JP2011507812A5 - - Google Patents
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- Publication number
- JP2011507812A5 JP2011507812A5 JP2010538335A JP2010538335A JP2011507812A5 JP 2011507812 A5 JP2011507812 A5 JP 2011507812A5 JP 2010538335 A JP2010538335 A JP 2010538335A JP 2010538335 A JP2010538335 A JP 2010538335A JP 2011507812 A5 JP2011507812 A5 JP 2011507812A5
- Authority
- JP
- Japan
- Prior art keywords
- fruit extract
- milk thistle
- liver
- necessary
- thistle fruit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 19
- 229940108312 milk thistle fruit extract Drugs 0.000 claims 10
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 6
- SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 claims 5
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 claims 5
- 229960004245 silymarin Drugs 0.000 claims 5
- 235000017700 silymarin Nutrition 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 3
- 238000001035 drying Methods 0.000 claims 3
- 238000001914 filtration Methods 0.000 claims 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
- 239000002798 polar solvent Substances 0.000 claims 3
- 208000004930 Fatty Liver Diseases 0.000 claims 2
- 206010019708 Hepatic steatosis Diseases 0.000 claims 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims 2
- 208000010706 fatty liver disease Diseases 0.000 claims 2
- 208000019423 liver disease Diseases 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000010298 pulverizing process Methods 0.000 claims 2
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 2
- 208000007788 Acute Liver Failure Diseases 0.000 claims 1
- 206010000804 Acute hepatic failure Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010019663 Hepatic failure Diseases 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 208000002720 Malnutrition Diseases 0.000 claims 1
- 208000001907 Mushroom Poisoning Diseases 0.000 claims 1
- 241000320380 Silybum Species 0.000 claims 1
- 235000010841 Silybum marianum Nutrition 0.000 claims 1
- 231100000836 acute liver failure Toxicity 0.000 claims 1
- 239000012223 aqueous fraction Substances 0.000 claims 1
- 239000008346 aqueous phase Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 235000013399 edible fruits Nutrition 0.000 claims 1
- 230000005989 gallbladder dysfunction Effects 0.000 claims 1
- 238000000227 grinding Methods 0.000 claims 1
- 230000002440 hepatic effect Effects 0.000 claims 1
- 206010019692 hepatic necrosis Diseases 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 230000005976 liver dysfunction Effects 0.000 claims 1
- 208000007903 liver failure Diseases 0.000 claims 1
- 231100000835 liver failure Toxicity 0.000 claims 1
- 231100000149 liver necrosis Toxicity 0.000 claims 1
- 230000001071 malnutrition Effects 0.000 claims 1
- 235000000824 malnutrition Nutrition 0.000 claims 1
- 208000015380 nutritional deficiency disease Diseases 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007063115 | 2007-12-23 | ||
| DE102007063115.6 | 2007-12-23 | ||
| DE102008039271A DE102008039271A1 (de) | 2007-12-23 | 2008-08-23 | Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung |
| DE102008039271.5 | 2008-08-23 | ||
| PCT/DE2008/002117 WO2009080006A2 (de) | 2007-12-23 | 2008-12-23 | Neuer mariendistelextrakt, verfahren zur herstellung und verwendung |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013260758A Division JP2014074051A (ja) | 2007-12-23 | 2013-12-18 | 新規ミルクシスル抽出物、調製方法、および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011507812A JP2011507812A (ja) | 2011-03-10 |
| JP2011507812A5 true JP2011507812A5 (enExample) | 2011-11-04 |
| JP5442632B2 JP5442632B2 (ja) | 2014-03-12 |
Family
ID=40690102
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010538335A Active JP5442632B2 (ja) | 2007-12-23 | 2008-12-23 | 新規ミルクシスル抽出物、調製方法、および使用 |
| JP2013260758A Pending JP2014074051A (ja) | 2007-12-23 | 2013-12-18 | 新規ミルクシスル抽出物、調製方法、および使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013260758A Pending JP2014074051A (ja) | 2007-12-23 | 2013-12-18 | 新規ミルクシスル抽出物、調製方法、および使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20110027396A1 (enExample) |
| EP (2) | EP2567703A3 (enExample) |
| JP (2) | JP5442632B2 (enExample) |
| KR (2) | KR101607445B1 (enExample) |
| CN (2) | CN101925360A (enExample) |
| AU (1) | AU2008340922B2 (enExample) |
| BR (1) | BRPI0822069B8 (enExample) |
| CA (2) | CA2709947C (enExample) |
| CY (1) | CY1115081T1 (enExample) |
| DE (1) | DE102008039271A1 (enExample) |
| DK (1) | DK2222320T3 (enExample) |
| ES (1) | ES2438003T3 (enExample) |
| HK (1) | HK1203352A1 (enExample) |
| HR (1) | HRP20131165T1 (enExample) |
| MX (1) | MX2010006982A (enExample) |
| PL (1) | PL2222320T3 (enExample) |
| PT (1) | PT2222320E (enExample) |
| RU (1) | RU2489161C2 (enExample) |
| SI (1) | SI2222320T1 (enExample) |
| WO (1) | WO2009080006A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5841048B2 (ja) * | 2009-05-14 | 2016-01-06 | エウロメッド・エセ・ア | ウイルス性肝炎の治療のための非晶質シリビニン |
| CN102225085B (zh) * | 2011-06-20 | 2012-09-05 | 黑龙江大学 | 一种从水飞蓟秸秆中提取水飞蓟总黄酮的方法 |
| KR101316806B1 (ko) * | 2011-08-02 | 2013-10-10 | (주)이뮤노텍 | 글루타치온과 실리마린을 유효성분으로 함유하는 항산화 및 간보호용 조성물 |
| KR101655396B1 (ko) * | 2013-08-06 | 2016-09-08 | 에스케이바이오랜드 주식회사 | 수용성 밀크씨슬 추출물 및 이의 제조방법 |
| JP2015113332A (ja) * | 2013-12-16 | 2015-06-22 | 花王株式会社 | 生薬粉体 |
| CN104744447B (zh) * | 2013-12-31 | 2017-12-26 | 天士力制药集团股份有限公司 | 水飞蓟宾迷迭香酸酯及其制备方法和用途 |
| CN104651037A (zh) * | 2014-01-17 | 2015-05-27 | 吴长军 | 一种亚临界流体萃取水飞蓟籽仁中油脂和蛋白的方法 |
| CN105622594B (zh) * | 2016-03-17 | 2019-05-17 | 江苏中兴药业有限公司 | 一种高纯度水飞蓟素的制备方法 |
| ES2706008B8 (es) * | 2017-09-22 | 2021-07-12 | Euromed S A | Procedimiento para la preparacion de una composicion a partir del cardo mariano y composicion obtenida |
| KR102242002B1 (ko) | 2019-02-21 | 2021-04-19 | 주식회사 노바케이메드 | 동충하초균사체로 고상발효된 홍삼 추출물을 유효성분으로 함유하는 지방간 질환 예방 또는 치료용 조성물 |
| CN111518090B (zh) * | 2020-05-12 | 2021-08-10 | 沈阳药科大学 | 黄烷黄酮衍生物及其制备方法和用途 |
| KR102669644B1 (ko) * | 2023-06-27 | 2024-05-27 | 한국자연한방 주식회사 | 실리마린 생체이용률이 증대된 밀크씨슬 추출물을 포함하는 지방간 개선, 예방 또는 치료용 조성물 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1767666C3 (de) | 1968-06-01 | 1986-07-31 | Dr. Madaus & Co, 5000 Koeln | Pharmazeutische Zubereitung gegen Lebererkrankungen |
| DE1923982C3 (de) | 1969-05-10 | 1978-07-13 | Hoechst Ag, 6000 Frankfurt | Flammfestmachen von Polyurethanschaumstoffen |
| DE2020407A1 (de) | 1970-04-27 | 1971-11-11 | Bernhard Dr Janiak | Technisches Verfahren zur Isolierung von Silimarin |
| FR2181188A5 (en) * | 1972-04-20 | 1973-11-30 | Dott Inverni Della Beffa | Polyhydroxyphenylchromones - by solvent extn of non-defatted fruit of Silybum marianum |
| US4061765A (en) * | 1973-01-19 | 1977-12-06 | Dr. Madaus & Co. | Polyhydroxyphenylchromanone salts and therapeutic composition |
| DD112261A1 (enExample) * | 1974-06-18 | 1975-04-05 | ||
| DE2914330A1 (de) | 1979-04-09 | 1980-10-30 | Madaus & Co Dr | Verfahren zur gewinnung von silymarin aus pflanzen |
| CH646695A5 (en) * | 1980-10-06 | 1984-12-14 | Madaus & Co Dr | Method of obtaining silymarin from plants |
| DE3225688A1 (de) * | 1982-07-09 | 1984-01-12 | Suschnik Matthias Dr | Verfahren zur gewinnung von silymarin aus silybum marianum |
| IT1241673B (it) | 1989-10-09 | 1994-01-27 | Istituto Biochimico Italiano | Complessi di inclusione di silibinina con ciclodestrina, loro preparazione e composizioni farmaceutiche che li contengono. |
| DE19501266A1 (de) | 1995-01-18 | 1996-07-25 | Madaus Ag | Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln |
| KR0161349B1 (ko) | 1995-01-20 | 1998-11-16 | 무라따 야스따까 | 압전 자기 조성물 |
| RU2102999C1 (ru) * | 1996-07-10 | 1998-01-27 | Куркин Владимир Александрович | Способ получения экстракта расторопши пятнистой |
| DE19744459A1 (de) * | 1997-10-08 | 1999-04-15 | Schwabe Willmar Gmbh & Co | Flavonolignan-Zubereitungen, insbesondere Silymarin-Zubereitungen |
| IN192343B (enExample) * | 2000-05-26 | 2004-04-10 | Ranbaxy Lab Ltd | |
| CZ292832B6 (cs) * | 2001-08-30 | 2003-12-17 | Ivax Pharmaceuticals S.R.O. | Způsob přípravy silymarinu se zvýšenou rozpustností |
| JP2003135023A (ja) * | 2001-10-30 | 2003-05-13 | Os Kogyo Kk | 健康食品 |
| US7238373B2 (en) * | 2003-04-04 | 2007-07-03 | Nutritox Llc | Nutritional supplement |
-
2008
- 2008-08-23 DE DE102008039271A patent/DE102008039271A1/de not_active Withdrawn
- 2008-12-23 WO PCT/DE2008/002117 patent/WO2009080006A2/de not_active Ceased
- 2008-12-23 JP JP2010538335A patent/JP5442632B2/ja active Active
- 2008-12-23 RU RU2010130855/15A patent/RU2489161C2/ru active
- 2008-12-23 PL PL08865199T patent/PL2222320T3/pl unknown
- 2008-12-23 US US12/810,178 patent/US20110027396A1/en not_active Abandoned
- 2008-12-23 MX MX2010006982A patent/MX2010006982A/es active IP Right Grant
- 2008-12-23 AU AU2008340922A patent/AU2008340922B2/en active Active
- 2008-12-23 EP EP12195762A patent/EP2567703A3/de not_active Withdrawn
- 2008-12-23 KR KR1020157006607A patent/KR101607445B1/ko active Active
- 2008-12-23 SI SI200831118T patent/SI2222320T1/sl unknown
- 2008-12-23 CN CN2008801254794A patent/CN101925360A/zh active Pending
- 2008-12-23 CA CA2709947A patent/CA2709947C/en active Active
- 2008-12-23 ES ES08865199.7T patent/ES2438003T3/es active Active
- 2008-12-23 DK DK08865199.7T patent/DK2222320T3/da active
- 2008-12-23 CN CN201410378585.0A patent/CN104189043A/zh active Pending
- 2008-12-23 KR KR1020107015846A patent/KR101541938B1/ko active Active
- 2008-12-23 CA CA2922846A patent/CA2922846A1/en not_active Abandoned
- 2008-12-23 EP EP08865199.7A patent/EP2222320B1/de active Active
- 2008-12-23 BR BRPI0822069A patent/BRPI0822069B8/pt active IP Right Grant
- 2008-12-23 PT PT88651997T patent/PT2222320E/pt unknown
- 2008-12-23 HR HRP20131165AT patent/HRP20131165T1/hr unknown
-
2011
- 2011-01-26 HK HK15103460.8A patent/HK1203352A1/xx unknown
-
2013
- 2013-12-13 CY CY20131101145T patent/CY1115081T1/el unknown
- 2013-12-18 JP JP2013260758A patent/JP2014074051A/ja active Pending
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