WO2016117852A3 - 티카그렐러 제조방법 및 이를 위한 신규한 중간체 - Google Patents
티카그렐러 제조방법 및 이를 위한 신규한 중간체 Download PDFInfo
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- WO2016117852A3 WO2016117852A3 PCT/KR2016/000102 KR2016000102W WO2016117852A3 WO 2016117852 A3 WO2016117852 A3 WO 2016117852A3 KR 2016000102 W KR2016000102 W KR 2016000102W WO 2016117852 A3 WO2016117852 A3 WO 2016117852A3
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- WO
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- novel intermediates
- ticagrelor
- intermediates therefor
- preparing ticagrelor
- preparing
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Abstract
본 발명의 하기 화학식 1로 표시되는 티카그렐러, (1 S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-디플루오로페닐)시클로프로필아미노] -5- (프로 필티오 )-3H-[l,2,3]트리아졸로 [4,5-d]피리미딘 -3-일] -5-(2-히드록시에톡시)시클로 펜탄 -1,2-디올의 신규한 제조방법 및 이에 사용되는 신규 중간체들에 관한 것이다. 본 발명에 따르면 티카그렐러를 신규한 중간체로부터 용이하게 제조할 수 있다: <화학식 1>
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2015-0010650 | 2015-01-22 | ||
KR20150010650 | 2015-01-22 | ||
KR10-2016-0000552 | 2016-01-04 | ||
KR1020160000552A KR101870918B1 (ko) | 2015-01-22 | 2016-01-04 | 티카그렐러 제조방법 및 이를 위한 신규한 중간체 |
Publications (2)
Publication Number | Publication Date |
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WO2016117852A2 WO2016117852A2 (ko) | 2016-07-28 |
WO2016117852A3 true WO2016117852A3 (ko) | 2016-10-27 |
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PCT/KR2016/000102 WO2016117852A2 (ko) | 2015-01-22 | 2016-01-06 | 티카그렐러 제조방법 및 이를 위한 신규한 중간체 |
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WO (1) | WO2016117852A2 (ko) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20080003458A (ko) * | 2000-06-02 | 2008-01-07 | 아스트라제네카 아베 | 신규 트리아졸로 피리미딘 화합물 |
WO2012138981A2 (en) * | 2011-04-06 | 2012-10-11 | Teva Pharmaceutical Industries Ltd. | New intermediates and processes for preparing ticagrelor |
US20130165696A1 (en) * | 2010-06-30 | 2013-06-27 | Actavis Group Ptc Ehf | Novel processes for the preparation of phenylcyclopropylamine derivatives and use thereof for preparing ticagrelor |
WO2013163892A1 (en) * | 2012-05-02 | 2013-11-07 | Sunshine Lake Pharma Co., Ltd. | Novel triazolo pyrimidine compounds and a process of preparation thereof |
WO2014086291A1 (zh) * | 2012-12-06 | 2014-06-12 | 博瑞生物医药技术(苏州)有限公司 | 一种制备替卡格雷的方法及其中间体 |
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2016
- 2016-01-06 WO PCT/KR2016/000102 patent/WO2016117852A2/ko active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20080003458A (ko) * | 2000-06-02 | 2008-01-07 | 아스트라제네카 아베 | 신규 트리아졸로 피리미딘 화합물 |
US20130165696A1 (en) * | 2010-06-30 | 2013-06-27 | Actavis Group Ptc Ehf | Novel processes for the preparation of phenylcyclopropylamine derivatives and use thereof for preparing ticagrelor |
WO2012138981A2 (en) * | 2011-04-06 | 2012-10-11 | Teva Pharmaceutical Industries Ltd. | New intermediates and processes for preparing ticagrelor |
WO2013163892A1 (en) * | 2012-05-02 | 2013-11-07 | Sunshine Lake Pharma Co., Ltd. | Novel triazolo pyrimidine compounds and a process of preparation thereof |
WO2014086291A1 (zh) * | 2012-12-06 | 2014-06-12 | 博瑞生物医药技术(苏州)有限公司 | 一种制备替卡格雷的方法及其中间体 |
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WO2016117852A2 (ko) | 2016-07-28 |
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