JP2010531293A5 - - Google Patents
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- Publication number
- JP2010531293A5 JP2010531293A5 JP2009553349A JP2009553349A JP2010531293A5 JP 2010531293 A5 JP2010531293 A5 JP 2010531293A5 JP 2009553349 A JP2009553349 A JP 2009553349A JP 2009553349 A JP2009553349 A JP 2009553349A JP 2010531293 A5 JP2010531293 A5 JP 2010531293A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- glycyl
- phenylalanyl
- salt
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 5-methyl-2-oxo-1,3-dioxol-4-yl group Chemical group 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000004423 acyloxy group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 125000006239 protecting group Chemical group 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000000405 phenylalanyl group Chemical group 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 claims 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009553349A JP5653043B2 (ja) | 2007-06-26 | 2008-06-26 | バソプレシン拮抗剤として使用されるベンゾアゼピン誘導体 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007167207 | 2007-06-26 | ||
| JP2007167207 | 2007-06-26 | ||
| PCT/JP2008/062033 WO2009001968A1 (en) | 2007-06-26 | 2008-06-26 | Benzazepine derivatives useful as vasopressin antagonists |
| JP2009553349A JP5653043B2 (ja) | 2007-06-26 | 2008-06-26 | バソプレシン拮抗剤として使用されるベンゾアゼピン誘導体 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014130326A Division JP5689195B2 (ja) | 2007-06-26 | 2014-06-25 | バソプレシン拮抗剤として使用されるベンゾアゼピン誘導体 |
| JP2014130327A Division JP5893085B2 (ja) | 2007-06-26 | 2014-06-25 | バソプレシン拮抗剤として使用されるベンゾアゼピン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010531293A JP2010531293A (ja) | 2010-09-24 |
| JP2010531293A5 true JP2010531293A5 (enExample) | 2013-02-07 |
| JP5653043B2 JP5653043B2 (ja) | 2015-01-14 |
Family
ID=39773045
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009553349A Expired - Fee Related JP5653043B2 (ja) | 2007-06-26 | 2008-06-26 | バソプレシン拮抗剤として使用されるベンゾアゼピン誘導体 |
| JP2014130326A Expired - Fee Related JP5689195B2 (ja) | 2007-06-26 | 2014-06-25 | バソプレシン拮抗剤として使用されるベンゾアゼピン誘導体 |
| JP2014130327A Expired - Fee Related JP5893085B2 (ja) | 2007-06-26 | 2014-06-25 | バソプレシン拮抗剤として使用されるベンゾアゼピン誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014130326A Expired - Fee Related JP5689195B2 (ja) | 2007-06-26 | 2014-06-25 | バソプレシン拮抗剤として使用されるベンゾアゼピン誘導体 |
| JP2014130327A Expired - Fee Related JP5893085B2 (ja) | 2007-06-26 | 2014-06-25 | バソプレシン拮抗剤として使用されるベンゾアゼピン誘導体 |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US8669229B2 (enExample) |
| EP (3) | EP2374798B1 (enExample) |
| JP (3) | JP5653043B2 (enExample) |
| KR (1) | KR101487201B1 (enExample) |
| CN (3) | CN101687805A (enExample) |
| AR (1) | AR067176A1 (enExample) |
| AT (1) | ATE545633T1 (enExample) |
| AU (1) | AU2008269918B2 (enExample) |
| BR (1) | BRPI0813768A2 (enExample) |
| CA (1) | CA2690335A1 (enExample) |
| CO (1) | CO6160295A2 (enExample) |
| CY (3) | CY1113519T1 (enExample) |
| DK (3) | DK2374798T3 (enExample) |
| ES (3) | ES2380085T3 (enExample) |
| HR (3) | HRP20120310T1 (enExample) |
| IL (1) | IL202561A0 (enExample) |
| MY (3) | MY148312A (enExample) |
| NZ (3) | NZ598064A (enExample) |
| PH (2) | PH12012501363A1 (enExample) |
| PL (3) | PL2374798T3 (enExample) |
| PT (3) | PT2374797E (enExample) |
| RU (1) | RU2471784C2 (enExample) |
| SG (2) | SG182230A1 (enExample) |
| SI (3) | SI2374797T1 (enExample) |
| TW (1) | TWI459947B (enExample) |
| UA (1) | UA98966C2 (enExample) |
| WO (1) | WO2009001968A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI459947B (zh) * | 2007-06-26 | 2014-11-11 | Otsuka Pharma Co Ltd | 苯并氮呯化合物及藥學製劑 |
| JP5656399B2 (ja) * | 2008-12-26 | 2015-01-21 | 大塚製薬株式会社 | 医薬及び医薬製剤 |
| CN102030709B (zh) * | 2009-09-25 | 2013-10-16 | 江苏豪森医药集团有限公司 | 用作加压素受体拮抗剂的苯并氮杂卓类化合物 |
| JP5717645B2 (ja) * | 2009-10-26 | 2015-05-13 | 大塚製薬株式会社 | ベンズアゼピン化合物 |
| GB201105537D0 (en) | 2011-03-31 | 2011-05-18 | Vantia Ltd | New process |
| CN102260213B (zh) * | 2011-05-31 | 2013-05-15 | 重庆福安药业(集团)股份有限公司 | 一种托伐普坦的制备方法 |
| TWI704919B (zh) | 2012-05-31 | 2020-09-21 | 日商大塚製藥股份有限公司 | 用於預防及/或治療多囊性腎臟病之藥物 |
| EP2941242B1 (en) * | 2012-12-28 | 2017-02-01 | Otsuka Pharmaceutical Co., Ltd. | Injectable depot formulation comprising optically active tolvaptan and process of producing the same |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| TWI660748B (zh) * | 2013-03-01 | 2019-06-01 | 日商大塚製藥股份有限公司 | 用於口服投藥之包含非晶型托伐普坦（Ｔｏｌｖａｐｔａｎ）的懸浮液 |
| TW201605488A (zh) | 2013-10-15 | 2016-02-16 | 大塚製藥股份有限公司 | 用以預防及／或治療多囊腎病之藥物 |
| US11911369B2 (en) * | 2015-03-03 | 2024-02-27 | Biohaven Therapeutics Ltd. | Prodrugs of riluzole and their method of use |
| WO2019003433A1 (ja) * | 2017-06-30 | 2019-01-03 | 大塚製薬株式会社 | ベンゾアゼピン誘導体 |
| CN107540672A (zh) * | 2017-10-10 | 2018-01-05 | 牡丹江医学院 | 一种治疗肝硬化的药物及其合成方法 |
| HU231206B1 (hu) | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepinek |
| TW201938171A (zh) | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物 |
| JP2020011957A (ja) * | 2019-07-22 | 2020-01-23 | コルセア ファーマ インコーポレイテッド | トレプロスチニル誘導体化合物およびその使用方法 |
| CN112851583B (zh) * | 2021-01-19 | 2023-09-08 | 徐州医科大学 | 新型苯并氮杂䓬类化合物、组合物及其用途 |
| KR20230143165A (ko) * | 2021-02-10 | 2023-10-11 | 상하이 센후이 메디슨 컴퍼니 리미티드 | 벤즈아제핀 화합물, 이의 제조 방법 및 이의 약학적 용도 |
| CN113112528A (zh) * | 2021-04-26 | 2021-07-13 | 中南财经政法大学 | 异常行为监控方法、装置、设备及存储介质 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5045478A (en) * | 1986-03-03 | 1991-09-03 | Becton Dickinson And Company | Vesicles and use thereof in an assay |
| US5258510A (en) * | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
| EP0602209A1 (en) | 1992-07-02 | 1994-06-22 | Otsuka Pharmaceutical Co., Ltd. | Oxytocin antagonist |
| TW270927B (enExample) * | 1992-10-16 | 1996-02-21 | Otsuka Pharma Co Ltd | |
| GB9726695D0 (en) | 1997-12-17 | 1998-02-18 | Smithkline Beecham Plc | Novel compounds |
| JP4210355B2 (ja) | 1997-07-03 | 2009-01-14 | 大塚製薬株式会社 | 固形製剤組成物 |
| EA004436B1 (ru) * | 1998-09-29 | 2004-04-29 | Уайт Холдингз Корпорейшн | Замещенные 3-цианохинолины в качестве ингибиторов протеинтирозинкиназ |
| DE60102815D1 (de) | 2000-05-15 | 2004-05-19 | Paratek Pharm Innc | 7-substituierte kondensierte ring-tetrazyclin- verbindungen |
| BRPI0516922A (pt) * | 2004-11-02 | 2008-09-23 | New River Pharmaceuticals Inc | composto de ribavirina, método para fazer um composto de ribavirina, método para usar um composto de ribavirina e composição farmacêutica |
| CA2633929A1 (en) * | 2005-12-27 | 2007-07-05 | Otsuka Pharmaceutical Co., Ltd. | Water-soluble benzoazepine compound and its pharmaceutical composition |
| TWI459947B (zh) * | 2007-06-26 | 2014-11-11 | Otsuka Pharma Co Ltd | 苯并氮呯化合物及藥學製劑 |
-
2008
- 2008-06-24 TW TW097123513A patent/TWI459947B/zh active
- 2008-06-26 UA UAA201000653A patent/UA98966C2/ru unknown
- 2008-06-26 SG SG2012047056A patent/SG182230A1/en unknown
- 2008-06-26 AR ARP080102749A patent/AR067176A1/es unknown
- 2008-06-26 JP JP2009553349A patent/JP5653043B2/ja not_active Expired - Fee Related
- 2008-06-26 SI SI200831177T patent/SI2374797T1/sl unknown
- 2008-06-26 EP EP11172829.1A patent/EP2374798B1/en not_active Not-in-force
- 2008-06-26 PT PT111728283T patent/PT2374797E/pt unknown
- 2008-06-26 EP EP08765871A patent/EP2170831B1/en not_active Not-in-force
- 2008-06-26 MY MYPI20095341A patent/MY148312A/en unknown
- 2008-06-26 CA CA2690335A patent/CA2690335A1/en not_active Abandoned
- 2008-06-26 DK DK11172829.1T patent/DK2374798T3/da active
- 2008-06-26 PL PL11172829T patent/PL2374798T3/pl unknown
- 2008-06-26 MY MYPI20124513 patent/MY152805A/en unknown
- 2008-06-26 NZ NZ598064A patent/NZ598064A/xx not_active IP Right Cessation
- 2008-06-26 DK DK08765871.2T patent/DK2170831T3/da active
- 2008-06-26 PT PT08765871T patent/PT2170831E/pt unknown
- 2008-06-26 US US12/666,751 patent/US8669229B2/en not_active Expired - Fee Related
- 2008-06-26 MY MYPI20124514 patent/MY150941A/en unknown
- 2008-06-26 WO PCT/JP2008/062033 patent/WO2009001968A1/en not_active Ceased
- 2008-06-26 PH PH1/2012/501363A patent/PH12012501363A1/en unknown
- 2008-06-26 CN CN200880022253A patent/CN101687805A/zh active Pending
- 2008-06-26 AT AT08765871T patent/ATE545633T1/de active
- 2008-06-26 ES ES08765871T patent/ES2380085T3/es active Active
- 2008-06-26 SI SI200831051T patent/SI2374798T1/sl unknown
- 2008-06-26 CN CN2013101949565A patent/CN103342680A/zh active Pending
- 2008-06-26 DK DK11172828.3T patent/DK2374797T3/da active
- 2008-06-26 PL PL08765871T patent/PL2170831T3/pl unknown
- 2008-06-26 ES ES11172828.3T patent/ES2460018T3/es active Active
- 2008-06-26 CN CN2013101948844A patent/CN103342679A/zh active Pending
- 2008-06-26 KR KR20107001719A patent/KR101487201B1/ko not_active Expired - Fee Related
- 2008-06-26 RU RU2010102229/04A patent/RU2471784C2/ru not_active IP Right Cessation
- 2008-06-26 NZ NZ598067A patent/NZ598067A/xx not_active IP Right Cessation
- 2008-06-26 HR HRP20120310AT patent/HRP20120310T1/hr unknown
- 2008-06-26 EP EP11172828.3A patent/EP2374797B1/en not_active Not-in-force
- 2008-06-26 PH PH1/2012/501362A patent/PH12012501362A1/en unknown
- 2008-06-26 SI SI200830557T patent/SI2170831T1/sl unknown
- 2008-06-26 SG SG2012047064A patent/SG182231A1/en unknown
- 2008-06-26 AU AU2008269918A patent/AU2008269918B2/en not_active Ceased
- 2008-06-26 NZ NZ581723A patent/NZ581723A/en not_active IP Right Cessation
- 2008-06-26 BR BRPI0813768-4A2A patent/BRPI0813768A2/pt not_active IP Right Cessation
- 2008-06-26 ES ES11172829T patent/ES2431515T3/es active Active
- 2008-06-26 PT PT111728291T patent/PT2374798E/pt unknown
- 2008-06-26 PL PL11172828T patent/PL2374797T3/pl unknown
-
2009
- 2009-12-07 IL IL202561A patent/IL202561A0/en unknown
-
2010
- 2010-01-26 CO CO10007691A patent/CO6160295A2/es unknown
-
2012
- 2012-05-04 CY CY20121100415T patent/CY1113519T1/el unknown
-
2013
- 2013-09-24 US US14/034,943 patent/US8785386B2/en not_active Expired - Fee Related
- 2013-09-24 US US14/034,979 patent/US9073868B2/en not_active Expired - Fee Related
- 2013-10-10 CY CY20131100894T patent/CY1114491T1/el unknown
- 2013-11-18 HR HRP20131095AT patent/HRP20131095T1/hr unknown
-
2014
- 2014-05-30 HR HRP20140501AT patent/HRP20140501T1/hr unknown
- 2014-06-11 CY CY20141100426T patent/CY1115226T1/el unknown
- 2014-06-25 JP JP2014130326A patent/JP5689195B2/ja not_active Expired - Fee Related
- 2014-06-25 JP JP2014130327A patent/JP5893085B2/ja not_active Expired - Fee Related
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