JP2012512176A5 - - Google Patents
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- Publication number
- JP2012512176A5 JP2012512176A5 JP2011540971A JP2011540971A JP2012512176A5 JP 2012512176 A5 JP2012512176 A5 JP 2012512176A5 JP 2011540971 A JP2011540971 A JP 2011540971A JP 2011540971 A JP2011540971 A JP 2011540971A JP 2012512176 A5 JP2012512176 A5 JP 2012512176A5
- Authority
- JP
- Japan
- Prior art keywords
- extract
- composition
- acid
- galactose
- arabinose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 19
- 229930182830 galactose Natural products 0.000 claims 12
- 239000000284 extract Substances 0.000 claims 11
- 239000002253 acid Substances 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 claims 7
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims 7
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 6
- 239000000287 crude extract Substances 0.000 claims 6
- 239000008103 glucose Substances 0.000 claims 6
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 4
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims 4
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims 4
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 claims 3
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 3
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 3
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 241000209219 Hordeum Species 0.000 claims 2
- 235000007340 Hordeum vulgare Nutrition 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 235000006533 astragalus Nutrition 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 241001061264 Astragalus Species 0.000 claims 1
- 241000045403 Astragalus propinquus Species 0.000 claims 1
- 235000018185 Betula X alpestris Nutrition 0.000 claims 1
- 235000018212 Betula X uliginosa Nutrition 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 102000003951 Erythropoietin Human genes 0.000 claims 1
- 108090000394 Erythropoietin Proteins 0.000 claims 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102000000646 Interleukin-3 Human genes 0.000 claims 1
- 108010002386 Interleukin-3 Proteins 0.000 claims 1
- 102000036693 Thrombopoietin Human genes 0.000 claims 1
- 108010041111 Thrombopoietin Proteins 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 230000010437 erythropoiesis Effects 0.000 claims 1
- 229940105423 erythropoietin Drugs 0.000 claims 1
- 230000011132 hemopoiesis Effects 0.000 claims 1
- 229940121364 interleukin derivative Drugs 0.000 claims 1
- 229940076264 interleukin-3 Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 210000004233 talus Anatomy 0.000 claims 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12258608P | 2008-12-15 | 2008-12-15 | |
| US61/122,586 | 2008-12-15 | ||
| PCT/US2009/068062 WO2010077867A2 (en) | 2008-12-15 | 2009-12-15 | Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012512176A JP2012512176A (ja) | 2012-05-31 |
| JP2012512176A5 true JP2012512176A5 (enExample) | 2013-02-14 |
| JP5732604B2 JP5732604B2 (ja) | 2015-06-10 |
Family
ID=42266446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540971A Active JP5732604B2 (ja) | 2008-12-15 | 2009-12-15 | キバナオウギ抽出物を含む組成物による特発性血小板減少性紫斑病の治療 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8137710B2 (enExample) |
| EP (1) | EP2376096B1 (enExample) |
| JP (1) | JP5732604B2 (enExample) |
| KR (1) | KR101780074B1 (enExample) |
| CN (1) | CN102300576B (enExample) |
| MY (1) | MY159317A (enExample) |
| SG (1) | SG172029A1 (enExample) |
| TW (1) | TWI507201B (enExample) |
| WO (1) | WO2010077867A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142726A (zh) * | 2013-02-21 | 2013-06-12 | 上海浦东高星生物技术研究所 | 溃疡止血粉 |
| JP2017525702A (ja) * | 2014-08-18 | 2017-09-07 | ファーマジェネシス， インコーポレイテッド | ポリガラクツロナンラムノガラクツロナン（ｐｇｒｇ１）組成物 |
| CN104173563A (zh) * | 2014-08-22 | 2014-12-03 | 上海中医药大学附属岳阳中西医结合医院 | 一种治疗免疫性血小板减少症的中药组合物 |
| CN104740405B (zh) * | 2015-04-14 | 2018-09-04 | 日照市中医医院 | 一种治疗过敏性紫癜性肾损害的中药制剂及制备方法 |
| CN104784419A (zh) * | 2015-04-24 | 2015-07-22 | 陕西郝其军制药股份有限公司 | 一种治疗免疫性血小板减少性紫癜的中药组合物及其制备方法 |
| JP2018087182A (ja) * | 2016-11-10 | 2018-06-07 | フィトヘルス・コーポレイションＰｈｙｔｏｈｅａｌｔｈ Ｃｏｒｐｏｒａｔｉｏｎ | がん免疫療法の効果を高める方法 |
| CN109199907A (zh) * | 2017-07-07 | 2019-01-15 | 怀特生技新药股份有限公司 | 黄芪萃取物在制备用于抑制黑色素生成的组合物中的应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4708949A (en) * | 1985-09-24 | 1987-11-24 | Yaguang Liu | Therapeutic composition from plant extracts |
| US4795742A (en) * | 1985-09-24 | 1989-01-03 | Yaguang Liu | Therapeutic composition from plant extracts |
| US5336506A (en) * | 1986-07-03 | 1994-08-09 | Advanced Magnetics Inc. | Targeting of therapeutic agents using polysaccharides |
| US5478576A (en) * | 1986-07-03 | 1995-12-26 | Advanced Magnetics, Inc. | Arabinogalactan derivatives and uses thereof |
| US5554386A (en) * | 1986-07-03 | 1996-09-10 | Advanced Magnetics, Inc. | Delivery of therapeutic agents to receptors using polysaccharides |
| US5679323A (en) * | 1986-07-03 | 1997-10-21 | Advanced Magnetics, Inc. | Hepatocyte-specific receptor-mediated endocytosis-type compositions |
| US5589591A (en) * | 1986-07-03 | 1996-12-31 | Advanced Magnetics, Inc. | Endotoxin-free polysaccharides |
| US4843067A (en) * | 1986-11-19 | 1989-06-27 | Yaguang Liu | Polysaccharide containing pharmaceutical composition for increasing the immune function |
| US4944946A (en) * | 1987-01-27 | 1990-07-31 | Yaguang Liu | Pharmaceutical composition for inhibiting viruses and increasing immune function (PII) |
| US5268467A (en) * | 1988-05-23 | 1993-12-07 | Verbiscar Anthony J | Immunomodulatory polysaccharide fractions from Astragalus plants |
| CN1027168C (zh) | 1989-05-13 | 1994-12-28 | 储大同 | 一种黄芪有效成分的提取方法 |
| US4950751A (en) * | 1989-06-02 | 1990-08-21 | The Nanci Corporation International | Method of isolating arabinogalactan from larch |
| IT1238685B (it) | 1990-02-09 | 1993-09-01 | Indena Spa | Polisaccaridi ad azione immunomodulatrice da astragalus membranaceous e composizioni farmaceutiche che li contengono |
| US5116969B1 (en) * | 1990-04-26 | 1997-04-01 | Larex International Inc | Ultrarefined arabinogalactan product |
| CN1025590C (zh) | 1990-07-20 | 1994-08-10 | 邓恺 | 肛瘘注射液的制备方法 |
| ES2049561B1 (es) | 1991-04-27 | 1994-12-16 | Andromaco Lab | Procedimiento para la obtencion de polimeros con actividad sobre el sistema hematopoyetico. |
| US5547997A (en) | 1991-10-01 | 1996-08-20 | Chemisches Laboratorium Dr. Kurt Richter Gmbh | Plant-derived cosmetic composition and method of treatment of skin |
| US5646029A (en) * | 1993-12-03 | 1997-07-08 | Cooperative Research Centre For Industrial Plant Biopolymers | Plant arabinogalactan protein (AGP) genes |
| US5756098A (en) * | 1995-12-12 | 1998-05-26 | The University Of Montana | Methods for the extraction of phytochemicals from fibrous plants in the absence of solvent |
| KR100195884B1 (ko) | 1996-02-12 | 1999-06-15 | 김박광 | 황기 추출물을 함유하는 혈당강하제 조성물 및 황기 추출물의 제조방법 |
| US5770217A (en) * | 1997-07-02 | 1998-06-23 | Atlatl, Inc. | Dietary supplement for hematological, immune and appetite enhancement |
| AU6203600A (en) * | 1999-06-30 | 2001-01-31 | Pharmagenesis, Inc. | Hematopoietic arabinogalactan composition |
| EP1294750A2 (en) | 2000-06-29 | 2003-03-26 | Pharmagenesis, Inc. | Acid-modified arabinogalactan protein composition |
| KR100440863B1 (ko) | 2001-05-24 | 2004-07-19 | 한국원자력연구소 | 조혈기능 증진 및 방사선 방호용 생약추출물 |
| KR100526404B1 (ko) | 2003-07-31 | 2005-11-08 | 학교법인 한림대학교 | 황기 추출물을 포함하는 뇌허혈성 신경세포손상 방지용조성물 |
| KR100449655B1 (ko) | 2003-11-17 | 2004-09-20 | 한국원자력연구소 | 조혈 및 면역기능 증강 및 방사선 방호용 기능성 식품 |
| JP2006070217A (ja) * | 2004-09-03 | 2006-03-16 | Kitasato Inst:The | オウギ属植物地上部由来の多糖および生体防御機能賦活化剤 |
| KR100697212B1 (ko) | 2005-01-29 | 2007-03-22 | 서울향료(주) | 황기 및 당귀의 혼합 생약재 추출물을 유효성분으로 하는,항암제 투여에 의해 유발되는 부작용 치료용 조혈 촉진제 |
| KR100760384B1 (ko) | 2006-02-22 | 2007-09-19 | 경희대학교 산학협력단 | 황기 추출물을 포함하는 혈관형성 촉진 및 골유합 효과를갖는 골절의 예방 및 치료용 조성물 |
-
2009
- 2009-12-15 EP EP09836839.2A patent/EP2376096B1/en active Active
- 2009-12-15 SG SG2011041787A patent/SG172029A1/en unknown
- 2009-12-15 WO PCT/US2009/068062 patent/WO2010077867A2/en not_active Ceased
- 2009-12-15 US US12/638,845 patent/US8137710B2/en active Active
- 2009-12-15 CN CN200980155742.9A patent/CN102300576B/zh active Active
- 2009-12-15 JP JP2011540971A patent/JP5732604B2/ja active Active
- 2009-12-15 KR KR1020117016274A patent/KR101780074B1/ko active Active
- 2009-12-15 TW TW098143056A patent/TWI507201B/zh active
- 2009-12-15 MY MYPI2011002701A patent/MY159317A/en unknown
-
2012
- 2012-02-07 US US13/368,319 patent/US8728543B2/en active Active
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