JP2011500586A5 - - Google Patents

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JP2011500586A5
JP2011500586A5 JP2010529054A JP2010529054A JP2011500586A5 JP 2011500586 A5 JP2011500586 A5 JP 2011500586A5 JP 2010529054 A JP2010529054 A JP 2010529054A JP 2010529054 A JP2010529054 A JP 2010529054A JP 2011500586 A5 JP2011500586 A5 JP 2011500586A5
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group
membered heterocyclic
hydrogen
alkyl
aromatic
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JP2010529054A
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Japanese (ja)
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JP2011500586A (ja
JP5733856B2 (ja
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Priority claimed from PCT/US2008/079410 external-priority patent/WO2009049086A1/en
Publication of JP2011500586A publication Critical patent/JP2011500586A/ja
Publication of JP2011500586A5 publication Critical patent/JP2011500586A5/ja
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Publication of JP5733856B2 publication Critical patent/JP5733856B2/ja
Expired - Fee Related legal-status Critical Current
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JP2010529054A 2007-10-09 2008-10-09 広帯域β−ラクタマーゼ阻害薬 Expired - Fee Related JP5733856B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US99794107P 2007-10-09 2007-10-09
US99789807P 2007-10-09 2007-10-09
US60/997,941 2007-10-09
US60/997,898 2007-10-09
PCT/US2008/079410 WO2009049086A1 (en) 2007-10-09 2008-10-09 Broad spectrum beta-lactamase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015081763A Division JP2015155435A (ja) 2007-10-09 2015-04-13 広帯域β−ラクタマーゼ阻害薬

Publications (3)

Publication Number Publication Date
JP2011500586A JP2011500586A (ja) 2011-01-06
JP2011500586A5 true JP2011500586A5 (https=) 2012-09-13
JP5733856B2 JP5733856B2 (ja) 2015-06-10

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ID=40549565

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2010529054A Expired - Fee Related JP5733856B2 (ja) 2007-10-09 2008-10-09 広帯域β−ラクタマーゼ阻害薬
JP2015081763A Pending JP2015155435A (ja) 2007-10-09 2015-04-13 広帯域β−ラクタマーゼ阻害薬
JP2017106751A Pending JP2017193558A (ja) 2007-10-09 2017-05-30 広帯域β−ラクタマーゼ阻害薬
JP2018139646A Pending JP2018193388A (ja) 2007-10-09 2018-07-25 広帯域β−ラクタマーゼ阻害薬

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2015081763A Pending JP2015155435A (ja) 2007-10-09 2015-04-13 広帯域β−ラクタマーゼ阻害薬
JP2017106751A Pending JP2017193558A (ja) 2007-10-09 2017-05-30 広帯域β−ラクタマーゼ阻害薬
JP2018139646A Pending JP2018193388A (ja) 2007-10-09 2018-07-25 広帯域β−ラクタマーゼ阻害薬

Country Status (5)

Country Link
US (6) US8883772B2 (https=)
EP (1) EP2209474A4 (https=)
JP (4) JP5733856B2 (https=)
CA (2) CA2935651A1 (https=)
WO (1) WO2009049086A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050227309A1 (en) 2004-01-21 2005-10-13 Corry Schuyler B Optically-detectable enzyme substrates and their method of use
EP2209474A4 (en) 2007-10-09 2013-07-24 Sopharmia Inc BROAD SPECTRUM BETA-LACTAMASE INHIBITORS
WO2013036783A2 (en) 2011-09-09 2013-03-14 Cubist Pharmaceuticals, Inc. Methods for treating intrapulmonary infections
JP6403289B2 (ja) * 2013-03-12 2018-10-10 グラディウス ファーマシューティカルズ コーポレーションGladius Pharmaceuticals Corporation 誘導体化3−スチリル−セファロスポリン
CN104805066B (zh) * 2015-05-18 2018-04-24 武汉菲吉乐科生物科技有限公司 一种葡萄球菌裂解酶及其应用
US20190100534A1 (en) * 2017-10-04 2019-04-04 Gladius Pharmaceuticals, Inc. Cephem Compounds with Latent Reactive Groups
EP3795149A4 (en) 2018-05-14 2022-01-05 National University Corporation Tokai National Higher Education and Research System BETA-LACTAMASE INHIBITOR
WO2020018462A1 (en) 2018-07-16 2020-01-23 Brown University A chromogenic beta-lactamase substrate
US12195755B2 (en) 2019-05-20 2025-01-14 Brown University Placental lipid bilayer for cell-free molecular interaction studies
US12509559B2 (en) 2019-10-28 2025-12-30 Brown University Bacterial beta-lactamase responsive hydrogels
WO2024160247A1 (zh) * 2023-02-02 2024-08-08 苏州信诺维医药科技股份有限公司 含β-内酰胺酶抑制剂的药物组合物及其应用

Family Cites Families (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL130098C (https=) 1963-07-15
US3971778A (en) * 1972-05-12 1976-07-27 Glaxo Laboratories Limited Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position
US4065620A (en) * 1971-06-14 1977-12-27 Eli Lilly And Company 3-(Substituted) vinyl cephalosporins
BE789817A (fr) * 1971-10-07 1973-04-06 Glaxo Lab Ltd Perfectionnements aux composes de cephalosporine
US3947413A (en) 1972-11-13 1976-03-30 Merck & Co., Inc. 3-α-Substituted cephalosporins
US4095021A (en) * 1973-12-21 1978-06-13 Glaxo Laboratories Limited 3-Carbamoyloxymethyl or N-methyl-carbamoyloxymethyl-7-[2-carboxymethoxyimino-2-(fur-2-yl or thien-2-yl)acetamido]ceph-3-em-4-carboxylic acids and derivatives thereof
DE2418841C3 (de) 1974-04-19 1979-04-26 Messerschmitt-Boelkow-Blohm Gmbh, 8000 Muenchen Wärmetauscher, insbesondere regenerativ gekühlte Brennkammern für Flüssigkeitsraketentriebwerke und Verfahren zu ihrer Herstellung
CA1136132A (en) * 1975-02-17 1982-11-23 Teruji Tsuji Cyclization to form cephem ring and intermediates therefor
US3983113A (en) * 1975-08-15 1976-09-28 Syntex (U.S.A.) Inc. Cephalosporin type antibacterials
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4094978A (en) * 1976-07-29 1978-06-13 Syntex (U.S.A.) Inc. 3-propenyl derivatives of cephalosporin, compositions and their use
JPS5331690A (en) 1976-09-01 1978-03-25 Shionogi & Co Ltd Oxadithiacephalosporins
JPS6011713B2 (ja) 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
LU77306A1 (https=) * 1977-05-09 1979-01-18
US4500457A (en) * 1977-05-09 1985-02-19 Ciba-Geigy Corporation Process for preparing thia-aza compounds with a beta-lactam ring
US4255423A (en) * 1977-07-27 1981-03-10 Merck & Co., Inc. Cephalosporin compounds
EP0003960B1 (de) * 1978-02-02 1983-06-29 Ciba-Geigy Ag 6-Substituierte Thia-Azaverbindungen, ihre Herstellung und diese enthaltende pharmazeutische Präparate
AR228726A1 (es) 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
FR2457296A1 (fr) * 1979-05-23 1980-12-19 Rhone Poulenc Ind Nouveaux derives de vinyl-3 cephalosporines et leur preparation
FR2474504A1 (fr) * 1979-05-23 1981-07-31 Rhone Poulenc Ind Nouvelles thiovinyl-3 cephalosporines, leur preparation et les medicaments qui les contiennent
CH645117A5 (fr) * 1979-05-23 1984-09-14 Rhone Poulenc Ind Thiovinyl-3 cephalosporines, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2457297A1 (fr) * 1979-05-23 1980-12-19 Rhone Poulenc Ind Nouvelles vinyl-3 cephalosporines, et leur preparation
US4388326A (en) * 1979-08-15 1983-06-14 Merck & Co., Inc. Phenyl hydroxypropyl sulfoxide enzyme inhibitors
US4558071A (en) * 1979-08-15 1985-12-10 Merck & Co., Inc. Phenyl, trihalomethyl or heteroaryl sulfoxides having a latent allyl group bound to sulfur as enzyme inhibitors
US4342758A (en) * 1979-08-15 1982-08-03 Merck & Co., Inc. Allylsulfoxide enzyme inhibitors
PT71651B (en) 1979-08-15 1982-01-21 Merck & Co Inc Process for preparing allysulfoxide enzyme inhibitors
US4654359A (en) * 1979-08-15 1987-03-31 Merck & Co., Inc. Allylsulfoxide enzyme inhibitors
US4760067A (en) * 1979-08-15 1988-07-26 Merck & Co., Inc. Allylsulfoxide enzyme inhibitors
NL8100539A (nl) * 1980-02-12 1981-09-01 Rhone Poulenc Ind Nieuwe thiolesters, de bereiding daarvan en hun gebruik bij syntheses.
FR2494280A1 (fr) 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouveaux derives de la cephalosporine et leur preparation
US4380512A (en) * 1980-12-11 1983-04-19 Bristol-Myers Company 2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone and salts and esters thereof
US4382931A (en) 1981-09-08 1983-05-10 Eli Lilly And Company 3'-Substituted quinolinium cephalosporins
US4546101A (en) * 1982-09-10 1985-10-08 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds useful for treating infectious diseases in human being and animals and processes for preparation thereof
GB8301694D0 (en) 1983-01-21 1983-02-23 Beecham Group Plc Beta-lactam antibacterial agents
US4520022A (en) * 1983-01-28 1985-05-28 Bristol-Myers Company Substituted vinyl cephalosporins
US4855420A (en) 1983-06-03 1989-08-08 Ici Pharma Cephalosporin derivatives
EP0133670A3 (de) * 1983-08-09 1985-12-18 Bayer Ag Verfahren zur Herstellung von 7-Acylamino-3-hydrocy-cephem-4-carbonsäuren und 7-Acylamino-3-hydroxy-1-de-thia-1-oxacephem-4-carbonsäuren
JPS60197693A (ja) 1984-03-19 1985-10-07 Eisai Co Ltd 3−(キヌクリジニウム)メチル−3−セフエム誘導体
IE58487B1 (en) * 1984-09-07 1993-09-22 Kaisha Maiji Seika New cephalosporin compounds and the production thereof
JPS61178991A (ja) * 1984-09-07 1986-08-11 Meiji Seika Kaisha Ltd 新規セフアロスポリン化合物
US4874856A (en) 1985-06-24 1989-10-17 Bristol-Myers Company 3-(substituted)propenyl-7-(aminothiazolylacetamido) ceph-3-em-4-carboxylic acids and esters thereof
US4692517A (en) 1986-03-20 1987-09-08 American Home Products Corporation C-3' acylaminooxy-7-[(2-aminothiazol-4-yl)-α-(substituted-oximino)acetyl]cephalosporin derivatives
JPS62270589A (ja) 1986-05-19 1987-11-24 Banyu Pharmaceut Co Ltd 新規セフアロスポリン誘導体
US4870168A (en) * 1987-02-26 1989-09-26 Bristol-Myers Company 3-Unsaturated alkyl cephems from 3-triflyl cephems
JPS63211286A (ja) 1987-02-27 1988-09-02 Sagami Chem Res Center β−ラクタム誘導体
DE3734004A1 (de) 1987-05-26 1988-12-15 Bayer Ag Substituierte vinylcephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US5171854A (en) * 1987-05-26 1992-12-15 Bayer Aktiengesellschaft Substituted vinylcephalosporins
DE3734005A1 (de) 1987-05-26 1988-12-15 Bayer Ag Substituierte vinylcephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPH01175982A (ja) 1987-12-28 1989-07-12 Mochida Pharmaceut Co Ltd 新規セファロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
US5073551A (en) * 1988-03-30 1991-12-17 Sagami Chemical Research Center Cephalosporin compounds
US5336768A (en) * 1988-05-24 1994-08-09 Hoffmann-La Roche Inc. Antibacterial cephalosporin compounds
JPH0228185A (ja) 1988-04-14 1990-01-30 Tanabe Seiyaku Co Ltd セファロスポリン化合物及びその合成中間体
GB8813945D0 (en) 1988-06-13 1988-07-20 Fujisawa Pharmaceutical Co New cephem compounds & process for preparation thereof
JPH0686463B2 (ja) * 1988-07-01 1994-11-02 明治製菓株式会社 新規セフェム化合物、その製造法及び抗菌剤
GB8817653D0 (en) 1988-07-25 1988-09-01 Fujisawa Pharmaceutical Co New cephem compounds & processes for preparation thereof
JPH0635464B2 (ja) * 1988-09-02 1994-05-11 明治製菓株式会社 新規セフェム化合物、その製造法及び抗菌剤
JPH0699448B2 (ja) 1989-02-22 1994-12-07 明治製菓株式会社 新規セファロスポリン化合物及び抗菌剤
JP2834771B2 (ja) * 1989-06-02 1998-12-14 エーザイ株式会社 チアゾリルアセトアミドセフェム誘導体
IL94946A0 (en) * 1989-07-13 1991-06-10 Eisai Co Ltd 3-substituted vinyl cephalosporin derivatives,their preparation and pharmaceutical compositions containing them
US5143910A (en) 1989-09-07 1992-09-01 Shionogi & Co., Ltd. Piperaziniocephalosporins
US5373001A (en) * 1990-06-15 1994-12-13 Roussel Uclaf Cephalosporins
US5397779A (en) * 1990-06-15 1995-03-14 Roussel-Uclaf Cephalosporins
US5126336A (en) 1990-08-23 1992-06-30 Bristol-Myers Squibb Company Antibiotic c-3 catechol-substituted cephalosporin compounds, compositions and method of use thereof
JPH04112891A (ja) 1990-09-04 1992-04-14 Ajinomoto Co Inc 新規オキシム誘導体及び該誘導体を含有する抗菌剤
DE4030706A1 (de) 1990-09-28 1992-04-02 Bayer Ag Neue 3-substituierte cephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US5194433A (en) 1990-11-13 1993-03-16 Bristol-Myers Squibb Company Antibiotic c-3 catechol-substituted cephalosporin compounds, compositions and method of use thereof
ES2157199T3 (es) 1991-03-08 2001-08-16 Biochemie Gmbh Nuevo procedimiento para la produccion de cefalosporinas y nuevos compuestos intermedios para este procedimiento.
US6248881B1 (en) * 1991-03-08 2001-06-19 Biochemie Gmbh Intermediates and process for the production of 3-vinyl cephalosporins
GB9111406D0 (en) 1991-05-28 1991-07-17 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
GB9118672D0 (en) 1991-08-30 1991-10-16 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
EP0544166A3 (en) 1991-11-26 1993-11-03 Hoffmann La Roche Cephalosporinderivatives
ATE208374T1 (de) 1992-02-18 2001-11-15 Otsuka Kagaku Kk Beta-laktam und cepham verbindungen und ihre herstellung
JP3224279B2 (ja) * 1992-07-27 2001-10-29 大塚化学株式会社 セフエム化合物の製造法
JPH06145176A (ja) 1992-11-10 1994-05-24 Kyoto Yakuhin Kogyo Kk セファロスポリン化合物、その製造法および中間体化合物
AU6291194A (en) * 1993-03-26 1994-10-24 Yamanouchi Pharmaceutical Co., Ltd. Cephalosporin derivative
JPH06345775A (ja) 1993-06-04 1994-12-20 Kyoto Yakuhin Kogyo Kk セファロスポリン化合物、その製造法および中間体化合物
KR100257130B1 (ko) * 1993-09-11 2000-05-15 성재갑 신규 세팔로스포린계 항생제 및 이의 제조방법
US5854227A (en) 1994-03-04 1998-12-29 Hartmann; John F. Therapeutic derivatives of diphosphonates
JPH093074A (ja) 1995-06-20 1997-01-07 Kyoto Yakuhin Kogyo Kk セファロスポリン化合物、その用途および中間体化合物
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
CN1239963A (zh) 1996-12-09 1999-12-29 明治制果株式会社 新的头孢烯衍生物
JP4157177B2 (ja) * 1997-06-04 2008-09-24 大塚化学ホールディングス株式会社 3−アルケニルセフェム化合物の製造法
ES2258980T3 (es) * 1999-08-16 2006-09-16 Revaax Pharmaceuticals Llc Composiciones farmaceuticas que comprenden acido clavulanico o derivados del mismo para el tratamiento de trastornos del comportamiento.
JP4510957B2 (ja) * 1999-09-01 2010-07-28 大塚化学株式会社 セフェム化合物の製造方法
AU9025601A (en) * 2000-09-22 2002-04-02 Zenyaku Kogyo Kabushiki Kaisya Cephem compounds and esbl-detecting reagents containing the same
TW200305422A (en) 2002-03-18 2003-11-01 Shionogi & Co Broad spectrum cefem compounds
CA2504730C (en) 2002-10-30 2011-04-12 Astellas Pharma Inc. Cephem compounds
EP1635812A2 (en) * 2003-06-10 2006-03-22 Fulcrum Pharmaceuticals, Inc. Beta-lactamase inhibitors and methods of use thereof
CN100384857C (zh) 2003-11-28 2008-04-30 浙江永宁制药厂 耐β-内酰胺酶的头孢菌素酯化合物及其盐
WO2007065288A2 (en) 2005-12-07 2007-06-14 Basilea Pharmaceutica Ag Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
WO2007096740A2 (en) 2006-02-20 2007-08-30 Orchid Research Laboratories Limited Novel cephalosporins
JP2009530228A (ja) 2006-03-16 2009-08-27 アステラス製薬株式会社 セフェム化合物および抗菌薬としての利用
EP2209474A4 (en) 2007-10-09 2013-07-24 Sopharmia Inc BROAD SPECTRUM BETA-LACTAMASE INHIBITORS
US9238657B2 (en) 2008-10-31 2016-01-19 Shionogi & Co., Ltd. Cephalosporin having catechol group
US20100261700A1 (en) * 2009-04-09 2010-10-14 Larry Sutton Beta-lactamase inhibitors
US20120329770A1 (en) 2010-02-26 2012-12-27 Gary Igor Dmitrienko Cephalosporin derivatives useful as beta-lactamase inhibitors and compositions and methods of use thereof
KR20130018845A (ko) 2010-04-05 2013-02-25 시오노기세야쿠 가부시키가이샤 카테콜기를 갖는 세펨 화합물
CN102918047A (zh) 2010-04-05 2013-02-06 盐野义制药株式会社 具有假儿茶酚基团的头孢烯类化合物
US9085589B2 (en) 2010-04-28 2015-07-21 Shionogi & Co., Ltd. Cephem derivative
KR101719556B1 (ko) 2011-03-30 2017-03-24 주식회사 레고켐 바이오사이언스 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물
US9334289B2 (en) 2011-04-28 2016-05-10 Shionogi & Co., Ltd. Cephem compound having catechol or pseudo-catechol structure
WO2013051597A1 (ja) 2011-10-04 2013-04-11 塩野義製薬株式会社 カテコール基を有するセフェム誘導体
TWI547496B (zh) 2011-10-04 2016-09-01 葛蘭素集團公司 抗菌化合物
JP6403289B2 (ja) 2013-03-12 2018-10-10 グラディウス ファーマシューティカルズ コーポレーションGladius Pharmaceuticals Corporation 誘導体化3−スチリル−セファロスポリン

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