ATE554774T1 - 2-methylen-19-nor-(20s-24epi)-1alpha,25- dihydrovitamin-d2 - Google Patents
2-methylen-19-nor-(20s-24epi)-1alpha,25- dihydrovitamin-d2Info
- Publication number
- ATE554774T1 ATE554774T1 AT06734708T AT06734708T ATE554774T1 AT E554774 T1 ATE554774 T1 AT E554774T1 AT 06734708 T AT06734708 T AT 06734708T AT 06734708 T AT06734708 T AT 06734708T AT E554774 T1 ATE554774 T1 AT E554774T1
- Authority
- AT
- Austria
- Prior art keywords
- 24epi
- dihydrovitamin
- 1alpha
- methylene
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65204405P | 2005-02-11 | 2005-02-11 | |
PCT/US2006/004679 WO2006086608A1 (en) | 2005-02-11 | 2006-02-10 | 2-METHYLENE-19-NOR-(20S-24EPI)-1α,25-DIHYDROXYVITAMIN-D2 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE554774T1 true ATE554774T1 (de) | 2012-05-15 |
Family
ID=36793376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06734708T ATE554774T1 (de) | 2005-02-11 | 2006-02-10 | 2-methylen-19-nor-(20s-24epi)-1alpha,25- dihydrovitamin-d2 |
Country Status (10)
Country | Link |
---|---|
US (1) | US7511030B2 (de) |
EP (1) | EP1848442B1 (de) |
JP (1) | JP5036565B2 (de) |
AT (1) | ATE554774T1 (de) |
AU (1) | AU2006213722B2 (de) |
CA (1) | CA2597568A1 (de) |
DK (1) | DK1848442T3 (de) |
MX (1) | MX2007009725A (de) |
NZ (1) | NZ561076A (de) |
WO (1) | WO2006086608A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1656157B1 (de) * | 2003-08-20 | 2011-12-21 | Wisconsin Alumni Research Foundation | 2-methylen-19-nor-vitamin d2-verbindungen |
US7713951B2 (en) * | 2004-04-09 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin D compounds |
WO2009111695A1 (en) * | 2008-03-06 | 2009-09-11 | Wisconsin Alumni Research Foundation | Methods of increasing epidermal skin thickness by topical administration of a 19-nor containing vitamin d compound |
US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
EP2556053B1 (de) * | 2010-03-23 | 2015-07-29 | Wisconsin Alumni Research Foundation | (20s)-2-methylen-19-nor-22-dimethyl-1alpha,25-dihydroxyvitamin d3 und (20r)-2-methylen-19-nor-22-dimethyl-1alpha,25-hydroxyvitamin d3 |
EP2556054B1 (de) * | 2010-03-23 | 2017-09-27 | Wisconsin Alumni Research Foundation | Diastereomere von 2-methylen-19-nor-22-methyl-1alpha,25-dihydroxyvitamin d3 |
ES2380477B2 (es) * | 2010-10-13 | 2012-11-16 | Universidad De Vigo | Procedimiento de obtención de "25-hidroxicetona de windaus" que comprende la reacción de julia-kocienski. |
JP6035331B2 (ja) * | 2011-06-14 | 2016-11-30 | ウイスコンシン アラムニ リサーチ ファンデーション | 3−デスオキシ−2−メチレン−19−ノル−ビタミンd類似体およびそれらの使用 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4588716A (en) * | 1984-05-04 | 1986-05-13 | Wisconsin Alumni Research Foundation | Method for treating metabolic bone disease in mammals |
US4666634A (en) * | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
JP2898882B2 (ja) * | 1993-04-05 | 1999-06-02 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | 2−位に置換基を有する19−ノル−ビタミンd3 化合物 |
US5552392A (en) * | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
US6673782B2 (en) * | 1999-04-29 | 2004-01-06 | Wisconsin Alumni Research Foundation | Treatment of systemic lupus erythematosis |
US6479474B2 (en) * | 1999-07-08 | 2002-11-12 | Wisconsin Alumni Research Foundation | Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis |
US7704979B2 (en) * | 2000-09-01 | 2010-04-27 | The University Of Tennessee Research Foundation | Materials and methods for the treatment or prevention of obesity |
US6384087B1 (en) * | 2000-09-01 | 2002-05-07 | University Of Tennesseee Research Corporation, Inc. | Materials and methods for the treatment or prevention of obesity |
MXPA03001969A (es) * | 2000-09-08 | 2003-06-24 | Wisconsin Alumni Res Found | 1-alfa-hidroxi-2-metilen-19-nor-homopregnacalciferol y sus aplicaciones terapeuticas. |
US6627622B2 (en) * | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
US6566352B1 (en) * | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
DE60310050T2 (de) * | 2002-03-29 | 2007-07-05 | Wisconsin Alumni Research Foundation, Madison | Ein verfahren zur herstellung von 1-alpha-hydroxy-2-methylen-19-nor-homopregnacalciferol |
US7259143B2 (en) * | 2002-09-05 | 2007-08-21 | Wisconsin Alumni Research Foundation | Method of extending the dose range of vitamin D compounds |
CA2516233C (en) * | 2003-04-10 | 2011-09-20 | Wisconsin Alumni Research Foundation | 2-propylidene-19-nor-vitamin d compounds |
EP1656157B1 (de) * | 2003-08-20 | 2011-12-21 | Wisconsin Alumni Research Foundation | 2-methylen-19-nor-vitamin d2-verbindungen |
AU2004273660B2 (en) * | 2003-09-19 | 2010-08-19 | Wisconsin Alumni Research Foundation (Warf) | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin D derivatives and parathyroid hormone |
EP1667692A1 (de) * | 2003-09-19 | 2006-06-14 | Pfizer Products Inc. | Pharmazeutische zusammensetzungen mit kombinationen von 2-alkyliden-19-nor-vitamin d derivaten und einem östrogen-agonisten/antagonisten |
WO2005027931A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and an ep2 or ep4 selective agonist |
WO2005027913A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue |
US7053075B2 (en) * | 2003-11-25 | 2006-05-30 | Deluca Hector F | Methods for reducing body fat using vitamin D compounds |
WO2005051323A2 (en) * | 2003-11-25 | 2005-06-09 | Wisconsin Alumni Research Foundation | Vitamin d analogs for obesity prevention and treatment |
-
2006
- 2006-02-10 AT AT06734708T patent/ATE554774T1/de active
- 2006-02-10 US US11/351,874 patent/US7511030B2/en not_active Expired - Fee Related
- 2006-02-10 DK DK06734708.8T patent/DK1848442T3/da active
- 2006-02-10 EP EP06734708A patent/EP1848442B1/de not_active Not-in-force
- 2006-02-10 NZ NZ561076A patent/NZ561076A/en not_active IP Right Cessation
- 2006-02-10 CA CA002597568A patent/CA2597568A1/en not_active Abandoned
- 2006-02-10 MX MX2007009725A patent/MX2007009725A/es active IP Right Grant
- 2006-02-10 JP JP2007555234A patent/JP5036565B2/ja not_active Expired - Fee Related
- 2006-02-10 WO PCT/US2006/004679 patent/WO2006086608A1/en active Application Filing
- 2006-02-10 AU AU2006213722A patent/AU2006213722B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP1848442A4 (de) | 2010-12-15 |
JP2008530109A (ja) | 2008-08-07 |
DK1848442T3 (da) | 2012-05-29 |
CA2597568A1 (en) | 2006-08-17 |
AU2006213722B2 (en) | 2011-09-22 |
MX2007009725A (es) | 2007-09-26 |
US20060183721A1 (en) | 2006-08-17 |
JP5036565B2 (ja) | 2012-09-26 |
NZ561076A (en) | 2010-01-29 |
WO2006086608A1 (en) | 2006-08-17 |
AU2006213722A1 (en) | 2006-08-17 |
EP1848442A1 (de) | 2007-10-31 |
US7511030B2 (en) | 2009-03-31 |
EP1848442B1 (de) | 2012-04-25 |
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