SG172029A1 - Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus - Google Patents

Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus Download PDF

Info

Publication number
SG172029A1
SG172029A1 SG2011041787A SG2011041787A SG172029A1 SG 172029 A1 SG172029 A1 SG 172029A1 SG 2011041787 A SG2011041787 A SG 2011041787A SG 2011041787 A SG2011041787 A SG 2011041787A SG 172029 A1 SG172029 A1 SG 172029A1
Authority
SG
Singapore
Prior art keywords
composition
extract
acid
galactose
arabinose
Prior art date
Application number
SG2011041787A
Other languages
English (en)
Inventor
Jinhua An
John M Fidler
John H Musser
Original Assignee
Ecopharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ecopharm Llc filed Critical Ecopharm Llc
Publication of SG172029A1 publication Critical patent/SG172029A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1816Erythropoietin [EPO]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/193Colony stimulating factors [CSF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/196Thrombopoietin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/202IL-3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
SG2011041787A 2008-12-15 2009-12-15 Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus SG172029A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12258608P 2008-12-15 2008-12-15
PCT/US2009/068062 WO2010077867A2 (en) 2008-12-15 2009-12-15 Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus

Publications (1)

Publication Number Publication Date
SG172029A1 true SG172029A1 (en) 2011-07-28

Family

ID=42266446

Family Applications (1)

Application Number Title Priority Date Filing Date
SG2011041787A SG172029A1 (en) 2008-12-15 2009-12-15 Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus

Country Status (9)

Country Link
US (2) US8137710B2 (enExample)
EP (1) EP2376096B1 (enExample)
JP (1) JP5732604B2 (enExample)
KR (1) KR101780074B1 (enExample)
CN (1) CN102300576B (enExample)
MY (1) MY159317A (enExample)
SG (1) SG172029A1 (enExample)
TW (1) TWI507201B (enExample)
WO (1) WO2010077867A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103142726A (zh) * 2013-02-21 2013-06-12 上海浦东高星生物技术研究所 溃疡止血粉
JP2017525702A (ja) * 2014-08-18 2017-09-07 ファーマジェネシス, インコーポレイテッド ポリガラクツロナンラムノガラクツロナン(pgrg1)組成物
CN104173563A (zh) * 2014-08-22 2014-12-03 上海中医药大学附属岳阳中西医结合医院 一种治疗免疫性血小板减少症的中药组合物
CN104740405B (zh) * 2015-04-14 2018-09-04 日照市中医医院 一种治疗过敏性紫癜性肾损害的中药制剂及制备方法
CN104784419A (zh) * 2015-04-24 2015-07-22 陕西郝其军制药股份有限公司 一种治疗免疫性血小板减少性紫癜的中药组合物及其制备方法
JP2018087182A (ja) * 2016-11-10 2018-06-07 フィトヘルス・コーポレイションPhytohealth Corporation がん免疫療法の効果を高める方法
CN109199907A (zh) * 2017-07-07 2019-01-15 怀特生技新药股份有限公司 黄芪萃取物在制备用于抑制黑色素生成的组合物中的应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708949A (en) * 1985-09-24 1987-11-24 Yaguang Liu Therapeutic composition from plant extracts
US4795742A (en) * 1985-09-24 1989-01-03 Yaguang Liu Therapeutic composition from plant extracts
US5336506A (en) * 1986-07-03 1994-08-09 Advanced Magnetics Inc. Targeting of therapeutic agents using polysaccharides
US5478576A (en) * 1986-07-03 1995-12-26 Advanced Magnetics, Inc. Arabinogalactan derivatives and uses thereof
US5554386A (en) * 1986-07-03 1996-09-10 Advanced Magnetics, Inc. Delivery of therapeutic agents to receptors using polysaccharides
US5679323A (en) * 1986-07-03 1997-10-21 Advanced Magnetics, Inc. Hepatocyte-specific receptor-mediated endocytosis-type compositions
US5589591A (en) * 1986-07-03 1996-12-31 Advanced Magnetics, Inc. Endotoxin-free polysaccharides
US4843067A (en) * 1986-11-19 1989-06-27 Yaguang Liu Polysaccharide containing pharmaceutical composition for increasing the immune function
US4944946A (en) * 1987-01-27 1990-07-31 Yaguang Liu Pharmaceutical composition for inhibiting viruses and increasing immune function (PII)
US5268467A (en) * 1988-05-23 1993-12-07 Verbiscar Anthony J Immunomodulatory polysaccharide fractions from Astragalus plants
CN1027168C (zh) 1989-05-13 1994-12-28 储大同 一种黄芪有效成分的提取方法
US4950751A (en) * 1989-06-02 1990-08-21 The Nanci Corporation International Method of isolating arabinogalactan from larch
IT1238685B (it) 1990-02-09 1993-09-01 Indena Spa Polisaccaridi ad azione immunomodulatrice da astragalus membranaceous e composizioni farmaceutiche che li contengono
US5116969B1 (en) * 1990-04-26 1997-04-01 Larex International Inc Ultrarefined arabinogalactan product
CN1025590C (zh) 1990-07-20 1994-08-10 邓恺 肛瘘注射液的制备方法
ES2049561B1 (es) 1991-04-27 1994-12-16 Andromaco Lab Procedimiento para la obtencion de polimeros con actividad sobre el sistema hematopoyetico.
US5547997A (en) 1991-10-01 1996-08-20 Chemisches Laboratorium Dr. Kurt Richter Gmbh Plant-derived cosmetic composition and method of treatment of skin
US5646029A (en) * 1993-12-03 1997-07-08 Cooperative Research Centre For Industrial Plant Biopolymers Plant arabinogalactan protein (AGP) genes
US5756098A (en) * 1995-12-12 1998-05-26 The University Of Montana Methods for the extraction of phytochemicals from fibrous plants in the absence of solvent
KR100195884B1 (ko) 1996-02-12 1999-06-15 김박광 황기 추출물을 함유하는 혈당강하제 조성물 및 황기 추출물의 제조방법
US5770217A (en) * 1997-07-02 1998-06-23 Atlatl, Inc. Dietary supplement for hematological, immune and appetite enhancement
AU6203600A (en) * 1999-06-30 2001-01-31 Pharmagenesis, Inc. Hematopoietic arabinogalactan composition
EP1294750A2 (en) 2000-06-29 2003-03-26 Pharmagenesis, Inc. Acid-modified arabinogalactan protein composition
KR100440863B1 (ko) 2001-05-24 2004-07-19 한국원자력연구소 조혈기능 증진 및 방사선 방호용 생약추출물
KR100526404B1 (ko) 2003-07-31 2005-11-08 학교법인 한림대학교 황기 추출물을 포함하는 뇌허혈성 신경세포손상 방지용조성물
KR100449655B1 (ko) 2003-11-17 2004-09-20 한국원자력연구소 조혈 및 면역기능 증강 및 방사선 방호용 기능성 식품
JP2006070217A (ja) * 2004-09-03 2006-03-16 Kitasato Inst:The オウギ属植物地上部由来の多糖および生体防御機能賦活化剤
KR100697212B1 (ko) 2005-01-29 2007-03-22 서울향료(주) 황기 및 당귀의 혼합 생약재 추출물을 유효성분으로 하는,항암제 투여에 의해 유발되는 부작용 치료용 조혈 촉진제
KR100760384B1 (ko) 2006-02-22 2007-09-19 경희대학교 산학협력단 황기 추출물을 포함하는 혈관형성 촉진 및 골유합 효과를갖는 골절의 예방 및 치료용 조성물

Also Published As

Publication number Publication date
EP2376096A4 (en) 2013-10-02
CN102300576A (zh) 2011-12-28
EP2376096B1 (en) 2019-07-24
US20120141412A1 (en) 2012-06-07
US8728543B2 (en) 2014-05-20
MY159317A (en) 2016-12-30
TW201026318A (en) 2010-07-16
TWI507201B (zh) 2015-11-11
KR101780074B1 (ko) 2017-09-19
JP2012512176A (ja) 2012-05-31
WO2010077867A2 (en) 2010-07-08
JP5732604B2 (ja) 2015-06-10
KR20110094343A (ko) 2011-08-23
EP2376096A2 (en) 2011-10-19
US8137710B2 (en) 2012-03-20
WO2010077867A3 (en) 2010-11-25
US20100158861A1 (en) 2010-06-24
CN102300576B (zh) 2014-03-05

Similar Documents

Publication Publication Date Title
US8728543B2 (en) Methods of treating idiopathic thrombocytopenic purpura with compositions comprising extracts of Astragalus membranaceus
JP7510743B2 (ja) 組換え酸性α-グルコシダーゼを含む製剤
US6991817B2 (en) Acid-modified arabinogalactan protein composition
JP2023505506A (ja) 化学療法または放射線療法で誘導された好中球減少症を治療する方法
JPH072685A (ja) 安定化された標準化ヤドリギレクチン製剤、ヤドリギレクチン濃縮物の製法及びヤドリギレクチンフラクションを含有する製剤の製法、及び自然免疫抵抗を高めるため及び腫瘍治療のための医薬品
EP4215186A1 (en) Treatment of celiac disease with tolerizing particles
KR20120008029A (ko) 면역 조절 치료제
US8562967B2 (en) Stable liquid formulations of G-CSF
EP1200482A1 (en) Hematopoietic arabinogalactan composition
EP2905026B1 (en) Peyer's patch activator
Li et al. Shennao fuyuan decoction and hUCMSC-exo combination therapy promotes lipid and atherosclerosis pathway activation and improves brain injury in middle cerebral artery occlusion rats: Traditional chinese medicine and exosomes for brain injuries
JP2016537428A (ja) エフェドラ・アラタ抽出物及びその使用方法
EP4582096A1 (en) Composition for preventing or treating lupus, comprising recombinant stabilized galectin 9 protein
WO2025002410A1 (en) G-csf dimer for use in the treatment or prevention of chemotherapy or radiotherapy induced neutropenia
KR20170047812A (ko) 으름덩굴 종자 추출물과 인삼이 혼합된 생약 혼합 추출물, 및 내독소를 포함하는 항암용 약학조성물
CA3238989A1 (en) A pharmaceutical formulation and a process for its preparation
CN114028544A (zh) 一种动员淋巴瘤和骨髓瘤干细胞的药物组合物
JP2022536582A (ja) ワクシニアウイルスによって炎症を起こしたウサギ皮膚由来の抽出物の造血系損傷の治療における使用
KR20160012210A (ko) 혈소판 감소증의 치료를 위한 조제약에서의 덴키신 사용