2763169T3 (es) | 2020-05-27 |
| PL2411507T3 (pl) | 2020-07-13 |
| DK2411507T3 (da) | 2020-01-06 |
| US20120258085A1 (en) | 2012-10-11 |
| US8877182B2 (en) | 2014-11-04 |
| EP2411507B1 (en) | 2019-09-25 |
| JP2018046840A (ja) | 2018-03-29 |
| KR20110132618A (ko) | 2011-12-08 |
| EP2411507A4 (en) | 2013-06-19 |
| CN102428173B (zh) | 2014-07-30 |
| KR101881520B1 (ko) | 2018-07-24 |
| JP2012521215A (ja) | 2012-09-13 |
| WO2010110734A1 (en) | 2010-09-30 |
| EP2411507A1 (en) | 2012-02-01 |
| JP6574823B2 (ja) | 2019-09-11 |
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