|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
US8063058B2
(en)
|
2008-04-16 |
2011-11-22 |
Portola Pharmaceuticals, Inc. |
Inhibitors of syk and JAK protein kinases
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
US11351168B1
(en)
|
2008-06-27 |
2022-06-07 |
Celgene Car Llc |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
NZ589843A
(en)
|
2008-06-27 |
2012-12-21 |
Avila Therapeutics Inc |
Pyrimidine heteroaryl compounds and uses thereof as protein kinase inhibitors
|
|
WO2010097248A1
(en)
*
|
2009-01-13 |
2010-09-02 |
Glaxo Group Limited |
Pyrimidinecarboxamide derivatives as inhibitors of syk kinase
|
|
JP5918693B2
(ja)
|
2009-05-05 |
2016-05-18 |
ダナ ファーバー キャンサー インスティテュート インコーポレイテッド |
Egfr阻害剤及び疾患の治療方法
|
|
EP2428508B9
(en)
|
2009-05-08 |
2016-04-20 |
Astellas Pharma Inc. |
Diamino heterocyclic carboxamide compound
|
|
US8410126B2
(en)
*
|
2009-05-29 |
2013-04-02 |
Boehringer Ingelheim International Gmbh |
Pyrimidine inhibitors of PKTK2
|
|
US8440689B2
(en)
|
2009-12-23 |
2013-05-14 |
Takeda Pharmaceutical Company Limited |
Fused heteroaromatic pyrrolidinones
|
|
PL2589592T3
(pl)
|
2010-06-30 |
2019-03-29 |
Fujifilm Corporation |
Nowe pochodne nikotynamidu lub ich sole
|
|
ES2617763T3
(es)
|
2010-08-10 |
2017-06-19 |
Celgene Avilomics Research, Inc. |
Sal de besilato de un inhibidor de BTK
|
|
JP5951610B2
(ja)
|
2010-08-27 |
2016-07-13 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung |
トリアゾロピラジン誘導体
|
|
SG187956A1
(en)
|
2010-08-27 |
2013-03-28 |
Merck Patent Gmbh |
Furopyridine derivatives
|
|
JP2014005206A
(ja)
*
|
2010-10-22 |
2014-01-16 |
Astellas Pharma Inc |
アリールアミノヘテロ環カルボキサミド化合物
|
|
WO2012061299A1
(en)
|
2010-11-01 |
2012-05-10 |
Avila Therapeutics, Inc. |
Heterocyclic compounds and uses thereof
|
|
US20130317029A1
(en)
*
|
2010-11-01 |
2013-11-28 |
Portola Pharmaceuticals, Inc. |
Oxypyrimidines as syk modulators
|
|
AU2011323484B2
(en)
|
2010-11-01 |
2016-10-06 |
Portola Pharmaceuticals, Inc. |
Benzamides and nicotinamides as Syk modulators
|
|
US9238629B2
(en)
|
2010-11-01 |
2016-01-19 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
EP2489663A1
(en)
|
2011-02-16 |
2012-08-22 |
Almirall, S.A. |
Compounds as syk kinase inhibitors
|
|
UA120740C2
(uk)
|
2011-04-22 |
2020-02-10 |
Сігнал Фармасьютікалз, Елелсі |
Заміщені діамінокарбоксамідні і діамінокарбонітрильні похідні піримідинів, їх композиції і способи лікування з їх допомогою
|
|
AU2016244228B2
(en)
*
|
2011-04-22 |
2019-02-21 |
Signal Pharmaceuticals, Llc |
Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
|
|
JP2014513687A
(ja)
|
2011-05-10 |
2014-06-05 |
メルク・シャープ・アンド・ドーム・コーポレーション |
Syk阻害薬としてのピリジルアミノピリジン
|
|
EP2706852B1
(en)
|
2011-05-10 |
2018-08-22 |
Merck Sharp & Dohme Corp. |
Bipyridylaminopyridines as syk inhibitors
|
|
MX2013013090A
(es)
|
2011-05-10 |
2013-12-16 |
Merck Sharp & Dohme |
Aminopirimidinas como inhibidores de tirosina cinaza del bazo.
|
|
EP2723739B1
(en)
|
2011-06-22 |
2016-08-24 |
Takeda Pharmaceutical Company Limited |
Substituted 6-aza-isoindolin-1-one derivatives
|
|
EP2763976B1
(en)
*
|
2011-10-05 |
2016-05-18 |
Merck Sharp & Dohme Corp. |
2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
|
|
WO2013052393A1
(en)
|
2011-10-05 |
2013-04-11 |
Merck Sharp & Dohme Corp. |
3-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS
|
|
EP2763974B1
(en)
|
2011-10-05 |
2016-09-14 |
Merck Sharp & Dohme Corp. |
Phenyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
|
|
JP2014532658A
(ja)
|
2011-10-28 |
2014-12-08 |
セルジーン アヴィロミクス リサーチ, インコーポレイテッド |
ブルトン型チロシンキナーゼ疾患または障害を治療する方法
|
|
US9221809B2
(en)
|
2011-10-31 |
2015-12-29 |
Merck Sharp & Dohme Corp. |
Aminopyrimidinones as interleukin receptor-associated kinase inhibitors
|
|
CA2856306A1
(en)
*
|
2011-11-23 |
2013-05-30 |
Portola Pharmaceuticals, Inc. |
Selective kinase inhibitors
|
|
CA2856301C
(en)
|
2011-11-23 |
2020-10-06 |
Portola Pharmaceuticals, Inc. |
Pyrazine kinase inhibitors
|
|
ES2661444T3
(es)
|
2011-12-28 |
2018-04-02 |
Fujifilm Corporation |
Nuevo derivado de nicotinamida o sal del mismo
|
|
CN104159891B
(zh)
*
|
2012-01-10 |
2016-09-07 |
霍夫曼-拉罗奇有限公司 |
哒嗪酰胺化合物和它们作为syk 抑制剂的用途
|
|
US9085540B2
(en)
*
|
2012-01-17 |
2015-07-21 |
Astellas Pharma Inc. |
Pyrazinecarboxamide compound
|
|
WO2013124025A1
(en)
|
2012-02-21 |
2013-08-29 |
Merck Patent Gmbh |
Furopyridine derivatives
|
|
EP2817310B1
(en)
|
2012-02-21 |
2018-03-21 |
Merck Patent GmbH |
8-substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrazines as syk tryrosine kinase inhibitors and gcn2 serin kinase inhibitors
|
|
UY34807A
(es)
|
2012-05-16 |
2013-12-31 |
Novartis Ag |
Derivados monocíclicos de heteroarilcicloalquil- diamina
|
|
WO2013192128A1
(en)
|
2012-06-20 |
2013-12-27 |
Merck Sharp & Dohme Corp. |
Imidazolyl analogs as syk inhibitors
|
|
WO2013192125A1
(en)
|
2012-06-20 |
2013-12-27 |
Merck Sharp & Dohme Corp. |
Pyrazolyl derivatives as syk inhibitors
|
|
US9416111B2
(en)
|
2012-06-22 |
2016-08-16 |
Merck Sharp & Dohme Corp. |
Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors
|
|
EP2863916B1
(en)
|
2012-06-22 |
2018-07-18 |
Merck Sharp & Dohme Corp. |
Substituted pyridine spleen tyrosine kinase (syk) inhibitors
|
|
US20140113931A1
(en)
*
|
2012-06-22 |
2014-04-24 |
Portola Pharmaceuticals, Inc. |
Substituted picolinamide kinase inhibitors
|
|
US9040530B2
(en)
*
|
2012-06-22 |
2015-05-26 |
Portola Pharmaceuticals, Inc. |
1,2,4-triazine-6-carboxamide kinase inhibitors
|
|
US9725462B2
(en)
|
2012-08-07 |
2017-08-08 |
Merck Patent Gmbh |
Pyridopyrimidine derivatives as protein kinase inhibitors
|
|
WO2014031438A2
(en)
|
2012-08-20 |
2014-02-27 |
Merck Sharp & Dohme Corp. |
SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS
|
|
JP6463680B2
(ja)
*
|
2012-09-18 |
2019-02-06 |
ジアルコ ファーマ リミテッドZiarco Pharma Ltd |
脾臓チロシンキナーゼi(syk)阻害剤としての2−(2−アミノシクロヘキシル)アミノピリミジン−5−カルボキサミド類
|
|
EP2900665B1
(en)
|
2012-09-28 |
2018-01-03 |
Merck Sharp & Dohme Corp. |
Triazolyl derivatives as syk inhibitors
|
|
NZ739834A
(en)
|
2012-10-02 |
2018-11-30 |
Bayer Cropscience Ag |
Heterocyclic compounds as pesticides
|
|
CA2883534A1
(en)
*
|
2012-10-19 |
2014-04-24 |
F. Hoffmann-La Roche Ag |
Inhibitors of syk
|
|
US9540333B2
(en)
*
|
2012-11-08 |
2017-01-10 |
Bristol-Myers Squibb Company |
Alkyl amide-substituted pyrimidine compounds useful in the modulation of IL-12, IL-23 and/or IFNα
|
|
WO2014093191A1
(en)
|
2012-12-12 |
2014-06-19 |
Merck Sharp & Dohme Corp. |
AMINO-PYRIMIDINE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS
|
|
EP2934525B1
(en)
|
2012-12-21 |
2019-05-08 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors
|
|
US9126950B2
(en)
|
2012-12-21 |
2015-09-08 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
AU2014214846A1
(en)
|
2013-02-08 |
2015-07-23 |
Celgene Avilomics Research, Inc. |
ERK inhibitors and uses thereof
|
|
US20160009694A1
(en)
*
|
2013-03-15 |
2016-01-14 |
Portola Pharmaceuticals, Inc. |
Cyclohexanediamine compounds and methods for their preparation
|
|
JP2016113366A
(ja)
*
|
2013-03-29 |
2016-06-23 |
大鵬薬品工業株式会社 |
アセトアミド基を有する1,2,4−トリアジン−6−カルボキサミド誘導体
|
|
WO2014176210A1
(en)
|
2013-04-26 |
2014-10-30 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
|
|
EP2988749B1
(en)
|
2013-04-26 |
2019-08-14 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors
|
|
IN2013MU02611A
(enExample)
|
2013-08-07 |
2015-06-12 |
Cadila Healthcare Ltd |
|
|
US9492471B2
(en)
|
2013-08-27 |
2016-11-15 |
Celgene Avilomics Research, Inc. |
Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
|
|
WO2015039613A1
(zh)
*
|
2013-09-18 |
2015-03-26 |
北京韩美药品有限公司 |
抑制btk和/或jak3激酶活性的化合物
|
|
JP6345786B2
(ja)
|
2013-12-05 |
2018-06-20 |
ファーマサイクリックス エルエルシー |
ブルトン型チロシンキナーゼの阻害剤
|
|
US9783531B2
(en)
|
2013-12-20 |
2017-10-10 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
|
|
EP3083559B1
(en)
|
2013-12-20 |
2021-03-10 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
|
|
EP3083560B1
(en)
|
2013-12-20 |
2021-10-27 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
|
|
NZ715903A
(en)
|
2014-01-30 |
2017-06-30 |
Signal Pharm Llc |
Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
|
|
EP3116506B1
(en)
|
2014-03-13 |
2019-04-17 |
Merck Sharp & Dohme Corp. |
2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
|
|
JP2017518737A
(ja)
|
2014-04-21 |
2017-07-13 |
ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. |
SYK標的治療薬のための抗pSYK抗体分子及びその使用
|
|
WO2016020403A1
(en)
*
|
2014-08-04 |
2016-02-11 |
Sandoz Ag |
Preparation of a benzoic acid derivative and its use for the preparation of suvorexant
|
|
WO2016025561A1
(en)
|
2014-08-13 |
2016-02-18 |
Celgene Avilomics Research, Inc. |
Forms and compositions of an erk inhibitor
|
|
CA3210612A1
(en)
|
2014-12-16 |
2016-06-23 |
Signal Pharmaceuticals, Llc |
Formulations of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
|
|
JP6903577B2
(ja)
|
2014-12-16 |
2021-07-14 |
シグナル ファーマシューティカルズ,エルエルシー |
皮膚におけるc−Jun N末端キナーゼの阻害の測定方法
|
|
WO2016123291A1
(en)
|
2015-01-29 |
2016-08-04 |
Signal Pharmaceuticals, Llc |
Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
|
|
CA2993173C
(en)
|
2015-07-24 |
2023-10-03 |
Celgene Corporation |
Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
|
|
ES2913119T3
(es)
*
|
2015-08-12 |
2022-05-31 |
Portola Pharm Inc |
Cerdulatinib para tratar mieloma
|
|
EP3442947B1
(en)
*
|
2016-04-15 |
2023-06-07 |
Epizyme, Inc. |
Amine-substituted aryl or heteroaryl compounds as ehmt1 and ehmt2 inhibitors
|
|
US11001570B2
(en)
*
|
2016-12-13 |
2021-05-11 |
Boehringer Ingelheim International Gmbh |
6-amino-quinolinone compounds and derivatives as BCL6 inhibitors
|
|
WO2018195450A1
(en)
|
2017-04-21 |
2018-10-25 |
Epizyme, Inc. |
Combination therapies with ehmt2 inhibitors
|
|
CN109384774B
(zh)
*
|
2017-08-11 |
2023-02-17 |
中国科学院上海药物研究所 |
一类多取代的吡嗪/三嗪酰胺类化合物及其制备方法和应用
|
|
JP2020537678A
(ja)
|
2017-10-19 |
2020-12-24 |
バイエル・アニマル・ヘルス・ゲーエムベーハー |
動物における疾患の治療および予防のための縮合ヘテロ芳香族ピロリドンの使用
|
|
JP7254076B2
(ja)
*
|
2017-11-19 |
2023-04-07 |
サンシャイン・レイク・ファーマ・カンパニー・リミテッド |
置換ヘテロアリール化合物及び使用方法
|
|
SG11202008765UA
(en)
*
|
2018-03-09 |
2020-10-29 |
Portola Pharm Inc |
Methods of use and pharmaceutical compositions of a selective syk inhibitor
|
|
SMT202400233T1
(it)
|
2018-04-18 |
2024-07-09 |
Constellation Pharmaceuticals Inc |
Modulatori di enzimi modificanti il metile, composizioni e usi degli stessi
|
|
EP3797108B1
(en)
|
2018-05-21 |
2022-07-20 |
Constellation Pharmaceuticals, Inc. |
Modulators of methyl modifying enzymes, compositions and uses thereof
|
|
FI3870579T3
(fi)
*
|
2018-10-22 |
2025-01-02 |
Alumis Inc |
Tyk2-inhibiittoreita ja niiden käyttöjä
|
|
KR20210142154A
(ko)
|
2019-03-21 |
2021-11-24 |
옹쎄오 |
암 치료를 위한 키나제 억제제와 조합된 dbait 분자
|
|
JP2023500906A
(ja)
|
2019-11-08 |
2023-01-11 |
インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) |
キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
|
|
WO2021148581A1
(en)
|
2020-01-22 |
2021-07-29 |
Onxeo |
Novel dbait molecule and its use
|
|
WO2021155185A1
(en)
*
|
2020-01-30 |
2021-08-05 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Aminopyrimidinylaminobenzonitrile derivatives as nek2 inhibitors
|
|
TW202227418A
(zh)
*
|
2020-10-12 |
2022-07-16 |
大陸商四川海思科製藥有限公司 |
一種雜環衍生物及其在醫藥上的應用
|
|
US20230416225A1
(en)
*
|
2020-11-09 |
2023-12-28 |
Merck Sharp & Dohme Llc |
Diaminopyrimidine carboxamide inhibitors of hpk1
|
|
US20240189309A1
(en)
*
|
2021-02-19 |
2024-06-13 |
Sudo Biosciences Limited |
Tyk2 inhibitors and uses thereof
|
|
TW202246233A
(zh)
*
|
2021-02-19 |
2022-12-01 |
英商蘇多生物科學有限公司 |
Tyk2抑制劑及其用途
|
|
KR20230159421A
(ko)
*
|
2021-02-19 |
2023-11-21 |
수도 바이오사이언시즈 리미티드 |
Tyk2 억제제 및 이의 용도
|
|
KR20230159420A
(ko)
*
|
2021-02-19 |
2023-11-21 |
수도 바이오사이언시즈 리미티드 |
Tyk2 억제제 및 이의 용도
|
|
US20240165123A1
(en)
*
|
2021-03-09 |
2024-05-23 |
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. |
Use of a compound containing a tricyclic heteroaryl group
|
|
CN115197196B
(zh)
*
|
2021-04-06 |
2024-06-18 |
扬子江药业集团有限公司 |
Tyk2抑制剂及其用途
|
|
WO2023108536A1
(en)
*
|
2021-12-16 |
2023-06-22 |
Lynk Pharmaceuticals Co. Ltd. |
Tyk2 inhibitors and compositions and methods thereof
|
|
WO2023109954A1
(en)
|
2021-12-16 |
2023-06-22 |
Lynk Pharmaceuticals Co. Ltd. |
Tyk2 inhibitors and compositions and methods thereof
|
|
CN116120282B
(zh)
*
|
2022-08-04 |
2024-02-20 |
苏州系统医学研究所 |
具有ev71和/或cva16病毒抑制活性的化合物及其应用
|
|
CN116925053A
(zh)
*
|
2023-07-26 |
2023-10-24 |
成都赜灵生物医药科技有限公司 |
甲磺酸普依司他中间体的杂质去除工艺
|
|
CN118440052B
(zh)
*
|
2024-07-05 |
2024-10-11 |
四川大学 |
一种化合物及其在制备tyk2激酶抑制剂中的用途
|
|
CN120665299A
(zh)
*
|
2025-05-23 |
2025-09-19 |
广东药科大学 |
一种金属有机框架材料及其制备方法和应用
|