JP2010536719A5 - - Google Patents

Download PDF

Info

Publication number
JP2010536719A5
JP2010536719A5 JP2010520440A JP2010520440A JP2010536719A5 JP 2010536719 A5 JP2010536719 A5 JP 2010536719A5 JP 2010520440 A JP2010520440 A JP 2010520440A JP 2010520440 A JP2010520440 A JP 2010520440A JP 2010536719 A5 JP2010536719 A5 JP 2010536719A5
Authority
JP
Japan
Prior art keywords
tumors
group
leukemia
head
chronic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010520440A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010536719A (ja
Filing date
Publication date
Priority claimed from DE102007038957A external-priority patent/DE102007038957A1/de
Application filed filed Critical
Publication of JP2010536719A publication Critical patent/JP2010536719A/ja
Publication of JP2010536719A5 publication Critical patent/JP2010536719A5/ja
Pending legal-status Critical Current

Links

JP2010520440A 2007-08-17 2008-07-18 ６−チオキソピリダジン誘導体 Pending JP2010536719A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007038957A DE102007038957A1 (de) 2007-08-17 2007-08-17 6-Thioxo-pyridazinderivate
PCT/EP2008/005928 WO2009024221A1 (de) 2007-08-17 2008-07-18 6-thioxo-pyridazinderivate

Publications (2)

Publication Number Publication Date
JP2010536719A JP2010536719A (ja) 2010-12-02
JP2010536719A5 true JP2010536719A5 (enExample) 2011-09-08

Family

ID=40029265

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010520440A Pending JP2010536719A (ja) 2007-08-17 2008-07-18 ６−チオキソピリダジン誘導体

Country Status (7)

Country Link
US (1) US20110136819A1 (enExample)
EP (1) EP2176236A1 (enExample)
JP (1) JP2010536719A (enExample)
AU (1) AU2008290896A1 (enExample)
CA (1) CA2696472A1 (enExample)
DE (1) DE102007038957A1 (enExample)
WO (1) WO2009024221A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007061963A1 (de) * 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
EP2588107A1 (en) 2010-07-01 2013-05-08 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
US20130158041A1 (en) * 2010-08-31 2013-06-20 Kevin Wilson Tyrosine Kinase Inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
JP2016507496A (ja) 2012-12-21 2016-03-10 ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｃｏｒｐ． ブロモドメイン阻害剤としての新規複素環式化合物
CN105473581B (zh) 2013-06-21 2019-04-23 齐尼思表观遗传学有限公司 作为溴结构域抑制剂的新取代的双环化合物
KR102307566B1 (ko) 2013-06-21 2021-10-05 제니쓰 에피제네틱스 리미티드 신규한 바이사이클릭 브로모도메인 억제제
CA2919948C (en) 2013-07-31 2020-07-21 Zenith Epigenetics Corp. Novel quinazolinones as bromodomain inhibitors
US10179125B2 (en) 2014-12-01 2019-01-15 Zenith Epigenetics Ltd. Substituted pyridines as bromodomain inhibitors
HK1245246A1 (zh) 2014-12-01 2018-08-24 恒翼生物医药科技(上海)有限公司 作为溴域抑制剂的取代吡啶酮
EP3229836B1 (en) 2014-12-09 2019-11-13 Institut National de la Sante et de la Recherche Medicale (INSERM) Human monoclonal antibodies against axl
WO2016092375A1 (en) 2014-12-11 2016-06-16 Zenith Epigenetics Corp. Substituted heterocycles as bromodomain inhibitors
CN107406438B (zh) 2014-12-17 2021-05-14 恒翼生物医药科技(上海)有限公司 溴结构域的抑制剂
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
SMT202300355T1 (it) 2018-11-06 2024-01-10 Edgewise Therapeutics Inc Composti di piridazinone e loro usi
KR102885525B1 (ko) 2018-11-06 2025-11-13 엣지와이즈 테라퓨틱스, 인크. 피리다지논 화합물 및 이의 용도
WO2020097258A1 (en) 2018-11-06 2020-05-14 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
EP4473968A3 (en) 2020-05-13 2025-03-26 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
CN117098541A (zh) 2020-11-25 2023-11-21 阿卡格拉医药公司 用于递送核酸的脂质纳米粒及相关使用方法
WO2023230587A2 (en) 2022-05-25 2023-11-30 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids and methods of use thereof
CN116768868B (zh) * 2023-08-15 2023-12-08 云南省药物研究所 一种哒嗪酮硫代衍生物及其制备方法和应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US817363A (en) * 1905-12-11 1906-04-10 Hugh B Cunningham Pipe-pulling jack.
JPS5795964A (en) 1980-12-04 1982-06-15 Morishita Seiyaku Kk Preparation of 2-substituted-3(2h)-pyridazinone derivative
US4397854A (en) 1981-05-14 1983-08-09 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
AU691673B2 (en) 1994-11-14 1998-05-21 Dow Agrosciences Llc Pyridazinones and their use as fungicides
US5635494A (en) 1995-04-21 1997-06-03 Rohm And Haas Company Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
CA2242425C (en) 1996-02-13 2006-07-18 Zeneca Limited Quinazoline derivatives as vegf inhibitors
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
BR9813998A (pt) 1997-11-19 2000-09-26 Kowa Co Novos derivados de piridazina e produtos medicinais contendo os mesmos como ingredientes efetivos
TWI241295B (en) * 1998-03-02 2005-10-11 Kowa Co Pyridazine derivative and medicine containing the same as effect component
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
US6248755B1 (en) 1999-04-06 2001-06-19 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
US6242461B1 (en) * 2000-01-25 2001-06-05 Pfizer Inc. Use of aryl substituted azabenzimidazoles in the treatment of HIV and AIDS related diseases
BR0111230A (pt) 2000-05-31 2003-06-10 Astrazeneca Ab Composto, e, uso e processo para a preparação do mesmo
KR20030014425A (ko) 2000-07-07 2003-02-17 앤지오젠 파마슈티칼스 리미티드 혈관 손상제인 콜치놀 유도체
EE200300015A (et) 2000-07-07 2004-10-15 Angiogene Pharmaceuticals Limited Kolhinooli derivaadid kui angiogeneesi inhibiitorid
MXPA04003668A (es) 2001-10-31 2004-07-22 Merck Patent Gmbh Inhibidores de fosfodiesteresa de tipo 4 y usos de los mismos.
BR0317430A (pt) * 2002-12-20 2005-10-25 Pharmacia Corp Compostos inibidores de quinase-2 de proteìna ativada por quinase de proteìna ativada por mitógeno
DE602005023172D1 (de) 2004-07-16 2010-10-07 Schering Corp Hydantoinderivate zur behandlung von entzündlichen erkrankungen
DE102005057924A1 (de) * 2005-12-05 2007-06-06 Merck Patent Gmbh Pyridazinonderivate
RS55630B1 (sr) * 2005-12-21 2017-06-30 Janssen Pharmaceutica Nv Triazolopiridazini kao modulatori tirozin kinaze
WO2007130383A2 (en) * 2006-04-28 2007-11-15 Northwestern University Compositions and treatments using pyridazine compounds and secretases
PE20121506A1 (es) * 2006-07-14 2012-11-26 Amgen Inc Compuestos triazolopiridinas como inhibidores de c-met
DE102007026341A1 (de) * 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
DE102007032507A1 (de) * 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
JP5423679B2 (ja) * 2007-10-31 2014-02-19 日産化学工業株式会社 ピリダジノン化合物及びｐ２ｘ７受容体阻害剤
DE102007061963A1 (de) * 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
CN101538245B (zh) * 2008-03-18 2011-02-16 中国科学院上海药物研究所 一类哒嗪酮类化合物及其制备方法和制备药物的用途
DE102008019907A1 (de) * 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
EP2328586A2 (en) * 2008-05-20 2011-06-08 Cephalon, Inc. Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands
DE102008028905A1 (de) * 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
CA2729993A1 (en) * 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
BRPI1013159A2 (pt) * 2009-03-30 2015-09-15 Sumitomo Chemical Co Uso de composto de piridazinona para controle de peste artrópode
AR082590A1 (es) * 2010-08-12 2012-12-19 Hoffmann La Roche Inhibidores de la tirosina-quinasa de bruton

Similar Documents

Publication Publication Date Title
JP2010532774A5 (enExample)
JP2011529033A5 (enExample)
JP2011500713A5 (enExample)
JP2016528162A5 (enExample)
JP2011516501A5 (enExample)
HRP20120802T1 (hr) Derivati piperidina i piperazina za lijeäśenje tumora
HRP20211652T1 (hr) Pirimidopirimidinoni korisni kao inhibitor wee-1 kinaze
JP2021502358A5 (enExample)
TN2011000240A1 (en) Hsp90 inhibitors for therapeutic treatment
JP2010209101A5 (enExample)
RU2014141934A (ru) Комбинация производного 6-оксо-1,6-дигидро-пиридазина, которая обладает противораковым действием с другими противоопухолевыми соединениями
RU2017124371A (ru) Комбинация производного 6-оксо-1,6-дигидро-пиридазина, обладающего противораковой активностью, с производным хиназолина
JP2017536397A5 (enExample)
MX2009007610A (es) Heterociclicos biciclicos, medicamentos que contienen estos compuestos, su utilizacion y procedimientos para su preparacion.
HRP20130549T4 (hr) Spojevi i njihove soli specifični za ppar receptore i egf receptore te njihova primjena u području medicine
JP2013537228A5 (enExample)
Satou et al. Treatment of superficial carcinoma in hypopharynx
CN114349807A (zh) 一种唾液酸连接吲哚菁绿Sia-ICG及其制备方法和应用
CN204033475U (zh) 一种内镜用透明帽
WO2001079557A3 (en) Gtp-binding protein useful in treatment and detection of cancer
MX2010003988A (es) Compuesto de isoxazol para el tratamiento de cancer.
RU2017124612A (ru) Комбинация производного 6-оксо-1, 6-дигидро-пиридазона, обладающего противораковой активностью, с ингибитором рэфр
CN207950279U (zh) 双引流通道非充气喉罩
RU2015117550A (ru) Комбинация производного 6-оксо-1,6-дигидро-пиридазина, имеющего противораковую активность, с мек ингибитором
RU2021130476A (ru) Соединения имидазолонилхинолина и их терапевтическое применение