ME02667B - Spiro-prstenasti spoj koji sadrži dušik i njegova upotreba u medicini - Google Patents
Spiro-prstenasti spoj koji sadrži dušik i njegova upotreba u mediciniInfo
- Publication number
- ME02667B ME02667B MEP-2017-74A MEP7417A ME02667B ME 02667 B ME02667 B ME 02667B ME P7417 A MEP7417 A ME P7417A ME 02667 B ME02667 B ME 02667B
- Authority
- ME
- Montenegro
- Prior art keywords
- nitrogen
- same
- ring compound
- medicinal use
- containing spiro
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009179502 | 2009-07-31 | ||
US27413709P | 2009-08-13 | 2009-08-13 | |
PCT/JP2010/062873 WO2011013785A1 (ja) | 2009-07-31 | 2010-07-30 | 含窒素スピロ環化合物及びその医薬用途 |
EP10804531.1A EP2460806B1 (en) | 2009-07-31 | 2010-07-30 | Nitrogen-containing spiro-ring compound and medicinal use of same |
Publications (1)
Publication Number | Publication Date |
---|---|
ME02667B true ME02667B (me) | 2017-06-20 |
Family
ID=43529436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-2017-74A ME02667B (me) | 2009-07-31 | 2010-07-30 | Spiro-prstenasti spoj koji sadrži dušik i njegova upotreba u medicini |
Country Status (31)
Country | Link |
---|---|
US (4) | US8609647B2 (me) |
EP (3) | EP3858349A1 (me) |
JP (8) | JP5520158B2 (me) |
KR (1) | KR101773208B1 (me) |
CN (1) | CN102510865B (me) |
AR (1) | AR077497A1 (me) |
AU (1) | AU2010278066B2 (me) |
BR (1) | BR112012002157B1 (me) |
CA (1) | CA2767899C (me) |
CO (1) | CO6491052A2 (me) |
CY (1) | CY1118747T1 (me) |
DK (1) | DK2460806T3 (me) |
ES (1) | ES2616705T3 (me) |
HR (1) | HRP20170447T1 (me) |
HU (1) | HUE033070T2 (me) |
IL (1) | IL217048A (me) |
LT (1) | LT2460806T (me) |
ME (1) | ME02667B (me) |
MX (1) | MX2012001313A (me) |
MY (1) | MY163495A (me) |
NZ (1) | NZ597994A (me) |
PE (1) | PE20121276A1 (me) |
PL (1) | PL2460806T3 (me) |
PT (1) | PT2460806T (me) |
RS (1) | RS55913B1 (me) |
RU (1) | RU2630694C2 (me) |
SG (1) | SG176918A1 (me) |
SI (1) | SI2460806T1 (me) |
TW (1) | TWI466885B (me) |
WO (1) | WO2011013785A1 (me) |
ZA (1) | ZA201200689B (me) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
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TWI466885B (zh) * | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
EP2485589A4 (en) * | 2009-09-04 | 2013-02-06 | Biogen Idec Inc | HETEROARYARY INHIBITORS OF BTK |
CA2808543C (en) * | 2010-08-20 | 2016-01-26 | Hutchison Medipharma Limited | Pyrrolopyrimidine compounds and uses thereof |
EP2651417B1 (en) | 2010-12-16 | 2016-11-30 | Calchan Limited | Ask1 inhibiting pyrrolopyrimidine derivatives |
SI2796460T1 (sl) | 2011-12-21 | 2018-10-30 | Jiangsu Hengrui Medicine Co. Ltd | Pirolni šestčlenski derivat heteroarilnega obroča, postopek priprave zanj in medicinske uporabe le-tega |
US20140343034A1 (en) * | 2013-04-25 | 2014-11-20 | Japan Tobacco Inc. | Skin barrier function improving agent |
KR102306276B1 (ko) | 2013-10-21 | 2021-09-30 | 니뽄 다바코 산교 가부시키가이샤 | 안질환의 치료제 또는 예방제 |
BR112016026641B1 (pt) * | 2014-05-28 | 2023-03-14 | Astrazeneca Ab | Processos para a preparação de azd5363 e novo intemediário utilizado nos mesmos |
AU2016289061B2 (en) * | 2015-07-07 | 2020-07-09 | Japan Tobacco Inc. | Method for producing 7H-pyrrolo[2, 3-d]pyrimidine derivative and intermediate thereof |
WO2017013270A1 (en) | 2015-07-23 | 2017-01-26 | Universite De Strasbourg | Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy |
PT3352734T (pt) | 2015-09-24 | 2020-03-31 | Japan Tobacco Inc | Tratamento de alopecia areata |
CN111646980B (zh) * | 2015-09-25 | 2021-08-27 | 迪哲(江苏)医药股份有限公司 | 用于抑制jak的化合物和方法 |
FI3405197T3 (fi) | 2016-01-21 | 2023-11-23 | Leo Pharma As | Kroonisen käsi-ihottuman hoito |
BR112019008812A2 (pt) * | 2016-11-23 | 2019-07-16 | Jiangsu Hengrui Medicine Co | método de preparação para e intermediário de derivado de pirrolo anel heteroaromático de seis elementos |
ES2926986T3 (es) * | 2016-12-21 | 2022-10-31 | Japan Tobacco Inc | Formas cristalinas de un inhibidor de la cinasa Janus |
CA3047891A1 (en) * | 2016-12-21 | 2018-06-28 | Japan Tobacco Inc. | Process for preparing 7h-pyrrolo[2,3-d]pyrimidine derivatives and synthetic intermediates thereof |
AU2017384316B2 (en) * | 2016-12-21 | 2022-04-14 | Japan Tobacco Inc. | Method for producing 7H-pyrrolo[2,3-d]pyrimidine derivative, and cocrystal of said derivative |
JP7101685B2 (ja) * | 2017-01-20 | 2022-07-15 | レオ ファーマ アクティーゼルスカブ | 新規jakキナーゼ阻害剤としての二環式アミン |
WO2018141842A1 (en) * | 2017-02-03 | 2018-08-09 | Leo Pharma A/S | 5-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-5-AZASPIRO[2.5]OCTANE-8-CARBOXYLIC ACID DERIVATIVES AS NOVEL JAK KINASE INHIBITORS |
CN111526874A (zh) * | 2017-10-10 | 2020-08-11 | 生物基因公司 | 用于制备螺环衍生物的方法 |
CA3089559A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
WO2020007698A1 (en) * | 2018-07-06 | 2020-01-09 | Leo Pharma A/S | Novel amino-imidazopyrimidine derivatives as janus kinase inhibitors and pharmaceutical use thereof |
WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
KR20220008893A (ko) | 2019-05-15 | 2022-01-21 | 레오 파마 에이/에스 | 피부 홍반성 루푸스의 치료 |
WO2021025129A1 (ja) * | 2019-08-07 | 2021-02-11 | ロート製薬株式会社 | 涙液分泌促進用眼科組成物 |
EP4070796A4 (en) * | 2019-12-27 | 2024-01-17 | Rohto Pharmaceutical Co., Ltd. | AQUEOUS COMPOSITION |
CN111606929B (zh) * | 2020-06-30 | 2023-07-07 | 中瀚(齐河县)生物医药科技有限公司 | 德高替尼的制备方法 |
CN111560021B (zh) * | 2020-06-30 | 2023-05-26 | 上海鲲博玖瑞医药科技发展有限公司 | 一种德高替尼中间体及其制备方法 |
CN111574540B (zh) * | 2020-06-30 | 2023-08-29 | 云南华派医药科技有限公司 | 一种德高替尼的制备方法 |
WO2022117075A1 (zh) * | 2020-12-04 | 2022-06-09 | 广州费米子科技有限责任公司 | 氮杂并环化合物、其制备方法及其用途 |
WO2022143629A1 (zh) * | 2020-12-29 | 2022-07-07 | 上海岸阔医药科技有限公司 | 治疗与抗肿瘤剂相关的皮肤疾病或病症的试剂和方法 |
TW202406553A (zh) | 2022-04-20 | 2024-02-16 | 丹麥商理奧藥品公司 | 前額纖維化禿髮之治療 |
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AR020590A1 (es) | 1998-06-02 | 2002-05-22 | Cadus Pharmaceutical Corp | 7-diazapurina-n-6 sustituida, un metodo para su preparacion, composiciones farmaceuticas que la comprenden |
PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
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