WO2016117852A3 - 티카그렐러 제조방법 및 이를 위한 신규한 중간체 - Google Patents

티카그렐러 제조방법 및 이를 위한 신규한 중간체 Download PDF

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Publication number
WO2016117852A3
WO2016117852A3 PCT/KR2016/000102 KR2016000102W WO2016117852A3 WO 2016117852 A3 WO2016117852 A3 WO 2016117852A3 KR 2016000102 W KR2016000102 W KR 2016000102W WO 2016117852 A3 WO2016117852 A3 WO 2016117852A3
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WO
WIPO (PCT)
Prior art keywords
novel intermediates
ticagrelor
intermediates therefor
preparing ticagrelor
preparing
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Application number
PCT/KR2016/000102
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English (en)
French (fr)
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WO2016117852A2 (ko
Inventor
김후숙
김재한
김용직
곽우영
임중인
차대원
신창용
Original Assignee
동아에스티 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority claimed from KR1020160000552A external-priority patent/KR101870918B1/ko
Application filed by 동아에스티 주식회사 filed Critical 동아에스티 주식회사
Publication of WO2016117852A2 publication Critical patent/WO2016117852A2/ko
Publication of WO2016117852A3 publication Critical patent/WO2016117852A3/ko

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Abstract

본 발명의 하기 화학식 1로 표시되는 티카그렐러, (1 S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-디플루오로페닐)시클로프로필아미노] -5- (프로 필티오 )-3H-[l,2,3]트리아졸로 [4,5-d]피리미딘 -3-일] -5-(2-히드록시에톡시)시클로 펜탄 -1,2-디올의 신규한 제조방법 및 이에 사용되는 신규 중간체들에 관한 것이다. 본 발명에 따르면 티카그렐러를 신규한 중간체로부터 용이하게 제조할 수 있다: <화학식 1>
PCT/KR2016/000102 2015-01-22 2016-01-06 티카그렐러 제조방법 및 이를 위한 신규한 중간체 WO2016117852A2 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2015-0010650 2015-01-22
KR20150010650 2015-01-22
KR10-2016-0000552 2016-01-04
KR1020160000552A KR101870918B1 (ko) 2015-01-22 2016-01-04 티카그렐러 제조방법 및 이를 위한 신규한 중간체

Publications (2)

Publication Number Publication Date
WO2016117852A2 WO2016117852A2 (ko) 2016-07-28
WO2016117852A3 true WO2016117852A3 (ko) 2016-10-27

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PCT/KR2016/000102 WO2016117852A2 (ko) 2015-01-22 2016-01-06 티카그렐러 제조방법 및 이를 위한 신규한 중간체

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WO (1) WO2016117852A2 (ko)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080003458A (ko) * 2000-06-02 2008-01-07 아스트라제네카 아베 신규 트리아졸로 피리미딘 화합물
WO2012138981A2 (en) * 2011-04-06 2012-10-11 Teva Pharmaceutical Industries Ltd. New intermediates and processes for preparing ticagrelor
US20130165696A1 (en) * 2010-06-30 2013-06-27 Actavis Group Ptc Ehf Novel processes for the preparation of phenylcyclopropylamine derivatives and use thereof for preparing ticagrelor
WO2013163892A1 (en) * 2012-05-02 2013-11-07 Sunshine Lake Pharma Co., Ltd. Novel triazolo pyrimidine compounds and a process of preparation thereof
WO2014086291A1 (zh) * 2012-12-06 2014-06-12 博瑞生物医药技术(苏州)有限公司 一种制备替卡格雷的方法及其中间体

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080003458A (ko) * 2000-06-02 2008-01-07 아스트라제네카 아베 신규 트리아졸로 피리미딘 화합물
US20130165696A1 (en) * 2010-06-30 2013-06-27 Actavis Group Ptc Ehf Novel processes for the preparation of phenylcyclopropylamine derivatives and use thereof for preparing ticagrelor
WO2012138981A2 (en) * 2011-04-06 2012-10-11 Teva Pharmaceutical Industries Ltd. New intermediates and processes for preparing ticagrelor
WO2013163892A1 (en) * 2012-05-02 2013-11-07 Sunshine Lake Pharma Co., Ltd. Novel triazolo pyrimidine compounds and a process of preparation thereof
WO2014086291A1 (zh) * 2012-12-06 2014-06-12 博瑞生物医药技术(苏州)有限公司 一种制备替卡格雷的方法及其中间体

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