UA94922C2 - Способ регулирования специфичности сигнализации тканевого фактора у млекопитающего, которое нуждается в этом, способ идентификации агента, который специфически ингибирует сигнализацию тканевого фактора - Google Patents

Способ регулирования специфичности сигнализации тканевого фактора у млекопитающего, которое нуждается в этом, способ идентификации агента, который специфически ингибирует сигнализацию тканевого фактора

Info

Publication number
UA94922C2
UA94922C2 UAA200807780A UAA200807780A UA94922C2 UA 94922 C2 UA94922 C2 UA 94922C2 UA A200807780 A UAA200807780 A UA A200807780A UA A200807780 A UAA200807780 A UA A200807780A UA 94922 C2 UA94922 C2 UA 94922C2
Authority
UA
Ukraine
Prior art keywords
tissue factor
factor signaling
mammalian subject
identifying
agent
Prior art date
Application number
UAA200807780A
Other languages
English (en)
Ukrainian (uk)
Inventor
Вулфрем Раф
Джассімуддін Ахамед
Хенрік Ферштіг
Барбара М. Мюллер
Original Assignee
Зе Скріпс Рісьорч Інстітьют
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зе Скріпс Рісьорч Інстітьют filed Critical Зе Скріпс Рісьорч Інстітьют
Publication of UA94922C2 publication Critical patent/UA94922C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Предлагаются композиции и способы лечения заболеваний, зависимых от сигнализации тканевого фактора / фактора VIIa, у млекопитающих. Ингибитор эффективно уменьшает вероятность появления болезни у млекопитающего. Представлены также методики скрининга модуляторов сигнализации тканевого фактора / фактора VIIa.
UAA200807780A 2005-11-07 2006-11-06 Способ регулирования специфичности сигнализации тканевого фактора у млекопитающего, которое нуждается в этом, способ идентификации агента, который специфически ингибирует сигнализацию тканевого фактора UA94922C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73414905P 2005-11-07 2005-11-07

Publications (1)

Publication Number Publication Date
UA94922C2 true UA94922C2 (ru) 2011-06-25

Family

ID=38023919

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200807780A UA94922C2 (ru) 2005-11-07 2006-11-06 Способ регулирования специфичности сигнализации тканевого фактора у млекопитающего, которое нуждается в этом, способ идентификации агента, который специфически ингибирует сигнализацию тканевого фактора

Country Status (13)

Country Link
US (1) US20100028358A1 (ru)
EP (1) EP1945261A4 (ru)
JP (1) JP5191392B2 (ru)
CN (1) CN101500592A (ru)
AU (1) AU2006311661B2 (ru)
BR (1) BRPI0618338A2 (ru)
CA (1) CA2628238A1 (ru)
EA (1) EA014900B1 (ru)
IL (1) IL191321A (ru)
NZ (1) NZ568762A (ru)
UA (1) UA94922C2 (ru)
WO (1) WO2007056352A2 (ru)
ZA (1) ZA200804082B (ru)

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UA109633C2 (uk) * 2008-12-09 2015-09-25 Антитіло людини проти тканинного фактора
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US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
WO2012033518A1 (en) * 2010-09-09 2012-03-15 The Scripps Research Institute Methods and compositions for treating metabolic disorders
US8722044B2 (en) * 2011-03-15 2014-05-13 Janssen Biotech, Inc. Human tissue factor antibody and uses thereof
WO2012139069A2 (en) * 2011-04-07 2012-10-11 Neotope Biosciences Limited Compositions and methods for treating diseases of protein aggregation involving ic3b deposition
US10140146B2 (en) * 2015-10-22 2018-11-27 Genband Us Llc Network management for elastic virtual network functions
CN106938051B (zh) * 2016-08-22 2019-10-11 复旦大学 靶向于组织因子的抗体-药物偶联物
EP3502141A4 (en) * 2016-08-22 2020-04-08 Fudan University TISSUE FACTOR TARGET ANTIBODIES, PREPARATION METHOD AND USE THEREOF
WO2019136309A1 (en) * 2018-01-04 2019-07-11 Iconic Therapeutics, Inc. Anti-tissue factor antibodies, antibody-drug conjugates, and related methods
CN112574286A (zh) * 2020-01-02 2021-03-30 东莞市东阳光生物药研发有限公司 多肽及其应用
AU2021304359A1 (en) * 2020-07-10 2023-03-02 Iconic Therapeutics Llc Inflammatory disease treatment using anti-tissue factor antibodies

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AU2006311661A1 (en) 2007-05-18
BRPI0618338A2 (pt) 2011-08-23
WO2007056352A2 (en) 2007-05-18
CA2628238A1 (en) 2007-05-18
WO2007056352A3 (en) 2009-04-30
IL191321A (en) 2012-05-31
JP2009514895A (ja) 2009-04-09
EP1945261A2 (en) 2008-07-23
EA200801276A1 (ru) 2009-08-28
ZA200804082B (en) 2010-02-24
EA014900B1 (ru) 2011-02-28
AU2006311661B2 (en) 2011-05-26
JP5191392B2 (ja) 2013-05-08
CN101500592A (zh) 2009-08-05
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US20100028358A1 (en) 2010-02-04
EP1945261A4 (en) 2010-05-12

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