CY1114378T1 - Μεθοδος χρησιμοποιησης συνδυασμου παραγωγου βενζοφαινονης ή αλατος αυτου και ανοσοκατασταλτικου παραγοντα, και φαρμακευτικη συνθεση που περιλαμβανει αυτα τα συστατικα - Google Patents

Μεθοδος χρησιμοποιησης συνδυασμου παραγωγου βενζοφαινονης ή αλατος αυτου και ανοσοκατασταλτικου παραγοντα, και φαρμακευτικη συνθεση που περιλαμβανει αυτα τα συστατικα

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Publication number
CY1114378T1
CY1114378T1 CY20131100787T CY131100787T CY1114378T1 CY 1114378 T1 CY1114378 T1 CY 1114378T1 CY 20131100787 T CY20131100787 T CY 20131100787T CY 131100787 T CY131100787 T CY 131100787T CY 1114378 T1 CY1114378 T1 CY 1114378T1
Authority
CY
Cyprus
Prior art keywords
group
salt
combination
pharmaceutical composition
optionally substituted
Prior art date
Application number
CY20131100787T
Other languages
English (en)
Inventor
Yukihiko Aikawa
Shunichi Shiozawa
Original Assignee
Toyama Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co., Ltd. filed Critical Toyama Chemical Co., Ltd.
Publication of CY1114378T1 publication Critical patent/CY1114378T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Φανερώνονται η χρήση ενός παραγώγου βενζοφαινόνης που παριστάνεται με τον γενικό τύπο (Ι) ή ενός άλατος αυτού και ενός ή περισσότερων ανοσοκατασταλτικών παραγόντων σε συνδυασμό, και μία φαρμακευτική σύνθεση που περιέχει το παράγωγο βενζοφαινόνης ή ένα άλας αυτού και έναν ή περισσότερους ανοσοκατασταλτικούς παράγοντες. Η χρήση και η σύνθεση είναι χρήσιμες για αντιμετώπιση ή πρόληψη αυτοάνοσων νόσων και των συναφών. (Στον τύπο, το R1 παριστάνει μία προαιρετικά υποκατεστημένη ετεροκυκλική ομάδα, μία υποκατεστημένη ομάδα φαινυλίου ή τα συναφή · το Ζ παριστάνει μία ομάδα αλκυλενίου ή τα συναφή · το R2 παριστάνει μία ομάδα καρβοξυλίου, που μπορεί να είναι προστατευμένη από μία ομάδα αλκυλίου, ή τα συναφή · το R3 παριστάνει μία προαιρετικά υποκατεστημένη ομάδα υδροξυλίου ή τα συναφή · το R4 παριστάνει μία προαιρετικά υποκατεστημένη ομάδα κυκλοαλκυλοξειδίου ή τα συναφή · και το R5 παριστάνει ένα άτομο υδρογόνου ή τα συναφή.)
CY20131100787T 2008-04-22 2013-09-10 Μεθοδος χρησιμοποιησης συνδυασμου παραγωγου βενζοφαινονης ή αλατος αυτου και ανοσοκατασταλτικου παραγοντα, και φαρμακευτικη συνθεση που περιλαμβανει αυτα τα συστατικα CY1114378T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008111295 2008-04-22
EP09735250.4A EP2266557B1 (en) 2008-04-22 2009-04-20 Combination of benzophenone derivative or salt thereof and immunosuppressing agent, and pharmaceutical composition comprising these components

Publications (1)

Publication Number Publication Date
CY1114378T1 true CY1114378T1 (el) 2016-08-31

Family

ID=41216830

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100787T CY1114378T1 (el) 2008-04-22 2013-09-10 Μεθοδος χρησιμοποιησης συνδυασμου παραγωγου βενζοφαινονης ή αλατος αυτου και ανοσοκατασταλτικου παραγοντα, και φαρμακευτικη συνθεση που περιλαμβανει αυτα τα συστατικα

Country Status (21)

Country Link
US (1) US9066977B2 (el)
EP (1) EP2266557B1 (el)
JP (2) JP5512511B2 (el)
KR (1) KR101525851B1 (el)
CN (2) CN102014889A (el)
AU (1) AU2009239053B2 (el)
BR (1) BRPI0910735A2 (el)
CA (1) CA2721920A1 (el)
CY (1) CY1114378T1 (el)
DK (1) DK2266557T3 (el)
ES (1) ES2429592T3 (el)
HR (1) HRP20130859T1 (el)
IL (1) IL208622A0 (el)
MX (1) MX2010011666A (el)
NZ (1) NZ588470A (el)
PL (1) PL2266557T3 (el)
PT (1) PT2266557E (el)
RU (1) RU2496490C2 (el)
SI (1) SI2266557T1 (el)
WO (1) WO2009131098A1 (el)
ZA (1) ZA201007133B (el)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100240891A1 (en) 2007-09-28 2010-09-23 Toyama Chemical Co., Ltd. Drug containing benzophenone derivative or its salt
US10537585B2 (en) 2017-12-18 2020-01-21 Dexcel Pharma Technologies Ltd. Compositions comprising dexamethasone

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1202957E (pt) 1999-07-16 2005-01-31 Leo Pharma As Aminobenzofenonas como inibidoras de il-1beta e tnf-alpha
MXPA02011376A (es) * 2000-05-22 2004-02-26 Leo Pharma As Benzofenonas como inhibidores de il-1beta y tnf-alfa.
MXPA02012660A (es) 2000-06-20 2004-05-14 Atherogenics Inc 1,3-(fenilo-substituido-bis)-2-propen-1-onas y su uso para el tratamiento de padecimientos transmitidos por el vcam-1.
JP2003040776A (ja) 2001-05-24 2003-02-13 Sankyo Co Ltd 関節炎を予防若しくは治療するための医薬組成物
ES2394963T3 (es) * 2001-11-16 2013-02-07 Toyama Chemical Co., Ltd. Nuevos derivados de benzofenona o sales de los mismos
TW200500065A (en) 2003-05-21 2005-01-01 Wyeth Corp Antiarthritic combinations
BRPI0707989A2 (pt) 2006-02-21 2011-05-17 Toyama Chemical Co Ltd métodos para preparar um derivado de ácido fenilpropiÈnico, um derivado de benzofenona, um derivado de 6-metil-1, 2-benzisoxazol-3(2h) -ona e ácido 2-oxo-2h-cromeno carboxìlico, derivado de 6-(halometil) -1, 2-benzisoxazol-3(2h) -ona, e, derivado de benzofenona ou um sal do mesmo
CA2652939C (en) 2006-05-26 2014-12-02 Kenji Yonezawa Novel crystal of 3-[5-[4-(cyclopentyloxy)-2- hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionic acid
RU2436576C2 (ru) 2006-05-26 2011-12-20 Тояма Кемикал Ко., Лтд. Пероральная композиция, содержащая 3-{5-[4-(циклопентилокси)-2-гидроксибензоил]-2-[(3-гидрокси-1,2-бензизоксазол-6-ил)метокси]фенил}пропионовую кислоту или ее соль
US20100240891A1 (en) 2007-09-28 2010-09-23 Toyama Chemical Co., Ltd. Drug containing benzophenone derivative or its salt

Also Published As

Publication number Publication date
JPWO2009131098A1 (ja) 2011-08-18
AU2009239053A1 (en) 2009-10-29
JP2014166984A (ja) 2014-09-11
BRPI0910735A2 (pt) 2019-09-24
DK2266557T3 (da) 2013-09-23
WO2009131098A1 (ja) 2009-10-29
CN102920711A (zh) 2013-02-13
KR20110025167A (ko) 2011-03-09
PL2266557T3 (pl) 2013-12-31
EP2266557B1 (en) 2013-08-14
RU2010147396A (ru) 2012-05-27
KR101525851B1 (ko) 2015-06-04
CN102014889A (zh) 2011-04-13
IL208622A0 (en) 2010-12-30
EP2266557A4 (en) 2011-09-21
RU2496490C2 (ru) 2013-10-27
US20110039813A1 (en) 2011-02-17
JP5698830B2 (ja) 2015-04-08
SI2266557T1 (sl) 2013-12-31
PT2266557E (pt) 2013-09-30
HRP20130859T1 (hr) 2013-10-11
US9066977B2 (en) 2015-06-30
EP2266557A1 (en) 2010-12-29
CA2721920A1 (en) 2009-10-29
ES2429592T3 (es) 2013-11-15
NZ588470A (en) 2012-12-21
JP5512511B2 (ja) 2014-06-04
ZA201007133B (en) 2011-12-28
MX2010011666A (es) 2010-12-06
AU2009239053B2 (en) 2014-04-03

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