JP2011529033A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011529033A5 JP2011529033A5 JP2011519189A JP2011519189A JP2011529033A5 JP 2011529033 A5 JP2011529033 A5 JP 2011529033A5 JP 2011519189 A JP2011519189 A JP 2011519189A JP 2011519189 A JP2011519189 A JP 2011519189A JP 2011529033 A5 JP2011529033 A5 JP 2011529033A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pyridin
- mol
- added
- prostate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13592008P | 2008-07-25 | 2008-07-25 | |
| US61/135,920 | 2008-07-25 | ||
| US22068509P | 2009-06-26 | 2009-06-26 | |
| US61/220,685 | 2009-06-26 | ||
| PCT/EP2009/059605 WO2010010191A1 (en) | 2008-07-25 | 2009-07-24 | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011529033A JP2011529033A (ja) | 2011-12-01 |
| JP2011529033A5 true JP2011529033A5 (enExample) | 2012-09-06 |
| JP5480261B2 JP5480261B2 (ja) | 2014-04-23 |
Family
ID=41021059
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519188A Active JP5559168B2 (ja) | 2008-07-25 | 2009-07-24 | 変性及び炎症性疾患の治療に有用な新規化合物 |
| JP2011519189A Active JP5480261B2 (ja) | 2008-07-25 | 2009-07-24 | 変性及び炎症性疾患の治療に有用な新規化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519188A Active JP5559168B2 (ja) | 2008-07-25 | 2009-07-24 | 変性及び炎症性疾患の治療に有用な新規化合物 |
Country Status (35)
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| JO3041B1 (ar) | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
| CN102459258B (zh) | 2009-06-05 | 2015-11-25 | 赛福伦公司 | 1,2,4-三唑并[1,5a]吡啶衍生物的制备和用途 |
| TWI462920B (zh) * | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
| JO3030B1 (ar) | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
| US20100331222A1 (en) * | 2009-06-26 | 2010-12-30 | Basf Se | Process for producing cellulose beads from solutions of cellulose in ionic liquid |
| WO2011140333A1 (en) | 2010-05-07 | 2011-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Identification of stabilizers of multimeric proteins |
| US20130143915A1 (en) | 2010-07-01 | 2013-06-06 | Cellzome Limited | Triazolopyridines as tyk2 inhibitors |
| AR086042A1 (es) | 2011-04-28 | 2013-11-13 | Galapagos Nv | Compuesto util para el tratamiento de enfermedades degenerativas e inflamatorias y composicion farmaceutica |
| BR112014032346A2 (pt) | 2012-06-26 | 2017-06-27 | Del Mar Pharmaceuticals | métodos para tratamento de malignidades resistentes ao inibidor de tirosina-quinase em pacientes com polimorfismos genéticos ou desregulações de ahi1 mutações empregando dianidrogalactitol, diacetildianidrogalactitol, dibromodulcitol, ou análogos ou derivados destes |
| US9169214B2 (en) | 2012-12-21 | 2015-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions |
| CN103965114B (zh) * | 2013-01-28 | 2016-01-06 | 苏州泽璟生物制药有限公司 | 氘代的苯基氨基嘧啶化合物以及包含该化合物的药物组合物 |
| US20160123982A1 (en) | 2013-02-04 | 2016-05-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for assaying jak2 activity in red blood cells and uses thereof |
| EP3010922B1 (en) * | 2013-06-19 | 2017-03-15 | Galapagos NV | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| ME02883B (me) | 2013-12-05 | 2018-04-20 | Pfizer | PIROLO[2,3-d]PIRIMIDINIL-, PIROLO[2,3-b]PIRAZINIL- I PIROLO[2,3-d] PIRIDINILAKRILAMIDI |
| US10226449B2 (en) | 2013-12-20 | 2019-03-12 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis and combinations thereof |
| GB201402071D0 (en) * | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| GB201402070D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
| EP3179857B1 (en) | 2014-08-14 | 2021-09-08 | Mamoun M. Alhamadsheh | Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life |
| TWI679205B (zh) | 2014-09-02 | 2019-12-11 | 日商日本新藥股份有限公司 | 吡唑并噻唑化合物及醫藥 |
| CN107428749B (zh) | 2015-01-28 | 2020-07-24 | 上海复旦张江生物医药股份有限公司 | 取代的咪唑并[1,2-α]吡啶-2-基胺化合物及其药物组合物和使用方法 |
| CA2982630A1 (en) * | 2015-04-13 | 2016-10-20 | Galapagos Nv | Methods for the treatment of inflammatory disorders |
| TR201909694T4 (tr) * | 2015-04-29 | 2019-07-22 | Wuxi Fortune Pharmaceutical Co Ltd | Janus kinaz (jak) inhibitörleri. |
| AU2016257892A1 (en) * | 2015-05-05 | 2017-11-09 | Concert Pharmaceuticals, Inc. | Deuterated filgotinib |
| CN105061420B (zh) * | 2015-06-04 | 2017-09-05 | 南京旗昌医药科技有限公司 | 一种jak抑制剂的晶型及其制备方法和应用 |
| CN104987333B (zh) * | 2015-07-14 | 2017-01-11 | 苏州富士莱医药股份有限公司 | 一种Filgotinib的合成方法 |
| WO2017012771A1 (en) | 2015-07-23 | 2017-01-26 | Ratiopharm Gmbh | Crystalline filgotinib sulfonic acid addition salts |
| WO2017012773A1 (en) | 2015-07-23 | 2017-01-26 | Ratiopharm Gmbh | Solid forms of filgotinib free base |
| WO2017012770A1 (en) | 2015-07-23 | 2017-01-26 | Ratiopharm Gmbh | Acid addition salts of filgotinib |
| CN105111207B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物d晶型及其制备方法 |
| CN105198878B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物f晶型及其制备方法 |
| CN105198877B (zh) * | 2015-09-18 | 2017-09-22 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物g晶型及其制备方法 |
| CN105218539B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物b晶型及其制备方法 |
| CN105198876B (zh) * | 2015-09-18 | 2017-09-29 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物h晶型及其制备方法 |
| CN105198879B (zh) * | 2015-09-18 | 2017-09-22 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物c晶型及其制备方法 |
| CN105198880B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物a晶型及其制备方法 |
| CN105111206B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物e晶型及其制备方法 |
| CN108349974B (zh) * | 2016-02-02 | 2021-04-30 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的吡啶酰胺类化合物及其应用 |
| TWI712604B (zh) | 2016-03-01 | 2020-12-11 | 日商日本新藥股份有限公司 | 具jak抑制作用之化合物之結晶 |
| JP6978098B2 (ja) * | 2016-07-26 | 2021-12-08 | スーヂョウ ロングバイオテック ファーマシューティカルズ カンパニー リミテッドSuzhou Longbiotech Pharmaceuticals Co., Ltd. | 選択的jak阻害剤としての化合物、該化合物の塩類および治療への使用 |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| CN107880038B (zh) * | 2016-09-30 | 2021-09-28 | 中国医药研究开发中心有限公司 | [1,2,4]三唑并[1,5-a]吡啶类化合物及其制备方法和医药用途 |
| JOP20190077A1 (ar) * | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| KR102417483B1 (ko) * | 2016-10-26 | 2022-07-05 | 얀센 파마슈티카 엔.브이. | 융합된 아자헤테로사이클릭 화합물 및 ampa 수용체 조절제로서의 이들의 용도 |
| CA3039676A1 (en) * | 2016-10-26 | 2018-05-03 | Janssen Pharmaceutica Nv | Fused bicylic pyridine compounds and their use as ampa receptor modulators |
| EA039352B1 (ru) * | 2017-01-19 | 2022-01-17 | Сучжоу Лонгбайотек Фармасьютикалз Ко., Лтд. | Соединение в качестве селективного ингибитора jak и его соли и терапевтическое применение |
| CN108341814B (zh) * | 2017-01-23 | 2021-09-03 | 上海翔锦生物科技有限公司 | Jak激酶抑制剂及其应用 |
| AU2018222739C1 (en) | 2017-02-17 | 2024-10-03 | Eidos Therapeutics, Inc. | Processes for preparing AG-10, its intermediates, and salts thereof |
| GB201702603D0 (en) | 2017-02-17 | 2017-04-05 | Galápagos Nv | Novel compositions and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| WO2018167283A1 (en) | 2017-03-17 | 2018-09-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling |
| EP3610264A1 (en) | 2017-04-13 | 2020-02-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma |
| WO2019149244A1 (zh) * | 2018-01-31 | 2019-08-08 | 南京明德新药研发股份有限公司 | Jak抑制剂及其应用 |
| KR102526964B1 (ko) | 2018-02-26 | 2023-04-28 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 복제 억제제로서의 치환된 피롤리진 화합물 |
| EP3758700B1 (en) * | 2018-02-28 | 2024-07-31 | University of Southern California | Compositions for modulating inflammatory and degenerative disorders |
| KR20200135996A (ko) | 2018-03-23 | 2020-12-04 | 에이도스 테라퓨틱스, 인코포레이티드 | Ag10을 사용하여 ttr 아밀로이드증을 치료하는 방법 |
| GB201808575D0 (en) | 2018-05-24 | 2018-07-11 | Galapagos Nv | Methods for the treatment of psoriatic arthrits |
| CA3104695A1 (en) | 2018-08-17 | 2020-02-20 | Eidos Therapeutics, Inc. | Formulations of ag10 |
| CA3106490C (en) * | 2018-08-23 | 2023-03-07 | Zhuhai United Laboratories Co., Ltd. | [1,2,4]triazolo[1,5-a]pyridine compound as jak inhibitor and use thereof |
| US10815227B2 (en) | 2018-08-27 | 2020-10-27 | Cadila Healthcare Limited | Processes for the preparation of filgotinib |
| WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
| WO2020097400A1 (en) * | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof |
| EP3876939A4 (en) | 2018-11-07 | 2022-08-10 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| US11633399B2 (en) | 2018-12-25 | 2023-04-25 | Sol-Gel Technologies Ltd. | Treatment of skin disorders with compositions comprising an EGFR inhibitor |
| US11427558B1 (en) | 2019-07-11 | 2022-08-30 | ESCAPE Bio, Inc. | Indazoles and azaindazoles as LRRK2 inhibitors |
| US20220274983A1 (en) * | 2019-08-06 | 2022-09-01 | Jiangsu Carephar Pharmaceutical Co., Ltd. | Jak kinase inhibitor and use thereof |
| US12214216B1 (en) | 2019-10-16 | 2025-02-04 | Helen Feng | Photon enhanced bone growth system and method |
| CN111072655B (zh) * | 2019-12-30 | 2021-12-10 | 深圳市坤健创新药物研究院 | 一种三氮唑并吡啶类化合物及其制备方法和药用组合物与应用 |
| CA3169832A1 (en) * | 2020-02-13 | 2021-08-19 | Zhuhai United Laboratories Co., Ltd. | Use of jak inhibitors in preparation of drugs for treatment of jak kinase related diseases |
| AU2021222686B2 (en) | 2020-02-21 | 2023-06-29 | Zhuhai United Laboratories Co., Ltd. | Crystalline form of JAK inhibitor and application thereof |
| US11691963B2 (en) | 2020-05-06 | 2023-07-04 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| CN111617318B (zh) * | 2020-05-26 | 2021-12-10 | 南京市儿童医院 | 可注射型儿童骺板再生水凝胶的制备方法 |
| CN114075189A (zh) * | 2020-08-11 | 2022-02-22 | 南京柯菲平盛辉制药有限公司 | 五元杂环并苯环类化合物及其制备方法和医药用途 |
| CN114075188A (zh) * | 2020-08-11 | 2022-02-22 | 南京柯菲平盛辉制药有限公司 | 芳香杂环酰胺类化合物及其制备方法和医药用途 |
| TW202241889A (zh) | 2020-12-23 | 2022-11-01 | 美商雅捷可斯治療公司 | 作為jak2抑制劑之6-雜芳基氧基苯并咪唑及氮雜苯并咪唑 |
| CN114394965B (zh) * | 2021-01-29 | 2023-09-12 | 深圳市乐土生物医药有限公司 | 三唑并吡啶类化合物及其制备方法与用途 |
| AU2022388555A1 (en) | 2021-11-09 | 2024-05-02 | Ajax Therapeutics, Inc. | 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| US12162881B2 (en) | 2021-11-09 | 2024-12-10 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of JAK2 |
| CN113773322B (zh) * | 2021-11-10 | 2022-02-11 | 奥锐特药业(天津)有限公司 | 一种Filgotinib的制备方法 |
| CN116354955A (zh) * | 2021-12-28 | 2023-06-30 | 上海科胜药物研发有限公司 | 一种菲戈替尼的制备方法 |
| CN116496268A (zh) * | 2022-01-18 | 2023-07-28 | 盛世泰科生物医药技术(苏州)有限公司 | 一种含环丙酰胺化合物及其应用 |
| US11596612B1 (en) | 2022-03-08 | 2023-03-07 | PTC Innovations, LLC | Topical anesthetics |
| US11746108B1 (en) * | 2022-06-13 | 2023-09-05 | Apm Therapeutics 1, Inc. | Triazolopyridine polymorph A |
| CN116687925B (zh) * | 2022-11-04 | 2024-10-22 | 中国科学院遗传与发育生物学研究所 | 一种侵蚀性蛋白酶抑制剂及其应用 |
| LU505465B1 (en) * | 2022-11-16 | 2024-05-14 | Adlai Nortye Biopharma Co Ltd | A pan-KRAS inhibitor compound |
| CN119462650B (zh) * | 2024-11-20 | 2025-10-17 | 沈阳药科大学 | 一种非戈替尼的合成方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2228451T3 (es) | 1999-01-29 | 2005-04-16 | Chugai Seiyaku Kabushiki Kaisha | Promotores de condrogenesis y derivados de indolin-2-ona. |
| JPWO2002087620A1 (ja) | 2001-04-27 | 2004-08-12 | 中外製薬株式会社 | 軟骨形成促進剤 |
| US6514989B1 (en) | 2001-07-20 | 2003-02-04 | Hoffmann-La Roche Inc. | Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives |
| WO2004072072A1 (en) | 2003-02-14 | 2004-08-26 | Pfizer Products Inc. | Triazolo-pyridines as anti-inflammatory compounds |
| TWI221602B (en) * | 2003-07-21 | 2004-10-01 | Benq Corp | Emergent disc-withdrawing apparatus |
| US20050222171A1 (en) * | 2004-01-22 | 2005-10-06 | Guido Bold | Organic compounds |
| EP2386856B1 (en) | 2004-06-21 | 2013-07-24 | Galapagos N.V. | Methods and means for treatment of osteoarthritis |
| BRPI0514327A (pt) | 2004-08-18 | 2008-06-10 | Pharmacia & Upjohn Co Llc | compostos triazolopiridina |
| MX2007004179A (es) | 2004-10-07 | 2007-06-07 | Warner Lambert Co | Derivados de triazolpiridina como agentes antibacterianos. |
| GB0515026D0 (en) * | 2005-07-21 | 2005-08-31 | Novartis Ag | Organic compounds |
| BRPI0716239A2 (pt) * | 2006-08-30 | 2013-08-13 | Cellzome Ltd | derivados de triazol como inibidores de cinase |
| ATE495743T1 (de) * | 2006-12-01 | 2011-02-15 | Galapagos Nv | Triazolopyridinverbindungen zur behandlung von degenerations- und entzündungskrankheiten |
| CL2008001626A1 (es) * | 2007-06-05 | 2009-06-05 | Takeda Pharmaceuticals Co | Compuestos derivados de heterociclos fusionados, agente farmaceutico que los comprende y su uso en la profilaxis y tratamiento del cancer. |
| MX2010000716A (es) * | 2007-07-18 | 2010-03-26 | Novartis Ag | Compuestos de heteroarilo biciclicos y su uso como inhibidores de cinasa. |
| WO2009017954A1 (en) * | 2007-08-01 | 2009-02-05 | Phenomix Corporation | Inhibitors of jak2 kinase |
| EP2181112A1 (en) | 2007-08-31 | 2010-05-05 | Merck Serono S.A. | Triazolopyridine compounds and their use as ask inhibitors |
| GB0719803D0 (en) * | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| US8811196B2 (en) * | 2008-02-19 | 2014-08-19 | Qualcomm Incorporated | Providing remote field testing for mobile devices |
| US20090217316A1 (en) * | 2008-02-22 | 2009-08-27 | Binita Gupta | Systems and Methods for Advertising Insertion Notification in a Real-Time Streaming Media Service |
| PE20110063A1 (es) | 2008-06-20 | 2011-02-16 | Genentech Inc | DERIVADOS DE [1, 2, 4]TRIAZOLO[1, 5-a]PIRIDINA COMO INHIBIDORES DE JAK |
| WO2010010184A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | [1, 2, 4] triazolo [1, 5-a] pyridines as jak inhibitors |
| WO2010010188A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
| WO2010010189A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| JO3041B1 (ar) | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
| WO2010010186A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| WO2010010187A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| DE102009000543A1 (de) * | 2009-02-02 | 2010-08-12 | Evonik Degussa Gmbh | Verfahren, Absorptionsmedien und Vorrichtung zur Absorption von CO2 aus Gasmischungen |
| JP5679995B2 (ja) * | 2009-02-02 | 2015-03-04 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | 酸性ガスの除去のための環式アミン含有吸収剤 |
| CN102459258B (zh) | 2009-06-05 | 2015-11-25 | 赛福伦公司 | 1,2,4-三唑并[1,5a]吡啶衍生物的制备和用途 |
| JO3030B1 (ar) | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
| TWI462920B (zh) | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
| US20130310340A1 (en) | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
| MA37775A1 (fr) | 2012-06-22 | 2017-04-28 | Galapagos Nv | Aminotriazolopyridine pour l'utilisation dans le traitement de l'inflammation, et compositions pharmaceutiques associées |
-
2009
- 2009-07-12 JO JOP/2009/0259A patent/JO3041B1/ar active
- 2009-07-22 AR ARP090102793A patent/AR072875A1/es active IP Right Grant
- 2009-07-23 CL CL2009001637A patent/CL2009001637A1/es unknown
- 2009-07-23 TW TW098124908A patent/TWI447118B/zh not_active IP Right Cessation
- 2009-07-24 PE PE2009000989A patent/PE20100152A1/es active IP Right Grant
- 2009-07-24 PL PL09781072T patent/PL2361251T3/pl unknown
- 2009-07-24 EP EP09781072.5A patent/EP2361251B1/en active Active
- 2009-07-24 WO PCT/EP2009/059604 patent/WO2010010190A1/en not_active Ceased
- 2009-07-24 ME MEP-2014-72A patent/ME02046B/me unknown
- 2009-07-24 ES ES09781072.5T patent/ES2485913T3/es active Active
- 2009-07-24 MY MYPI20093101A patent/MY157615A/en unknown
- 2009-07-24 CA CA2730757A patent/CA2730757A1/en not_active Abandoned
- 2009-07-24 PT PT97810725T patent/PT2361251E/pt unknown
- 2009-07-24 BR BRPI0916862A patent/BRPI0916862B8/pt not_active IP Right Cessation
- 2009-07-24 RS RS20130214A patent/RS52823B/sr unknown
- 2009-07-24 EP EP09781073A patent/EP2346864B1/en active Active
- 2009-07-24 EA EA201170257A patent/EA018587B1/ru not_active IP Right Cessation
- 2009-07-24 US US12/508,950 patent/US8242274B2/en active Active
- 2009-07-24 WO PCT/EP2009/059605 patent/WO2010010191A1/en not_active Ceased
- 2009-07-24 RS RS20140345A patent/RS53406B/sr unknown
- 2009-07-24 UY UY0001032006A patent/UY32006A/es active IP Right Grant
- 2009-07-24 HR HRP20140681AT patent/HRP20140681T1/hr unknown
- 2009-07-24 NZ NZ590646A patent/NZ590646A/en not_active IP Right Cessation
- 2009-07-24 AU AU2009273143A patent/AU2009273143B2/en active Active
- 2009-07-24 DK DK09781072.5T patent/DK2361251T3/da active
- 2009-07-24 ES ES09781073T patent/ES2406691T3/es active Active
- 2009-07-24 US US13/055,936 patent/US8853240B2/en active Active
- 2009-07-24 SI SI200930973T patent/SI2361251T1/sl unknown
- 2009-07-24 SI SI200930582T patent/SI2346864T1/sl unknown
- 2009-07-24 DK DK09781073.3T patent/DK2346864T3/da active
- 2009-07-24 EA EA201170255A patent/EA018080B1/ru unknown
- 2009-07-24 MX MX2011000758A patent/MX2011000758A/es active IP Right Grant
- 2009-07-24 KR KR1020117004383A patent/KR101711911B1/ko active Active
- 2009-07-24 CA CA2730762A patent/CA2730762C/en active Active
- 2009-07-24 JP JP2011519188A patent/JP5559168B2/ja active Active
- 2009-07-24 PT PT97810733T patent/PT2346864E/pt unknown
- 2009-07-24 CN CN2009801291247A patent/CN102105472B/zh active Active
- 2009-07-24 PL PL09781073T patent/PL2346864T3/pl unknown
- 2009-07-24 AU AU2009273144A patent/AU2009273144B2/en not_active Ceased
- 2009-07-24 MX MX2011000756A patent/MX2011000756A/es active IP Right Grant
- 2009-07-24 KR KR1020117004384A patent/KR101676391B1/ko not_active Expired - Fee Related
- 2009-07-24 JP JP2011519189A patent/JP5480261B2/ja active Active
- 2009-07-24 BR BRPI0916659A patent/BRPI0916659B8/pt active IP Right Grant
- 2009-07-24 CN CN200980129088.4A patent/CN102105471B/zh active Active
- 2009-07-24 HR HRP20130357AT patent/HRP20130357T1/hr unknown
-
2010
- 2010-12-26 IL IL210261A patent/IL210261A/en active IP Right Grant
- 2010-12-26 IL IL210262A patent/IL210262A/en active IP Right Grant
-
2011
- 2011-01-14 ZA ZA2011/00396A patent/ZA201100396B/en unknown
- 2011-01-18 ZA ZA2011/00472A patent/ZA201100472B/en unknown
- 2011-01-18 DO DO2011000022A patent/DOP2011000022A/es unknown
- 2011-02-11 MA MA33602A patent/MA32551B1/fr unknown
- 2011-02-16 CR CR20110092A patent/CR20110092A/es unknown
- 2011-02-24 CO CO11022531A patent/CO6361925A2/es active IP Right Grant
-
2012
- 2012-08-10 US US13/572,043 patent/US20120309784A1/en not_active Abandoned
-
2013
- 2013-04-24 CY CY20131100335T patent/CY1113945T1/el unknown
- 2013-05-15 SM SM201300051T patent/SMT201300051B/xx unknown
-
2014
- 2014-06-17 SM SM201400072T patent/SMT201400072B/xx unknown
- 2014-07-29 CY CY20141100572T patent/CY1115569T1/el unknown
- 2014-10-06 US US14/507,396 patent/US9415037B2/en active Active
-
2016
- 2016-08-15 US US15/236,578 patent/US10206907B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011529033A5 (enExample) | ||
| JP2011529032A5 (enExample) | ||
| JP7604006B2 (ja) | Ash1l阻害剤及びそれを用いた治療方法 | |
| US10246464B2 (en) | Thienopyrimidine and thienopyridine compounds and methods of use thereof | |
| ES2826443T3 (es) | Inhibidores de proteínas mutantes KRAS G12C | |
| ES2987829T3 (es) | Compuestos heterocíclicos para obtención de imágenes y tratamiento del cáncer y métodos para su uso | |
| MX2009001534A (es) | Preparacion de (r,r)-fenoterol y analogos de (r,r)- o (r,s)-fenoterol y su uso en el tratamiento de insuficiencia cardiaca congestiva. | |
| CR20220609A (es) | Antagonistas del receptor de lpa y usos de los mismos | |
| MA33818B1 (fr) | Nouveaux antagonistes du récepteur ccr2 et leurs utilisations | |
| MX2011008799A (es) | Polipeptidos, dominios variables de anticuerpos, y antagonistas anti-tnfr1 mejorados. | |
| TW200808314A (en) | Treatment of chemokine mediated diseases | |
| EA201000785A1 (ru) | Композиции для доставки в легкие | |
| UA100777C2 (ru) | Вдыхаемые частички, содержащие тиотропий | |
| CN111542318A (zh) | Ash1l降解剂及用其进行治疗的方法 | |
| ATE495744T1 (de) | Opioide zur behandlung von chronisch-obstruktiver lungenerkrankung (copd) | |
| JP2016503765A5 (enExample) | ||
| JP2016529218A5 (enExample) | ||
| JP2012509279A5 (enExample) | ||
| US12466813B2 (en) | PRC1 inhibitors and methods of treatment therewith | |
| JP2013544892A5 (enExample) | ||
| MX2009007610A (es) | Heterociclicos biciclicos, medicamentos que contienen estos compuestos, su utilizacion y procedimientos para su preparacion. | |
| EA201100422A1 (ru) | (фенил)амиды 7-(пиперазин-1-илметил)-1h-индол-2-карбоновой кислоты и родственные соединения в качестве ингибиторов мар-киназы p38 для лечения заболеваний дыхательных путей | |
| WO2008020269A3 (en) | A method of treating tumors with azaxanthones | |
| JP2016505049A5 (enExample) | ||
| CN103896911A (zh) | 2-(3,4-二甲氧基)苯甲酰基-5-(4-取代苯乙炔基)噻吩及其制备方法及应用 |