MX2016015613A - Procesos para la preparacion de azd5363 e intermedios novedosos utilizados en el mismo. - Google Patents
Procesos para la preparacion de azd5363 e intermedios novedosos utilizados en el mismo.Info
- Publication number
- MX2016015613A MX2016015613A MX2016015613A MX2016015613A MX2016015613A MX 2016015613 A MX2016015613 A MX 2016015613A MX 2016015613 A MX2016015613 A MX 2016015613A MX 2016015613 A MX2016015613 A MX 2016015613A MX 2016015613 A MX2016015613 A MX 2016015613A
- Authority
- MX
- Mexico
- Prior art keywords
- azd5363
- salt
- preparation
- processes
- pyrrolo
- Prior art date
Links
- JDUBGYFRJFOXQC-KRWDZBQOSA-N 4-amino-n-[(1s)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide Chemical compound C1([C@H](CCO)NC(=O)C2(CCN(CC2)C=2C=3C=CNC=3N=CN=2)N)=CC=C(Cl)C=C1 JDUBGYFRJFOXQC-KRWDZBQOSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 5
- JGNACDMQJLVKIU-VIFPVBQESA-N (3s)-3-amino-3-(4-chlorophenyl)propan-1-ol Chemical compound OCC[C@H](N)C1=CC=C(Cl)C=C1 JGNACDMQJLVKIU-VIFPVBQESA-N 0.000 abstract 1
- MCVJPGUKMSRBRG-UHFFFAOYSA-N 8-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-oxa-1,8-diazaspiro[4.5]decane-2,4-dione Chemical compound O=C1NC2(CCN(CC2)C2=NC=NC3=C2C=CN3)C(=O)O1 MCVJPGUKMSRBRG-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se proporciona un proceso para la preparación de AZD5363 o una sal de AZD5363 que comprende: (a) la reacción de 8-(7H-pirrolo[2,3-d]pirimidin-4-il)-3-oxa-1,8-diazaespiro[4.5]dec ano-2,4-diona o una sal del mismo, con (S)-3-amino-3-(4-clorofenil )propan-1-ol, o una sal del mismo, en presencia de base; y (b) ya sea aislar AZD5363 o aislar AZD5363 como una sal. 8-(7H-pirrolo[2,3-d]pirimidin-4-iI)-3-oxa-1,8-diazaspiro[4.5]deca no-2,4-diona se proporciona y se prepara haciendo reaccionar ácido 4- (alquiloxicarbonilamino)-1-(7H-pirrolo[2,3-d]pirimidin-4- il) piperidin-4-carboxílico, o una sal del mismo, con un agente de ciclación.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462003593P | 2014-05-28 | 2014-05-28 | |
| PCT/GB2015/051525 WO2015181532A1 (en) | 2014-05-28 | 2015-05-26 | Processes for the preparation of azd5363 and novel intermediate used therein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016015613A true MX2016015613A (es) | 2017-04-13 |
Family
ID=53268840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016015613A MX2016015613A (es) | 2014-05-28 | 2015-05-26 | Procesos para la preparacion de azd5363 e intermedios novedosos utilizados en el mismo. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9879017B2 (es) |
| EP (1) | EP3148998B1 (es) |
| JP (1) | JP6538725B2 (es) |
| KR (1) | KR102518994B1 (es) |
| CN (1) | CN106661033B (es) |
| AR (1) | AR100648A1 (es) |
| AU (1) | AU2015265696B2 (es) |
| BR (1) | BR112016026641B1 (es) |
| CA (1) | CA2948444C (es) |
| ES (1) | ES2691223T3 (es) |
| IL (1) | IL248848B (es) |
| MX (1) | MX2016015613A (es) |
| MY (1) | MY173661A (es) |
| RU (1) | RU2674027C2 (es) |
| TW (1) | TWI687421B (es) |
| WO (1) | WO2015181532A1 (es) |
| ZA (1) | ZA201608823B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018071602B1 (pt) * | 2016-04-29 | 2024-02-27 | Iomet Pharma Ltd. | Compostos de imidazopiridina substituídos, sua composição e seus usos como inibidores da indolamina 2,3-dioxigenase e/ou triptofano-2,3- dioxigenase |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179569A (en) * | 1975-03-14 | 1979-12-18 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl)-N-phenylamides |
| JPS59225161A (ja) * | 1983-04-11 | 1984-12-18 | ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ | Ｎ−アリ−ル−α−アミノ−カルボキサミド類 |
| US4675403A (en) * | 1985-10-16 | 1987-06-23 | American Home Products Corporation | 3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity |
| US8921376B2 (en) * | 2005-05-20 | 2014-12-30 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| GB0608184D0 (en) * | 2006-04-25 | 2006-06-07 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| FR2913978B1 (fr) * | 2007-03-21 | 2009-07-03 | Centre Nat Rech Scient | Procede de synthese de peptides sans solvant |
| CN101861321B (zh) | 2007-10-11 | 2013-02-06 | 阿斯利康(瑞典)有限公司 | 作为蛋白激酶b抑制剂的吡咯并[2,3-d]嘧啶衍生物 |
| US8349899B1 (en) * | 2008-12-03 | 2013-01-08 | Arrowhead Center, Inc. | Selective inhibitors of EG5 motors and methods of use |
| TWI466885B (zh) * | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
| ES2646759T3 (es) * | 2011-09-12 | 2017-12-15 | Merck Patent Gmbh | Derivados de aminopirimidina para uso como moduladores de la actividad de la quinasa |
| AU2013204533B2 (en) * | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
-
2015
- 2015-05-26 BR BR112016026641-2A patent/BR112016026641B1/pt active IP Right Grant
- 2015-05-26 KR KR1020167032702A patent/KR102518994B1/ko active IP Right Grant
- 2015-05-26 EP EP15725113.3A patent/EP3148998B1/en active Active
- 2015-05-26 MY MYPI2016704347A patent/MY173661A/en unknown
- 2015-05-26 RU RU2016147508A patent/RU2674027C2/ru active
- 2015-05-26 JP JP2016569688A patent/JP6538725B2/ja active Active
- 2015-05-26 MX MX2016015613A patent/MX2016015613A/es active IP Right Grant
- 2015-05-26 ES ES15725113.3T patent/ES2691223T3/es active Active
- 2015-05-26 US US15/313,631 patent/US9879017B2/en active Active
- 2015-05-26 CN CN201580034606.XA patent/CN106661033B/zh active Active
- 2015-05-26 WO PCT/GB2015/051525 patent/WO2015181532A1/en active Application Filing
- 2015-05-26 CA CA2948444A patent/CA2948444C/en active Active
- 2015-05-26 AU AU2015265696A patent/AU2015265696B2/en active Active
- 2015-05-27 TW TW104117034A patent/TWI687421B/zh active
- 2015-05-28 AR ARP150101689A patent/AR100648A1/es unknown
-
2016
- 2016-11-09 IL IL248848A patent/IL248848B/en active IP Right Grant
- 2016-12-21 ZA ZA2016/08823A patent/ZA201608823B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6538725B2 (ja) | 2019-07-03 |
| EP3148998B1 (en) | 2018-07-11 |
| JP2017516790A (ja) | 2017-06-22 |
| US20170210745A1 (en) | 2017-07-27 |
| AR100648A1 (es) | 2016-10-19 |
| RU2674027C2 (ru) | 2018-12-04 |
| AU2015265696B2 (en) | 2018-01-18 |
| KR20170012250A (ko) | 2017-02-02 |
| ES2691223T3 (es) | 2018-11-26 |
| CN106661033A (zh) | 2017-05-10 |
| CA2948444C (en) | 2022-07-26 |
| RU2016147508A (ru) | 2018-06-28 |
| EP3148998A1 (en) | 2017-04-05 |
| TWI687421B (zh) | 2020-03-11 |
| BR112016026641B1 (pt) | 2023-03-14 |
| BR112016026641A2 (pt) | 2017-08-15 |
| KR102518994B1 (ko) | 2023-04-05 |
| AU2015265696A1 (en) | 2016-11-24 |
| IL248848A0 (en) | 2017-01-31 |
| WO2015181532A1 (en) | 2015-12-03 |
| RU2016147508A3 (es) | 2018-10-29 |
| ZA201608823B (en) | 2018-11-28 |
| MY173661A (en) | 2020-02-14 |
| CN106661033B (zh) | 2018-11-06 |
| TW201609739A (zh) | 2016-03-16 |
| CA2948444A1 (en) | 2015-12-03 |
| IL248848B (en) | 2020-01-30 |
| US9879017B2 (en) | 2018-01-30 |
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant or registration |