JP2010536719A - ６−チオキソピリダジン誘導体 - Google Patents
６−チオキソピリダジン誘導体 Download PDFInfo
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- JP2010536719A JP2010536719A JP2010520440A JP2010520440A JP2010536719A JP 2010536719 A JP2010536719 A JP 2010536719A JP 2010520440 A JP2010520440 A JP 2010520440A JP 2010520440 A JP2010520440 A JP 2010520440A JP 2010536719 A JP2010536719 A JP 2010536719A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/18—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007038957A DE102007038957A1 (de) | 2007-08-17 | 2007-08-17 | 6-Thioxo-pyridazinderivate |
| PCT/EP2008/005928 WO2009024221A1 (de) | 2007-08-17 | 2008-07-18 | 6-thioxo-pyridazinderivate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010536719A true JP2010536719A (ja) | 2010-12-02 |
| JP2010536719A5 JP2010536719A5 (enExample) | 2011-09-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010520440A Pending JP2010536719A (ja) | 2007-08-17 | 2008-07-18 | ６−チオキソピリダジン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110136819A1 (enExample) |
| EP (1) | EP2176236A1 (enExample) |
| JP (1) | JP2010536719A (enExample) |
| AU (1) | AU2008290896A1 (enExample) |
| CA (1) | CA2696472A1 (enExample) |
| DE (1) | DE102007038957A1 (enExample) |
| WO (1) | WO2009024221A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011506500A (ja) * | 2007-12-21 | 2011-03-03 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｍｅｔキナーゼ阻害剤としての２−ベンジルピリダジノン誘導体 |
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| US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| AU2011296312A1 (en) * | 2010-08-31 | 2013-02-28 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| CN105073744B (zh) | 2012-12-21 | 2019-11-08 | 齐尼思表观遗传学有限公司 | 作为溴结构域抑制剂的新型杂环化合物 |
| WO2015004533A2 (en) | 2013-06-21 | 2015-01-15 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
| SG10201710705UA (en) | 2013-06-21 | 2018-02-27 | Zenith Epigenetics Ltd | Novel bicyclic bromodomain inhibitors |
| EP3027604B1 (en) | 2013-07-31 | 2019-02-20 | Zenith Epigenetics Ltd. | Novel quinazolinones as bromodomain inhibitors |
| HK1246273B (en) | 2014-12-01 | 2019-12-06 | 恒翼生物医药(上海)股份有限公司 | Substituted pyridines as bromodomain inhibitors |
| HK1245246A1 (zh) | 2014-12-01 | 2018-08-24 | 恒翼生物医药科技(上海)有限公司 | 作为溴域抑制剂的取代吡啶酮 |
| JP6864953B2 (ja) | 2014-12-09 | 2021-04-28 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Ａｘｌに対するヒトモノクローナル抗体 |
| JP2017537946A (ja) | 2014-12-11 | 2017-12-21 | ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｌｔｄ． | ブロモドメイン阻害剤としての置換複素環 |
| CA2966450A1 (en) | 2014-12-17 | 2016-06-23 | Olesya KHARENKO | Inhibitors of bromodomains |
| WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
| CA3118904A1 (en) | 2018-11-06 | 2020-05-14 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| JP7170133B2 (ja) | 2018-11-06 | 2022-11-11 | エッジワイズ セラピューティクス， インコーポレイテッド | ピリダジノン化合物およびその使用 |
| DK3877376T3 (da) | 2018-11-06 | 2023-10-02 | Edgewise Therapeutics Inc | Pyridazinonforbindelser og anvendelser deraf |
| AU2021385572A1 (en) | 2020-11-25 | 2023-06-22 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids, and related methods of use |
| CN119562806A (zh) | 2022-05-25 | 2025-03-04 | 阿卡格拉医药公司 | 用于递送核酸的脂质纳米粒及其使用方法 |
| CN116768868B (zh) * | 2023-08-15 | 2023-12-08 | 云南省药物研究所 | 一种哒嗪酮硫代衍生物及其制备方法和应用 |
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2007
- 2007-08-17 DE DE102007038957A patent/DE102007038957A1/de not_active Withdrawn
-
2008
- 2008-07-18 US US12/673,704 patent/US20110136819A1/en not_active Abandoned
- 2008-07-18 WO PCT/EP2008/005928 patent/WO2009024221A1/de not_active Ceased
- 2008-07-18 AU AU2008290896A patent/AU2008290896A1/en not_active Abandoned
- 2008-07-18 EP EP08774029A patent/EP2176236A1/de not_active Withdrawn
- 2008-07-18 JP JP2010520440A patent/JP2010536719A/ja active Pending
- 2008-07-18 CA CA2696472A patent/CA2696472A1/en not_active Abandoned
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| WO2007065518A1 (de) * | 2005-12-05 | 2007-06-14 | Merck Patent Gmbh | Pyridiazinonderivate zur behandlung von tumoren |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011506500A (ja) * | 2007-12-21 | 2011-03-03 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｍｅｔキナーゼ阻害剤としての２−ベンジルピリダジノン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2696472A1 (en) | 2009-02-26 |
| EP2176236A1 (de) | 2010-04-21 |
| DE102007038957A1 (de) | 2009-02-19 |
| US20110136819A1 (en) | 2011-06-09 |
| AU2008290896A1 (en) | 2009-02-26 |
| WO2009024221A1 (de) | 2009-02-26 |
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