JP2011526609A5 - - Google Patents
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- Publication number
- JP2011526609A5 JP2011526609A5 JP2011515511A JP2011515511A JP2011526609A5 JP 2011526609 A5 JP2011526609 A5 JP 2011526609A5 JP 2011515511 A JP2011515511 A JP 2011515511A JP 2011515511 A JP2011515511 A JP 2011515511A JP 2011526609 A5 JP2011526609 A5 JP 2011526609A5
- Authority
- JP
- Japan
- Prior art keywords
- delivery system
- progestogen
- polymer composition
- intrauterine delivery
- intrauterine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims description 10
- 230000000694 effects Effects 0.000 claims description 9
- 208000032843 Hemorrhage Diseases 0.000 claims description 8
- 230000000740 bleeding effect Effects 0.000 claims description 8
- 230000002357 endometrial effect Effects 0.000 claims description 5
- 229960004400 levonorgestrel Drugs 0.000 claims description 5
- 230000002175 menstrual effect Effects 0.000 claims description 4
- 239000000583 progesterone congener Substances 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 13
- 229920000642 polymer Polymers 0.000 claims 13
- -1 didrgestosterone Chemical compound 0.000 claims 8
- 230000002159 abnormal effect Effects 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 239000012528 membrane Substances 0.000 claims 6
- 239000013543 active substance Substances 0.000 claims 5
- 230000001788 irregular Effects 0.000 claims 4
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 3
- PJJGZPJJTHBVMX-UHFFFAOYSA-N 5,7-Dihydroxyisoflavone Chemical compound C=1C(O)=CC(O)=C(C2=O)C=1OC=C2C1=CC=CC=C1 PJJGZPJJTHBVMX-UHFFFAOYSA-N 0.000 claims 2
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 claims 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 2
- 206010046788 Uterine haemorrhage Diseases 0.000 claims 2
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 2
- POZRVZJJTULAOH-LHZXLZLDSA-N danazol Chemical compound C1[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=CC2=C1C=NO2 POZRVZJJTULAOH-LHZXLZLDSA-N 0.000 claims 2
- 229960000766 danazol Drugs 0.000 claims 2
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims 2
- CHNXZKVNWQUJIB-CEGNMAFCSA-N ethisterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 CHNXZKVNWQUJIB-CEGNMAFCSA-N 0.000 claims 2
- 229960003464 mefenamic acid Drugs 0.000 claims 2
- 229960001652 norethindrone acetate Drugs 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims 2
- 229960000401 tranexamic acid Drugs 0.000 claims 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 1
- ATXHVCQZZJYMCF-XUDSTZEESA-N Allylestrenol Chemical compound C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)CC=C)[C@@H]4[C@@H]3CCC2=C1 ATXHVCQZZJYMCF-XUDSTZEESA-N 0.000 claims 1
- 201000000736 Amenorrhea Diseases 0.000 claims 1
- 206010001928 Amenorrhoea Diseases 0.000 claims 1
- 102000009151 Luteinizing Hormone Human genes 0.000 claims 1
- 108010073521 Luteinizing Hormone Proteins 0.000 claims 1
- YNVGQYHLRCDXFQ-XGXHKTLJSA-N Lynestrenol Chemical compound C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 YNVGQYHLRCDXFQ-XGXHKTLJSA-N 0.000 claims 1
- ICTXHFFSOAJUMG-SLHNCBLASA-N Norethynodrel Chemical compound C1CC(=O)CC2=C1[C@H]1CC[C@](C)([C@](CC3)(O)C#C)[C@@H]3[C@@H]1CC2 ICTXHFFSOAJUMG-SLHNCBLASA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229960002692 allylestrenol Drugs 0.000 claims 1
- 231100000540 amenorrhea Toxicity 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 229960000978 cyproterone acetate Drugs 0.000 claims 1
- UWFYSQMTEOIJJG-FDTZYFLXSA-N cyproterone acetate Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 UWFYSQMTEOIJJG-FDTZYFLXSA-N 0.000 claims 1
- 229960004976 desogestrel Drugs 0.000 claims 1
- RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 claims 1
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 claims 1
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 1
- 229960004845 drospirenone Drugs 0.000 claims 1
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 claims 1
- 229960000445 ethisterone Drugs 0.000 claims 1
- ONKUMRGIYFNPJW-KIEAKMPYSA-N ethynodiol diacetate Chemical compound C1C[C@]2(C)[C@@](C#C)(OC(C)=O)CC[C@H]2[C@@H]2CCC3=C[C@@H](OC(=O)C)CC[C@@H]3[C@H]21 ONKUMRGIYFNPJW-KIEAKMPYSA-N 0.000 claims 1
- 229960002941 etonogestrel Drugs 0.000 claims 1
- GCKFUYQCUCGESZ-BPIQYHPVSA-N etonogestrel Chemical compound O=C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 GCKFUYQCUCGESZ-BPIQYHPVSA-N 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229940040129 luteinizing hormone Drugs 0.000 claims 1
- 229960001910 lynestrenol Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960002985 medroxyprogesterone acetate Drugs 0.000 claims 1
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 claims 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims 1
- 229960001858 norethynodrel Drugs 0.000 claims 1
- 229960000417 norgestimate Drugs 0.000 claims 1
- KIQQMECNKUGGKA-NMYWJIRASA-N norgestimate Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(OC(C)=O)C#C)[C@@H]4[C@@H]3CCC2=C\1 KIQQMECNKUGGKA-NMYWJIRASA-N 0.000 claims 1
- 229960002831 norgestrienone Drugs 0.000 claims 1
- GVDMJXQHPUYPHP-FYQPLNBISA-N norgestrienone Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)C#C)C=C3)C3=C21 GVDMJXQHPUYPHP-FYQPLNBISA-N 0.000 claims 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 1
- 229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 230000007407 health benefit Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000009802 hysterectomy Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 208000007106 menorrhagia Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229940110234 mirena Drugs 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08397516A EP2140860A1 (en) | 2008-07-03 | 2008-07-03 | An improved method of contraception |
| EP08397516.9 | 2008-07-03 | ||
| PCT/FI2009/050598 WO2010000943A1 (en) | 2008-07-03 | 2009-07-01 | An intrauterine delivery system for contraception |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014045808A Division JP6008893B2 (ja) | 2008-07-03 | 2014-03-10 | 避妊のための子宮内用送達システム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011526609A JP2011526609A (ja) | 2011-10-13 |
| JP2011526609A5 true JP2011526609A5 (enExample) | 2012-07-19 |
Family
ID=40020198
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011515511A Pending JP2011526609A (ja) | 2008-07-03 | 2009-07-01 | 避妊のための子宮内用送達システム |
| JP2014045808A Active JP6008893B2 (ja) | 2008-07-03 | 2014-03-10 | 避妊のための子宮内用送達システム |
| JP2016114446A Pending JP2016166245A (ja) | 2008-07-03 | 2016-06-08 | 避妊のための子宮内用送達システム |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014045808A Active JP6008893B2 (ja) | 2008-07-03 | 2014-03-10 | 避妊のための子宮内用送達システム |
| JP2016114446A Pending JP2016166245A (ja) | 2008-07-03 | 2016-06-08 | 避妊のための子宮内用送達システム |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US20110146693A1 (enExample) |
| EP (3) | EP2140860A1 (enExample) |
| JP (3) | JP2011526609A (enExample) |
| KR (2) | KR20110026516A (enExample) |
| CN (2) | CN103976816A (enExample) |
| AR (1) | AR072544A1 (enExample) |
| CA (1) | CA2730040A1 (enExample) |
| CL (1) | CL2009001490A1 (enExample) |
| CY (1) | CY1120878T1 (enExample) |
| DK (1) | DK2905014T3 (enExample) |
| ES (1) | ES2673154T3 (enExample) |
| HR (1) | HRP20180869T1 (enExample) |
| HU (1) | HUE037520T2 (enExample) |
| LT (1) | LT2905014T (enExample) |
| PE (1) | PE20100057A1 (enExample) |
| PL (1) | PL2905014T3 (enExample) |
| PT (1) | PT2905014T (enExample) |
| SI (1) | SI2905014T1 (enExample) |
| SM (1) | SMT201800295T1 (enExample) |
| TR (1) | TR201807996T4 (enExample) |
| TW (2) | TWI602556B (enExample) |
| UY (1) | UY31957A (enExample) |
| WO (1) | WO2010000943A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2494706C2 (ru) | 2008-09-17 | 2013-10-10 | Байер Ой | Устройство для введения |
| FI20080524A0 (fi) | 2008-09-17 | 2008-09-17 | Bayer Schering Pharma Oy | Insertteri |
| FI20080523A0 (fi) | 2008-09-17 | 2008-09-17 | Bayer Schering Pharma Oy | Insertteri |
| DE202012012713U1 (de) * | 2011-03-04 | 2014-01-23 | Arstat, Inc. | Intravaginale Arzneimittelabgabevorrichtung |
| US10028858B2 (en) | 2011-07-11 | 2018-07-24 | Medicines360 | Intrauterine systems, IUD insertion devices, and related methods and kits therefor |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| RS62297B1 (sr) | 2011-11-23 | 2021-09-30 | Therapeuticsmd Inc | Prirodne kombinovane hormonske supstitucione formulacije i terapije |
| AR089765A1 (es) | 2012-01-23 | 2014-09-17 | Bayer Oy | Un sistema para el suministro de un farmaco |
| TW201350122A (zh) * | 2012-04-23 | 2013-12-16 | Bayer Pharma AG | 18-甲基-15β,16β-亞甲基-19-降-20-螺氧-4-烯-3-酮的子宮內用途,包含18-甲基-15β,16β-亞甲基-19-降-20-螺氧-4-烯-3-酮的子宮內系統,及其於避孕及婦科治療之用途 |
| USD718435S1 (en) | 2012-05-30 | 2014-11-25 | Medicines360 | Intrauterine insertion device |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| SE539540C2 (sv) | 2013-09-12 | 2017-10-10 | Qpharma Ab | Ett läkemedelsavgivningssystem för en eller flera aktiva beståndsdelar |
| CN105636577A (zh) * | 2013-10-18 | 2016-06-01 | 拜耳股份有限公司 | 子宫内递送系统 |
| JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. | 天然の併用ホルモン補充療法剤及び療法 |
| WO2015189853A1 (en) | 2014-06-13 | 2015-12-17 | Meril Endo Surgery Private Limited | An intrauterine device |
| TWI730948B (zh) * | 2014-12-08 | 2021-06-21 | 芬蘭商拜耳股份有限公司 | 新穎的熱塑性聚胺甲酸酯,彼等材料於製造子宮內系統之t-框架之用途及由此等材料製成之t-框架 |
| LT3247327T (lt) * | 2015-01-21 | 2019-10-10 | Bayer Oy | Vaisto pateikimo sistema, apimanti nesteroidinį priešuždegiminį (nsaid) ir progestogeninį junginį, ir gamybos būdai |
| US20180140640A1 (en) | 2015-04-22 | 2018-05-24 | Cadens Beheer B.V. | Improved contraceptive methods and compositions and devices for use therein |
| FI3294300T3 (fi) | 2015-05-13 | 2025-03-06 | Bayer Oy | Pitkävaikutteinen lääkkeenantolaite implantin tai kierukan muodossa, joka käsittää levonorgestreelia ja etinyyliestradiolia |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| CN108430453B (zh) * | 2015-12-21 | 2023-03-17 | 拜耳股份有限公司 | 制造药物递送装置的方法和根据该方法制成的药物递送装置 |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| GB2555373A (en) * | 2016-08-23 | 2018-05-02 | Reproductive Medicine And Gynaecology Associates Ltd | Implant |
| AU201617347S (en) * | 2016-12-23 | 2017-01-23 | Jurox Pty Ltd | intravaginal device |
| AU2018340266A1 (en) * | 2017-09-27 | 2020-03-05 | Bayer Oy | A method for modifying release of a therapeutically active agent from an elastomeric matrix |
| EP3727361A4 (en) | 2017-12-22 | 2022-01-12 | Alyra Biotech Pty Ltd | TREATMENT OF PAIN AND/OR PAIN-RELATED SYMPTOMS RELATED TO DYSMENORRHEA |
| US20200268932A1 (en) * | 2019-02-22 | 2020-08-27 | Arsenal Aaa, Llc. | Crosslinkable polymer compositions |
| EP3962489B1 (en) * | 2019-02-22 | 2023-03-22 | Elkem Silicones USA Corp. | Drug delivery silicone compositon to improve active ingredient elution |
| KR102260999B1 (ko) * | 2019-03-27 | 2021-06-04 | (주)엠케어코리아 | 난소암 검사용 임플란트 및 이를 포함하는 검사킷 및 이를 이용한 난소암 검사방법 |
| WO2020237325A1 (en) | 2019-05-31 | 2020-12-03 | Alyra Biotech Pty Ltd | Methods, compositions and devices for treating neuroinflammatory conditions |
| CN110215447A (zh) * | 2019-06-14 | 2019-09-10 | 上海市计划生育科学研究所 | 甲芬那酸在避孕药物中的应用及其制备的杀精避孕药物 |
| WO2021102220A1 (en) | 2019-11-21 | 2021-05-27 | Coopersurgical, Inc. | Packaging systems for implantable devices and related methods |
| CN116807727B (zh) * | 2023-08-29 | 2023-11-21 | 上海宇度医学科技股份有限公司 | 一种妇产科医师用临床取环器 |
| WO2025106820A1 (en) * | 2023-11-16 | 2025-05-22 | University Of South Florida | Method of preventing progesterone contraceptive-induced abnormal uterine bleeding (aub) |
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| US4495934A (en) | 1978-07-25 | 1985-01-29 | Shaw Jr Seth T | IUD Arrangement |
| US4284074A (en) * | 1978-07-26 | 1981-08-18 | Shaw Jr Seth T | IUD Arrangement |
| AU538963B2 (en) | 1979-07-09 | 1984-09-06 | Seth Thomas Shaw Jr. | Drug for use with an iud |
| FR2539027B1 (fr) * | 1983-01-07 | 1987-03-06 | Levrier Marc | Systeme endo-uterin contraceptif et therapeutique associant cuivre, argent, hormone naturelle et acide iso amino caproique |
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| FI103051B (fi) | 1997-08-22 | 1999-04-15 | Schering Oy | Uusia blokkikopolymeerejä ja niiden valmistus |
| FI107339B (fi) | 1998-06-30 | 2001-07-13 | Leiras Oy | Lääkeaineiden läpäisynopeutta säätävä kalvo tai matriisi |
| US6056976A (en) | 1998-11-12 | 2000-05-02 | Leiras Oy | Elastomer, its preparation and use |
| US20050033163A1 (en) | 2001-04-24 | 2005-02-10 | Impres Medical, Inc. | Intrauterine implant and methods of use |
| DE10045380A1 (de) * | 2000-09-14 | 2002-04-04 | Schering Ag | Verfahren zur Kontrazeption und dessen Darreichungsform |
| WO2002038159A1 (fr) * | 2000-11-10 | 2002-05-16 | Mitsubishi Pharma Corporation | Medicaments pour l'hyperplasie endometriale |
| AU2002313517B2 (en) * | 2001-08-31 | 2007-09-06 | Bayer Schering Pharma Oy | Drug delivery system |
| JP2003221338A (ja) * | 2002-01-29 | 2003-08-05 | Masao Igarashi | 子宮腺筋症治療製剤 |
| ATE461681T1 (de) * | 2003-04-29 | 2010-04-15 | Gen Hospital Corp | Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln |
| GB0320238D0 (en) * | 2003-08-29 | 2003-10-01 | Medical Res Council | Treatment of disease |
| FI123188B (fi) * | 2005-04-05 | 2012-12-14 | Bayer Oy | Ultraäänellä havaittavissa oleva kohdunsisäinen järjestelmä |
| US7862552B2 (en) * | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
| CN100441156C (zh) * | 2006-09-30 | 2008-12-10 | 华中科技大学 | 一种复合材料宫内节育器 |
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2008
- 2008-07-03 EP EP08397516A patent/EP2140860A1/en not_active Withdrawn
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2009
- 2009-06-11 TW TW104133303A patent/TWI602556B/zh not_active IP Right Cessation
- 2009-06-11 TW TW098119470A patent/TW201002288A/zh unknown
- 2009-06-26 CL CL2009001490A patent/CL2009001490A1/es unknown
- 2009-07-01 LT LTEP14193392.9T patent/LT2905014T/lt unknown
- 2009-07-01 PT PT141933929T patent/PT2905014T/pt unknown
- 2009-07-01 US US12/995,905 patent/US20110146693A1/en not_active Abandoned
- 2009-07-01 SM SM20180295T patent/SMT201800295T1/it unknown
- 2009-07-01 PE PE2009000913A patent/PE20100057A1/es active IP Right Grant
- 2009-07-01 KR KR1020117002766A patent/KR20110026516A/ko not_active Ceased
- 2009-07-01 CN CN201410149061.4A patent/CN103976816A/zh active Pending
- 2009-07-01 KR KR1020157033151A patent/KR101659530B1/ko not_active Expired - Fee Related
- 2009-07-01 HU HUE14193392A patent/HUE037520T2/hu unknown
- 2009-07-01 JP JP2011515511A patent/JP2011526609A/ja active Pending
- 2009-07-01 ES ES14193392.9T patent/ES2673154T3/es active Active
- 2009-07-01 TR TR2018/07996T patent/TR201807996T4/tr unknown
- 2009-07-01 CA CA2730040A patent/CA2730040A1/en not_active Abandoned
- 2009-07-01 CN CN2009801259913A patent/CN102088954A/zh active Pending
- 2009-07-01 AR ARP090102452A patent/AR072544A1/es not_active Application Discontinuation
- 2009-07-01 WO PCT/FI2009/050598 patent/WO2010000943A1/en not_active Ceased
- 2009-07-01 DK DK14193392.9T patent/DK2905014T3/en active
- 2009-07-01 EP EP09772630.1A patent/EP2313084A4/en not_active Withdrawn
- 2009-07-01 SI SI200931850T patent/SI2905014T1/en unknown
- 2009-07-01 PL PL14193392T patent/PL2905014T3/pl unknown
- 2009-07-01 EP EP14193392.9A patent/EP2905014B1/en active Active
- 2009-07-02 UY UY0001031957A patent/UY31957A/es unknown
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- 2013-07-03 US US13/934,913 patent/US9999592B2/en active Active
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- 2014-03-10 JP JP2014045808A patent/JP6008893B2/ja active Active
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