JP2012504639A5 - - Google Patents
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- JP2012504639A5 JP2012504639A5 JP2011530218A JP2011530218A JP2012504639A5 JP 2012504639 A5 JP2012504639 A5 JP 2012504639A5 JP 2011530218 A JP2011530218 A JP 2011530218A JP 2011530218 A JP2011530218 A JP 2011530218A JP 2012504639 A5 JP2012504639 A5 JP 2012504639A5
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- Prior art keywords
- alkyl
- haloalkyl
- independently selected
- alkynyl
- alkenyl
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- 0 CC([*+])(C1)CC1(CC#N)[n]1ncc(-c2c(cc[n]3)c3ncn2)c1 Chemical compound CC([*+])(C1)CC1(CC#N)[n]1ncc(-c2c(cc[n]3)c3ncn2)c1 0.000 description 4
- WSRSPJKCIMNPIK-UHFFFAOYSA-N CC1C(CCN)C1 Chemical compound CC1C(CCN)C1 WSRSPJKCIMNPIK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10224208P | 2008-10-02 | 2008-10-02 | |
| US61/102,242 | 2008-10-02 | ||
| PCT/US2009/059203 WO2010039939A1 (en) | 2008-10-02 | 2009-10-01 | Janus kinase inhibitors for treatment of dry eye and other eye related diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015042933A Division JP2015127332A (ja) | 2008-10-02 | 2015-03-04 | ドライアイおよび他の目に関連する疾患を治療するためのヤヌスキナーゼ阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012504639A JP2012504639A (ja) | 2012-02-23 |
| JP2012504639A5 true JP2012504639A5 (enExample) | 2013-02-07 |
Family
ID=41572626
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530218A Withdrawn JP2012504639A (ja) | 2008-10-02 | 2009-10-01 | ドライアイおよび他の目に関連する疾患を治療するためのヤヌスキナーゼ阻害剤 |
| JP2015042933A Pending JP2015127332A (ja) | 2008-10-02 | 2015-03-04 | ドライアイおよび他の目に関連する疾患を治療するためのヤヌスキナーゼ阻害剤 |
| JP2017000685A Pending JP2017057231A (ja) | 2008-10-02 | 2017-01-05 | ドライアイおよび他の目に関連する疾患を治療するためのヤヌスキナーゼ阻害剤 |
| JP2017246134A Pending JP2018044012A (ja) | 2008-10-02 | 2017-12-22 | ドライアイおよび他の目に関連する疾患を治療するためのヤヌスキナーゼ阻害剤 |
| JP2020002245A Pending JP2020050682A (ja) | 2008-10-02 | 2020-01-09 | ドライアイおよび他の目に関連する疾患を治療するためのヤヌスキナーゼ阻害剤 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015042933A Pending JP2015127332A (ja) | 2008-10-02 | 2015-03-04 | ドライアイおよび他の目に関連する疾患を治療するためのヤヌスキナーゼ阻害剤 |
| JP2017000685A Pending JP2017057231A (ja) | 2008-10-02 | 2017-01-05 | ドライアイおよび他の目に関連する疾患を治療するためのヤヌスキナーゼ阻害剤 |
| JP2017246134A Pending JP2018044012A (ja) | 2008-10-02 | 2017-12-22 | ドライアイおよび他の目に関連する疾患を治療するためのヤヌスキナーゼ阻害剤 |
| JP2020002245A Pending JP2020050682A (ja) | 2008-10-02 | 2020-01-09 | ドライアイおよび他の目に関連する疾患を治療するためのヤヌスキナーゼ阻害剤 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US20100113416A1 (enExample) |
| EP (2) | EP2349260B1 (enExample) |
| JP (5) | JP2012504639A (enExample) |
| AR (2) | AR073530A1 (enExample) |
| CA (2) | CA3064247A1 (enExample) |
| CL (1) | CL2009001884A1 (enExample) |
| CY (1) | CY1117317T1 (enExample) |
| DK (1) | DK2349260T3 (enExample) |
| ES (1) | ES2564203T3 (enExample) |
| HR (1) | HRP20160330T1 (enExample) |
| HU (1) | HUE028499T2 (enExample) |
| PL (1) | PL2349260T3 (enExample) |
| PT (1) | PT2349260E (enExample) |
| RS (1) | RS54651B1 (enExample) |
| SI (1) | SI2349260T1 (enExample) |
| SM (1) | SMT201600080B (enExample) |
| TW (2) | TWI643622B (enExample) |
| WO (1) | WO2010039939A1 (enExample) |
Families Citing this family (126)
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| WO2005105814A1 (en) * | 2004-04-28 | 2005-11-10 | Incyte Corporation | Tetracyclic inhibitors of janus kinases |
| CN103214484B (zh) | 2005-12-13 | 2016-07-06 | 因塞特控股公司 | 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]嘧啶 |
| SG174026A1 (en) | 2006-08-03 | 2011-09-29 | Nitec Pharma Ag | Delayed-release glucocorticoid treatment of rheumatoid disease |
| EP2101819B1 (en) | 2006-11-20 | 2013-01-09 | President and Fellows of Harvard College | Methods, compositions, and kits for treating pain and pruritis |
| HUE029236T2 (en) | 2007-06-13 | 2017-02-28 | Incyte Holdings Corp | (R) -3- (4- (7H-Pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrazol-1-yl) -3-cyclopentylpropanenitrile Crystalline salts of Janus kinase inhibitor |
| CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
| MX2010005300A (es) * | 2007-11-16 | 2010-06-25 | Incyte Corp | 4-pirazolil-n-arilpirimidin-2-aminas y 4-pirazolil-n-heteroarilpir imidin-2-aminas como inhibidores de cinasas janus. |
| PE20211639A1 (es) | 2009-01-15 | 2021-08-24 | Incyte Holdings Corp | Procesos para preparar inhibidores de jak y compuestos intermediarios relacionado |
| AU2010207740B2 (en) * | 2009-01-26 | 2016-06-16 | Nitec Pharma Ag | Delayed-release glucocorticoid treatment of asthma |
| MY156727A (en) * | 2009-05-22 | 2016-03-15 | Incyte Corp | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| EP2432472B1 (en) | 2009-05-22 | 2019-10-02 | Incyte Holdings Corporation | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
| EP2995303A1 (en) | 2009-07-10 | 2016-03-16 | President and Fellows of Harvard College | Permanently charged sodium and calcium channel blockers as anti-inflammatory agents |
| TW201113285A (en) * | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| MX2012004180A (es) * | 2009-10-09 | 2012-07-17 | Incyte Corp | Derivados de hidroxil, ceto y glucuronido de 3-(4-7h-pirrolo[2,3-d ]pirimidin-a-il)-1h-pirazol-1-il)-3-ciclopentilpropanonitrilo. |
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