CY1116208T1 - Υδατο-διαλυτη ενωση βενζοαζεπινης και η φαρμακευτικη συνθεση αυτης - Google Patents

Υδατο-διαλυτη ενωση βενζοαζεπινης και η φαρμακευτικη συνθεση αυτης

Info

Publication number
CY1116208T1
CY1116208T1 CY20151100385T CY151100385T CY1116208T1 CY 1116208 T1 CY1116208 T1 CY 1116208T1 CY 20151100385 T CY20151100385 T CY 20151100385T CY 151100385 T CY151100385 T CY 151100385T CY 1116208 T1 CY1116208 T1 CY 1116208T1
Authority
CY
Cyprus
Prior art keywords
water
benzoaazepine
pharmaceutical composition
soluble compound
atom
Prior art date
Application number
CY20151100385T
Other languages
English (en)
Inventor
Makoto Komatsu
Fumitaka Goto
Yasuhiro Menjo
Keigo Yamada
Takakuni Matsuda
Yusuke Kato
Original Assignee
Otsuka Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37877008&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1116208(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharmaceutical Co., Ltd. filed Critical Otsuka Pharmaceutical Co., Ltd.
Publication of CY1116208T1 publication Critical patent/CY1116208T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • C07F9/5535—Seven-(or more) membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει μία ένωση βενζοαζεπίνης που αντιπροσωπεύεται από τον ακόλουθο γενικό τύπο (1): ή ένα άλας αυτής, στον οποίο το R αντιπροσωπεύει ένα άτομο υδρογόνου, μία υδροξυ ομάδα προαιρετικά προστατευμένη με μία ομάδα προστασίας, κλπ., το R1 αντιπροσωπεύει ένα άτομο υδρογόνου ή μια ομάδα προστασίας της υδροξυ ομάδας, και το Χ αντιπροσωπεύει ένα άτομο οξυγόνου ή ένα άτομο θείου. Η ένωση βενζοαζεπίνης της παρούσας εφεύρεσης και τα άλατα αυτής έχουν υψηλή διαλυτότητα στο νερό, και μπορούν να χρησιμοποιηθούν κατάλληλα για ενέσεις.
CY20151100385T 2005-12-27 2015-04-27 Υδατο-διαλυτη ενωση βενζοαζεπινης και η φαρμακευτικη συνθεση αυτης CY1116208T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005375457 2005-12-27
EP06843686.4A EP1968990B1 (en) 2005-12-27 2006-12-22 Water-soluble benzoazepine compound and its pharmaceutical composition

Publications (1)

Publication Number Publication Date
CY1116208T1 true CY1116208T1 (el) 2017-02-08

Family

ID=37877008

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151100385T CY1116208T1 (el) 2005-12-27 2015-04-27 Υδατο-διαλυτη ενωση βενζοαζεπινης και η φαρμακευτικη συνθεση αυτης

Country Status (23)

Country Link
US (6) US20100004206A1 (el)
EP (2) EP1968990B1 (el)
JP (2) JP4644287B2 (el)
KR (1) KR101008931B1 (el)
CN (1) CN101346390B (el)
AR (2) AR058737A1 (el)
AU (1) AU2006330277B2 (el)
BR (1) BRPI0620715A2 (el)
CA (1) CA2633929A1 (el)
CY (1) CY1116208T1 (el)
DK (1) DK1968990T3 (el)
ES (1) ES2533007T3 (el)
HK (1) HK1121461A1 (el)
IL (1) IL191935A (el)
MY (1) MY146042A (el)
NO (1) NO342436B1 (el)
PL (1) PL1968990T3 (el)
PT (1) PT1968990E (el)
RU (1) RU2418804C2 (el)
SI (1) SI1968990T1 (el)
TW (1) TWI323257B (el)
WO (1) WO2007074915A1 (el)
ZA (1) ZA200805011B (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5590780B2 (ja) * 2007-06-26 2014-09-17 大塚製薬株式会社 医薬
TWI459947B (zh) 2007-06-26 2014-11-11 Otsuka Pharma Co Ltd 苯并氮呯化合物及藥學製劑
AU2009257174A1 (en) * 2008-06-09 2009-12-17 Dimerix Bioscience Pty Ltd Novel receptor hetero-dimers/-oligomers
CN102020609A (zh) * 2009-09-17 2011-04-20 北京本草天源药物研究院 托伐普坦晶体或无定形物及其制备方法
DE102010041263A1 (de) * 2010-09-23 2012-03-29 Siemens Medical Instruments Pte. Ltd. Hörgerätegehäuse mit Dichtungslippe
TWI704919B (zh) 2012-05-31 2020-09-21 日商大塚製藥股份有限公司 用於預防及/或治療多囊性腎臟病之藥物
EP2941242B1 (en) * 2012-12-28 2017-02-01 Otsuka Pharmaceutical Co., Ltd. Injectable depot formulation comprising optically active tolvaptan and process of producing the same
TW201605488A (zh) 2013-10-15 2016-02-16 大塚製藥股份有限公司 用以預防及／或治療多囊腎病之藥物
AU2017291826B2 (en) * 2016-07-07 2021-10-21 Cyclerion Therapeutics, Inc. Phosphorus prodrugs of sGC stimulators
JP2021014406A (ja) * 2017-10-25 2021-02-12 トーアエイヨー株式会社 バソプレシン受容体拮抗剤
CN113383001A (zh) * 2019-01-30 2021-09-10 大塚制药株式会社 生产苯并氮杂卓化合物的方法
KR20210144811A (ko) 2019-03-28 2021-11-30 오츠카 세이야쿠 가부시키가이샤 벤조아제핀 화합물-함유 제약 조성물
EA202192646A1 (ru) * 2019-03-28 2021-12-09 Оцука Фармасьютикал Ко., Лтд. Лиофилизированная композиция, содержащая соединение бензоазепина
KR20230143165A (ko) 2021-02-10 2023-10-11 상하이 센후이 메디슨 컴퍼니 리미티드 벤즈아제핀 화합물, 이의 제조 방법 및 이의 약학적 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043273A (en) 1989-08-17 1991-08-27 Monsanto Company Phosphorylated glycosidase inhibitor prodrugs
US5753677A (en) * 1989-10-20 1998-05-19 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
US5258510A (en) 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
TW198715B (el) 1991-04-19 1993-01-21 Dtsuka Seiyaku Kk
US5466683A (en) * 1994-08-25 1995-11-14 Teva Pharmaceutical Industries Ltd. Water-soluble analogs of carbamazepine
GB9602080D0 (en) 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
JP4210355B2 (ja) 1997-07-03 2009-01-14 大塚製薬株式会社 固形製剤組成物
US5972882A (en) * 1997-12-15 1999-10-26 University Of Kansas Medical Center Treatment of polycystic kidney disease using vasopressin V2 receptor antagonists
US6436989B1 (en) * 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
TWI322689B (en) 2003-02-24 2010-04-01 Otsuka Pharma Co Ltd Method for treating severe heart failure and medicament therefor

Also Published As

Publication number Publication date
AR107193A2 (es) 2018-03-28
AU2006330277A1 (en) 2007-07-05
EP1968990B1 (en) 2015-02-11
TWI323257B (en) 2010-04-11
US20130331358A1 (en) 2013-12-12
US20120277188A1 (en) 2012-11-01
JP4644287B2 (ja) 2011-03-02
PT1968990E (pt) 2015-03-16
IL191935A0 (en) 2008-12-29
US20100004206A1 (en) 2010-01-07
WO2007074915A1 (en) 2007-07-05
BRPI0620715A2 (pt) 2011-11-22
CN101346390A (zh) 2009-01-14
ES2533007T3 (es) 2015-04-06
AR058737A1 (es) 2008-02-20
HK1121461A1 (en) 2009-04-24
IL191935A (en) 2013-07-31
MY146042A (en) 2012-06-15
TW200734309A (en) 2007-09-16
EP1968990A1 (en) 2008-09-17
JP2009521397A (ja) 2009-06-04
PL1968990T3 (pl) 2015-06-30
US20110082110A1 (en) 2011-04-07
US20110098250A1 (en) 2011-04-28
AU2006330277B2 (en) 2011-10-06
US9809609B2 (en) 2017-11-07
JP2011046731A (ja) 2011-03-10
US20120277189A1 (en) 2012-11-01
ZA200805011B (en) 2009-11-25
WO2007074915A8 (en) 2007-11-08
KR20080078916A (ko) 2008-08-28
RU2418804C2 (ru) 2011-05-20
JP5550522B2 (ja) 2014-07-16
CA2633929A1 (en) 2007-07-05
SI1968990T1 (sl) 2015-05-29
US9303052B2 (en) 2016-04-05
NO20082630L (no) 2008-09-16
CN101346390B (zh) 2011-11-09
NO342436B1 (no) 2018-05-22
DK1968990T3 (da) 2015-04-27
RU2008130887A (ru) 2010-02-10
KR101008931B1 (ko) 2011-01-17
EP2674436A1 (en) 2013-12-18

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