EA201170196A1 - Производные бензазепинов и их применение в качестве h3 гистаминовых антагонистов - Google Patents
Производные бензазепинов и их применение в качестве h3 гистаминовых антагонистовInfo
- Publication number
- EA201170196A1 EA201170196A1 EA201170196A EA201170196A EA201170196A1 EA 201170196 A1 EA201170196 A1 EA 201170196A1 EA 201170196 A EA201170196 A EA 201170196A EA 201170196 A EA201170196 A EA 201170196A EA 201170196 A1 EA201170196 A1 EA 201170196A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cycloalkyl
- alkylene
- group
- substituents
- optionally substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Соединение формулы (1)где R1 представляет собой группу, выбранную из возможно замещенных Сциклоалкила, Cалкила, Салкилен-Сциклоалкилаили гетероциклила; n имеет значение 0, 1, 2, 3 или 4, при этом алкиленовая группа -(СН)- возможно замещена; А представляет собой группу, выбранную из -N(R2)CO-, -CON(R2)-, -OC(O)-, -С(O)O-, -СО-, -C(R2)(OR3)-, -C(=N-O-R3)-, -C(=CR2R3)-, -Сциклоалкилен-, -C(R2)(галогено Cалкил)-, Cалкилена и -C(OR3)(галогено Cалкил)-; каждый из R2 и R3 независимо выбран из Н, Cалкала и Сциклоалкила или R2 вместе с примыкающим атомом азота и Z может образовывать N-содержащую гетероциклильную группу, которая возможно может иметь заместители; Х отсутствует или представляет собой Cалкилен яли Салкенилен, каждый из которых возможно может иметь в качестве заместителей одну или более чем одну Cалкильную группу, OR16, атом галогена или галогено Cалкил; Z выбран из арила, гетероарила, Сциклоалкила и гетероциклила, каждый из которых возможно замещен, или Z может представлять собой Н или вместе с примыкающим атомом азота и R2 может образовывать N-содержащую гетероциклильную группу, которая возможно может иметь заместители, где, когда А представляет собой -СО-, Z присоединен к Х или А через атом углерода, и где, когда А представляет собой -N(R2)CO- и Z представляет собой Н, R1 представляет собой Сциклоалкил; или его фармацевтически приемлемая соль или эфир
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0813254A GB0813254D0 (en) | 2008-07-18 | 2008-07-18 | Compounds and their use |
GB0905231A GB0905231D0 (en) | 2009-03-26 | 2009-03-26 | Compounds and their use |
PCT/GB2009/001774 WO2010007382A1 (en) | 2008-07-18 | 2009-07-17 | Benzazepine derivatives and their use as hstamine h3 antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201170196A1 true EA201170196A1 (ru) | 2011-12-30 |
Family
ID=41051104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201170196A EA201170196A1 (ru) | 2008-07-18 | 2009-07-17 | Производные бензазепинов и их применение в качестве h3 гистаминовых антагонистов |
Country Status (19)
Country | Link |
---|---|
US (1) | US20110124626A1 (ru) |
EP (1) | EP2326625A1 (ru) |
JP (1) | JP2011528341A (ru) |
KR (1) | KR20110036044A (ru) |
CN (1) | CN102099339A (ru) |
AU (1) | AU2009272486A1 (ru) |
CA (1) | CA2731196A1 (ru) |
CL (1) | CL2011000043A1 (ru) |
CO (1) | CO6341614A2 (ru) |
CR (1) | CR20110049A (ru) |
DO (1) | DOP2011000015A (ru) |
EA (1) | EA201170196A1 (ru) |
EC (1) | ECSP11010838A (ru) |
GE (1) | GEP20125590B (ru) |
IL (1) | IL210722A0 (ru) |
MA (1) | MA32550B1 (ru) |
MX (1) | MX2011000460A (ru) |
PE (1) | PE20110408A1 (ru) |
WO (1) | WO2010007382A1 (ru) |
Families Citing this family (30)
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US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
SG173312A1 (en) | 2006-06-23 | 2011-08-29 | Abbott Lab | Cyclopropyl amine derivatives as histamin h3 receptor modulators |
US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
EP2942346B1 (en) | 2009-02-17 | 2020-05-06 | Syntrix Biosystems, Inc. | Pyridinecarboxamides as cxcr2 modulators |
BRPI1009090A2 (pt) | 2009-03-26 | 2016-03-01 | Takeda Pharmaceutical | composto, pró-droga, medicamento, métodos, e, uso do composto |
US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
WO2011083316A1 (en) * | 2010-01-08 | 2011-07-14 | Takeda Pharmaceutical Company Limited | Benzazepine derivatives for the treatment of central nervous system disorders |
WO2011083315A1 (en) | 2010-01-08 | 2011-07-14 | Takeda Pharmaceutical Company Limited | Compounds and their use |
WO2011083314A1 (en) * | 2010-01-08 | 2011-07-14 | Takeda Pharmaceutical Company Limited | Benzazepine derivatives for the treatment of central nervous system disorders |
TW201206939A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
TW201206901A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
JP5833105B2 (ja) | 2010-05-11 | 2015-12-16 | サノフイ | 置換n−ヘテロアリールスピロラクタムビピロリジン類、その製造及び治療的使用 |
EP2569303A1 (en) | 2010-05-11 | 2013-03-20 | Sanofi | Substituted n-alkyl and n-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
WO2011143161A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof |
TW201206444A (en) * | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
US8779149B2 (en) | 2010-08-23 | 2014-07-15 | Syntrix Biosystems, Inc. | Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators |
WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
US8969365B2 (en) | 2013-08-02 | 2015-03-03 | Syntrix Biosystems, Inc. | Thiopyrimidinecarboxamides as CXCR1/2 modulators |
US10561676B2 (en) | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
US10266515B2 (en) | 2013-12-30 | 2019-04-23 | Lifesci Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
US9611252B2 (en) | 2013-12-30 | 2017-04-04 | Lifesci Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
EA035410B1 (ru) * | 2014-07-16 | 2020-06-09 | Лайфсай Фармасьютикалс, Инк. | Терапевтические соединения-ингибиторы |
GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
WO2018011628A1 (en) | 2016-07-11 | 2018-01-18 | Lifesci Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
GB201617758D0 (en) * | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
US10660909B2 (en) | 2016-11-17 | 2020-05-26 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
RU2761436C1 (ru) | 2017-11-17 | 2021-12-08 | Целликс Био Прайвет Лимитед | Композиции и способы лечения нарушений со стороны органа зрения |
CN114736195B (zh) * | 2022-03-01 | 2022-11-15 | 天水师范学院 | 一种氧硫杂环戊烷-苯并香豆素化合物及其制备方法和作为荧光探针的用途 |
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TW197435B (ru) * | 1990-11-22 | 1993-01-01 | Takeda Pharm Industry Co Ltd | |
WO2001082925A1 (fr) * | 2000-04-28 | 2001-11-08 | Takeda Chemical Industries, Ltd. | Antagonistes de l'hormone concentrant la melanine |
AU2001256733A1 (en) * | 2000-05-16 | 2001-11-26 | Takeda Chemical Industries Ltd. | Melanin-concentrating hormone antagonist |
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GB0329214D0 (en) * | 2003-12-17 | 2004-01-21 | Glaxo Group Ltd | Novel compounds |
JP4982184B2 (ja) * | 2003-12-18 | 2012-07-25 | アボット ゲーエムベーハー ウント カンパニー カーゲー | テトラヒドロベンズアゼピンおよびドーパミンd3レセプターの調節におけるこれらの使用 |
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US20080249154A1 (en) * | 2003-12-26 | 2008-10-09 | Ono Pharmaceutical Co., Ltd. | Preventive and/or Therapeutic Agent For Disease In Which Mitochondrial Benzodiazephine Receptor Participates |
GB0405628D0 (en) * | 2004-03-12 | 2004-04-21 | Glaxo Group Ltd | Novel compounds |
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US8557812B2 (en) * | 2004-08-20 | 2013-10-15 | The Regents Of The University Of Michigan | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof |
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-
2009
- 2009-07-17 MX MX2011000460A patent/MX2011000460A/es not_active Application Discontinuation
- 2009-07-17 JP JP2011517994A patent/JP2011528341A/ja not_active Withdrawn
- 2009-07-17 PE PE2011000024A patent/PE20110408A1/es not_active Application Discontinuation
- 2009-07-17 AU AU2009272486A patent/AU2009272486A1/en not_active Abandoned
- 2009-07-17 CN CN200980127932.XA patent/CN102099339A/zh active Pending
- 2009-07-17 KR KR1020117001319A patent/KR20110036044A/ko not_active Application Discontinuation
- 2009-07-17 EP EP09784728A patent/EP2326625A1/en not_active Withdrawn
- 2009-07-17 CA CA2731196A patent/CA2731196A1/en not_active Abandoned
- 2009-07-17 WO PCT/GB2009/001774 patent/WO2010007382A1/en active Application Filing
- 2009-07-17 US US13/054,688 patent/US20110124626A1/en not_active Abandoned
- 2009-07-17 GE GEAP200912098A patent/GEP20125590B/en unknown
- 2009-07-17 EA EA201170196A patent/EA201170196A1/ru unknown
-
2011
- 2011-01-07 CL CL2011000043A patent/CL2011000043A1/es unknown
- 2011-01-13 CO CO11003062A patent/CO6341614A2/es not_active Application Discontinuation
- 2011-01-14 DO DO2011000015A patent/DOP2011000015A/es unknown
- 2011-01-18 IL IL210722A patent/IL210722A0/en unknown
- 2011-01-25 CR CR20110049A patent/CR20110049A/es unknown
- 2011-02-10 MA MA33600A patent/MA32550B1/fr unknown
- 2011-02-18 EC EC2011010838A patent/ECSP11010838A/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20110124626A1 (en) | 2011-05-26 |
CR20110049A (es) | 2011-06-22 |
MA32550B1 (fr) | 2011-08-01 |
CL2011000043A1 (es) | 2011-10-28 |
AU2009272486A1 (en) | 2010-01-21 |
JP2011528341A (ja) | 2011-11-17 |
GEP20125590B (en) | 2012-07-25 |
PE20110408A1 (es) | 2011-06-22 |
IL210722A0 (en) | 2011-03-31 |
EP2326625A1 (en) | 2011-06-01 |
WO2010007382A8 (en) | 2010-03-18 |
CN102099339A (zh) | 2011-06-15 |
KR20110036044A (ko) | 2011-04-06 |
DOP2011000015A (es) | 2011-04-15 |
WO2010007382A1 (en) | 2010-01-21 |
CA2731196A1 (en) | 2010-01-21 |
CO6341614A2 (es) | 2011-11-21 |
MX2011000460A (es) | 2011-03-15 |
ECSP11010838A (es) | 2011-05-31 |
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