CY1118747T1 - Ενωση σπειρο-δακτυλιου που περιεχει αζωτο και ιατρικη χρηση αυτης - Google Patents
Ενωση σπειρο-δακτυλιου που περιεχει αζωτο και ιατρικη χρηση αυτηςInfo
- Publication number
- CY1118747T1 CY1118747T1 CY20171100348T CY171100348T CY1118747T1 CY 1118747 T1 CY1118747 T1 CY 1118747T1 CY 20171100348 T CY20171100348 T CY 20171100348T CY 171100348 T CY171100348 T CY 171100348T CY 1118747 T1 CY1118747 T1 CY 1118747T1
- Authority
- CY
- Cyprus
- Prior art keywords
- nitrogen
- spirit
- medical use
- ring connection
- disease
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Μια ένωση του ακόλουθου γενικού τύπου [I]; στον οποίο κάθε σύμβολο έχει την ίδια σημασία όπως ορίζεται στο παρόν, ή ένα φαρμακευτικά αποδεκτό άλας αυτής, ή μια επιδιαλυτωμένη μορφή αυτής και η φαρμακευτική χρήση αυτής στην αντιμετώπιση της απόρριψης μοσχεύματος οργάνου, της αντίδρασης μοσχεύματος έναντι ξενιστή μετά από μεταμόσχευση, αυτοάνοσου νοσήματος, αλλεργικού νοσήματος και της χρόνιας μυελοϋπερπλαστικής νόσου.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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JP2009179502 | 2009-07-31 | ||
US27413709P | 2009-08-13 | 2009-08-13 | |
PCT/JP2010/062873 WO2011013785A1 (ja) | 2009-07-31 | 2010-07-30 | 含窒素スピロ環化合物及びその医薬用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1118747T1 true CY1118747T1 (el) | 2017-07-12 |
Family
ID=43529436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171100348T CY1118747T1 (el) | 2009-07-31 | 2017-03-20 | Ενωση σπειρο-δακτυλιου που περιεχει αζωτο και ιατρικη χρηση αυτης |
Country Status (31)
Country | Link |
---|---|
US (4) | US8609647B2 (el) |
EP (3) | EP2460806B1 (el) |
JP (8) | JP5520158B2 (el) |
KR (1) | KR101773208B1 (el) |
CN (1) | CN102510865B (el) |
AR (1) | AR077497A1 (el) |
AU (1) | AU2010278066B2 (el) |
BR (1) | BR112012002157B1 (el) |
CA (1) | CA2767899C (el) |
CO (1) | CO6491052A2 (el) |
CY (1) | CY1118747T1 (el) |
DK (1) | DK2460806T3 (el) |
ES (1) | ES2616705T3 (el) |
HR (1) | HRP20170447T1 (el) |
HU (1) | HUE033070T2 (el) |
IL (1) | IL217048A (el) |
LT (1) | LT2460806T (el) |
ME (1) | ME02667B (el) |
MX (1) | MX2012001313A (el) |
MY (1) | MY163495A (el) |
NZ (1) | NZ597994A (el) |
PE (1) | PE20121276A1 (el) |
PL (1) | PL2460806T3 (el) |
PT (1) | PT2460806T (el) |
RS (1) | RS55913B1 (el) |
RU (1) | RU2630694C2 (el) |
SG (1) | SG176918A1 (el) |
SI (1) | SI2460806T1 (el) |
TW (1) | TWI466885B (el) |
WO (1) | WO2011013785A1 (el) |
ZA (1) | ZA201200689B (el) |
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TWI466885B (zh) * | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
US9029359B2 (en) | 2009-09-04 | 2015-05-12 | Biogen Idec Ma, Inc. | Heteroaryl Btk inhibitors |
CN103119045B (zh) * | 2010-08-20 | 2016-02-17 | 和记黄埔医药(上海)有限公司 | 吡咯并嘧啶化合物及其用途 |
PL2651417T3 (pl) | 2010-12-16 | 2017-08-31 | Calchan Limited | Pochodne pirolopirymidyny hamujące ASK1 |
JP6075736B2 (ja) | 2011-12-21 | 2017-02-08 | ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co.,Ltd. | ピロール−6員ヘテロアリール環誘導体、その合成法およびその医薬用途 |
US20140343034A1 (en) * | 2013-04-25 | 2014-11-20 | Japan Tobacco Inc. | Skin barrier function improving agent |
MY176525A (en) * | 2013-10-21 | 2020-08-13 | Japan Tobacco Inc | Therapeutic agent for ocular disease or prophylactic agent for ocular disease |
MX2016015613A (es) * | 2014-05-28 | 2017-04-13 | Astrazeneca Ab | Procesos para la preparacion de azd5363 e intermedios novedosos utilizados en el mismo. |
CA2991020A1 (en) * | 2015-07-07 | 2017-01-12 | Japan Tobacco Inc. | Method for producing 7h-pyrrolo[2, 3-d]pyrimidine derivative and intermediate thereof |
WO2017013270A1 (en) | 2015-07-23 | 2017-01-26 | Universite De Strasbourg | Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy |
BR112018005771B1 (pt) * | 2015-09-24 | 2023-12-05 | Leo Pharma A/S | Uso de um composto |
CN108368091B (zh) * | 2015-09-25 | 2020-08-11 | 迪哲(江苏)医药有限公司 | 用于抑制jak的化合物和方法 |
PL3405197T3 (pl) | 2016-01-21 | 2024-02-12 | Leo Pharma A/S | Zastosowanie delgocytynibu w leczeniu przewlekłego wyprysku dłoni |
CA3040981A1 (en) * | 2016-11-23 | 2018-05-31 | Bing Liu | Preparation method for and intermediate of pyrrolo six-membered heteroaromatic ring derivative |
CN110325536A (zh) * | 2016-12-21 | 2019-10-11 | 日本烟草产业株式会社 | Janus激酶抑制剂的晶体形式 |
US11312728B2 (en) | 2016-12-21 | 2022-04-26 | Japan Tobacco Inc. | Process for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives and co-crystals thereof |
AU2017384317C1 (en) | 2016-12-21 | 2022-06-30 | Japan Tobacco Inc. | PROCESS FOR PREPARING 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES AND SYNTHETIC INTERMEDIATES THEREOF |
EP3571198B1 (en) * | 2017-01-20 | 2023-02-01 | LEO Pharma A/S | Bicyclic amines as jak kinase inhibitors |
EP3576743B1 (en) * | 2017-02-03 | 2023-01-18 | LEO Pharma A/S | 5-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2 5]octane-8-carboxylic acid derivatives as jak kinase inhibitors |
CN111526874A (zh) * | 2017-10-10 | 2020-08-11 | 生物基因公司 | 用于制备螺环衍生物的方法 |
MX2020008106A (es) * | 2018-01-31 | 2020-09-25 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos. |
WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
SG11202110777XA (en) | 2019-05-15 | 2021-11-29 | Leo Pharma As | Treatment of cutaneous lupus erythematosus |
WO2021025129A1 (ja) * | 2019-08-07 | 2021-02-11 | ロート製薬株式会社 | 涙液分泌促進用眼科組成物 |
US20230101139A1 (en) * | 2019-12-27 | 2023-03-30 | Rohto Pharmaceutical Co., Ltd. | Aqueous Composition |
CN111606929B (zh) * | 2020-06-30 | 2023-07-07 | 中瀚(齐河县)生物医药科技有限公司 | 德高替尼的制备方法 |
CN111574540B (zh) * | 2020-06-30 | 2023-08-29 | 云南华派医药科技有限公司 | 一种德高替尼的制备方法 |
CN111560021B (zh) * | 2020-06-30 | 2023-05-26 | 上海鲲博玖瑞医药科技发展有限公司 | 一种德高替尼中间体及其制备方法 |
TW202227452A (zh) * | 2020-12-04 | 2022-07-16 | 大陸商廣州費米子科技有限責任公司 | 氮雜並環化合物、其製備方法、抑制酪氨酸激酶的方法、藥物組成物及其用途 |
TW202241439A (zh) * | 2020-12-29 | 2022-11-01 | 大陸商上海岸闊醫藥科技有限公司 | 治療與抗腫瘤劑相關的皮膚疾病或病症的試劑和方法 |
TW202406553A (zh) | 2022-04-20 | 2024-02-16 | 丹麥商理奧藥品公司 | 前額纖維化禿髮之治療 |
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