KR101780074B1 - 황기 추출물을 포함하는 조성물을 이용한 특발성 혈소판감소성자반병의 치료 - Google Patents

황기 추출물을 포함하는 조성물을 이용한 특발성 혈소판감소성자반병의 치료 Download PDF

Info

Publication number
KR101780074B1
KR101780074B1 KR1020117016274A KR20117016274A KR101780074B1 KR 101780074 B1 KR101780074 B1 KR 101780074B1 KR 1020117016274 A KR1020117016274 A KR 1020117016274A KR 20117016274 A KR20117016274 A KR 20117016274A KR 101780074 B1 KR101780074 B1 KR 101780074B1
Authority
KR
South Korea
Prior art keywords
mol
extract
delete delete
galactose
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020117016274A
Other languages
English (en)
Korean (ko)
Other versions
KR20110094343A (ko
Inventor
진후아 안
존 엠. 필들러
존 에이치. 무써
Original Assignee
에코팜, 엘엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에코팜, 엘엘씨 filed Critical 에코팜, 엘엘씨
Publication of KR20110094343A publication Critical patent/KR20110094343A/ko
Application granted granted Critical
Publication of KR101780074B1 publication Critical patent/KR101780074B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/196—Thrombopoietin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/202—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
KR1020117016274A 2008-12-15 2009-12-15 황기 추출물을 포함하는 조성물을 이용한 특발성 혈소판감소성자반병의 치료 Active KR101780074B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12258608P 2008-12-15 2008-12-15
US61/122,586 2008-12-15
PCT/US2009/068062 WO2010077867A2 (en) 2008-12-15 2009-12-15 Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus

Publications (2)

Publication Number Publication Date
KR20110094343A KR20110094343A (ko) 2011-08-23
KR101780074B1 true KR101780074B1 (ko) 2017-09-19

Family

ID=42266446

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117016274A Active KR101780074B1 (ko) 2008-12-15 2009-12-15 황기 추출물을 포함하는 조성물을 이용한 특발성 혈소판감소성자반병의 치료

Country Status (9)

Country Link
US (2) US8137710B2 (enExample)
EP (1) EP2376096B1 (enExample)
JP (1) JP5732604B2 (enExample)
KR (1) KR101780074B1 (enExample)
CN (1) CN102300576B (enExample)
MY (1) MY159317A (enExample)
SG (1) SG172029A1 (enExample)
TW (1) TWI507201B (enExample)
WO (1) WO2010077867A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103142726A (zh) * 2013-02-21 2013-06-12 上海浦东高星生物技术研究所 溃疡止血粉
WO2016028714A1 (en) * 2014-08-18 2016-02-25 Pharmagenesis, Inc. Polygalacturonan rhamnogalacturonan1 (pgrg1) composition
CN104173563A (zh) * 2014-08-22 2014-12-03 上海中医药大学附属岳阳中西医结合医院 一种治疗免疫性血小板减少症的中药组合物
CN104740405B (zh) * 2015-04-14 2018-09-04 日照市中医医院 一种治疗过敏性紫癜性肾损害的中药制剂及制备方法
CN104784419A (zh) * 2015-04-24 2015-07-22 陕西郝其军制药股份有限公司 一种治疗免疫性血小板减少性紫癜的中药组合物及其制备方法
JP2018087182A (ja) * 2016-11-10 2018-06-07 フィトヘルス・コーポレイションＰｈｙｔｏｈｅａｌｔｈ Ｃｏｒｐｏｒａｔｉｏｎ がん免疫療法の効果を高める方法
CN109199907A (zh) * 2017-07-07 2019-01-15 怀特生技新药股份有限公司 黄芪萃取物在制备用于抑制黑色素生成的组合物中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004502703A (ja) 2000-06-29 2004-01-29 ファーマジェネシス，　インコーポレイテッド 酸修飾アラビノガラクタンタンパク質組成物
JP2006070217A (ja) 2004-09-03 2006-03-16 Kitasato Inst:The オウギ属植物地上部由来の多糖および生体防御機能賦活化剤

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795742A (en) * 1985-09-24 1989-01-03 Yaguang Liu Therapeutic composition from plant extracts
US4708949A (en) * 1985-09-24 1987-11-24 Yaguang Liu Therapeutic composition from plant extracts
US5554386A (en) * 1986-07-03 1996-09-10 Advanced Magnetics, Inc. Delivery of therapeutic agents to receptors using polysaccharides
US5679323A (en) * 1986-07-03 1997-10-21 Advanced Magnetics, Inc. Hepatocyte-specific receptor-mediated endocytosis-type compositions
US5589591A (en) * 1986-07-03 1996-12-31 Advanced Magnetics, Inc. Endotoxin-free polysaccharides
US5336506A (en) * 1986-07-03 1994-08-09 Advanced Magnetics Inc. Targeting of therapeutic agents using polysaccharides
US5478576A (en) * 1986-07-03 1995-12-26 Advanced Magnetics, Inc. Arabinogalactan derivatives and uses thereof
US4843067A (en) * 1986-11-19 1989-06-27 Yaguang Liu Polysaccharide containing pharmaceutical composition for increasing the immune function
US4944946A (en) * 1987-01-27 1990-07-31 Yaguang Liu Pharmaceutical composition for inhibiting viruses and increasing immune function (PII)
US5268467A (en) * 1988-05-23 1993-12-07 Verbiscar Anthony J Immunomodulatory polysaccharide fractions from Astragalus plants
CN1027168C (zh) 1989-05-13 1994-12-28 储大同 一种黄芪有效成分的提取方法
US4950751A (en) * 1989-06-02 1990-08-21 The Nanci Corporation International Method of isolating arabinogalactan from larch
IT1238685B (it) 1990-02-09 1993-09-01 Indena Spa Polisaccaridi ad azione immunomodulatrice da astragalus membranaceous e composizioni farmaceutiche che li contengono
US5116969B1 (en) * 1990-04-26 1997-04-01 Larex International Inc Ultrarefined arabinogalactan product
CN1025590C (zh) 1990-07-20 1994-08-10 邓恺 肛瘘注射液的制备方法
ES2049561B1 (es) 1991-04-27 1994-12-16 Andromaco Lab Procedimiento para la obtencion de polimeros con actividad sobre el sistema hematopoyetico.
US5547997A (en) 1991-10-01 1996-08-20 Chemisches Laboratorium Dr. Kurt Richter Gmbh Plant-derived cosmetic composition and method of treatment of skin
US5646029A (en) * 1993-12-03 1997-07-08 Cooperative Research Centre For Industrial Plant Biopolymers Plant arabinogalactan protein (AGP) genes
US5756098A (en) * 1995-12-12 1998-05-26 The University Of Montana Methods for the extraction of phytochemicals from fibrous plants in the absence of solvent
KR100195884B1 (ko) 1996-02-12 1999-06-15 김박광 황기 추출물을 함유하는 혈당강하제 조성물 및 황기 추출물의 제조방법
US5770217A (en) * 1997-07-02 1998-06-23 Atlatl, Inc. Dietary supplement for hematological, immune and appetite enhancement
TWI240629B (en) 1999-06-30 2005-10-01 Pharmagenesis Inc Hematopoietic arabinogalactan composition
KR100440863B1 (ko) 2001-05-24 2004-07-19 한국원자력연구소 조혈기능 증진 및 방사선 방호용 생약추출물
KR100526404B1 (ko) 2003-07-31 2005-11-08 학교법인 한림대학교 황기 추출물을 포함하는 뇌허혈성 신경세포손상 방지용조성물
KR100449655B1 (ko) 2003-11-17 2004-09-20 한국원자력연구소 조혈 및 면역기능 증강 및 방사선 방호용 기능성 식품
KR100697212B1 (ko) 2005-01-29 2007-03-22 서울향료(주) 황기 및 당귀의 혼합 생약재 추출물을 유효성분으로 하는,항암제 투여에 의해 유발되는 부작용 치료용 조혈 촉진제
KR100760384B1 (ko) 2006-02-22 2007-09-19 경희대학교 산학협력단 황기 추출물을 포함하는 혈관형성 촉진 및 골유합 효과를갖는 골절의 예방 및 치료용 조성물

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004502703A (ja) 2000-06-29 2004-01-29 ファーマジェネシス，　インコーポレイテッド 酸修飾アラビノガラクタンタンパク質組成物
JP2006070217A (ja) 2004-09-03 2006-03-16 Kitasato Inst:The オウギ属植物地上部由来の多糖および生体防御機能賦活化剤

Also Published As

Publication number Publication date
WO2010077867A2 (en) 2010-07-08
MY159317A (en) 2016-12-30
US20100158861A1 (en) 2010-06-24
CN102300576B (zh) 2014-03-05
US8728543B2 (en) 2014-05-20
US8137710B2 (en) 2012-03-20
KR20110094343A (ko) 2011-08-23
EP2376096B1 (en) 2019-07-24
JP2012512176A (ja) 2012-05-31
CN102300576A (zh) 2011-12-28
EP2376096A4 (en) 2013-10-02
US20120141412A1 (en) 2012-06-07
EP2376096A2 (en) 2011-10-19
SG172029A1 (en) 2011-07-28
JP5732604B2 (ja) 2015-06-10
TWI507201B (zh) 2015-11-11
WO2010077867A3 (en) 2010-11-25
TW201026318A (en) 2010-07-16

Similar Documents

Publication Publication Date Title
KR101780074B1 (ko) 황기 추출물을 포함하는 조성물을 이용한 특발성 혈소판감소성자반병의 치료
CN1842341B (zh) 从人参叶和茎分离的抗癌以及抗转移活性级分
Dunn et al. Lenograstim: an update of its pharmacological properties and use in chemotherapy-induced neutropenia and related clinical settings
US20030211077A1 (en) Acid-modified arabinogalactan protein composition
CN107206053A (zh) 用于治疗血细胞减少症或减少血细胞减少症的持续时间的佛波醇酯组合物和方法
US9468685B2 (en) Methods of preparing a liquid formulation of G-CSF
HU207229B (en) Process for producing pharmaceutical compositions containing gm-csf for treating leukocyte disfunction
WO2001000682A1 (en) Hematopoietic arabinogalactan composition
CN107260750A (zh) 人参皂苷Rb1在制备治疗免疫性复发性流产药物中的用途及其药物组合物
JPH07113001A (ja) 新規多糖体及び該多糖体を有効成分とする放射線防護剤
De Simone et al. Report of the symposium on the use of intravenous gammaglobulin in adults infected with the human immunodeficiency virus
HK40059370A (en) Pharmaceutical composition for treating aplastic anemia
HK1245813B (en) Anti-cgrp antibody formulation
HK1245813A1 (en) Anti-cgrp antibody formulation
KR20160012210A (ko) 혈소판 감소증의 치료를 위한 조제약에서의 덴키신 사용

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

P22-X000 Classification modified

St.27 status event code: A-2-2-P10-P22-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R11-asn-PN2301

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R14-asn-PN2301

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-OTH-PR1001 (AS PROVIDED BY THE NATIONAL OFFICE)

Year of fee payment: 9