DK2411507T3 - Ekspansion af nk-celler - Google Patents
Ekspansion af nk-celler Download PDFInfo
- Publication number
- DK2411507T3 DK2411507T3 DK10756430.4T DK10756430T DK2411507T3 DK 2411507 T3 DK2411507 T3 DK 2411507T3 DK 10756430 T DK10756430 T DK 10756430T DK 2411507 T3 DK2411507 T3 DK 2411507T3
- Authority
- DK
- Denmark
- Prior art keywords
- expansion
- cells
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1164—NK cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16359009P | 2009-03-26 | 2009-03-26 | |
| PCT/SE2010/050333 WO2010110734A1 (en) | 2009-03-26 | 2010-03-25 | Expansion of nk cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2411507T3 true DK2411507T3 (da) | 2020-01-06 |
Family
ID=42781254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10756430.4T DK2411507T3 (da) | 2009-03-26 | 2010-03-25 | Ekspansion af nk-celler |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8877182B2 (enExample) |
| EP (1) | EP2411507B1 (enExample) |
| JP (3) | JP2012521215A (enExample) |
| KR (1) | KR101881520B1 (enExample) |
| CN (1) | CN102428173B (enExample) |
| DK (1) | DK2411507T3 (enExample) |
| ES (1) | ES2763169T3 (enExample) |
| PL (1) | PL2411507T3 (enExample) |
| PT (1) | PT2411507T (enExample) |
| WO (1) | WO2010110734A1 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2700617C (en) | 2007-09-28 | 2018-11-06 | Celgene Cellular Therapeutics | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| JP5996533B2 (ja) | 2010-07-13 | 2016-09-21 | アントフロゲネシス コーポレーション | ナチュラルキラー細胞を生成させる方法 |
| JP5572863B2 (ja) * | 2011-06-24 | 2014-08-20 | 国立大学法人九州大学 | Ｎｋ細胞の増幅方法 |
| JP6010136B2 (ja) * | 2011-12-22 | 2016-10-19 | モガム バイオテクノロジー インスティチュート | ナチュラルキラー細胞の製造方法、その方法により製造されたナチュラルキラー細胞、並びにそれを含む腫瘍及び感染性疾患治療用組成物 |
| US10066207B2 (en) | 2012-04-18 | 2018-09-04 | Board Of Trustees Of Michigan State University | Natural killer cells with enhanced immune response |
| KR101525199B1 (ko) * | 2012-09-13 | 2015-06-04 | (주)케이셀바이오 | 100㎖ 이하 말초혈액으로부터 ｎｋ세포의 대량 증식 방법 |
| CN102994449A (zh) * | 2012-12-13 | 2013-03-27 | 上海柯莱逊生物技术有限公司 | 一种体外扩增nk细胞的方法 |
| US9511092B2 (en) | 2013-01-28 | 2016-12-06 | St. Jude Children's Research Hospital, Inc. | Chimeric receptor with NKG2D specificity for use in cell therapy against cancer and infectious disease |
| CN115137753A (zh) | 2013-02-05 | 2022-10-04 | 细胞结构公司 | 来自胎盘的自然杀伤细胞 |
| US20160075996A1 (en) * | 2013-03-27 | 2016-03-17 | Biotherapy Institute Of Japan | Method for producing nk cell-enriched blood preparation |
| US10260038B2 (en) | 2013-05-10 | 2019-04-16 | Whitehead Institute For Biomedical Research | Protein modification of living cells using sortase |
| WO2015125113A1 (en) * | 2014-02-21 | 2015-08-27 | Dr. Reddy's Laboratories Limited | Method of culturing high cell density pbmc's |
| CN105002139B (zh) * | 2014-04-25 | 2019-02-01 | 中国医学科学院肿瘤医院 | 一种cd3+cd8+cd56+t细胞亚型促进nk细胞增殖的方法 |
| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| CN104357390B (zh) * | 2014-10-15 | 2017-07-07 | 恒瑞源正（深圳）生物科技有限公司 | 同时扩增cd3+cd56+cik细胞和cd3‑cd56+nk细胞的方法 |
| KR101697473B1 (ko) | 2014-11-26 | 2017-01-18 | 주식회사 녹십자랩셀 | T 세포를 이용한 자연살해세포의 배양방법 |
| JP7572700B2 (ja) * | 2015-10-19 | 2024-10-24 | ユニバーシティ オブ メリーランド ボルチモア | 改変ヒト初代血液樹状細胞株を生成するための方法 |
| CN105624109B (zh) * | 2016-02-26 | 2019-07-12 | 广州赛莱拉干细胞科技股份有限公司 | 一种使用生物反应器培养nkt细胞的方法 |
| CN107779434A (zh) * | 2016-08-30 | 2018-03-09 | 天津市康婷生物工程有限公司 | 高效扩增人外周血nk细胞的实验方法 |
| EP3580341A4 (en) | 2017-02-09 | 2020-11-04 | Indapta Therapeutics, Inc. | Engineered natural killer (nk) cells and compositions and methods thereof |
| BR112019019917A2 (pt) | 2017-03-27 | 2020-04-22 | Nat Univ Singapore | receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais |
| WO2018182511A1 (en) | 2017-03-27 | 2018-10-04 | National University Of Singapore | Stimulatory cell lines for ex vivo expansion and activation of natural killer cells |
| AU2018271755B2 (en) | 2017-05-26 | 2021-12-23 | Green Cross Lab Cell Corporation | Method for culturing natural killer cell, using transformed T cell |
| CN107541491A (zh) * | 2017-10-12 | 2018-01-05 | 广州金晟生物科技有限公司 | 一种nk细胞体外培养方法 |
| KR102265437B1 (ko) | 2017-11-24 | 2021-06-15 | 의료법인 성광의료재단 | Nk 배양용 조성물 및 이를 이용하여 nk 세포를 배양하는 방법 |
| CN108060130B (zh) * | 2017-12-29 | 2018-12-07 | 广州沙艾生物科技有限公司 | 控制培养箱适于免疫细胞的诱导扩增的方法 |
| CN108192868B (zh) * | 2017-12-29 | 2018-12-07 | 广州沙艾生物科技有限公司 | 免疫细胞的诱导扩增方法 |
| EP3746095A4 (en) | 2018-02-01 | 2021-04-21 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| AU2019219454A1 (en) | 2018-02-09 | 2020-08-27 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| ES2973728T3 (es) * | 2018-03-13 | 2024-06-24 | Fundacion Para La Investigacion Biomedica Del Hospital Univ La Paz | Anticuerpo anti-CXCR4 combinado con linfocitos citolíticos naturales activados y expandidos para inmunoterapia contra el cáncer |
| KR102232321B1 (ko) * | 2018-03-23 | 2021-03-26 | 주식회사 녹십자랩셀 | 자연살해세포의 제조방법 |
| WO2019182392A1 (ko) * | 2018-03-23 | 2019-09-26 | 주식회사 녹십자랩셀 | 자연살해세포의 제조방법 |
| SG11202008976YA (en) | 2018-04-02 | 2020-10-29 | Nat Univ Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| GB201807050D0 (en) | 2018-04-30 | 2018-06-13 | Cellprotect Nordic Pharmaceuticals Ab | Medical uses |
| KR102069704B1 (ko) * | 2018-05-16 | 2020-01-23 | 고려대학교 산학협력단 | Hdac 억제제를 이용한 사람 유래 자연살해세포의 확장 배양법 |
| EP3822341A4 (en) * | 2018-05-31 | 2022-03-09 | Korea University Research and Business Foundation | EXPANSION AND CULTURE OF HUMAN-DERIVED NATURAL KILLER CELLS USING IGFBP2 |
| CN110628715B (zh) * | 2018-06-21 | 2022-11-25 | 精准生技股份有限公司 | 体外扩增自然杀手细胞及自然杀手t细胞的方法及其医药组成物 |
| JP7560882B2 (ja) | 2018-08-29 | 2024-10-03 | ナショナル ユニヴァーシティー オブ シンガポール | 遺伝子修飾免疫細胞の生存及び増加を特異的に刺激するための方法 |
| PH12021550950A1 (en) | 2018-11-14 | 2022-05-02 | Green Cross Lab Cell Corp | Method for culturing cord blood-derived natural killer cells using transformed t cells |
| CN113891934A (zh) | 2018-11-21 | 2022-01-04 | 因达普塔治疗公司 | 扩增天然杀伤（nk）细胞子集的方法以及相关组合物和方法 |
| CN118546959A (zh) | 2019-03-05 | 2024-08-27 | 恩卡尔塔公司 | Cd19定向性嵌合抗原受体及其在免疫疗法中的用途 |
| EP3941489A4 (en) * | 2019-03-21 | 2022-12-28 | Gamida-Cell Ltd. | EXTENDED NK CELL FRACTIONS SUITABLE FOR POLYTHERAPY TRANSPLANTATION |
| US11453862B2 (en) | 2019-07-08 | 2022-09-27 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| JP7213976B2 (ja) * | 2019-07-08 | 2023-01-27 | イミュニティーバイオ、インコーポレイテッド | 単核細胞由来のｎｋ細胞 |
| EP4096688A1 (en) | 2020-01-28 | 2022-12-07 | Sorrento Therapeutics, Inc. | Natural killer cells for treatment of coronavirus infection |
| US11883432B2 (en) | 2020-12-18 | 2024-01-30 | Century Therapeutics, Inc. | Chimeric antigen receptor system with adaptable receptor specificity |
| US20240307536A1 (en) * | 2021-01-12 | 2024-09-19 | Hadasit Medical Research Services And Development Ltd. | Improved adoptive cell transfer therapy for cancer |
| GB202115389D0 (en) | 2021-10-26 | 2021-12-08 | XNK Therapeutics AB | Methods |
| WO2023081813A1 (en) | 2021-11-05 | 2023-05-11 | St. Jude Children's Research Hospital, Inc. | Zip cytokine receptors |
| WO2023240182A1 (en) | 2022-06-08 | 2023-12-14 | St. Jude Children's Research Hospital, Inc. | Disruption of kdm4a in t cells to enhance immunotherapy |
| WO2024059787A1 (en) | 2022-09-16 | 2024-03-21 | St. Jude Children's Research Hospital, Inc. | Disruption of asxl1 in t cells to enhance immunotherapy |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001037671A1 (en) | 1999-11-24 | 2001-05-31 | Hope Ernest G | Anti-angiogenic cellular agent for cancer therapy |
| US20030119185A1 (en) * | 2000-02-24 | 2003-06-26 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| CN1444648A (zh) * | 2000-06-06 | 2003-09-24 | 麒麟麦酒株式会社 | 扩增自然杀伤t细胞的方法 |
| US20030068306A1 (en) | 2001-09-14 | 2003-04-10 | Dilber Mehmet Sirac | Medium |
| NZ551428A (en) * | 2004-06-18 | 2010-03-26 | Genentech Inc | Use of apo2L receptor agonists and NK cells or NK cell activators |
| WO2006072625A2 (en) | 2005-01-06 | 2006-07-13 | Novo Nordisk A/S | Anti-kir combination treatments and methods |
| WO2009060865A1 (ja) * | 2007-11-05 | 2009-05-14 | Tsuneo Kuramochi | 医薬組成物及び医薬組成物の製造方法 |
| US20090123442A1 (en) * | 2007-11-09 | 2009-05-14 | Avaris Ab | Expanded nk cells |
| KR20090127974A (ko) | 2008-06-10 | 2009-12-15 | 주식회사 엔케이바이오 | 자기활성화 림프구 배양용 배지 조성물 |
-
2010
- 2010-03-25 ES ES10756430T patent/ES2763169T3/es active Active
- 2010-03-25 WO PCT/SE2010/050333 patent/WO2010110734A1/en not_active Ceased
- 2010-03-25 DK DK10756430.4T patent/DK2411507T3/da active
- 2010-03-25 JP JP2012501965A patent/JP2012521215A/ja active Pending
- 2010-03-25 US US13/260,004 patent/US8877182B2/en active Active
- 2010-03-25 PT PT107564304T patent/PT2411507T/pt unknown
- 2010-03-25 PL PL10756430T patent/PL2411507T3/pl unknown
- 2010-03-25 CN CN201080021237.8A patent/CN102428173B/zh active Active
- 2010-03-25 EP EP10756430.4A patent/EP2411507B1/en active Active
- 2010-03-25 KR KR1020117025234A patent/KR101881520B1/ko active Active
-
2015
- 2015-12-25 JP JP2015254493A patent/JP2016105713A/ja active Pending
-
2017
- 2017-10-27 JP JP2017208238A patent/JP6574823B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2411507A4 (en) | 2013-06-19 |
| PL2411507T3 (pl) | 2020-07-13 |
| KR20110132618A (ko) | 2011-12-08 |
| CN102428173A (zh) | 2012-04-25 |
| EP2411507A1 (en) | 2012-02-01 |
| JP2016105713A (ja) | 2016-06-16 |
| JP6574823B2 (ja) | 2019-09-11 |
| KR101881520B1 (ko) | 2018-07-24 |
| WO2010110734A1 (en) | 2010-09-30 |
| US8877182B2 (en) | 2014-11-04 |
| PT2411507T (pt) | 2020-01-09 |
| CN102428173B (zh) | 2014-07-30 |
| ES2763169T3 (es) | 2020-05-27 |
| EP2411507B1 (en) | 2019-09-25 |
| US20120258085A1 (en) | 2012-10-11 |
| JP2018046840A (ja) | 2018-03-29 |
| JP2012521215A (ja) | 2012-09-13 |
| HK1170258A1 (en) | 2013-02-22 |
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