JP2011046700A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011046700A5 JP2011046700A5 JP2010171260A JP2010171260A JP2011046700A5 JP 2011046700 A5 JP2011046700 A5 JP 2011046700A5 JP 2010171260 A JP2010171260 A JP 2010171260A JP 2010171260 A JP2010171260 A JP 2010171260A JP 2011046700 A5 JP2011046700 A5 JP 2011046700A5
- Authority
- JP
- Japan
- Prior art keywords
- solvate
- pharmaceutically acceptable
- acceptable salt
- group
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 48
- 150000003839 salts Chemical class 0.000 claims 48
- 239000012453 solvate Substances 0.000 claims 48
- 239000000126 substance Substances 0.000 claims 17
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 11
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 229940122245 Janus kinase inhibitor Drugs 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 230000001225 therapeutic effect Effects 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 230000003449 preventive effect Effects 0.000 claims 4
- 230000000069 prophylactic effect Effects 0.000 claims 4
- 238000002054 transplantation Methods 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 125000003320 C2-C6 alkenyloxy group Chemical group 0.000 claims 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 2
- 206010013774 Dry eye Diseases 0.000 claims 2
- 102000015617 Janus Kinases Human genes 0.000 claims 2
- 108010024121 Janus Kinases Proteins 0.000 claims 2
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 102000006503 Janus Kinase 2 Human genes 0.000 claims 1
- 108010019437 Janus Kinase 2 Proteins 0.000 claims 1
- 102000006500 Janus Kinase 3 Human genes 0.000 claims 1
- 108010019421 Janus Kinase 3 Proteins 0.000 claims 1
- 229940121730 Janus kinase 2 inhibitor Drugs 0.000 claims 1
- 229940123241 Janus kinase 3 inhibitor Drugs 0.000 claims 1
- 229940124384 agent for atopic dermatitis Drugs 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010171260A JP5520158B2 (ja) | 2009-07-31 | 2010-07-30 | 含窒素スピロ環化合物及びその医薬用途 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009179502 | 2009-07-31 | ||
| JP2009179502 | 2009-07-31 | ||
| JP2010171260A JP5520158B2 (ja) | 2009-07-31 | 2010-07-30 | 含窒素スピロ環化合物及びその医薬用途 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014077850A Division JP2014141516A (ja) | 2009-07-31 | 2014-04-04 | 含窒素スピロ環化合物及びその医薬用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011046700A JP2011046700A (ja) | 2011-03-10 |
| JP2011046700A5 true JP2011046700A5 (enExample) | 2014-02-13 |
| JP5520158B2 JP5520158B2 (ja) | 2014-06-11 |
Family
ID=43529436
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010171260A Active JP5520158B2 (ja) | 2009-07-31 | 2010-07-30 | 含窒素スピロ環化合物及びその医薬用途 |
| JP2014077850A Pending JP2014141516A (ja) | 2009-07-31 | 2014-04-04 | 含窒素スピロ環化合物及びその医薬用途 |
| JP2015224910A Ceased JP2016029104A (ja) | 2009-07-31 | 2015-11-17 | 含窒素スピロ環化合物及びその医薬用途 |
| JP2016214954A Ceased JP2017019877A (ja) | 2009-07-31 | 2016-11-02 | 含窒素スピロ環化合物及びその医薬用途 |
| JP2018028525A Ceased JP2018111701A (ja) | 2009-07-31 | 2018-02-21 | 含窒素スピロ環化合物及びその医薬用途 |
| JP2019219283A Withdrawn JP2020033384A (ja) | 2009-07-31 | 2019-12-04 | 含窒素スピロ環化合物及びその医薬用途 |
| JP2021144545A Withdrawn JP2021183653A (ja) | 2009-07-31 | 2021-09-06 | 含窒素スピロ環化合物及びその医薬用途 |
| JP2023128376A Withdrawn JP2023138641A (ja) | 2009-07-31 | 2023-08-07 | 含窒素スピロ環化合物及びその医薬用途 |
| JP2025077764A Withdrawn JP2025109780A (ja) | 2009-07-31 | 2025-05-08 | 含窒素スピロ環化合物及びその医薬用途 |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014077850A Pending JP2014141516A (ja) | 2009-07-31 | 2014-04-04 | 含窒素スピロ環化合物及びその医薬用途 |
| JP2015224910A Ceased JP2016029104A (ja) | 2009-07-31 | 2015-11-17 | 含窒素スピロ環化合物及びその医薬用途 |
| JP2016214954A Ceased JP2017019877A (ja) | 2009-07-31 | 2016-11-02 | 含窒素スピロ環化合物及びその医薬用途 |
| JP2018028525A Ceased JP2018111701A (ja) | 2009-07-31 | 2018-02-21 | 含窒素スピロ環化合物及びその医薬用途 |
| JP2019219283A Withdrawn JP2020033384A (ja) | 2009-07-31 | 2019-12-04 | 含窒素スピロ環化合物及びその医薬用途 |
| JP2021144545A Withdrawn JP2021183653A (ja) | 2009-07-31 | 2021-09-06 | 含窒素スピロ環化合物及びその医薬用途 |
| JP2023128376A Withdrawn JP2023138641A (ja) | 2009-07-31 | 2023-08-07 | 含窒素スピロ環化合物及びその医薬用途 |
| JP2025077764A Withdrawn JP2025109780A (ja) | 2009-07-31 | 2025-05-08 | 含窒素スピロ環化合物及びその医薬用途 |
Country Status (35)
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI466885B (zh) * | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
| WO2011029043A1 (en) * | 2009-09-04 | 2011-03-10 | Biogen Idec Ma Inc. | Heteroaryl btk inhibitors |
| BR112013003864B1 (pt) * | 2010-08-20 | 2021-08-31 | Hutchison Medipharma Limited | Compostos de pirrolpirimidina, composição e uso dos mesmos |
| PL2651417T3 (pl) | 2010-12-16 | 2017-08-31 | Calchan Limited | Pochodne pirolopirymidyny hamujące ASK1 |
| JP6075736B2 (ja) | 2011-12-21 | 2017-02-08 | ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． | ピロール−６員ヘテロアリール環誘導体、その合成法およびその医薬用途 |
| US20140343034A1 (en) * | 2013-04-25 | 2014-11-20 | Japan Tobacco Inc. | Skin barrier function improving agent |
| WO2015060208A1 (ja) | 2013-10-21 | 2015-04-30 | 日本たばこ産業株式会社 | 眼疾患の治療剤又は予防剤 |
| KR102518994B1 (ko) * | 2014-05-28 | 2023-04-05 | 아스트라제네카 아베 | Azd5363의 제조 방법 및 그에 사용되는 신규 중간체 |
| BR112017026173A2 (pt) * | 2015-07-07 | 2018-08-14 | Japan Tobacco, Inc. | Método para produção de derivado de 7h-pirrolo [2,3-d]pirimidina e intermediário do mesmo |
| WO2017013270A1 (en) | 2015-07-23 | 2017-01-26 | Universite De Strasbourg | Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy |
| CN108135834B (zh) | 2015-09-24 | 2021-07-27 | 利奥制药有限公司 | 斑秃的治疗 |
| KR102774784B1 (ko) * | 2015-09-25 | 2025-02-27 | 디잘 (지앙수) 파마슈티칼 씨오., 리미티드 | Jak를 억제하기 위한 화합물 및 방법 |
| ES2963784T3 (es) * | 2016-01-21 | 2024-04-02 | Leo Pharma As | Uso de delgocitinib para el tratamiento del eccema crónico de manos |
| PE20190501A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores nmda espiro-lactam y metodos de uso de los mismos |
| WO2018095320A1 (zh) | 2016-11-23 | 2018-05-31 | 江苏恒瑞医药股份有限公司 | 吡咯并六元杂芳环类衍生物的制备方法及中间体 |
| BR112019012267A2 (pt) * | 2016-12-21 | 2019-12-03 | Japan Tobacco, Inc. | processo para a preparação do derivado de 7h-pirrolo [2,3-d]pirimidina e cocristais do mesmo |
| PL3560932T3 (pl) * | 2016-12-21 | 2026-06-29 | Japan Tobacco Inc. | Sposób wytwarzania pochodnych 7H‑pirolo[2,3‑d]pirymidyny i ich syntetycznych produktów pośrednich |
| TWI822666B (zh) * | 2016-12-21 | 2023-11-21 | 日商日本煙草產業股份有限公司 | Ｊａｎｕｓ激酶抑制劑之結晶型 |
| CN110291090A (zh) * | 2017-01-20 | 2019-09-27 | 利奥制药有限公司 | 作为新型jak激酶抑制剂的双环胺 |
| US10799507B2 (en) * | 2017-02-03 | 2020-10-13 | Leo Pharma A/S | 5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.5]octane-8-carboxylic acid derivatives as novel JAK kinase inhibitors |
| MX2020003821A (es) * | 2017-10-10 | 2023-01-12 | Biogen Inc | Proceso de elaboración de espiroderivados. |
| JP2021512109A (ja) * | 2018-01-31 | 2021-05-13 | アプティニックス インコーポレイテッド | スピロラクタム系ｎｍｄａ受容体修飾因子およびその使用 |
| WO2020007698A1 (en) * | 2018-07-06 | 2020-01-09 | Leo Pharma A/S | Novel amino-imidazopyrimidine derivatives as janus kinase inhibitors and pharmaceutical use thereof |
| WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
| FI3968997T3 (fi) | 2019-05-15 | 2026-06-09 | Leo Pharma As | Delgositinibin formulaatio voiteen muodossa |
| JP7597714B2 (ja) * | 2019-08-07 | 2024-12-10 | ロート製薬株式会社 | 涙液分泌促進用眼科組成物 |
| CN119367282A (zh) * | 2019-12-27 | 2025-01-28 | 乐敦制药株式会社 | 水性组合物 |
| CN111606929B (zh) * | 2020-06-30 | 2023-07-07 | 中瀚(齐河县)生物医药科技有限公司 | 德高替尼的制备方法 |
| CN111560021B (zh) * | 2020-06-30 | 2023-05-26 | 上海鲲博玖瑞医药科技发展有限公司 | 一种德高替尼中间体及其制备方法 |
| CN111574540B (zh) * | 2020-06-30 | 2023-08-29 | 云南华派医药科技有限公司 | 一种德高替尼的制备方法 |
| TW202227452A (zh) * | 2020-12-04 | 2022-07-16 | 大陸商廣州費米子科技有限責任公司 | 氮雜並環化合物、其製備方法、抑制酪氨酸激酶的方法、藥物組成物及其用途 |
| TW202241439A (zh) * | 2020-12-29 | 2022-11-01 | 大陸商上海岸闊醫藥科技有限公司 | 治療與抗腫瘤劑相關的皮膚疾病或病症的試劑和方法 |
| JP2025514747A (ja) | 2022-04-20 | 2025-05-09 | レオ ファーマ アクティーゼルスカブ | 前頭部線維性脱毛症の治療 |
| AU2024229918A1 (en) | 2023-02-28 | 2025-09-18 | Assia Chemical Industries Ltd. | Solid state forms of delgocitinib and process thereof |
| JP2026509302A (ja) | 2023-03-17 | 2026-03-17 | レオ ファーマ アクティーゼルスカブ | 中等症ないし重症の慢性手湿疹を有する患者における慢性手湿疹を処置する方法 |
| WO2024225445A1 (en) | 2023-04-27 | 2024-10-31 | Japan Tobacco Inc. | Crystalline form of delgocitinib |
| WO2025085050A1 (en) * | 2023-10-16 | 2025-04-24 | Leo Pharma A/S | Treatment of frontal fibrosing alopecia |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0103836A3 (en) | 1998-06-02 | 2003-05-28 | Osi Pharmaceuticals Inc Uniond | Pyrrolo[2,3d]pyrimidine compositions and their use |
| PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| AU3951899A (en) * | 1998-06-19 | 2000-01-05 | Pfizer Products Inc. | Pyrrolo(2,3-d)pyrimidine compounds |
| OA12118A (en) * | 1999-12-10 | 2006-05-04 | Pfizer Prod Inc | PyrroloÄ2,3-dÜpyrimidine compounds. |
| PT1519939E (pt) * | 2002-07-05 | 2010-02-10 | Targacept Inc | Compostos n-arildiazaspirocíclicos e métodos para a sua preparação e utilização |
| WO2005047286A1 (ja) | 2003-11-13 | 2005-05-26 | Ono Pharmaceutical Co., Ltd. | スピロ複素環化合物 |
| AR054416A1 (es) * | 2004-12-22 | 2007-06-27 | Incyte Corp | Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas. |
| US20090111805A1 (en) | 2005-02-24 | 2009-04-30 | Pfizer Inc. | Bicyclic heteroaromatic derivatives useful as anticancer agents |
| JP2008545660A (ja) * | 2005-05-20 | 2008-12-18 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼ阻害剤として有用なピロロピリジン化合物 |
| JP5071374B2 (ja) * | 2005-07-14 | 2012-11-14 | アステラス製薬株式会社 | ヘテロ環ヤヌスキナーゼ３阻害剤 |
| HUE028588T2 (hu) | 2005-12-13 | 2016-12-28 | Incyte Holdings Corp | Heteroaril-szubsztituált pirrolo[2,3-b]piridinek és pirrolo[2,3-b]pirimidinek mint Janus-kináz inhibitorok |
| GB0526246D0 (en) * | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| WO2007084667A2 (en) | 2006-01-19 | 2007-07-26 | Osi Pharmaceutical, Inc. | Fused heterobicyclic kinase inhibitors |
| US20070208001A1 (en) | 2006-03-03 | 2007-09-06 | Jincong Zhuo | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| WO2008029237A2 (en) | 2006-09-05 | 2008-03-13 | Pfizer Products Inc. | Combination therapies for rheumatoid arthritis |
| CA2674518A1 (en) | 2006-12-22 | 2008-07-03 | F.Hoffmann-La Roche Ag | Spiro-piperidine derivatives |
| CL2008000467A1 (es) * | 2007-02-14 | 2008-08-22 | Janssen Pharmaceutica Nv | Compuestos derivados de 2-aminopirimidina, moduladores del receptor histamina h4; su procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno inflamatorio seleccionado de alegia, asma |
| EP2142550A1 (en) * | 2007-04-02 | 2010-01-13 | Palau Pharma, S.A. | Pyrrolopyrimidine derivatives as jak3 inhibitors |
| WO2009047255A1 (en) * | 2007-10-09 | 2009-04-16 | Ucb Pharma, S.A. | Heterobicyclic compounds as histamine h4-receptor antagonists |
| TW200940542A (en) | 2008-01-09 | 2009-10-01 | Array Biopharma Inc | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| CL2009001152A1 (es) | 2008-05-13 | 2009-10-16 | Array Biopharma Inc | Compuestos derivados de n-(4-(cicloalquilo nitrogenado-1-il)-1h-pirrolo[2,3-b]piridin-3-il)amida, inhibidores de cinasa; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una enfermedad proliferativa. |
| CA2728559A1 (en) | 2008-07-03 | 2010-01-07 | Exelixis Inc. | Cdk modulators |
| NZ596479A (en) | 2009-05-22 | 2014-01-31 | Incyte Corp | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| GB0913342D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | Compounds - 801 |
| TWI466885B (zh) * | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
| WO2011029043A1 (en) | 2009-09-04 | 2011-03-10 | Biogen Idec Ma Inc. | Heteroaryl btk inhibitors |
| JP2018028525A (ja) * | 2016-08-15 | 2018-02-22 | 小野 信行 | イオンレーザーと重水素を利用した核融合炉 |
| JP6229778B2 (ja) * | 2016-09-21 | 2017-11-15 | サミー株式会社 | 遊技機 |
-
2010
- 2010-07-22 TW TW99124110A patent/TWI466885B/zh active
- 2010-07-23 AR ARP100102681A patent/AR077497A1/es active IP Right Grant
- 2010-07-30 HU HUE10804531A patent/HUE033070T2/hu unknown
- 2010-07-30 SM SM20170166T patent/SMT201700166T1/it unknown
- 2010-07-30 AU AU2010278066A patent/AU2010278066B2/en active Active
- 2010-07-30 PT PT108045311T patent/PT2460806T/pt unknown
- 2010-07-30 SG SG2011094117A patent/SG176918A1/en unknown
- 2010-07-30 PE PE2012000097A patent/PE20121276A1/es active IP Right Grant
- 2010-07-30 RS RS20170305A patent/RS55913B1/sr unknown
- 2010-07-30 EP EP17150170.3A patent/EP3181570A1/en not_active Withdrawn
- 2010-07-30 SI SI201031426A patent/SI2460806T1/sl unknown
- 2010-07-30 PL PL10804531T patent/PL2460806T3/pl unknown
- 2010-07-30 US US12/847,025 patent/US8609647B2/en active Active
- 2010-07-30 MX MX2012001313A patent/MX2012001313A/es active IP Right Grant
- 2010-07-30 HR HRP20170447TT patent/HRP20170447T1/hr unknown
- 2010-07-30 NZ NZ597994A patent/NZ597994A/xx unknown
- 2010-07-30 WO PCT/JP2010/062873 patent/WO2011013785A1/ja not_active Ceased
- 2010-07-30 KR KR1020127001455A patent/KR101773208B1/ko active Active
- 2010-07-30 CA CA2767899A patent/CA2767899C/en active Active
- 2010-07-30 ME MEP-2017-74A patent/ME02667B/me unknown
- 2010-07-30 LT LTEP10804531.1T patent/LT2460806T/lt unknown
- 2010-07-30 CN CN201080034068.1A patent/CN102510865B/zh active Active
- 2010-07-30 BR BR112012002157-5A patent/BR112012002157B1/pt active IP Right Grant
- 2010-07-30 EP EP10804531.1A patent/EP2460806B1/en active Active
- 2010-07-30 EP EP21159390.0A patent/EP3858349A1/en not_active Withdrawn
- 2010-07-30 MY MYPI2012000155A patent/MY163495A/en unknown
- 2010-07-30 ES ES10804531.1T patent/ES2616705T3/es active Active
- 2010-07-30 JP JP2010171260A patent/JP5520158B2/ja active Active
- 2010-07-30 RU RU2012106344A patent/RU2630694C2/ru active
- 2010-07-30 DK DK10804531.1T patent/DK2460806T3/en active
-
2011
- 2011-12-18 IL IL217048A patent/IL217048A/en active IP Right Grant
-
2012
- 2012-01-18 CO CO12006869A patent/CO6491052A2/es active IP Right Grant
- 2012-01-27 ZA ZA2012/00689A patent/ZA201200689B/en unknown
-
2013
- 2013-11-12 US US14/077,446 patent/US20140187534A1/en not_active Abandoned
-
2014
- 2014-04-04 JP JP2014077850A patent/JP2014141516A/ja active Pending
-
2015
- 2015-11-17 JP JP2015224910A patent/JP2016029104A/ja not_active Ceased
-
2016
- 2016-11-02 JP JP2016214954A patent/JP2017019877A/ja not_active Ceased
-
2017
- 2017-03-20 CY CY20171100348T patent/CY1118747T1/el unknown
-
2018
- 2018-02-21 JP JP2018028525A patent/JP2018111701A/ja not_active Ceased
-
2019
- 2019-12-04 JP JP2019219283A patent/JP2020033384A/ja not_active Withdrawn
-
2021
- 2021-09-06 JP JP2021144545A patent/JP2021183653A/ja not_active Withdrawn
- 2021-12-21 US US17/557,174 patent/US20230023377A1/en not_active Abandoned
-
2023
- 2023-05-05 US US18/143,720 patent/US20240150367A1/en not_active Abandoned
- 2023-08-07 JP JP2023128376A patent/JP2023138641A/ja not_active Withdrawn
-
2025
- 2025-02-28 FI FIC20250012C patent/FIC20250012I1/fi unknown
- 2025-02-28 FR FR25C1010C patent/FR25C1010I2/fr active Active
- 2025-02-28 CY CY2025008C patent/CY2025008I2/el unknown
- 2025-03-03 LT LTPA2025511C patent/LTC2460806I2/lt unknown
- 2025-03-03 HU HUS2500013C patent/HUS2500013I1/hu unknown
- 2025-03-04 NL NL301321C patent/NL301321I2/nl unknown
- 2025-05-08 JP JP2025077764A patent/JP2025109780A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2012106344A (ru) | Азотсодержащее спироциклическое соединение и его применение в медицине | |
| RU2017125025A (ru) | Конденсированные кольцевые гетероарильные соединения и их применение в качестве ингибиторов trk | |
| RU2378263C2 (ru) | Производные 5-фенилтиазола и их применение в качестве ингибиторов рi3 киназы | |
| JP2010535722A5 (enExample) | ||
| JP2014517017A5 (ja) | 化合物、その医薬組成物、及び癌治療用の阻害薬としてのその使用 | |
| EA201001455A1 (ru) | Пиридины и пиразины в качестве ингибиторов pi3k (фосфатидилинозиткиназы-3) | |
| EA201391558A1 (ru) | Тетрагидропиразоло[1,5-а]пиримидины как противотуберкулезные соединения | |
| JP2013063968A5 (enExample) | ||
| JP2007508359A5 (enExample) | ||
| MY155133A (en) | Compounds having crth2 antagonist activity | |
| RU2012127334A (ru) | Производные 5-замещенного хиназолинона, содержащие их композиции и способы их применения | |
| JP2015501799A5 (enExample) | ||
| DE60103136D1 (de) | Imidazol derivate als raf kinase inhibitoren | |
| JP2012526143A5 (enExample) | ||
| JP2011037841A5 (enExample) | ||
| JP2010506942A5 (enExample) | ||
| RU2015155585A (ru) | 4-алкинилимидазольное производное и лекарственное средство, включающее такое производное в качестве активного ингредиента | |
| JP2013532652A5 (enExample) | ||
| RU2012112050A (ru) | Производные дигидроптеридинона, способ их получения и фармацевтическое применение | |
| RU2013141559A (ru) | Способ ингибирования клеток опухоли гамартомы | |
| JP2016531868A5 (enExample) | ||
| JP2021522262A5 (enExample) | ||
| IN2014DN07283A (enExample) | ||
| JP2017531677A5 (enExample) | ||
| JP2015524843A5 (enExample) |