JP2012520247A5 - - Google Patents
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- Publication number
- JP2012520247A5 JP2012520247A5 JP2011553350A JP2011553350A JP2012520247A5 JP 2012520247 A5 JP2012520247 A5 JP 2012520247A5 JP 2011553350 A JP2011553350 A JP 2011553350A JP 2011553350 A JP2011553350 A JP 2011553350A JP 2012520247 A5 JP2012520247 A5 JP 2012520247A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heteroaryl
- aryl
- unsubstituted
- polysubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 101
- 125000001072 heteroaryl group Chemical group 0.000 claims 24
- 229920006395 saturated elastomer Polymers 0.000 claims 22
- 125000003118 aryl group Chemical group 0.000 claims 18
- 125000000623 heterocyclic group Chemical group 0.000 claims 15
- 125000001424 substituent group Chemical group 0.000 claims 11
- 125000004404 heteroalkyl group Chemical group 0.000 claims 10
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 125000001544 thienyl group Chemical group 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 125000005418 aryl aryl group Chemical group 0.000 claims 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 235000005152 nicotinamide Nutrition 0.000 claims 2
- 150000005480 nicotinamides Chemical class 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229960003966 nicotinamide Drugs 0.000 claims 1
- 239000011570 nicotinamide Substances 0.000 claims 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09003598 | 2009-03-12 | ||
| EP09003598.1 | 2009-03-12 | ||
| PCT/EP2010/001507 WO2010102809A1 (de) | 2009-03-12 | 2010-03-11 | Substituierte nicotinamide als kcnq2/3 modulatoren |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012520247A JP2012520247A (ja) | 2012-09-06 |
| JP2012520247A5 true JP2012520247A5 (enExample) | 2014-08-21 |
| JP5670359B2 JP5670359B2 (ja) | 2015-02-18 |
Family
ID=40933299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011553350A Expired - Fee Related JP5670359B2 (ja) | 2009-03-12 | 2010-03-11 | Ｋｃｎｑ２／３モジュレータとしての置換されたニコチンアミド |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US8178684B2 (enExample) |
| EP (1) | EP2406226B1 (enExample) |
| JP (1) | JP5670359B2 (enExample) |
| KR (1) | KR20110132592A (enExample) |
| CN (1) | CN102369188B (enExample) |
| AR (1) | AR075540A1 (enExample) |
| AU (1) | AU2010223511B2 (enExample) |
| BR (1) | BRPI1008948A2 (enExample) |
| CA (1) | CA2754998C (enExample) |
| CO (1) | CO6410303A2 (enExample) |
| CY (1) | CY1116787T1 (enExample) |
| DK (1) | DK2406226T3 (enExample) |
| EC (1) | ECSP11011347A (enExample) |
| ES (1) | ES2556772T3 (enExample) |
| HR (1) | HRP20151260T1 (enExample) |
| HU (1) | HUE026170T2 (enExample) |
| IL (1) | IL214946A (enExample) |
| MX (1) | MX2011009127A (enExample) |
| NZ (1) | NZ595628A (enExample) |
| PE (1) | PE20120780A1 (enExample) |
| PL (1) | PL2406226T3 (enExample) |
| PT (1) | PT2406226E (enExample) |
| RU (1) | RU2529904C2 (enExample) |
| SI (1) | SI2406226T1 (enExample) |
| TW (1) | TWI475020B (enExample) |
| WO (1) | WO2010102809A1 (enExample) |
| ZA (1) | ZA201107442B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI504395B (zh) * | 2009-03-10 | 2015-10-21 | Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier | |
| CA2754934A1 (en) * | 2009-03-10 | 2010-09-16 | Gruenenthal Gmbh | Substituted 3-aminoisoxazolopyridines as kcnq2/3 modulators |
| TW201038565A (en) | 2009-03-12 | 2010-11-01 | Gruenenthal Gmbh | Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators |
| TWI461197B (zh) | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier | |
| PT2609083E (pt) | 2010-08-27 | 2015-07-01 | Gruenenthal Gmbh | 2-oxi-quinolina-3-carboxamidas substituídas como moduladores de kcnq2/3 |
| WO2012025237A1 (en) | 2010-08-27 | 2012-03-01 | Grünenthal GmbH | Substituted 2-amino-quinoline-3-carboxamides as kcnq2/3 modulators |
| CA2809287C (en) | 2010-08-27 | 2018-05-22 | Gruenenthal Gmbh | Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as kcnq2/3 modulators |
| EP2611780A1 (en) | 2010-09-01 | 2013-07-10 | Grünenthal GmbH | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as kcnq2/3 modulators |
| US8552200B2 (en) * | 2010-10-20 | 2013-10-08 | Gruenenthal Gmbh | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators |
| US9168259B2 (en) | 2010-10-20 | 2015-10-27 | Grünenthal GmbH | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators |
| AU2015201122B2 (en) * | 2010-10-20 | 2016-02-25 | Grunenthal Gmbh | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators |
| FR2968661B1 (fr) * | 2010-12-14 | 2016-01-01 | Oreal | Procede de depigmentation des matieres keratiniques a l'aide de composes thiopyridinones |
| WO2013156155A1 (en) | 2012-04-18 | 2013-10-24 | Grünenthal GmbH | Substituted 4-aminobenzamides as kcnq2/3 modulators |
| LT2888233T (lt) * | 2012-04-18 | 2017-01-10 | Grünenthal GmbH | Pakeistieji 6-amino-nikotinamidai, turintys oh-turinčią grupę, kaip kcnq2/3 moduliatoriai |
| WO2014056620A1 (en) * | 2012-10-11 | 2014-04-17 | Grünenthal GmbH | Treatment and/or prophylaxis of tspo mediated diseases and/or disorders |
| US9284286B2 (en) | 2012-11-28 | 2016-03-15 | Grünenthal GmbH | Specific carboxamides as KCNQ2/3 modulators |
| US9248122B2 (en) | 2012-11-28 | 2016-02-02 | Grünenthal GmbH | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators |
| CN104513171B (zh) * | 2013-09-30 | 2017-09-01 | 中国科学院过程工程研究所 | 一种玛咖酰胺的合成方法及其用途 |
| BR112017008178A2 (pt) * | 2014-10-24 | 2017-12-19 | Ono Pharmaceutical Co | ativador do canal de kcnq2-5 |
| US11046683B2 (en) | 2016-12-15 | 2021-06-29 | Ono Pharmaceutical Co., Ltd. | Activator of TREK (TWIK RElated K+ channels) channels |
| DE102018212006B3 (de) | 2018-07-18 | 2019-10-31 | Universität Greifswald | Thioether als Modulatoren von Kv7.2/Kv7.3-Kanälen |
| CN111840267A (zh) * | 2020-08-05 | 2020-10-30 | 牡丹江医学院 | 一种治疗小儿口腔黏膜疾病的药物及其制备方法 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2532939A1 (fr) | 1982-09-13 | 1984-03-16 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus |
| DE4032147A1 (de) | 1990-10-10 | 1992-04-16 | Bayer Ag | Verwendung von substituierten 2-mercaptonicotinsaeurederivaten zur bekaempfung von endoparasiten, neue substituierte 2-mercaptonicotinsaeurederivate und verfahren zu ihrer herstellung |
| EP0716077A1 (de) | 1994-12-08 | 1996-06-12 | Ciba-Geigy Ag | Aromatisch substituierte Omega-Aminoalkansäureamide und Alkansäurediamide und ihre Verwendung als Renininhibitoren |
| WO1996026925A1 (en) | 1995-03-01 | 1996-09-06 | Banyu Pharmaceutical Co., Ltd. | Arylthioacetamide derivatives |
| DE19738616A1 (de) | 1997-09-04 | 1999-03-11 | Clariant Gmbh | 4-Hydroxychinolin-3-carbonsäure-Derivate als Lichtschutzmittel |
| EP1147094A1 (en) | 1999-01-15 | 2001-10-24 | Novo Nordisk A/S | Non-peptide glp-1 agonists |
| AU772075B2 (en) * | 1999-08-04 | 2004-04-08 | Icagen, Inc. | Methods for treating or preventing pain and anxiety |
| DE60037321T4 (de) | 1999-08-04 | 2010-01-07 | Icagen, Inc. | Benzanilide als öffner des kaliumkanals |
| ES2261463T3 (es) * | 2000-08-14 | 2006-11-16 | Ortho-Mcneil Pharmaceutical, Inc. | Pirazoles sustituidos. |
| JP2005508833A (ja) * | 2001-02-20 | 2005-04-07 | ブリストル−マイヤーズ スクイブ カンパニー | Ｋｃｎｑカリウムチャネル・モジュレーターとしての２，４−ジ置換ピリミジン−５−カルボキサミド誘導体 |
| JP2005507853A (ja) | 2001-02-20 | 2005-03-24 | ブリストル−マイヤーズ スクイブ カンパニー | Ｋｃｎｑカリウムチャンネルモジュレーター並びに片頭痛および機構的に関連する疾患の治療におけるそれらの使用 |
| US6593349B2 (en) | 2001-03-19 | 2003-07-15 | Icagen, Inc. | Bisarylamines as potassium channel openers |
| EP1372654A4 (en) | 2001-04-06 | 2007-10-03 | Smithkline Beecham Corp | QUINOLINE INHIBITORS OF HYAK1 AND HYAK3 KINASES |
| JP2005539081A (ja) | 2002-09-17 | 2005-12-22 | ファルマシア コーポレイション | 芳香族肝臓ｘ受容体モジュレーター |
| EP1585522B1 (en) | 2002-12-23 | 2010-11-17 | Icagen, Inc. | Quinazolinones as potassium channel modulators |
| EP1449841A1 (en) | 2003-02-19 | 2004-08-25 | Bayer CropScience SA | New fungicidal compounds |
| WO2005035514A2 (en) * | 2003-10-08 | 2005-04-21 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters containing cycloalkyl or pyranyl groups |
| AU2005238292A1 (en) * | 2004-05-04 | 2005-11-10 | Pfizer Inc. | Ortho substituted aryl or heteroaryl amide compounds |
| WO2006051311A1 (en) | 2004-11-12 | 2006-05-18 | Galapagos Nv | Nitrogen heteroaromatic compounds which bind to the active site of protein kinase enzymes |
| PL2298766T3 (pl) | 2005-03-03 | 2014-09-30 | H Lundbeck As | Preparaty farmaceutyczne zawierające podstawione pochodne pirydyny |
| ES2325558T3 (es) | 2005-07-20 | 2009-09-08 | Eli Lilly And Company | Derivados de piridina como inhibidores de dipeptidilpeptidasa. |
| US7670416B2 (en) * | 2005-08-04 | 2010-03-02 | I-Tech Ab | Use of a combination of substances to prevent biofouling organisms |
| CN101277939A (zh) | 2005-09-09 | 2008-10-01 | 布里斯托尔-迈尔斯斯奎布公司 | 无环ikur抑制剂 |
| US20090291973A1 (en) | 2005-11-18 | 2009-11-26 | Neurosearch A/S | Novel Quinazoline Derivatives and Their Medical Use |
| AU2007275683B2 (en) | 2006-07-20 | 2012-05-10 | Amgen Inc. | Di-amino-substituted heterocyclic compounds and methods of use |
| ATE456392T1 (de) | 2006-07-20 | 2010-02-15 | Amgen Inc | Benzoädüisoxazol-derivate als c-kit-tyrosinkinase-hemmer zur behandlung von erkrankungen im zusammenhang mit der überproduktion von histamin |
| WO2008012532A2 (en) | 2006-07-27 | 2008-01-31 | Astrazeneca Ab | : pyridine-3-carboxamide compounds and their use for inhibiting 11-beta-hydroxysteroid dehydrogenase |
| US20080039542A1 (en) * | 2006-08-11 | 2008-02-14 | General Electric Company | Composition and associated method |
| US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| JP5341084B2 (ja) * | 2007-08-03 | 2013-11-13 | エフ．ホフマン−ラ ロシュ アーゲー | Ｔａａｒ１リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体 |
| DE102007044277A1 (de) * | 2007-09-17 | 2009-03-19 | Grünenthal GmbH | Substituierte Nicotinamid-Verbindungen und deren Verwendung in Arzneimitteln |
| WO2009052078A1 (en) | 2007-10-19 | 2009-04-23 | Boehringer Ingelheim International Gmbh | Ccr10 antagonists |
| US8367700B2 (en) | 2008-12-17 | 2013-02-05 | Gruenenthal Gmbh | Substituted 4-(1.2,3,4-tetrahydroisoquinolin-2-yl)-4-oxobutyric acid amide as KCNQ2/3 modulators |
| TWI504395B (zh) | 2009-03-10 | 2015-10-21 | Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier | |
| CA2754934A1 (en) | 2009-03-10 | 2010-09-16 | Gruenenthal Gmbh | Substituted 3-aminoisoxazolopyridines as kcnq2/3 modulators |
| TW201038565A (en) | 2009-03-12 | 2010-11-01 | Gruenenthal Gmbh | Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators |
| TWI461197B (zh) | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier | |
| WO2012025237A1 (en) | 2010-08-27 | 2012-03-01 | Grünenthal GmbH | Substituted 2-amino-quinoline-3-carboxamides as kcnq2/3 modulators |
| AR082734A1 (es) | 2010-08-27 | 2012-12-26 | Gruenenthal Gmbh | Quinolino-3-carboxamidas sustituidas como moduladores de kcnq2/3 |
-
2010
- 2010-02-26 TW TW099105569A patent/TWI475020B/zh not_active IP Right Cessation
- 2010-03-10 US US12/720,894 patent/US8178684B2/en not_active Expired - Fee Related
- 2010-03-11 HR HRP20151260TT patent/HRP20151260T1/hr unknown
- 2010-03-11 PE PE2011001566A patent/PE20120780A1/es not_active Application Discontinuation
- 2010-03-11 PL PL10708139T patent/PL2406226T3/pl unknown
- 2010-03-11 ES ES10708139.0T patent/ES2556772T3/es active Active
- 2010-03-11 BR BRPI1008948A patent/BRPI1008948A2/pt not_active IP Right Cessation
- 2010-03-11 WO PCT/EP2010/001507 patent/WO2010102809A1/de not_active Ceased
- 2010-03-11 AU AU2010223511A patent/AU2010223511B2/en not_active Ceased
- 2010-03-11 JP JP2011553350A patent/JP5670359B2/ja not_active Expired - Fee Related
- 2010-03-11 EP EP10708139.0A patent/EP2406226B1/de not_active Not-in-force
- 2010-03-11 SI SI201031053T patent/SI2406226T1/sl unknown
- 2010-03-11 DK DK10708139.0T patent/DK2406226T3/en active
- 2010-03-11 CN CN201080011221.9A patent/CN102369188B/zh not_active Expired - Fee Related
- 2010-03-11 RU RU2011141186/04A patent/RU2529904C2/ru not_active IP Right Cessation
- 2010-03-11 KR KR1020117023798A patent/KR20110132592A/ko not_active Abandoned
- 2010-03-11 PT PT107081390T patent/PT2406226E/pt unknown
- 2010-03-11 MX MX2011009127A patent/MX2011009127A/es active IP Right Grant
- 2010-03-11 NZ NZ595628A patent/NZ595628A/xx not_active IP Right Cessation
- 2010-03-11 HU HUE10708139A patent/HUE026170T2/en unknown
- 2010-03-11 CA CA2754998A patent/CA2754998C/en not_active Expired - Fee Related
- 2010-03-12 AR ARP100100778A patent/AR075540A1/es unknown
-
2011
- 2011-08-17 CO CO11104403A patent/CO6410303A2/es active IP Right Grant
- 2011-09-04 IL IL214946A patent/IL214946A/en not_active IP Right Cessation
- 2011-09-23 EC EC2011011347A patent/ECSP11011347A/es unknown
- 2011-10-11 ZA ZA2011/07442A patent/ZA201107442B/en unknown
-
2012
- 2012-03-30 US US13/434,915 patent/US8586755B2/en not_active Expired - Fee Related
-
2015
- 2015-10-09 CY CY20151100914T patent/CY1116787T1/el unknown
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