JP2012511023A5 - - Google Patents
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- JP2012511023A5 JP2012511023A5 JP2011539755A JP2011539755A JP2012511023A5 JP 2012511023 A5 JP2012511023 A5 JP 2012511023A5 JP 2011539755 A JP2011539755 A JP 2011539755A JP 2011539755 A JP2011539755 A JP 2011539755A JP 2012511023 A5 JP2012511023 A5 JP 2012511023A5
- Authority
- JP
- Japan
- Prior art keywords
- integer
- compound
- pharmaceutically acceptable
- tissue
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12022608P | 2008-12-05 | 2008-12-05 | |
| US61/120,226 | 2008-12-05 | ||
| US18034109P | 2009-05-21 | 2009-05-21 | |
| US61/180,341 | 2009-05-21 | ||
| PCT/US2009/066836 WO2010065902A2 (en) | 2008-12-05 | 2009-12-04 | Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof for inhibiting psma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012511023A JP2012511023A (ja) | 2012-05-17 |
| JP2012511023A5 true JP2012511023A5 (https=) | 2012-11-01 |
| JP5220203B2 JP5220203B2 (ja) | 2013-06-26 |
Family
ID=42076951
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011539757A Ceased JP2012511024A (ja) | 2008-12-05 | 2009-12-04 | 癌の治療及び撮像用のｃａ−ｉｘ特異性放射性医薬品 |
| JP2011539752A Pending JP2012511022A (ja) | 2008-12-05 | 2009-12-04 | テクネチウム及びレニウム−ビス（ヘテロアリール）錯体及びその使用方法 |
| JP2011539755A Active JP5220203B2 (ja) | 2008-12-05 | 2009-12-04 | テクネチウム−及びレニウム−ビス（ヘテロアリール）錯体及びｐｓｍａを阻害するその使用方法 |
| JP2014145241A Active JP5856247B2 (ja) | 2008-12-05 | 2014-07-15 | テクネチウム及びレニウム−ビス（ヘテロアリール）錯体及びその使用方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011539757A Ceased JP2012511024A (ja) | 2008-12-05 | 2009-12-04 | 癌の治療及び撮像用のｃａ−ｉｘ特異性放射性医薬品 |
| JP2011539752A Pending JP2012511022A (ja) | 2008-12-05 | 2009-12-04 | テクネチウム及びレニウム−ビス（ヘテロアリール）錯体及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014145241A Active JP5856247B2 (ja) | 2008-12-05 | 2014-07-15 | テクネチウム及びレニウム−ビス（ヘテロアリール）錯体及びその使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8211401B2 (https=) |
| EP (4) | EP2389361B1 (https=) |
| JP (4) | JP2012511024A (https=) |
| CN (3) | CN102272100B (https=) |
| AU (3) | AU2009322171A1 (https=) |
| BR (3) | BRPI0922840A2 (https=) |
| CA (3) | CA2745958A1 (https=) |
| ES (2) | ES2595128T3 (https=) |
| HU (2) | HUE030681T2 (https=) |
| PL (2) | PL2706057T3 (https=) |
| RU (3) | RU2539584C2 (https=) |
| TW (3) | TW201034691A (https=) |
| WO (1) | WO2010065902A2 (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4464384A3 (en) | 2007-08-17 | 2025-01-08 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
| USRE47609E1 (en) | 2007-12-28 | 2019-09-17 | Exini Diagnostics Ab | System for detecting bone cancer metastases |
| CA2711678A1 (en) | 2008-01-09 | 2009-07-16 | Molecular Insight Pharmaceuticals, Inc. | Inhibitors of carbonic anhydrase ix |
| TW201034691A (en) * | 2008-12-05 | 2010-10-01 | Molecular Insight Pharm Inc | Technetium-and rhenium-bis(heteroaryl) complexes and methods of use thereof |
| WO2010065906A2 (en) | 2008-12-05 | 2010-06-10 | Molecular Insight Pharmaceuticals, Inc. | Ca-ix specific radiopharmaceuticals for the treatment and imaging of cancer |
| WO2010065899A2 (en) | 2008-12-05 | 2010-06-10 | Molecular Insight Pharmaceuticals, Inc. | Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof |
| AU2010260195B2 (en) | 2009-06-15 | 2014-11-20 | Molecular Insight Pharmaceuticals, Inc. | Process for production of heterodimers of glutamic acid |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| US9687572B2 (en) | 2010-12-06 | 2017-06-27 | Molecular Insight Pharmaceuticals, Inc. | PSMA-targeted dendrimers |
| WO2013022797A1 (en) * | 2011-08-05 | 2013-02-14 | Molecular Insight Pharmaceuticals | Radiolabeled prostate specific membrane antigen inhibitors |
| WO2013028664A1 (en) | 2011-08-22 | 2013-02-28 | Siemens Medical Solutions Usa, Inc. | Psma imaging agents |
| CN113149921B (zh) | 2011-11-30 | 2024-11-29 | 约翰霍普金斯大学 | 前列腺特异性膜抗原(psma)的同源多价抑制剂和异源多价抑制剂以及其用途 |
| EP2800471A4 (en) | 2012-01-06 | 2015-11-04 | Molecular Insight Pharm Inc | METAL COMPLEX OF POLY (CARBOXYL) AMINE CONTAINING LIGANDS HAVING AFFINITY FOR CARBON IX ANHYDRASE |
| FR2989085A1 (fr) * | 2012-04-05 | 2013-10-11 | Commissariat Energie Atomique | Radiotraceurs, procedes de preparation et applications |
| BR112015011118B1 (pt) * | 2012-11-15 | 2022-12-13 | Endocyte, Inc | Conjugado; composição farmacêutica; e uso de um conjugado |
| EP3300746B1 (en) * | 2013-01-14 | 2019-05-15 | Molecular Insight Pharmaceuticals, Inc. | Triazine based radiopharmaceuticals and radioimaging agents |
| AU2014257164B2 (en) * | 2013-04-22 | 2018-10-11 | Abbvie Inc. | Thiazoles and uses thereof |
| LT4095130T (lt) | 2013-10-18 | 2024-04-25 | Novartis Ag | Žymėti prostatos specifinio membranos antigeno (psma) inhibitoriai, jų naudojimas kaip vizualizavimo medžiagų ir farmacinių medžiagų prostatos vėžiui gydyti |
| WO2015058151A2 (en) * | 2013-10-18 | 2015-04-23 | Molecular Insight Pharmaceuticals, Inc. | Methods of using spect/ct analysis for staging cancer |
| BR112016010927A2 (pt) | 2013-11-14 | 2017-08-08 | Endocyte Inc | Conjugado de fórmula |
| EP2993171A1 (en) * | 2014-09-04 | 2016-03-09 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for the production of 18F-labeled PSMA-specific PET-tracers |
| AU2015315465B2 (en) | 2014-09-08 | 2019-08-29 | Molecular Insight Pharmaceuticals, Inc. | Organ protection in PSMA-targeted radionuclide therapy of prostate cancer |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| AU2016333334B2 (en) * | 2015-09-30 | 2019-07-25 | Deutsches Krebsforschungszentrum | 18F-tagged inhibitors of prostate specific membrane antigen (PSMA) and their use as imaging agents for prostate cancer |
| KR101639599B1 (ko) * | 2015-11-09 | 2016-07-14 | 서울대학교산학협력단 | 펩타이드 싸이오우레아 유도체, 이를 포함하는 방사성 동위원소 표지 화합물 및 이를 유효 성분으로 함유하는 전립선암 치료 또는 진단용 약학적 조성물 |
| EP3192810A1 (en) * | 2016-01-14 | 2017-07-19 | Deutsches Krebsforschungszentrum | Psma binding antibody and uses thereof |
| CN105510511B (zh) * | 2016-01-23 | 2017-04-12 | 河北科技大学 | 一种2‑氨基丁醇对映异构体的hplc分离检测方法 |
| HRP20240215T1 (hr) * | 2016-03-22 | 2024-04-26 | The Johns Hopkins University | Sredstva sa visokim afinitetom za ciljani učinak na membranski antigen specifičan za prostatu za endoradioterapiju raka prostate |
| CN109843339B (zh) | 2016-06-23 | 2023-07-07 | 康奈尔大学 | 影响肿瘤杀伤的双重靶向构建体 |
| US10806806B2 (en) | 2016-06-23 | 2020-10-20 | Cornell University | Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies |
| CN113035327B (zh) | 2016-10-27 | 2025-02-07 | 普罗热尼奇制药公司 | 用于医学图像分析的网络、决策支持系统和相关图形用户界面(gui)应用 |
| IL315062A (en) | 2017-04-05 | 2024-10-01 | Univ Cornell | Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies |
| WO2018222778A1 (en) * | 2017-05-30 | 2018-12-06 | The Johns Hopkins University | Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer |
| SG11202005511VA (en) | 2017-12-13 | 2020-07-29 | Sciencons AS | Complex comprising a psma-targeting compound linked to a lead or thorium radionuclide |
| US10973486B2 (en) | 2018-01-08 | 2021-04-13 | Progenics Pharmaceuticals, Inc. | Systems and methods for rapid neural network-based image segmentation and radiopharmaceutical uptake determination |
| US12602772B2 (en) | 2018-01-08 | 2026-04-14 | Progenics Pharmaceuticals, Inc. | Systems and methods for rapid neural network-based image segmentation and radiopharmaceutical uptake determination |
| JP7448476B2 (ja) | 2018-01-08 | 2024-03-12 | プロジェニクス ファーマシューティカルズ， インコーポレイテッド | 高速ニューラルネットワークベースの画像セグメント化および放射性医薬品摂取判定のためのシステムおよび方法 |
| KR20250126870A (ko) * | 2018-02-06 | 2025-08-25 | 더 존스 홉킨스 유니버시티 | 암 방사선 치료를 위한 psma 표적 방사성 할로겐화 우레아-폴리아미노카복실레이트 |
| RU2692126C1 (ru) * | 2018-02-13 | 2019-06-21 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) | Способ получения производного мочевины с хелатным центром, тропного к простат-специфичному мембранному антигену для связывания технеция-99м/рения для диагностики/лечения рака предстательной железы |
| US12208102B2 (en) | 2018-04-17 | 2025-01-28 | Endocyte, Inc. | Methods of treating cancer |
| WO2019246445A1 (en) * | 2018-06-20 | 2019-12-26 | The Research Foundation For The State University Of New York | Triazamacrocycle-derived chelator compositions for coordination of imaging and therapy metal ions and methods of using same |
| WO2020045638A1 (ja) * | 2018-08-30 | 2020-03-05 | 日本メジフィジックス株式会社 | 放射性イミダゾチアジアゾール誘導体化合物 |
| JP7568628B2 (ja) | 2019-01-07 | 2024-10-16 | エクシーニ ディアグノスティクス アーべー | プラットホーム非依存の全身画像セグメント化のためのシステムおよび方法 |
| EP4564288A3 (en) | 2019-04-24 | 2025-09-17 | Progenics Pharmaceuticals, Inc. | Systems and methods for automated and interactive analysis of bone scan images for detection of metastases |
| JP7539921B2 (ja) | 2019-04-24 | 2024-08-26 | プロジェニクス ファーマシューティカルズ， インコーポレイテッド | 核医学画像における強度ウィンドウ処理の双方向調節のためのシステムおよび方法 |
| CN114096264B (zh) | 2019-05-20 | 2025-03-14 | 因多塞特股份有限公司 | 制备psma缀合物的方法 |
| US12417533B2 (en) | 2019-09-27 | 2025-09-16 | Progenics Pharmaceuticals, Inc. | Systems and methods for artificial intelligence-based image analysis for cancer assessment |
| US11900597B2 (en) | 2019-09-27 | 2024-02-13 | Progenics Pharmaceuticals, Inc. | Systems and methods for artificial intelligence-based image analysis for cancer assessment |
| US11564621B2 (en) | 2019-09-27 | 2023-01-31 | Progenies Pharmacenticals, Inc. | Systems and methods for artificial intelligence-based image analysis for cancer assessment |
| US11544407B1 (en) | 2019-09-27 | 2023-01-03 | Progenics Pharmaceuticals, Inc. | Systems and methods for secure cloud-based medical image upload and processing |
| US11386988B2 (en) | 2020-04-23 | 2022-07-12 | Exini Diagnostics Ab | Systems and methods for deep-learning-based segmentation of composite images |
| US11321844B2 (en) | 2020-04-23 | 2022-05-03 | Exini Diagnostics Ab | Systems and methods for deep-learning-based segmentation of composite images |
| US11721428B2 (en) | 2020-07-06 | 2023-08-08 | Exini Diagnostics Ab | Systems and methods for artificial intelligence-based image analysis for detection and characterization of lesions |
| WO2022008374A1 (en) | 2020-07-06 | 2022-01-13 | Exini Diagnostics Ab | Systems and methods for artificial intelligence-based image analysis for detection and characterization of lesions |
| EP4326246A4 (en) * | 2021-04-23 | 2026-04-15 | Wisconsin Alumni Res Found | PSMA-TARGETING LIGANDS WITH OPTIMAL IMAGING AND THERAPY PROPERTIES |
| US12597127B2 (en) | 2021-10-08 | 2026-04-07 | Exini Diagnostics Ab | Systems and methods for automated identification and classification of lesions in local lymph and distant metastases |
| EP4439713A4 (en) * | 2021-12-24 | 2025-04-30 | LG Energy Solution, Ltd. | POSITIVE ELECTRODE ACTIVE MATERIAL AND POSITIVE ELECTRODE AND LITHIUM SECONDARY BATTERY THEREFORE |
| AU2023282844A1 (en) | 2022-06-08 | 2024-11-28 | Exini Diagnostics Ab | Systems and methods for assessing disease burden and progression |
| US20240285248A1 (en) | 2023-02-13 | 2024-08-29 | Progenics Pharmaceuticals, Inc. | Systems and methods for predicting biochemical progression free survival in prostate cancer patients |
| WO2024211651A1 (en) | 2023-04-07 | 2024-10-10 | Progenics Pharmaceuticals, Inc. | Systems and methods for facilitating lesion inspection and analysis |
| WO2025072177A1 (en) | 2023-09-25 | 2025-04-03 | Progenics Pharmaceuticals, Inc. | Systems and methods for automated cancer staging and risk prediction |
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| WO2010065899A2 (en) * | 2008-12-05 | 2010-06-10 | Molecular Insight Pharmaceuticals, Inc. | Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof |
-
2009
- 2009-12-04 TW TW098141540A patent/TW201034691A/zh unknown
- 2009-12-04 CN CN200980153722.8A patent/CN102272100B/zh active Active
- 2009-12-04 EP EP09775429.5A patent/EP2389361B1/en active Active
- 2009-12-04 WO PCT/US2009/066836 patent/WO2010065902A2/en not_active Ceased
- 2009-12-04 AU AU2009322171A patent/AU2009322171A1/en not_active Abandoned
- 2009-12-04 US US12/631,337 patent/US8211401B2/en active Active
- 2009-12-04 ES ES09775429.5T patent/ES2595128T3/es active Active
- 2009-12-04 CN CN2009801538771A patent/CN102272101A/zh active Pending
- 2009-12-04 ES ES13195617.9T patent/ES2574514T3/es active Active
- 2009-12-04 JP JP2011539757A patent/JP2012511024A/ja not_active Ceased
- 2009-12-04 HU HUE09775429A patent/HUE030681T2/en unknown
- 2009-12-04 HU HUE13195617A patent/HUE029940T2/en unknown
- 2009-12-04 CA CA2745958A patent/CA2745958A1/en not_active Abandoned
- 2009-12-04 JP JP2011539752A patent/JP2012511022A/ja active Pending
- 2009-12-04 BR BRPI0922840A patent/BRPI0922840A2/pt active IP Right Grant
- 2009-12-04 EP EP14155382.6A patent/EP2759535A1/en not_active Withdrawn
- 2009-12-04 RU RU2011127462/04A patent/RU2539584C2/ru active
- 2009-12-04 JP JP2011539755A patent/JP5220203B2/ja active Active
- 2009-12-04 PL PL13195617.9T patent/PL2706057T3/pl unknown
- 2009-12-04 TW TW098141536A patent/TW201034690A/zh unknown
- 2009-12-04 TW TW098141532A patent/TW201034689A/zh unknown
- 2009-12-04 RU RU2011127467/04A patent/RU2539565C2/ru not_active IP Right Cessation
- 2009-12-04 CA CA2745955A patent/CA2745955C/en active Active
- 2009-12-04 RU RU2011127468/04A patent/RU2532912C2/ru active
- 2009-12-04 AU AU2009322167A patent/AU2009322167B2/en active Active
- 2009-12-04 EP EP09765209A patent/EP2373621A2/en not_active Withdrawn
- 2009-12-04 BR BRPI0922779A patent/BRPI0922779A8/pt active Search and Examination
- 2009-12-04 PL PL09775429T patent/PL2389361T3/pl unknown
- 2009-12-04 BR BRPI0922839-0A patent/BRPI0922839A2/pt not_active IP Right Cessation
- 2009-12-04 AU AU2009322164A patent/AU2009322164B2/en active Active
- 2009-12-04 EP EP09775430A patent/EP2373622A2/en not_active Withdrawn
- 2009-12-04 CN CN2009801538786A patent/CN102272102A/zh active Pending
- 2009-12-04 CA CA2745918A patent/CA2745918C/en active Active
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2014
- 2014-07-15 JP JP2014145241A patent/JP5856247B2/ja active Active
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