JP2011502994A5 - - Google Patents

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Publication number
JP2011502994A5
JP2011502994A5 JP2010532265A JP2010532265A JP2011502994A5 JP 2011502994 A5 JP2011502994 A5 JP 2011502994A5 JP 2010532265 A JP2010532265 A JP 2010532265A JP 2010532265 A JP2010532265 A JP 2010532265A JP 2011502994 A5 JP2011502994 A5 JP 2011502994A5
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JP
Japan
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independently
group
halogen
optionally
aliphatic
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JP2010532265A
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English (en)
Japanese (ja)
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JP2011502994A (ja
JP5444239B2 (ja
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Priority claimed from PCT/US2008/081933 external-priority patent/WO2009073300A1/en
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Publication of JP2011502994A5 publication Critical patent/JP2011502994A5/ja
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Publication of JP5444239B2 publication Critical patent/JP5444239B2/ja
Expired - Fee Related legal-status Critical Current
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JP2010532265A 2007-11-02 2008-10-31 タンパク質キナーゼC−θとしての[1H−ピラゾロ[3,4−B]ピリジン−4−イル]−フェニレンまたは−ピリジン−2−イル誘導体 Expired - Fee Related JP5444239B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US98487507P 2007-11-02 2007-11-02
US60/984,875 2007-11-02
US4457508P 2008-04-14 2008-04-14
US61/044,575 2008-04-14
US10080808P 2008-09-29 2008-09-29
US61/100,808 2008-09-29
PCT/US2008/081933 WO2009073300A1 (en) 2007-11-02 2008-10-31 [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or -pyridin-2-yle derivatives as protein kinase c-theta

Publications (3)

Publication Number Publication Date
JP2011502994A JP2011502994A (ja) 2011-01-27
JP2011502994A5 true JP2011502994A5 (enExample) 2012-12-13
JP5444239B2 JP5444239B2 (ja) 2014-03-19

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JP2010532265A Expired - Fee Related JP5444239B2 (ja) 2007-11-02 2008-10-31 タンパク質キナーゼC−θとしての[1H−ピラゾロ[3,4−B]ピリジン−4−イル]−フェニレンまたは−ピリジン−2−イル誘導体

Country Status (16)

Country Link
US (2) US8173635B2 (enExample)
EP (1) EP2215089B1 (enExample)
JP (1) JP5444239B2 (enExample)
KR (1) KR20100093552A (enExample)
CN (1) CN101903384A (enExample)
AR (1) AR069174A1 (enExample)
AU (1) AU2008331733A1 (enExample)
CA (1) CA2704266A1 (enExample)
CL (1) CL2008003280A1 (enExample)
ES (1) ES2389992T3 (enExample)
IL (1) IL205458A0 (enExample)
MX (1) MX2010004819A (enExample)
NZ (1) NZ585063A (enExample)
TW (1) TW200924762A (enExample)
WO (1) WO2009073300A1 (enExample)
ZA (1) ZA201003050B (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3456189B2 (ja) 2000-03-31 2003-10-14 日本電気株式会社 移動通信システム
AR060316A1 (es) 2006-01-17 2008-06-11 Vertex Pharma Azaindoles de utilidad como inhibidores de janus quinasas
US8247421B2 (en) 2006-12-21 2012-08-21 Vertex Pharmaceuticals Incorporated 5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors
CA2704266A1 (en) 2007-11-02 2009-06-11 Vertex Pharmaceuticals Incorporated [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or -pyridin-2-yle derivatives as protein kinase c-theta
EP2262498A2 (en) * 2008-03-10 2010-12-22 Vertex Pharmceuticals Incorporated Pyrimidines and pyridines useful as inhibitors of protein kinases
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
CA2732765A1 (en) * 2008-08-06 2010-02-11 Vertex Pharmaceuticals Incorporated Aminopyridine kinase inhibitors
CN105924386A (zh) 2009-03-25 2016-09-07 Abbvie 公司 抗病毒化合物和其用途
WO2010129668A1 (en) * 2009-05-06 2010-11-11 Vertex Pharmaceuticals Incorporated Pyrazolopyridines
GEAP202213376A (en) 2009-06-17 2022-02-25 Vertex Pharmaceuticals Incorporated Us Inhibitors of influenza viruses replication
MX2012008643A (es) 2010-01-27 2013-02-26 Vertex Pharma Inhibidores de cinasas de pirazolopiridinas.
CN102869663A (zh) 2010-01-27 2013-01-09 沃泰克斯药物股份有限公司 吡唑并吡嗪激酶抑制剂
US9067932B2 (en) 2010-01-27 2015-06-30 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
EP2528916A1 (en) * 2010-01-27 2012-12-05 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
EP2566866A1 (en) * 2010-05-05 2013-03-13 Vertex Pharmaceuticals Incorporated 4 substituted pyrazolopyrimidines useful as pkc-theta inhibitors
CN103492381A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
EP2651941A1 (en) 2010-12-16 2013-10-23 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
JP2013545818A (ja) 2010-12-16 2013-12-26 バーテックス ファーマシューティカルズ インコーポレイテッド インフルエンザウイルス複製阻害物質
UA118010C2 (uk) * 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
EP2858984A1 (en) 2012-06-08 2015-04-15 Vertex Pharmaceuticals Inc. Inhibitors of influenza viruses replication
WO2014120907A1 (en) 2013-01-30 2014-08-07 Ecolab Usa Inc. Hydrogen sulfide scavengers
HUE052178T2 (hu) 2013-11-13 2021-04-28 Vertex Pharma Eljárások influenzavírus-replikáció inhibitorainak elõállítására
LT3068776T (lt) 2013-11-13 2019-08-12 Vertex Pharmaceuticals Incorporated Gripo virusų replikacijos inhibitoriai
RU2016129380A (ru) 2013-12-20 2018-01-25 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Замещенные диаминопиримидильные соединения, их композиции и способы лечения с их участием
WO2016004272A1 (en) 2014-07-02 2016-01-07 Pharmacyclics Llc Inhibitors of bruton's tyrosine kinase
WO2016046130A1 (en) * 2014-09-22 2016-03-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of fibrosis
BR112017021486B1 (pt) 2015-04-22 2022-03-22 Championx Usa Inc Método para tratar sulfeto de hidrogênio em uma corrente
JP6857617B2 (ja) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated インフルエンザウイルスの複製の阻害剤
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
EP3347441B1 (en) 2015-09-08 2020-06-10 Ecolab USA Inc. Hydrocarbon soluble/dispersible hemiformals as hydrogen sulfide scavengers
US10584286B2 (en) 2015-09-08 2020-03-10 Ecolab Usa Inc. Hydrogen sulfide scavengers
US10336950B2 (en) 2016-07-29 2019-07-02 Ecolab Usa Inc. Antifouling and hydrogen sulfide scavenging compositions and methods
CN115215886B (zh) * 2016-09-09 2024-10-11 诺华股份有限公司 作为内体Toll样受体抑制剂的化合物及组合物
WO2019014415A1 (en) 2017-07-13 2019-01-17 Ecolab USA, Inc. METHOD FOR REMOVING A COMPOUND CONTAINING SULFUR BY ADDITION OF A COMPOSITION
EP3914676A1 (en) 2019-01-23 2021-12-01 ChampionX USA Inc. Complete removal of solids during hydrogen sulfide scavenging operations using a scavenger and a michael acceptor
MX2021012285A (es) 2019-04-09 2021-12-15 Nurix Therapeutics Inc Compuestos de piperidina 3-sustituidos para inhibicion del protooncogen-b de linfoma de linea b de casitas (cbl-b) y uso de un inhibidor de cbl-b en combinacion con una vacuna contra el cancer y/o con un virus oncolitico.
CN111529533B (zh) * 2020-06-05 2021-06-11 南华大学附属第一医院 溴结构域蛋白4抑制剂jq1或其衍生物在制备治疗脓毒症肠屏障损伤药物中的应用
KR20240024063A (ko) * 2021-05-06 2024-02-23 엑스사이언티아 에이아이 리미티드 Pkc-세타 조정제
KR20240024062A (ko) * 2021-05-06 2024-02-23 엑스사이언티아 에이아이 리미티드 Pkc-세타 조정제

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2080531A (en) * 1936-01-08 1937-05-18 United Shoe Machinery Corp Manufacture of shoes
US3314941A (en) * 1964-06-23 1967-04-18 American Cyanamid Co Novel substituted pyridodiazepins
GB1159487A (en) 1968-04-04 1969-07-23 Standard Telephones Cables Ltd Capacitors
US4988705A (en) * 1985-06-13 1991-01-29 Schering Corporation Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives
JP2890448B2 (ja) 1988-04-26 1999-05-17 日産化学工業株式会社 ピラゾロピリジン系メバロノラクトン類
US5100768A (en) * 1989-05-09 1992-03-31 Kabushiki Kaisha Toshiba Photosensitive composition
JPH03206450A (ja) * 1990-01-09 1991-09-09 Fuji Photo Film Co Ltd 新規な色素形成カプラー及びそれを用いたハロゲン化銀カラー写真感光材料及びその処理方法
JPH03271289A (ja) 1990-03-16 1991-12-03 Nissan Chem Ind Ltd ピラゾロピリジン誘導体の製造法及びジヒドロピラゾロピリジン誘導体
US5338740A (en) * 1993-07-13 1994-08-16 Pfizer Inc. Angiotensin II receptor antagonists
US5646330A (en) * 1995-02-17 1997-07-08 Ciba-Geigy Corporation Production of enantiomerically enriched ortho-substituted α,α-diaromatic methanols
US6194581B1 (en) * 1995-04-07 2001-02-27 Merck & Co., Inc. Substituted pyridines useful as modulators of acetylcholine receptors
SE9704544D0 (sv) * 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
US6452008B2 (en) * 1998-02-25 2002-09-17 Sumitomo Pharmaceuticals Company, Limited Pyridone derivatives and process for preparing the same
GB9908410D0 (en) * 1999-04-13 1999-06-09 Pfizer Ltd Pyridines
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
AR029289A1 (es) * 2000-07-05 2003-06-18 Ishihara Sangyo Kaisha Derivado de benzoilpiridina o su sal, fungicida que lo contiene como un ingrediente activo, su proceso de produccion e intermediario para producirlo
JP2002020386A (ja) 2000-07-07 2002-01-23 Ono Pharmaceut Co Ltd ピラゾロピリジン誘導体
DE10035908A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
AU2001288432A1 (en) * 2000-09-01 2002-03-22 Icos Corporation Materials and methods to potentiate cancer treatment
GB0128287D0 (en) 2001-11-26 2002-01-16 Smithkline Beecham Plc Novel method and compounds
US20030187026A1 (en) * 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
CA2470214A1 (en) * 2001-12-13 2003-06-26 Abbott Laboratories 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer
DE10222550A1 (de) * 2002-05-17 2003-11-27 Bayer Ag Substituierte Benzyl-pyrazolopyridine
EP2508204B1 (en) * 2002-06-26 2014-09-24 Ono Pharmaceutical Co., Ltd. Remedies for diseases caused by vascular contraction or dilation
BR0313396A (pt) 2002-08-12 2005-06-28 Sugen Inc 3-pirrolil-piridopirazóis e 3-pirrolil-indazóis, como inibidores de quinase
DE602004022633D1 (de) * 2003-01-30 2009-10-01 Boehringer Ingelheim Pharma 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen
EP1601357A4 (en) 2003-03-10 2007-10-03 Schering Corp HETEROCYCLIC KINASE INHIBITORS: METHOD OF USE AND SYNTHESIS
US20050203067A1 (en) * 2003-05-12 2005-09-15 Hresko Michelle C. Pesticidal compositions and methods
BRPI0412876A (pt) * 2003-07-22 2006-10-03 Janssen Pharmaceutica Nv derivados de quinolinona como inibidores de c-fms quinase
WO2005044181A2 (en) 2003-09-09 2005-05-19 Temple University-Of The Commonwealth System Of Higher Education Protection of tissues and cells from cytotoxic effects of ionizing radiation by abl inhibitors
WO2005061476A2 (en) * 2003-12-22 2005-07-07 Basilea Pharmaceutica Ag Aroylfuranes and aroylthiophenes
UY29177A1 (es) 2004-10-25 2006-05-31 Astex Therapeutics Ltd Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
WO2006050076A1 (en) 2004-10-29 2006-05-11 Janssen Pharmaceutica, N.V. Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders
ES2386027T3 (es) 2004-10-29 2012-08-07 Abbott Laboratories Inhibidores de quinasas novedosos
EP1812450A2 (en) 2004-11-10 2007-08-01 Eli Lilly And Company Tgf-beta inhibitors
DE102004061288A1 (de) * 2004-12-14 2006-06-29 Schering Ag 3-Amino-Pyrazolo[3,4b]pyridine als Inhibitoren von Proteintyrosinkinasen, deren Herstellung und Verwendung als Arzneimittel
PE20061119A1 (es) * 2005-01-19 2006-11-27 Aventis Pharma Sa PIRAZOLO PIRIDINAS SUSTITUIDAS COMO INHIBIDORES DE CINASAS FAK, KDR Y Tie
WO2006101456A1 (en) 2005-03-21 2006-09-28 S*Bio Pte Ltd Bicyclic heterocycles hydroxamate compounds useful as histone deacetylase (hdac) inhibitors
AU2006247322A1 (en) * 2005-05-16 2006-11-23 Irm Llc Pyrrolopyridine derivatives as protein kinase inhibitors
MX2007014377A (es) 2005-05-17 2008-02-06 Plexxikon Inc Inhibidores de proteina cinasa de derivados de pirrol (2,3-b) piridina.
DE102005035417A1 (de) 2005-07-28 2007-02-01 Robert Bosch Gmbh Entfernungsmessgerät und Verfahren zum Befestigen einer elektrooptischen Einheit an einer Leiterträgereinheit
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
DE102005048897A1 (de) 2005-10-12 2007-04-19 Sanofi-Aventis Deutschland Gmbh Diacylindazol-derivate als Inhibitoren von Lipasen und Phospholipasen
EP1968568A4 (en) 2005-12-22 2011-04-13 Glaxosmithkline Llc HEMMER OF NUTS ACTIVITY
US20070208053A1 (en) * 2006-01-19 2007-09-06 Arnold Lee D Fused heterobicyclic kinase inhibitors
WO2007125321A2 (en) 2006-04-25 2007-11-08 Astex Therapeutics Limited Purine and deazapurine derivatives as pharmaceutical compounds
TW200815438A (en) 2006-06-13 2008-04-01 Bayer Schering Pharma Ag Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
NZ576278A (en) 2006-10-19 2011-12-22 Signal Pharm Llc Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors
JP2008132121A (ja) * 2006-11-28 2008-06-12 Sanshin Kinzoku Kogyo Kk 移動ラック装置
US8338455B2 (en) 2006-12-20 2012-12-25 Amgen Inc. Compounds and methods of use
WO2008132121A1 (en) * 2007-04-26 2008-11-06 Glaxo Group Limited Lh-indazole-3-amine compounds as ikk1 inhibitors
CA2704266A1 (en) 2007-11-02 2009-06-11 Vertex Pharmaceuticals Incorporated [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or -pyridin-2-yle derivatives as protein kinase c-theta

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