JP2011529033A5 - - Google Patents

Download PDF

Info

Publication number
JP2011529033A5
JP2011529033A5 JP2011519189A JP2011519189A JP2011529033A5 JP 2011529033 A5 JP2011529033 A5 JP 2011529033A5 JP 2011519189 A JP2011519189 A JP 2011519189A JP 2011519189 A JP2011519189 A JP 2011519189A JP 2011529033 A5 JP2011529033 A5 JP 2011529033A5
Authority
JP
Japan
Prior art keywords
cancer
pyridin
mol
added
prostate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011519189A
Other languages
English (en)
Japanese (ja)
Other versions
JP5480261B2 (ja
JP2011529033A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2009/059605 external-priority patent/WO2010010191A1/en
Publication of JP2011529033A publication Critical patent/JP2011529033A/ja
Publication of JP2011529033A5 publication Critical patent/JP2011529033A5/ja
Application granted granted Critical
Publication of JP5480261B2 publication Critical patent/JP5480261B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011519189A 2008-07-25 2009-07-24 変性及び炎症性疾患の治療に有用な新規化合物 Active JP5480261B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13592008P 2008-07-25 2008-07-25
US61/135,920 2008-07-25
US22068509P 2009-06-26 2009-06-26
US61/220,685 2009-06-26
PCT/EP2009/059605 WO2010010191A1 (en) 2008-07-25 2009-07-24 Novel compounds useful for the treatment of degenerative and inflammatory diseases.

Publications (3)

Publication Number Publication Date
JP2011529033A JP2011529033A (ja) 2011-12-01
JP2011529033A5 true JP2011529033A5 (enExample) 2012-09-06
JP5480261B2 JP5480261B2 (ja) 2014-04-23

Family

ID=41021059

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011519189A Active JP5480261B2 (ja) 2008-07-25 2009-07-24 変性及び炎症性疾患の治療に有用な新規化合物
JP2011519188A Active JP5559168B2 (ja) 2008-07-25 2009-07-24 変性及び炎症性疾患の治療に有用な新規化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011519188A Active JP5559168B2 (ja) 2008-07-25 2009-07-24 変性及び炎症性疾患の治療に有用な新規化合物

Country Status (35)

Country Link
US (5) US8242274B2 (enExample)
EP (2) EP2361251B1 (enExample)
JP (2) JP5480261B2 (enExample)
KR (2) KR101676391B1 (enExample)
CN (2) CN102105472B (enExample)
AR (1) AR072875A1 (enExample)
AU (2) AU2009273144B2 (enExample)
BR (2) BRPI0916659B8 (enExample)
CA (2) CA2730762C (enExample)
CL (1) CL2009001637A1 (enExample)
CO (1) CO6361925A2 (enExample)
CR (1) CR20110092A (enExample)
CY (2) CY1113945T1 (enExample)
DK (2) DK2361251T3 (enExample)
DO (1) DOP2011000022A (enExample)
EA (2) EA018587B1 (enExample)
ES (2) ES2485913T3 (enExample)
HR (2) HRP20140681T1 (enExample)
IL (2) IL210261A (enExample)
JO (1) JO3041B1 (enExample)
MA (1) MA32551B1 (enExample)
ME (1) ME02046B (enExample)
MX (2) MX2011000756A (enExample)
MY (1) MY157615A (enExample)
NZ (1) NZ590646A (enExample)
PE (1) PE20100152A1 (enExample)
PL (2) PL2346864T3 (enExample)
PT (2) PT2361251E (enExample)
RS (2) RS52823B (enExample)
SI (2) SI2361251T1 (enExample)
SM (2) SMT201300051B (enExample)
TW (1) TWI447118B (enExample)
UY (1) UY32006A (enExample)
WO (2) WO2010010190A1 (enExample)
ZA (2) ZA201100396B (enExample)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0719803D0 (en) 2007-10-10 2007-11-21 Cancer Rec Tech Ltd Therapeutic compounds and their use
JO3041B1 (ar) * 2008-07-25 2016-09-05 Galapagos Nv مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
BRPI1009637A2 (pt) 2009-06-05 2019-04-30 Cephalon, Inc composto, composição e uso de um composto
US20100331222A1 (en) * 2009-06-26 2010-12-30 Basf Se Process for producing cellulose beads from solutions of cellulose in ionic liquid
TWI462920B (zh) 2009-06-26 2014-12-01 葛萊伯格有限公司 用於治療退化性及發炎疾病之新穎化合物
JO3030B1 (ar) * 2009-06-26 2016-09-05 Galapagos Nv مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات
US8877795B2 (en) 2010-05-07 2014-11-04 The Board Of Trustees Of The Leland Stanford Junior University Identification of stabilizers of multimeric proteins
WO2012000970A1 (en) 2010-07-01 2012-01-05 Cellzome Limited Triazolopyridines as tyk2 inhibitors
AR086042A1 (es) 2011-04-28 2013-11-13 Galapagos Nv Compuesto util para el tratamiento de enfermedades degenerativas e inflamatorias y composicion farmaceutica
JP6280546B2 (ja) 2012-06-26 2018-02-14 デル マー ファーマシューティカルズ ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法
US9169214B2 (en) 2012-12-21 2015-10-27 The Board Of Trustees Of The Leland Stanford Junior University Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
CN103965114B (zh) * 2013-01-28 2016-01-06 苏州泽璟生物制药有限公司 氘代的苯基氨基嘧啶化合物以及包含该化合物的药物组合物
EP2951590A1 (en) 2013-02-04 2015-12-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for assaying jak2 activity in red blood cells and uses thereof
EP3010922B1 (en) * 2013-06-19 2017-03-15 Galapagos NV Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
MD4649C1 (ro) 2013-12-05 2020-04-30 Pfizer Inc. Pirol[2,3-d]pirimidinil, pirol[2,3-b]pirazinil şi pirol[2,3-d]piridinil acrilamide
KR20160100329A (ko) 2013-12-20 2016-08-23 3-브이 바이오사이언시스, 인코포레이티드 지질 합성의 헤테로사이클릭 조절물질 및 이들의 조합물
GB201402070D0 (en) * 2014-02-07 2014-03-26 Galapagos Nv Pharmaceutical compositions for the treatment of inflammatory disorders
GB201402071D0 (en) 2014-02-07 2014-03-26 Galapagos Nv Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
JP6543342B2 (ja) 2014-08-14 2019-07-10 アルハマドシャー，マモウン，エム． 血清半減期を延長するための、調節可能リンカーを介した薬学的活性剤とトランスサイレチンリガンドのコンジュゲーション
TWI679205B (zh) 2014-09-02 2019-12-11 日商日本新藥股份有限公司 吡唑并噻唑化合物及醫藥
KR101987994B1 (ko) 2015-01-28 2019-06-11 제이엔 테라퓨틱스 치환된 이미다조[1,2-a]피리딘-2-일아민 화합물, 및 약학 조성물 및 이의 사용 방법
KR20170134750A (ko) * 2015-04-13 2017-12-06 갈라파고스 엔.브이. 염증 질환의 치료 방법
ES2734048T3 (es) * 2015-04-29 2019-12-04 Wuxi Fortune Pharmaceutical Co Ltd Inhibidores de Janus cinasas (JAK)
AU2016257892A1 (en) * 2015-05-05 2017-11-09 Concert Pharmaceuticals, Inc. Deuterated filgotinib
CN105061420B (zh) * 2015-06-04 2017-09-05 南京旗昌医药科技有限公司 一种jak抑制剂的晶型及其制备方法和应用
CN104987333B (zh) * 2015-07-14 2017-01-11 苏州富士莱医药股份有限公司 一种Filgotinib的合成方法
WO2017012770A1 (en) 2015-07-23 2017-01-26 Ratiopharm Gmbh Acid addition salts of filgotinib
WO2017012773A1 (en) 2015-07-23 2017-01-26 Ratiopharm Gmbh Solid forms of filgotinib free base
WO2017012771A1 (en) 2015-07-23 2017-01-26 Ratiopharm Gmbh Crystalline filgotinib sulfonic acid addition salts
CN105111207B (zh) * 2015-09-18 2017-07-25 上海宣创生物科技有限公司 一种环丙烷甲酰胺衍生物d晶型及其制备方法
CN105111206B (zh) * 2015-09-18 2017-07-25 上海宣创生物科技有限公司 一种环丙烷甲酰胺衍生物e晶型及其制备方法
CN105198879B (zh) * 2015-09-18 2017-09-22 上海宣创生物科技有限公司 一种环丙烷甲酰胺衍生物c晶型及其制备方法
CN105198878B (zh) * 2015-09-18 2017-07-25 上海宣创生物科技有限公司 一种环丙烷甲酰胺衍生物f晶型及其制备方法
CN105198880B (zh) * 2015-09-18 2017-07-25 上海宣创生物科技有限公司 一种环丙烷甲酰胺衍生物a晶型及其制备方法
CN105198877B (zh) * 2015-09-18 2017-09-22 上海宣创生物科技有限公司 一种环丙烷甲酰胺衍生物g晶型及其制备方法
CN105198876B (zh) * 2015-09-18 2017-09-29 上海宣创生物科技有限公司 一种环丙烷甲酰胺衍生物h晶型及其制备方法
CN105218539B (zh) * 2015-09-18 2017-07-25 上海宣创生物科技有限公司 一种环丙烷甲酰胺衍生物b晶型及其制备方法
WO2017133423A1 (zh) * 2016-02-02 2017-08-10 深圳市塔吉瑞生物医药有限公司 一种取代的吡啶酰胺类化合物及其应用
TWI712604B (zh) 2016-03-01 2020-12-11 日商日本新藥股份有限公司 具jak抑制作用之化合物之結晶
CN109790158B (zh) * 2016-07-26 2022-06-24 苏州隆博泰药业有限公司 作为jak抑制剂杂环化合物，该化合物的盐类及其治疗用途
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
CN107880038B (zh) * 2016-09-30 2021-09-28 中国医药研究开发中心有限公司 [1,2,4]三唑并[1,5-a]吡啶类化合物及其制备方法和医药用途
JOP20190077A1 (ar) * 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
KR102417483B1 (ko) * 2016-10-26 2022-07-05 얀센 파마슈티카 엔.브이. 융합된 아자헤테로사이클릭 화합물 및 ampa 수용체 조절제로서의 이들의 용도
JP6953527B2 (ja) * 2016-10-26 2021-10-27 ヤンセン ファーマシューティカ エヌ．ベー． 縮合二環ピリジン化合物、及びａｍｐａ受容体調節因子としてのそれらの使用
EA039352B1 (ru) * 2017-01-19 2022-01-17 Сучжоу Лонгбайотек Фармасьютикалз Ко., Лтд. Соединение в качестве селективного ингибитора jak и его соли и терапевтическое применение
CN108341814B (zh) * 2017-01-23 2021-09-03 上海翔锦生物科技有限公司 Jak激酶抑制剂及其应用
GB201702603D0 (en) 2017-02-17 2017-04-05 Galápagos Nv Novel compositions and pharmaceutical compositions thereof for the treatment of inflammatory disorders
IL298196A (en) 2017-02-17 2023-01-01 Eidos Therapeutics Inc Processes for preparing ag-10, its intermediates, and salts thereof
WO2018167283A1 (en) 2017-03-17 2018-09-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling
WO2018189335A1 (en) 2017-04-13 2018-10-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma
WO2019149244A1 (zh) * 2018-01-31 2019-08-08 南京明德新药研发股份有限公司 Jak抑制剂及其应用
CA3091142C (en) 2018-02-26 2023-04-11 Gilead Sciences, Inc. Substituted pyrrolizine compounds and uses thereof
CA3090545A1 (en) 2018-02-28 2019-09-06 University Of Southern California Compositions and methods for modulating inflammatory and degenerative disorder
KR20200135996A (ko) 2018-03-23 2020-12-04 에이도스 테라퓨틱스, 인코포레이티드 Ag10을 사용하여 ttr 아밀로이드증을 치료하는 방법
GB201808575D0 (en) 2018-05-24 2018-07-11 Galapagos Nv Methods for the treatment of psoriatic arthrits
MA53238A (fr) 2018-08-17 2022-04-13 Eidos Therapeutics Inc Formules d'ag10
PL3842431T3 (pl) * 2018-08-23 2024-05-20 Zhuhai United Laboratories Co., Ltd. Związek [1,2,4]triazolo[1,5-a]pirydyny jako inhibitor jak i jego zastosowanie
US10815227B2 (en) 2018-08-27 2020-10-27 Cadila Healthcare Limited Processes for the preparation of filgotinib
WO2020092015A1 (en) 2018-11-02 2020-05-07 University Of Rochester Therapeutic mitigation of epithelial infection
EP3877371A4 (en) * 2018-11-07 2022-07-27 Dana-Farber Cancer Institute, Inc. IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES USED AS JANUS KINASE 2 INHIBITORS AND ASSOCIATED USES
US12415816B2 (en) 2018-11-07 2025-09-16 Dana-Farber Cancer Institute, Inc. Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof
US11633399B2 (en) 2018-12-25 2023-04-25 Sol-Gel Technologies Ltd. Treatment of skin disorders with compositions comprising an EGFR inhibitor
US11427558B1 (en) 2019-07-11 2022-08-30 ESCAPE Bio, Inc. Indazoles and azaindazoles as LRRK2 inhibitors
US20220274983A1 (en) * 2019-08-06 2022-09-01 Jiangsu Carephar Pharmaceutical Co., Ltd. Jak kinase inhibitor and use thereof
US12214216B1 (en) 2019-10-16 2025-02-04 Helen Feng Photon enhanced bone growth system and method
CN111072655B (zh) * 2019-12-30 2021-12-10 深圳市坤健创新药物研究院 一种三氮唑并吡啶类化合物及其制备方法和药用组合物与应用
KR102856998B1 (ko) * 2020-02-13 2025-09-05 주하이 유나이티드 라보라토리즈 컴퍼니 리미티드 Jak 키나아제 관련 질병의 치료를 위한 약물의 제조에 있어서 jak 억제제의 용도
ES3037893T3 (en) * 2020-02-21 2025-10-07 Zhuhai United Laboratories Co Ltd Crystalline form of jak inhibitor and application thereof
EP4146639A1 (en) 2020-05-06 2023-03-15 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
CN111617318B (zh) * 2020-05-26 2021-12-10 南京市儿童医院 可注射型儿童骺板再生水凝胶的制备方法
CN114075189A (zh) * 2020-08-11 2022-02-22 南京柯菲平盛辉制药有限公司 五元杂环并苯环类化合物及其制备方法和医药用途
CN114075188A (zh) * 2020-08-11 2022-02-22 南京柯菲平盛辉制药有限公司 芳香杂环酰胺类化合物及其制备方法和医药用途
TW202241889A (zh) 2020-12-23 2022-11-01 美商雅捷可斯治療公司 作為ｊａｋ２抑制劑之６－雜芳基氧基苯并咪唑及氮雜苯并咪唑
CN114394965B (zh) * 2021-01-29 2023-09-12 深圳市乐土生物医药有限公司 三唑并吡啶类化合物及其制备方法与用途
WO2023086320A1 (en) 2021-11-09 2023-05-19 Ajax Therapeutics, Inc. Forms and compositions of inhibitors of jak2
JP7782035B2 (ja) 2021-11-09 2025-12-08 エイジャックス セラピューティクス， インコーポレイテッド Ｊａｋ２阻害剤としての６－ヘテロアリールオキシベンゾイミダゾール及びアザベンゾイミダゾール
CN113773322B (zh) * 2021-11-10 2022-02-11 奥锐特药业(天津)有限公司 一种Filgotinib的制备方法
CN116354955A (zh) * 2021-12-28 2023-06-30 上海科胜药物研发有限公司 一种菲戈替尼的制备方法
CN116496268A (zh) * 2022-01-18 2023-07-28 盛世泰科生物医药技术(苏州)有限公司 一种含环丙酰胺化合物及其应用
US11596612B1 (en) 2022-03-08 2023-03-07 PTC Innovations, LLC Topical anesthetics
US11746108B1 (en) * 2022-06-13 2023-09-05 Apm Therapeutics 1, Inc. Triazolopyridine polymorph A
CN116687925B (zh) * 2022-11-04 2024-10-22 中国科学院遗传与发育生物学研究所 一种侵蚀性蛋白酶抑制剂及其应用
LU505465B1 (en) * 2022-11-16 2024-05-14 Adlai Nortye Biopharma Co Ltd A pan-KRAS inhibitor compound
CN119462650B (zh) * 2024-11-20 2025-10-17 沈阳药科大学 一种非戈替尼的合成方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2318600A (en) 1999-01-29 2000-08-18 Chugai Seiyaku Kabushiki Kaisha Chondrongenesis promotors and indolin-2-one derivatives
JPWO2002087620A1 (ja) 2001-04-27 2004-08-12 中外製薬株式会社 軟骨形成促進剤
US6514989B1 (en) * 2001-07-20 2003-02-04 Hoffmann-La Roche Inc. Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives
ATE334131T1 (de) 2003-02-14 2006-08-15 Pfizer Prod Inc Triazolopyridine als entzündungshemmende verbindungen
TWI221602B (en) * 2003-07-21 2004-10-01 Benq Corp Emergent disc-withdrawing apparatus
US20050222171A1 (en) 2004-01-22 2005-10-06 Guido Bold Organic compounds
WO2005124342A2 (en) 2004-06-21 2005-12-29 Galapagos N.V. Methods and means for treatment of osteoarthritis
EP1786811A2 (en) 2004-08-18 2007-05-23 Pharmacia & Upjohn Company LLC Triazolopyridine compounds
CA2582482A1 (en) 2004-10-07 2006-04-13 Warner-Lambert Company Llc Triazolopyridine derivatives as antibacterial agents
GB0515026D0 (en) * 2005-07-21 2005-08-31 Novartis Ag Organic compounds
AU2007291190A1 (en) * 2006-08-30 2008-03-06 Cellzome Limited Triazole derivatives as kinase inhibitors
DE602007012133D1 (de) * 2006-12-01 2011-03-03 Andrew Burritt Triazolopyridinverbindungen zur behandlung von degenerations- und entzündungskrankheiten
CL2008001626A1 (es) 2007-06-05 2009-06-05 Takeda Pharmaceuticals Co Compuestos derivados de heterociclos fusionados, agente farmaceutico que los comprende y su uso en la profilaxis y tratamiento del cancer.
AU2008277628B2 (en) * 2007-07-18 2012-03-15 Novartis Ag Bicyclic heteroaryl compounds and their use as kinase inhibitors
WO2009017954A1 (en) * 2007-08-01 2009-02-05 Phenomix Corporation Inhibitors of jak2 kinase
CA2691448A1 (en) * 2007-08-31 2009-03-05 Dominique Swinnen Triazolopyridine compounds and their use as ask inhibitors
GB0719803D0 (en) 2007-10-10 2007-11-21 Cancer Rec Tech Ltd Therapeutic compounds and their use
US8811196B2 (en) * 2008-02-19 2014-08-19 Qualcomm Incorporated Providing remote field testing for mobile devices
US20090217316A1 (en) * 2008-02-22 2009-08-27 Binita Gupta Systems and Methods for Advertising Insertion Notification in a Real-Time Streaming Media Service
EP2296475A4 (en) 2008-06-20 2014-03-05 Genentech Inc TRIAZOLOPYRIDINE COMPOUNDS JAK KINASE INHIBITORS AND METHODS
WO2010010186A1 (en) * 2008-07-25 2010-01-28 Galapagos Nv Novel compounds useful for the treatment of degenerative and inflammatory diseases
WO2010010189A1 (en) 2008-07-25 2010-01-28 Galapagos Nv Novel compounds useful for the treatment of degenerative and inflammatory diseases
JO3041B1 (ar) 2008-07-25 2016-09-05 Galapagos Nv مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
WO2010010187A1 (en) 2008-07-25 2010-01-28 Galapagos Nv Novel compounds useful for the treatment of degenerative and inflammatory diseases
WO2010010184A1 (en) 2008-07-25 2010-01-28 Galapagos Nv [1, 2, 4] triazolo [1, 5-a] pyridines as jak inhibitors
WO2010010188A1 (en) 2008-07-25 2010-01-28 Galapagos Nv Novel compounds useful for the treatment of degenerative and inflammatory diseases.
DE102009000543A1 (de) * 2009-02-02 2010-08-12 Evonik Degussa Gmbh Verfahren, Absorptionsmedien und Vorrichtung zur Absorption von CO2 aus Gasmischungen
JP5679995B2 (ja) * 2009-02-02 2015-03-04 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 酸性ガスの除去のための環式アミン含有吸収剤
BRPI1009637A2 (pt) 2009-06-05 2019-04-30 Cephalon, Inc composto, composição e uso de um composto
TWI462920B (zh) 2009-06-26 2014-12-01 葛萊伯格有限公司 用於治療退化性及發炎疾病之新穎化合物
JO3030B1 (ar) 2009-06-26 2016-09-05 Galapagos Nv مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات
US20130310340A1 (en) 2012-05-16 2013-11-21 Rigel Pharmaceuticals, Inc. Method of treating muscular degradation
SI2863950T1 (sl) 2012-06-22 2018-10-30 Galapagos Nv Aminotriazolopiridin za uporabo pri zdravljenju vnetja in njegovi farmacevtski sestavki

Similar Documents

Publication Publication Date Title
JP2011529033A5 (enExample)
JP2011529032A5 (enExample)
JP7604006B2 (ja) Ａｓｈ１ｌ阻害剤及びそれを用いた治療方法
US10246464B2 (en) Thienopyrimidine and thienopyridine compounds and methods of use thereof
ES2826443T3 (es) Inhibidores de proteínas mutantes KRAS G12C
ES2987829T3 (es) Compuestos heterocíclicos para obtención de imágenes y tratamiento del cáncer y métodos para su uso
MX2009001534A (es) Preparacion de (r,r)-fenoterol y analogos de (r,r)- o (r,s)-fenoterol y su uso en el tratamiento de insuficiencia cardiaca congestiva.
CR20220609A (es) Antagonistas del receptor de lpa y usos de los mismos
MA33818B1 (fr) Nouveaux antagonistes du récepteur ccr2 et leurs utilisations
MX2011008799A (es) Polipeptidos, dominios variables de anticuerpos, y antagonistas anti-tnfr1 mejorados.
TW200808314A (en) Treatment of chemokine mediated diseases
CN111542318A (zh) Ash1l降解剂及用其进行治疗的方法
EA201000785A1 (ru) Композиции для доставки в легкие
UA100777C2 (ru) Вдыхаемые частички, содержащие тиотропий
NZ580009A (en) Combination therapies comprising quinoxaline inhibitors of pi3k-alpha for use in the treatment of cancer
ATE495744T1 (de) Opioide zur behandlung von chronisch-obstruktiver lungenerkrankung (copd)
JP2016503765A5 (enExample)
JP2016529218A5 (enExample)
PH12012500826A1 (en) Stable anti-tnfr1 polypeptides, antibody variable domains & antagonists
JP2012509279A5 (enExample)
US12466813B2 (en) PRC1 inhibitors and methods of treatment therewith
MX2009007610A (es) Heterociclicos biciclicos, medicamentos que contienen estos compuestos, su utilizacion y procedimientos para su preparacion.
JP2017536397A5 (enExample)
EA201100422A1 (ru) (фенил)амиды 7-(пиперазин-1-илметил)-1h-индол-2-карбоновой кислоты и родственные соединения в качестве ингибиторов мар-киназы p38 для лечения заболеваний дыхательных путей
WO2008020269A3 (en) A method of treating tumors with azaxanthones