|
WO2015164330A1
(en)
|
2014-04-21 |
2015-10-29 |
Millennium Pharmaceuticals, Inc. |
Anti-psyk antibody molecules and use of same for syk-targeted therapy
|
|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
US8063058B2
(en)
|
2008-04-16 |
2011-11-22 |
Portola Pharmaceuticals, Inc. |
Inhibitors of syk and JAK protein kinases
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
AU2009262068C1
(en)
|
2008-06-27 |
2015-07-02 |
Celgene Car Llc |
Heteroaryl compounds and uses thereof
|
|
US11351168B1
(en)
|
2008-06-27 |
2022-06-07 |
Celgene Car Llc |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
CA2749403A1
(en)
*
|
2009-01-13 |
2010-09-02 |
Glaxo Group Limited |
Pyrimidinecarboxamide derivatives as inhibitors of syk kinase
|
|
KR101705158B1
(ko)
|
2009-05-05 |
2017-02-09 |
다나-파버 캔서 인스티튜트 인크. |
Ｅｇｆｒ 억제제 및 질환 치료방법
|
|
MX2011011875A
(es)
|
2009-05-08 |
2011-12-08 |
Astellas Pharma Inc |
Compuesto de carboxamida heterociclica diamino.
|
|
US8410126B2
(en)
*
|
2009-05-29 |
2013-04-02 |
Boehringer Ingelheim International Gmbh |
Pyrimidine inhibitors of PKTK2
|
|
EP2516434B1
(en)
|
2009-12-23 |
2015-05-27 |
Takeda Pharmaceutical Company Limited |
Fused heteroaromatic pyrrolidinones as syk inhibitors
|
|
JP5744021B2
(ja)
|
2010-06-30 |
2015-07-01 |
富士フイルム株式会社 |
新規なニコチンアミド誘導体またはその塩
|
|
PH12013500246A1
(en)
|
2010-08-10 |
2019-10-11 |
Celgene Avilomics Res Inc |
Besylate salt of a btk inhibitor
|
|
CA2809331C
(en)
|
2010-08-27 |
2018-09-25 |
Merck Patent Gmbh |
Triazolopyrazine derivatives
|
|
SG187956A1
(en)
|
2010-08-27 |
2013-03-28 |
Merck Patent Gmbh |
Furopyridine derivatives
|
|
JP2014005206A
(ja)
*
|
2010-10-22 |
2014-01-16 |
Astellas Pharma Inc |
アリールアミノヘテロ環カルボキサミド化合物
|
|
JP5956999B2
(ja)
|
2010-11-01 |
2016-07-27 |
セルジーン アヴィロミクス リサーチ， インコーポレイテッド |
ヘテロアリール化合物およびその使用
|
|
BR112013010564B1
(pt)
|
2010-11-01 |
2021-09-21 |
Celgene Car Llc |
Compostos heterocíclicos e composições compreendendo os mesmos
|
|
WO2012061415A1
(en)
*
|
2010-11-01 |
2012-05-10 |
Portola Pharmaceuticals, Inc. |
Oxypyrimidines as syk modulators
|
|
AU2011323484B2
(en)
*
|
2010-11-01 |
2016-10-06 |
Portola Pharmaceuticals, Inc. |
Benzamides and nicotinamides as Syk modulators
|
|
EP2489663A1
(en)
|
2011-02-16 |
2012-08-22 |
Almirall, S.A. |
Compounds as syk kinase inhibitors
|
|
AU2016244228B2
(en)
*
|
2011-04-22 |
2019-02-21 |
Signal Pharmaceuticals, Llc |
Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
|
|
TWI548621B
(zh)
*
|
2011-04-22 |
2016-09-11 |
標誌製藥公司 |
經取代之二胺基甲醯胺及二胺基甲腈嘧啶、其組合物、及以該等治療之方法
|
|
WO2012154518A1
(en)
|
2011-05-10 |
2012-11-15 |
Merck Sharp & Dohme Corp. |
Bipyridylaminopyridines as syk inhibitors
|
|
CA2834062A1
(en)
|
2011-05-10 |
2012-11-15 |
Merck Sharp & Dohme Corp. |
Pyridyl aminopyridines as syk inhibitors
|
|
AU2012253885A1
(en)
|
2011-05-10 |
2013-10-31 |
Merck Sharp & Dohme Corp. |
Aminopyrimidines as Syk inhibitors
|
|
WO2012177714A1
(en)
|
2011-06-22 |
2012-12-27 |
Takeda Pharmaceutical Company Limited |
Substituted 6-aza-isoindolin-1-one derivatives
|
|
EP2763976B1
(en)
*
|
2011-10-05 |
2016-05-18 |
Merck Sharp & Dohme Corp. |
2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
|
|
US8987456B2
(en)
|
2011-10-05 |
2015-03-24 |
Merck Sharp & Dohme Corp. |
3-pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors
|
|
WO2013052391A1
(en)
|
2011-10-05 |
2013-04-11 |
Merck Sharp & Dohme Corp. |
PHENYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS
|
|
JP2014532658A
(ja)
|
2011-10-28 |
2014-12-08 |
セルジーン アヴィロミクス リサーチ， インコーポレイテッド |
ブルトン型チロシンキナーゼ疾患または障害を治療する方法
|
|
EP2773207B1
(en)
*
|
2011-10-31 |
2018-03-07 |
Merck Sharp & Dohme Corp. |
Aminopyrimidinones as interleukin receptor-associated kinase inhibitors
|
|
EP2782579B1
(en)
|
2011-11-23 |
2019-01-02 |
Portola Pharmaceuticals, Inc. |
Pyrazine kinase inhibitors
|
|
WO2013078468A1
(en)
*
|
2011-11-23 |
2013-05-30 |
Portola Pharmaceuticals, Inc. |
Selective kinase inhibitors
|
|
DK2799431T3
(en)
|
2011-12-28 |
2018-03-26 |
Fujifilm Corp |
Hitherto unknown nicotinamide derivatives or salts thereof
|
|
KR20140108594A
(ko)
*
|
2012-01-10 |
2014-09-11 |
에프. 호프만-라 로슈 아게 |
피리다진 아미드 화합물 및 syk 저해제로서의 이의 용도
|
|
HUE033177T2
(en)
*
|
2012-01-17 |
2017-11-28 |
Astellas Pharma Inc |
Pyrazine carboxamide compound
|
|
ES2606638T3
(es)
|
2012-02-21 |
2017-03-24 |
Merck Patent Gmbh |
Derivados de furopiridina
|
|
JP6479476B2
(ja)
|
2012-02-21 |
2019-03-06 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ |
ＳｙｋチロシンキナーゼインヒビターおよびＧＣＮ２セリンキナーゼインヒビターとしての８−置換２−アミノー［１，２，４］トリアゾロ［１，５−Ａ］ピラジン類
|
|
UY34807A
(es)
*
|
2012-05-16 |
2013-12-31 |
Novartis Ag |
Derivados monocíclicos de heteroarilcicloalquil- diamina
|
|
EP2863913B1
(en)
|
2012-06-20 |
2018-09-12 |
Merck Sharp & Dohme Corp. |
Imidazolyl analogs as syk inhibitors
|
|
WO2013192125A1
(en)
|
2012-06-20 |
2013-12-27 |
Merck Sharp & Dohme Corp. |
Pyrazolyl derivatives as syk inhibitors
|
|
US9040530B2
(en)
*
|
2012-06-22 |
2015-05-26 |
Portola Pharmaceuticals, Inc. |
1,2,4-triazine-6-carboxamide kinase inhibitors
|
|
WO2013192088A1
(en)
|
2012-06-22 |
2013-12-27 |
Merck Sharp & Dohme Corp. |
SUBSTITUTED DIAZINE AND TRIAZINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS
|
|
US9376418B2
(en)
|
2012-06-22 |
2016-06-28 |
Merck Sharp & Dohme Corp. |
Substituted pyridine spleen tyrosine kinase (SYK) inhibitors
|
|
US20140113931A1
(en)
*
|
2012-06-22 |
2014-04-24 |
Portola Pharmaceuticals, Inc. |
Substituted picolinamide kinase inhibitors
|
|
CA2881279C
(en)
|
2012-08-07 |
2020-07-07 |
Merck Patent Gmbh |
Pyridopyrimidine derivatives as protein kinase inhibitors
|
|
EP2884982B1
(en)
|
2012-08-20 |
2017-09-20 |
Merck Sharp & Dohme Corp. |
SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS
|
|
US9533989B2
(en)
|
2012-09-18 |
2017-01-03 |
Ziarco Pharma Ltd. |
Substituted pyrimidine-5-carboxamides as spleen tyrosine kinase inhibitors
|
|
WO2014048065A1
(en)
|
2012-09-28 |
2014-04-03 |
Merck Sharp & Dohme Corp. |
Triazolyl derivatives as syk inhibitors
|
|
DK2903440T3
(en)
|
2012-10-02 |
2017-12-11 |
Bayer Cropscience Ag |
THETEROCYCLIC COMPOUNDS AS PESTICIDES
|
|
MX2015004801A
(es)
*
|
2012-10-19 |
2015-08-14 |
Hoffmann La Roche |
Inhibidores de la syk.
|
|
CA2890935A1
(en)
*
|
2012-11-08 |
2014-05-15 |
Bristol-Myers Squibb Company |
Alkyl amide-substituted pyrimidine compounds useful in the modulation of il-12, il-23 and/or ifn.alpha.
|
|
EP2931281B1
(en)
|
2012-12-12 |
2018-01-17 |
Merck Sharp & Dohme Corp. |
Amino-pyrimidine-containing spleen tyrosine kinase inhibitors
|
|
EP2934525B1
(en)
|
2012-12-21 |
2019-05-08 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors
|
|
US9126950B2
(en)
|
2012-12-21 |
2015-09-08 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
CN105188371A
(zh)
|
2013-02-08 |
2015-12-23 |
西建阿维拉米斯研究公司 |
Erk抑制剂及其用途
|
|
WO2014152768A1
(en)
*
|
2013-03-15 |
2014-09-25 |
Portola Pharmaceuticals, Inc. |
Cyclohexanediamine compounds and methods for their preparation
|
|
JP2016113366A
(ja)
*
|
2013-03-29 |
2016-06-23 |
大鵬薬品工業株式会社 |
アセトアミド基を有する１，２，４−トリアジン−６−カルボキサミド誘導体
|
|
EP2988744A4
(en)
|
2013-04-26 |
2016-11-02 |
Merck Sharp & Dohme |
THIAZOLSUBSTITUTED AMINOHETEROARYLE AS MILZTYROSINKINASE INHIBITOR
|
|
WO2014176216A1
(en)
|
2013-04-26 |
2014-10-30 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors
|
|
KR101665301B1
(ko)
|
2013-08-07 |
2016-10-11 |
카딜라 핼쓰캐어 리미티드 |
야누스 키나제의 억제제로서 n-시아노메틸아미드
|
|
US9492471B2
(en)
|
2013-08-27 |
2016-11-15 |
Celgene Avilomics Research, Inc. |
Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
|
|
WO2015039613A1
(zh)
*
|
2013-09-18 |
2015-03-26 |
北京韩美药品有限公司 |
抑制btk和/或jak3激酶活性的化合物
|
|
AU2014360446A1
(en)
|
2013-12-05 |
2016-06-09 |
Pharmacyclics, Llc |
Inhibitors of Bruton's tyrosine kinase
|
|
US9670196B2
(en)
|
2013-12-20 |
2017-06-06 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminoheteroaryls as Spleen Tyrosine Kinase inhibitors
|
|
EP3083559B1
(en)
|
2013-12-20 |
2021-03-10 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
|
|
WO2015094997A1
(en)
|
2013-12-20 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
|
|
NZ715903A
(en)
|
2014-01-30 |
2017-06-30 |
Signal Pharm Llc |
Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
|
|
WO2015138273A1
(en)
|
2014-03-13 |
2015-09-17 |
Merck Sharp & Dohme Corp. |
2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
|
|
WO2016020403A1
(en)
*
|
2014-08-04 |
2016-02-11 |
Sandoz Ag |
Preparation of a benzoic acid derivative and its use for the preparation of suvorexant
|
|
WO2016025561A1
(en)
|
2014-08-13 |
2016-02-18 |
Celgene Avilomics Research, Inc. |
Forms and compositions of an erk inhibitor
|
|
EP3712134B1
(en)
|
2014-12-16 |
2023-11-29 |
Signal Pharmaceuticals, LLC |
Salts of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methycyclohexylamino)-pyrimidine-5-carboxamide
|
|
US9513297B2
(en)
|
2014-12-16 |
2016-12-06 |
Signal Pharmaceuticals, Llc |
Methods for measurement of inhibition of c-Jun N-terminal kinase in skin
|
|
EP3250557B1
(en)
|
2015-01-29 |
2024-11-20 |
Signal Pharmaceuticals, LLC |
Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
|
|
EP3325432B1
(en)
|
2015-07-24 |
2020-09-02 |
Celgene Corporation |
Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
|
|
ES2913119T3
(es)
*
|
2015-08-12 |
2022-05-31 |
Portola Pharm Inc |
Cerdulatinib para tratar mieloma
|
|
IL307931A
(en)
*
|
2016-04-15 |
2023-12-01 |
Epizyme Inc |
Amine-substituted aryl or heteroaryl compounds as ehmt1 and ehmt2 inhibitors
|
|
JP6999688B2
(ja)
*
|
2016-12-13 |
2022-02-10 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Ｂｃｌ６阻害剤としての新規の６－アミノキノリノン化合物および誘導体
|
|
WO2018195450A1
(en)
|
2017-04-21 |
2018-10-25 |
Epizyme, Inc. |
Combination therapies with ehmt2 inhibitors
|
|
CN109384774B
(zh)
*
|
2017-08-11 |
2023-02-17 |
中国科学院上海药物研究所 |
一类多取代的吡嗪/三嗪酰胺类化合物及其制备方法和应用
|
|
AU2018350683A1
(en)
|
2017-10-19 |
2020-04-02 |
Bayer Animal Health Gmbh |
Use of fused heteroaromatic pyrrolidones for treatment and prevention of diseases in animals
|
|
WO2019099311A1
(en)
*
|
2017-11-19 |
2019-05-23 |
Sunshine Lake Pharma Co., Ltd. |
Substituted heteroaryl compounds and methods of use
|
|
KR20210018193A
(ko)
*
|
2018-03-09 |
2021-02-17 |
포톨라 파마슈티컬스, 인코포레이티드 |
선택적 syk 억제자의 사용 방법 및 약학적 조성물
|
|
MX2020010999A
(es)
|
2018-04-18 |
2021-01-20 |
Constellation Pharmaceuticals Inc |
Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos.
|
|
EP3797108B1
(en)
|
2018-05-21 |
2022-07-20 |
Constellation Pharmaceuticals, Inc. |
Modulators of methyl modifying enzymes, compositions and uses thereof
|
|
RS66346B1
(sr)
*
|
2018-10-22 |
2025-01-31 |
Alumis Inc |
Inhibitori tyk2 i njihova upotreba
|
|
CA3129665A1
(en)
|
2019-03-21 |
2020-09-24 |
Onxeo |
A dbait molecule in combination with kinase inhibitor for the treatment of cancer
|
|
PE20220562A1
(es)
|
2019-07-24 |
2022-04-13 |
Constellation Pharmaceuticals Inc |
Formas cristalinas de 7-cloro-2-(4-(3-metoxiazetidin-1-il)ciclohexil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-oxo-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioxol-5-carboxamida
|
|
KR20220098759A
(ko)
|
2019-11-08 |
2022-07-12 |
인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) |
키나제 억제제에 대해 내성을 획득한 암의 치료 방법
|
|
WO2021148581A1
(en)
|
2020-01-22 |
2021-07-29 |
Onxeo |
Novel dbait molecule and its use
|
|
JP2023513016A
(ja)
*
|
2020-01-30 |
2023-03-30 |
スミトモ ファーマ オンコロジー， インコーポレイテッド |
Ｎｅｋ２阻害剤としてのアミノピリミジニルアミノベンゾニトリル誘導体
|
|
IL301385A
(en)
|
2020-09-16 |
2023-05-01 |
Alumis Inc |
TYK2 inhibitors and their use
|
|
TW202227418A
(zh)
*
|
2020-10-12 |
2022-07-16 |
大陸商四川海思科製藥有限公司 |
一種雜環衍生物及其在醫藥上的應用
|
|
US20230416225A1
(en)
*
|
2020-11-09 |
2023-12-28 |
Merck Sharp & Dohme Llc |
Diaminopyrimidine carboxamide inhibitors of hpk1
|
|
US12668594B2
(en)
|
2020-12-23 |
2026-06-30 |
Sudo Biosciences Limited |
TYK2 inhibitors and uses thereof
|
|
CN117377669A
(zh)
*
|
2021-02-19 |
2024-01-09 |
苏多生物科学有限公司 |
Tyk2抑制剂及其用途
|
|
KR20230159421A
(ko)
|
2021-02-19 |
2023-11-21 |
수도 바이오사이언시즈 리미티드 |
Tyk2 억제제 및 이의 용도
|
|
CN117242072A
(zh)
*
|
2021-02-19 |
2023-12-15 |
苏多生物科学有限公司 |
Tyk2抑制剂及其用途
|
|
CN117120440A
(zh)
*
|
2021-02-19 |
2023-11-24 |
苏多生物科学有限公司 |
Tyk2抑制剂及其用途
|
|
WO2022175745A1
(en)
*
|
2021-02-19 |
2022-08-25 |
Sudo Biosciences Limited |
Tyk2 inhibitors and uses thereof
|
|
TW202302583A
(zh)
*
|
2021-02-19 |
2023-01-16 |
英商蘇多生物科學有限公司 |
Ｔｙｋ２抑制劑及其用途
|
|
IL305119A
(en)
|
2021-02-19 |
2023-10-01 |
Sudo Biosciences Ltd |
Tyk2 inhibitors and uses thereof
|
|
CN120617271A
(zh)
*
|
2021-03-09 |
2025-09-12 |
石药集团中奇制药技术（石家庄）有限公司 |
一种含有三环杂芳基的化合物的用途
|
|
CN115197196B
(zh)
*
|
2021-04-06 |
2024-06-18 |
扬子江药业集团有限公司 |
Tyk2抑制剂及其用途
|
|
TW202339749A
(zh)
*
|
2021-12-16 |
2023-10-16 |
大陸商凌科藥業有限公司 |
Ｔｙｋ２抑制劑及其組合物和方法
|
|
WO2023108536A1
(en)
*
|
2021-12-16 |
2023-06-22 |
Lynk Pharmaceuticals Co. Ltd. |
Tyk2 inhibitors and compositions and methods thereof
|
|
CN116120282B
(zh)
*
|
2022-08-04 |
2024-02-20 |
苏州系统医学研究所 |
具有ev71和/或cva16病毒抑制活性的化合物及其应用
|
|
CN116925053A
(zh)
*
|
2023-07-26 |
2023-10-24 |
成都赜灵生物医药科技有限公司 |
甲磺酸普依司他中间体的杂质去除工艺
|
|
CN118440052B
(zh)
*
|
2024-07-05 |
2024-10-11 |
四川大学 |
一种化合物及其在制备tyk2激酶抑制剂中的用途
|
|
CN120665299B
(zh)
*
|
2025-05-23 |
2026-03-27 |
广东药科大学 |
一种金属有机框架材料及其制备方法和应用
|