JP2012508163A5 - - Google Patents

Download PDF

Info

Publication number
JP2012508163A5
JP2012508163A5 JP2011533632A JP2011533632A JP2012508163A5 JP 2012508163 A5 JP2012508163 A5 JP 2012508163A5 JP 2011533632 A JP2011533632 A JP 2011533632A JP 2011533632 A JP2011533632 A JP 2011533632A JP 2012508163 A5 JP2012508163 A5 JP 2012508163A5
Authority
JP
Japan
Prior art keywords
antibody construct
acute lymphoblastic
lymphoblastic leukemia
single chain
construct according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011533632A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012508163A (ja
JP5798036B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2009/007969 external-priority patent/WO2010052013A1/en
Publication of JP2012508163A publication Critical patent/JP2012508163A/ja
Publication of JP2012508163A5 publication Critical patent/JP2012508163A5/ja
Application granted granted Critical
Publication of JP5798036B2 publication Critical patent/JP5798036B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011533632A 2008-11-07 2009-11-06 小児急性リンパ芽球性白血病の新規治療 Active JP5798036B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US11232308P 2008-11-07 2008-11-07
US61/112,323 2008-11-07
US18329109P 2009-06-02 2009-06-02
US61/183,291 2009-06-02
US22126909P 2009-06-29 2009-06-29
US61/221,269 2009-06-29
PCT/EP2009/007969 WO2010052013A1 (en) 2008-11-07 2009-11-06 Treatment of pediatric acute lymphoblastic leukemia

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015163116A Division JP6130451B2 (ja) 2008-11-07 2015-08-20 小児急性リンパ芽球性白血病の新規治療

Publications (3)

Publication Number Publication Date
JP2012508163A JP2012508163A (ja) 2012-04-05
JP2012508163A5 true JP2012508163A5 (enExample) 2013-03-21
JP5798036B2 JP5798036B2 (ja) 2015-10-21

Family

ID=41796119

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011533632A Active JP5798036B2 (ja) 2008-11-07 2009-11-06 小児急性リンパ芽球性白血病の新規治療
JP2015163116A Active JP6130451B2 (ja) 2008-11-07 2015-08-20 小児急性リンパ芽球性白血病の新規治療

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015163116A Active JP6130451B2 (ja) 2008-11-07 2015-08-20 小児急性リンパ芽球性白血病の新規治療

Country Status (27)

Country Link
US (2) US20110262440A1 (enExample)
EP (4) EP3330293B1 (enExample)
JP (2) JP5798036B2 (enExample)
KR (1) KR101695329B1 (enExample)
CN (2) CN102209729B (enExample)
AU (1) AU2009313039B2 (enExample)
BR (1) BRPI0921341A2 (enExample)
CA (1) CA2742242C (enExample)
CY (3) CY1116160T1 (enExample)
DK (3) DK2344539T3 (enExample)
ES (3) ES2662929T3 (enExample)
HK (1) HK1255590B (enExample)
HR (3) HRP20150400T1 (enExample)
HU (3) HUE025452T2 (enExample)
IL (1) IL212651A (enExample)
LT (2) LT3330293T (enExample)
MX (1) MX2011002931A (enExample)
NO (1) NO2918604T3 (enExample)
NZ (1) NZ591312A (enExample)
PL (3) PL2344539T3 (enExample)
PT (3) PT3330293T (enExample)
RS (3) RS59348B1 (enExample)
RU (3) RU2536933C2 (enExample)
SG (1) SG195549A1 (enExample)
SI (3) SI3330293T1 (enExample)
SM (3) SMT201900546T1 (enExample)
WO (1) WO2010052013A1 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6358588A (ja) * 1986-08-29 1988-03-14 Toshiba Corp バ−コ−ド読取装置
DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
JP5798036B2 (ja) * 2008-11-07 2015-10-21 アムゲン リサーチ (ミュンヘン) ゲーエムベーハー 小児急性リンパ芽球性白血病の新規治療
EP3517961B1 (en) * 2009-01-09 2020-12-30 Oxford BioMedica (UK) Limited Factors
US20150231241A1 (en) * 2012-08-14 2015-08-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
IL282953B2 (en) * 2012-11-13 2026-02-01 Tron Translationale Onkologie An Der Johannes Gutenberg Univ Mainz Gemeinnutzige Gmbh Agents for the treatment of claudin-expressing cancers
TWI682941B (zh) 2013-02-01 2020-01-21 美商再生元醫藥公司 含嵌合恆定區之抗體
CN103131777A (zh) * 2013-02-05 2013-06-05 南京艾迪康医学检验所有限公司 用于检测e2a-pbx融合基因相对表达量的试剂盒
EP3105252B1 (en) 2014-02-12 2019-07-24 Michael Uhlin Bispecific antibodies for use in stem cell transplantation
TWI754319B (zh) 2014-03-19 2022-02-01 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
SI3149480T1 (sl) 2014-05-30 2019-05-31 Amgen Research (Munich) Gmbh Stratifikacija tveganj pri bolnikih z akutno limfoblastno levkemijo prekurzorjev b
US20170252364A1 (en) 2014-07-30 2017-09-07 Mor Research Applications Ltd. Compositions for treatment of acute lymphoblastic leukemia and methods of use thereof
US20170239294A1 (en) * 2014-10-15 2017-08-24 Novartis Ag Compositions and methods for treating b-lymphoid malignancies
ES2809455T3 (es) 2014-11-17 2021-03-04 Regeneron Pharma Métodos para tratamiento tumoral usando anticuerpo biespecífico CD3xCD20
AU2016215110A1 (en) 2015-02-05 2017-09-21 Stc.Unm Anti-pre-BCR antagonists and methods
DK3277725T3 (da) 2015-03-30 2021-01-11 Regeneron Pharma Konstante tungkædeområder med reduceret binding til FC-gammareceptorer
PL3280729T3 (pl) 2015-04-08 2022-08-22 Novartis Ag Terapie cd20, terapie cd22 i terapie skojarzone komórką eksprymującą chimeryczny receptor antygenowy (car) cd19
SI3298042T1 (sl) 2015-05-20 2025-03-31 Amgen Research (Munich) Gmbh Deplecija B celic kot diagnostični marker
MY195059A (en) 2015-09-23 2023-01-05 Regeneron Pharma Optimized Anti-CD3 Bispecific Antibodies and Uses Thereof
CN108602889A (zh) * 2015-12-22 2018-09-28 瑞泽恩制药公司 医治急性成淋巴细胞性白血病的双特异性抗cd20/抗cd3抗体
GB201602974D0 (en) * 2016-02-19 2016-04-06 Clube Jasper R Engineered cells & methods (1)
EP3430052A2 (en) * 2016-03-14 2019-01-23 Millennium Pharmaceuticals, Inc. Method of preventing graft versus host disease
WO2017214207A2 (en) * 2016-06-06 2017-12-14 Juno Therapeutics, Inc. Methods for the treatment of b cell malignancies using adoptive cell therapy
US11590167B2 (en) 2016-12-03 2023-02-28 Juno Therapeutic, Inc. Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors
MA48763A (fr) * 2017-05-05 2020-04-08 Amgen Inc Composition pharmaceutique comprenant des constructions d'anticorps bispécifiques pour un stockage et une administration améliorés
IL327498A (en) 2017-06-02 2026-05-01 Juno Therapeutics Inc Articles of manufacture and methods for treatment using adoptive cell therapy
WO2019089858A2 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
KR102083481B1 (ko) 2018-03-22 2020-03-02 강원대학교산학협력단 아연-키토산 나노 입자를 포함한 급성 림프구성 백혈병 치료용 약학조성물
ES3009025T3 (en) 2018-08-31 2025-03-25 Regeneron Pharma Dosing strategy that mitigates cytokine release syndrome for cd3/cd20 bispecific antibodies
AU2020214336B2 (en) * 2019-01-30 2026-06-04 The Wistar Institute Of Anatomy And Biology DNA-encoded bispecific T-cell engagers targeting cancer antigens and methods of use in cancer theraputics
JP7137696B2 (ja) 2019-05-14 2022-09-14 プロヴェンション・バイオ・インコーポレイテッド 1型糖尿病を予防するための方法および組成物
AU2020279224B2 (en) 2019-05-21 2024-12-05 Novartis Ag Trispecific binding molecules against BCMA and uses thereof
UY38701A (es) 2019-05-21 2020-12-31 Novartis Ag Moléculas de unión a cd19, conjugados, composiciones que las comprenden y usos de las mismas
JP6881658B2 (ja) 2019-07-05 2021-06-02 小野薬品工業株式会社 Pd−1/cd3二重特異性タンパク質による血液がん治療
KR20230092863A (ko) 2020-06-11 2023-06-26 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
MX2023009433A (es) 2021-02-16 2023-11-29 Children´S Health Care D/B/A/ Children´S Minnesota Metodos para el tratamiento de b-all mediante la administracion de un antagonista del complejo pre-bcr.
MX2023013851A (es) 2021-05-24 2023-12-08 Provention Bio Inc Metodos para el tratamiento de diabetes tipo 1.
KR20240099263A (ko) 2021-10-15 2024-06-28 암젠 리서치 (뮌헨) 게엠베하 Cd19 결합 t 세포 관여 항체의 피하 투여
US12698512B2 (en) 2023-11-06 2026-08-04 City Of Hope Methods comprising oncolytic viruses expressing CD19T and bispecific T cell engagers
AU2024406222A1 (en) 2023-12-20 2026-06-04 Bristol-Myers Squibb Company Antibodies targeting il-18 receptor beta (il-18rβ) and related methods
WO2025250648A1 (en) * 2024-05-28 2025-12-04 Ohio State Innovation Foundation Methods and compositions comprising tagless blinatumomab
WO2026072671A1 (en) 2024-09-24 2026-04-02 City Of Hope Methods comprising oncolytic viruses expressing bcmat and bcma-targeted therapies

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4119397A (en) * 1996-08-28 1998-03-19 Viva Diagnostika Diagnostische Produkte Gmbh Novel combination preparations and their use in immunodiagnosis and immunotherapy
CA2326389C (en) 1998-04-21 2007-01-23 Micromet Gesellschaft Fur Biomedizinische Forschung Mbh Novel cd19xcd3 specific polypeptides and uses thereof
AU2004242846A1 (en) * 2003-05-31 2004-12-09 Micromet Ag Pharmaceutical compositions comprising bispecific anti-CD3, anti-CD19 antibody constructs for the treatment of B-cell related disorders
US8076459B2 (en) * 2003-10-16 2011-12-13 Micromet Ag Multispecfic deimmunized CD3-binders
US8007796B2 (en) * 2005-12-16 2011-08-30 Micromet Ag Means and methods for the treatment of tumorous diseases
RS53263B (sr) * 2006-08-14 2014-08-29 Xencor Inc. Optimizovana antitela usmerena na cd19
EP2352763B2 (en) * 2008-10-01 2022-09-21 Amgen Research (Munich) GmbH Bispecific single chain antibodies with specificity for high molecular weight target antigens
JP5798036B2 (ja) * 2008-11-07 2015-10-21 アムゲン リサーチ (ミュンヘン) ゲーエムベーハー 小児急性リンパ芽球性白血病の新規治療
RU2538965C2 (ru) * 2009-01-19 2015-01-10 Эббви Инк. Вызывающие апоптоз средства для лечения рака и иммунных и аутоиммунных заболеваний
NZ616828A (en) * 2009-01-19 2015-03-27 Abbvie Inc Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8486933B2 (en) * 2009-05-27 2013-07-16 Abbvie Inc. Pyrimidine inhibitors of kinase activity
KR20120085781A (ko) * 2009-09-20 2012-08-01 아보트 러보러터리즈 Bcl-2 단백질 관련 질환을 치료하는데 사용하기 위한 abt-263 결정 형태 및 용매화물
NZ598732A (en) * 2009-10-27 2014-09-26 Amgen Res Munich Gmbh Dosage regimen for administering a cd19xcd3 bispecific antibody

Similar Documents

Publication Publication Date Title
HRP20191715T1 (hr) Liječenje dječje akutne limfoblastične leukemije sa bispecifičnim protutijelima protiv cd3xcd19
HRP20151168T1 (hr) Lijeäśenje akutne limfoblastiäśne leukemije
Tyor et al. Cytokine expression in the brain during the acquired immunodeficiency syndrome
Fioravanti et al. Effector CD8+ T cell-derived interleukin-10 enhances acute liver immunopathology
EP2953634B1 (en) Methods for expansion or depletion of t-regulatory cells
Lehner et al. Immunological basis for latency, recurrences, and putative oncogenicity of herpes simplex virus
Bhela et al. The plasticity and stability of regulatory T cells during viral-induced inflammatory lesions
JP2009286793A5 (enExample)
JP2010132660A5 (enExample)
Eliassen et al. The interplay between natural killer cells and human herpesvirus-6
Palmer et al. IFNγ-producing, virus-specific CD8+ effector cells acquire the ability to produce IL-10 as a result of entry into the infected lung environment
Hillyer et al. Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis
Chen et al. Anti-VCAM 1 antibody-coated mesenchymal stromal cells attenuate experimental colitis via immunomodulation
Imaeda et al. Interleukin-33 suppresses Notch ligand expression and prevents goblet cell depletion in dextran sulfate sodium-induced colitis
Tanaka et al. Dermatomyositis: a contemporary review for oral health care providers
McTavish et al. Immune characteristics correlating with HSV‐1 immune control and effect of squaric acid dibutyl ester on immune characteristics of subjects with frequent herpes labialis episodes
JP2022507609A (ja) 誘導された制御性T(iTREG)細胞を使用したALS治療
Mudter et al. Insight into Crohn’s disease pathomorphology
Samah et al. Nerve growth factor stimulation promotes CXCL-12 attraction of monocytes but decreases human immunodeficiency virus replication in attracted population
Vey et al. A phase I study of the anti-natural killer inhibitory receptor (KIR) monoclonal antibody (1-7F9, IPH2101) in elderly patients with acute myeloid leukemia (AML): clinical and immunological effects of a single dose followed by repeated dosing.
CN113413464A (zh) 抗pd-l1抗体在急性呼吸窘迫综合征治疗药物中的应用
Bykov et al. The usage of the oral liquid in the laboratory effectiveness monitoring of treatment of the dental diseases
US20240307346A1 (en) Method for treating or preventing a disease of incomplete immune reconstitution in aids using (5r)-5-hydroxytriptolide
Gye et al. Pemphigus vulgaris in pregnancy associated with herpes virus type 1 infection
Madsen et al. AB0131 INDUCTION OF COLLAGEN CHAIN FORMATION IN RESPONSE TO FIBROTIC FACTORS IN DERMAL AND PULMONARY FIBROBLASTS