JP2012511314A5 - - Google Patents
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- JP2012511314A5 JP2012511314A5 JP2011540083A JP2011540083A JP2012511314A5 JP 2012511314 A5 JP2012511314 A5 JP 2012511314A5 JP 2011540083 A JP2011540083 A JP 2011540083A JP 2011540083 A JP2011540083 A JP 2011540083A JP 2012511314 A5 JP2012511314 A5 JP 2012511314A5
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- 108010000499 Thromboplastin Proteins 0.000 claims description 26
- 102000002262 Thromboplastin Human genes 0.000 claims description 26
- 238000003556 assay Methods 0.000 claims description 13
- 230000002401 inhibitory effect Effects 0.000 claims description 5
- 230000026731 phosphorylation Effects 0.000 claims description 4
- 238000006366 phosphorylation reaction Methods 0.000 claims description 4
- 108090001007 Interleukin-8 Proteins 0.000 claims description 2
- 230000023555 blood coagulation Effects 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims 47
- 125000003275 alpha amino acid group Chemical group 0.000 claims 33
- 150000001413 amino acids Chemical class 0.000 claims 33
- 230000004048 modification Effects 0.000 claims 22
- 238000012986 modification Methods 0.000 claims 22
- 101000635804 Homo sapiens Tissue factor Proteins 0.000 claims 17
- 238000000034 method Methods 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 6
- 101000635833 Mus musculus Tissue factor Proteins 0.000 claims 5
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 3
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000005764 inhibitory process Effects 0.000 claims 3
- 210000004881 tumor cell Anatomy 0.000 claims 3
- 238000002965 ELISA Methods 0.000 claims 2
- 230000008021 deposition Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000017066 negative regulation of growth Effects 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000005747 tumor angiogenesis Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20133508P | 2008-12-09 | 2008-12-09 | |
| DKPA200801744 | 2008-12-09 | ||
| US61/201,335 | 2008-12-09 | ||
| DKPA200801744 | 2008-12-09 | ||
| PCT/EP2009/066755 WO2010066803A2 (en) | 2008-12-09 | 2009-12-09 | Human antibodies aganist tissue factor. |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015246927A Division JP6236056B2 (ja) | 2008-12-09 | 2015-12-18 | ヒト組織因子に対するヒト抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012511314A JP2012511314A (ja) | 2012-05-24 |
| JP2012511314A5 true JP2012511314A5 (OSRAM) | 2015-01-22 |
| JP5860285B2 JP5860285B2 (ja) | 2016-02-16 |
Family
ID=59050110
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540083A Active JP5860285B2 (ja) | 2008-12-09 | 2009-12-09 | ヒト組織因子に対するヒト抗体 |
| JP2015246927A Active JP6236056B2 (ja) | 2008-12-09 | 2015-12-18 | ヒト組織因子に対するヒト抗体 |
| JP2017207768A Active JP6592491B2 (ja) | 2008-12-09 | 2017-10-27 | ヒト組織因子に対するヒト抗体 |
| JP2019171368A Active JP7069095B2 (ja) | 2008-12-09 | 2019-09-20 | ヒト組織因子に対するヒト抗体 |
| JP2022011455A Pending JP2022078018A (ja) | 2008-12-09 | 2022-01-28 | ヒト組織因子に対するヒト抗体 |
| JP2023186212A Pending JP2024001285A (ja) | 2008-12-09 | 2023-10-31 | ヒト組織因子に対するヒト抗体 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015246927A Active JP6236056B2 (ja) | 2008-12-09 | 2015-12-18 | ヒト組織因子に対するヒト抗体 |
| JP2017207768A Active JP6592491B2 (ja) | 2008-12-09 | 2017-10-27 | ヒト組織因子に対するヒト抗体 |
| JP2019171368A Active JP7069095B2 (ja) | 2008-12-09 | 2019-09-20 | ヒト組織因子に対するヒト抗体 |
| JP2022011455A Pending JP2022078018A (ja) | 2008-12-09 | 2022-01-28 | ヒト組織因子に対するヒト抗体 |
| JP2023186212A Pending JP2024001285A (ja) | 2008-12-09 | 2023-10-31 | ヒト組織因子に対するヒト抗体 |
Country Status (21)
| Country | Link |
|---|---|
| US (7) | US9150658B2 (OSRAM) |
| EP (3) | EP2376537B1 (OSRAM) |
| JP (6) | JP5860285B2 (OSRAM) |
| KR (2) | KR101736447B1 (OSRAM) |
| CN (3) | CN102317319B (OSRAM) |
| AU (1) | AU2009324412B2 (OSRAM) |
| BR (1) | BRPI0922350B8 (OSRAM) |
| CA (2) | CA3017575A1 (OSRAM) |
| DK (1) | DK2376537T3 (OSRAM) |
| EA (1) | EA201100923A1 (OSRAM) |
| ES (1) | ES2604635T3 (OSRAM) |
| IL (1) | IL212856A (OSRAM) |
| MX (2) | MX338754B (OSRAM) |
| NZ (1) | NZ786274A (OSRAM) |
| PL (1) | PL2376537T3 (OSRAM) |
| PT (1) | PT2376537T (OSRAM) |
| SG (1) | SG10201500140VA (OSRAM) |
| SI (1) | SI2376537T1 (OSRAM) |
| UA (1) | UA109633C2 (OSRAM) |
| WO (1) | WO2010066803A2 (OSRAM) |
| ZA (1) | ZA201103723B (OSRAM) |
Families Citing this family (67)
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| NZ540555A (en) | 2002-11-15 | 2008-04-30 | Genmab As | Antibody therapeutics for treatingand/or preventing diseases associated with cells expressing CD25, including autoimmune diseases, inflammatory and hyperproliferative skin disorders |
| AU2009324092A1 (en) * | 2008-12-03 | 2011-06-23 | Genmab A/S | Antibody variants having modifications in the constant region |
| UA109633C2 (uk) * | 2008-12-09 | 2015-09-25 | Антитіло людини проти тканинного фактора | |
| IL299365A (en) | 2010-05-27 | 2023-02-01 | Genmab As | Monoclonal antibodies against 2HER |
| SMT201700547T1 (it) * | 2010-06-15 | 2018-01-11 | Genmab As | Coniugati di farmaco anticorpo umano contro il fattore tissutale |
| EP4279513A3 (en) | 2010-11-30 | 2024-02-28 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
| US8722044B2 (en) * | 2011-03-15 | 2014-05-13 | Janssen Biotech, Inc. | Human tissue factor antibody and uses thereof |
| US20140170149A1 (en) * | 2011-04-20 | 2014-06-19 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
| CA2832387A1 (en) * | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecifc antibodies against her2 |
| UA117901C2 (uk) | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
| US9555109B2 (en) * | 2012-01-20 | 2017-01-31 | University Of Cincinnati | Method of inhibiting cell proliferation induced by alternatively spliced tissue factor by administering a monoclonal antibody |
| EP3632462A1 (en) | 2012-07-06 | 2020-04-08 | Genmab B.V. | Dimeric protein with triple mutations |
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| KR20210096697A (ko) | 2013-01-10 | 2021-08-05 | 젠맵 비. 브이 | 인간 IgG1 Fc 영역 변이체 및 그의 용도 |
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| HRP20241036T1 (hr) | 2013-11-21 | 2024-11-08 | Genmab A/S | Liofilizirana formulacija konjugata protutijelo-lijek |
| WO2016077720A1 (en) * | 2014-11-14 | 2016-05-19 | Protein One, Llc | Binding agents and uses thereof |
| US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11000548B2 (en) | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
| IL284985B2 (en) | 2015-02-18 | 2023-03-01 | Enlivex Therapeutics R& D Ltd | Combined immunotherapy and cytokine control therapy for cancer treatment |
| CA2982452A1 (en) | 2015-04-21 | 2016-10-27 | Enlivex Therapeutics Ltd. | Therapeutic pooled blood apoptotic cell preparations and uses thereof |
| WO2018036117A1 (zh) * | 2016-08-22 | 2018-03-01 | 复旦大学 | 靶向于组织因子的抗体、其制备方法和用途 |
| WO2017028823A1 (zh) * | 2015-08-20 | 2017-02-23 | 复旦大学 | 靶向于组织因子的抗体、其制备方法和用途 |
| DK3347054T3 (da) | 2015-09-11 | 2021-07-19 | Genmab As | Dosisregimer til anti-TF-antistoflægemiddelkonjugater |
| US11730761B2 (en) | 2016-02-18 | 2023-08-22 | Enlivex Therapeutics Rdo Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| CN106938051B (zh) | 2016-08-22 | 2019-10-11 | 复旦大学 | 靶向于组织因子的抗体-药物偶联物 |
| US11021533B2 (en) | 2016-11-02 | 2021-06-01 | Vanderbilt University | Human Zika virus antibodies and methods of use therefor |
| US12269859B2 (en) | 2016-12-02 | 2025-04-08 | Angeles Therapeutics, Inc. | Synthetic immune receptors and methods of use thereof |
| TW201922796A (zh) * | 2017-10-30 | 2019-06-16 | 國立研究開發法人國立癌症研究中心 | 可用於實體腫瘤治療之抗體及其抗體－藥物共軛物以及含其之抗癌劑 |
| EA202090741A1 (ru) * | 2017-11-02 | 2020-07-30 | Генмаб А/С | Конъюгаты антитела к тканевому фактору и лекарственного средства и их применение в лечении рака |
| KR20200118029A (ko) | 2018-01-04 | 2020-10-14 | 아이코닉 테라퓨틱스, 인코포레이티드 | 항-조직 인자 항체, 항체-약물 결합체, 및 관련 방법 |
| CN112105388A (zh) * | 2018-03-07 | 2020-12-18 | 展马博联合股份有限公司 | 抗组织因子抗体-药物偶联物及其在癌症治疗中的应用 |
| TWI841554B (zh) | 2018-03-21 | 2024-05-11 | 丹麥商珍美寶股份有限公司 | 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法 |
| TW202010755A (zh) | 2018-05-07 | 2020-03-16 | 丹麥商珍美寶股份有限公司 | 使用抗ｐｄ－１抗體與抗組織因子抗體－藥物共軛體之組合以治療癌症之方法 |
| KR102882368B1 (ko) | 2018-05-07 | 2025-11-07 | 젠맵 에이/에스 | 항-pd-1 항체와 항-조직 인자 항체-약물 접합체의 조합을 사용하여 암을 치료하는 방법 |
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| TWI844571B (zh) | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法 |
| CN109840471B (zh) * | 2018-12-14 | 2023-04-14 | 天津大学 | 一种基于改进Unet网络模型的可行道路分割方法 |
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| CN113692415B (zh) | 2019-04-17 | 2025-01-07 | 诺和诺德股份有限公司 | 双特异性抗体 |
| TW202131954A (zh) | 2019-11-07 | 2021-09-01 | 丹麥商珍美寶股份有限公司 | 利用鉑類劑與抗組織因子抗體－藥物共軛體之組合來治療癌症之方法 |
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