JP2010538653A5 - - Google Patents
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- JP2010538653A5 JP2010538653A5 JP2010525014A JP2010525014A JP2010538653A5 JP 2010538653 A5 JP2010538653 A5 JP 2010538653A5 JP 2010525014 A JP2010525014 A JP 2010525014A JP 2010525014 A JP2010525014 A JP 2010525014A JP 2010538653 A5 JP2010538653 A5 JP 2010538653A5
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- 108091070501 miRNA Proteins 0.000 claims 106
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 55
- 201000010099 disease Diseases 0.000 claims 49
- 230000001105 regulatory effect Effects 0.000 claims 27
- 238000000034 method Methods 0.000 claims 17
- 108091033773 MiR-155 Proteins 0.000 claims 16
- 108091062762 miR-21 stem-loop Proteins 0.000 claims 13
- 108091041631 miR-21-1 stem-loop Proteins 0.000 claims 13
- 108091044442 miR-21-2 stem-loop Proteins 0.000 claims 13
- -1 miR-016 Proteins 0.000 claims 11
- 108091028049 Mir-221 microRNA Proteins 0.000 claims 9
- 101001120822 Homo sapiens Putative microRNA 17 host gene protein Proteins 0.000 claims 8
- 108091028684 Mir-145 Proteins 0.000 claims 8
- 108091062140 Mir-223 Proteins 0.000 claims 8
- 102100026055 Putative microRNA 17 host gene protein Human genes 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 8
- 108091050874 miR-19a stem-loop Proteins 0.000 claims 8
- 108091086850 miR-19a-1 stem-loop Proteins 0.000 claims 8
- 108091088468 miR-19a-2 stem-loop Proteins 0.000 claims 8
- 108091061917 miR-221 stem-loop Proteins 0.000 claims 8
- 108091063489 miR-221-1 stem-loop Proteins 0.000 claims 8
- 108091055391 miR-221-2 stem-loop Proteins 0.000 claims 8
- 108091031076 miR-221-3 stem-loop Proteins 0.000 claims 8
- 206010033128 Ovarian cancer Diseases 0.000 claims 7
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 7
- 108091033433 MiR-191 Proteins 0.000 claims 6
- 108091060585 Mir-31 Proteins 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 108091091360 miR-125b stem-loop Proteins 0.000 claims 6
- 108091048308 miR-210 stem-loop Proteins 0.000 claims 6
- 108091059456 miR-92-1 stem-loop Proteins 0.000 claims 6
- 108091084336 miR-92-2 stem-loop Proteins 0.000 claims 6
- 108091007774 MIR107 Proteins 0.000 claims 5
- 108091046841 MiR-150 Proteins 0.000 claims 5
- 108091062154 Mir-205 Proteins 0.000 claims 5
- 108091092722 miR-23b stem-loop Proteins 0.000 claims 5
- 108091031298 miR-23b-1 stem-loop Proteins 0.000 claims 5
- 108091082339 miR-23b-2 stem-loop Proteins 0.000 claims 5
- 206010028537 myelofibrosis Diseases 0.000 claims 5
- 108091007773 MIR100 Proteins 0.000 claims 4
- 108091028141 MiR-203 Proteins 0.000 claims 4
- 108091007419 MiR-27 Proteins 0.000 claims 4
- 108091027766 Mir-143 Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 108091037473 miR-103 stem-loop Proteins 0.000 claims 4
- 108091079012 miR-133a Proteins 0.000 claims 4
- 108091024038 miR-133a stem-loop Proteins 0.000 claims 4
- 108091047577 miR-149 stem-loop Proteins 0.000 claims 4
- 108091035696 miR-149-1 stem-loop Proteins 0.000 claims 4
- 108091031096 miR-149-2 stem-loop Proteins 0.000 claims 4
- 108091074057 miR-16-1 stem-loop Proteins 0.000 claims 4
- 108091047758 miR-185 stem-loop Proteins 0.000 claims 4
- 108091039812 miR-28 stem-loop Proteins 0.000 claims 4
- 108091088477 miR-29a stem-loop Proteins 0.000 claims 4
- 108091029716 miR-29a-1 stem-loop Proteins 0.000 claims 4
- 108091092089 miR-29a-2 stem-loop Proteins 0.000 claims 4
- 108091066559 miR-29a-3 stem-loop Proteins 0.000 claims 4
- 108091007432 miR-29b Proteins 0.000 claims 4
- 108091091696 miR-331 stem-loop Proteins 0.000 claims 4
- 108091029119 miR-34a stem-loop Proteins 0.000 claims 4
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 208000003950 B-cell lymphoma Diseases 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
- 241000711549 Hepacivirus C Species 0.000 claims 3
- 241000725303 Human immunodeficiency virus Species 0.000 claims 3
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 3
- 206010021143 Hypoxia Diseases 0.000 claims 3
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 206010038389 Renal cancer Diseases 0.000 claims 3
- 208000005485 Thrombocytosis Diseases 0.000 claims 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
- 206010046798 Uterine leiomyoma Diseases 0.000 claims 3
- 208000017733 acquired polycythemia vera Diseases 0.000 claims 3
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 3
- 201000010897 colon adenocarcinoma Diseases 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 3
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 3
- 230000001146 hypoxic effect Effects 0.000 claims 3
- 201000010982 kidney cancer Diseases 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 108091091751 miR-17 stem-loop Proteins 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000037244 polycythemia vera Diseases 0.000 claims 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims 3
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- 108091007780 MiR-122 Proteins 0.000 claims 2
- 108091093082 MiR-146 Proteins 0.000 claims 2
- 108091026807 MiR-214 Proteins 0.000 claims 2
- 108091028695 MiR-224 Proteins 0.000 claims 2
- 108091028076 Mir-127 Proteins 0.000 claims 2
- 108091061943 Mir-218 microRNA precursor family Proteins 0.000 claims 2
- 108091080995 Mir-9/mir-79 microRNA precursor family Proteins 0.000 claims 2
- 108091027559 Mir-96 microRNA Proteins 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 239000000090 biomarker Substances 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 201000010260 leiomyoma Diseases 0.000 claims 2
- 108091050170 miR-103-1 stem-loop Proteins 0.000 claims 2
- 108091079786 miR-105 stem-loop Proteins 0.000 claims 2
- 108091064157 miR-106a stem-loop Proteins 0.000 claims 2
- 108091035155 miR-10a stem-loop Proteins 0.000 claims 2
- 108091051828 miR-122 stem-loop Proteins 0.000 claims 2
- 108091070946 miR-128 stem-loop Proteins 0.000 claims 2
- 108091071817 miR-128b stem-loop Proteins 0.000 claims 2
- 108091079016 miR-133b Proteins 0.000 claims 2
- 108091043162 miR-133b stem-loop Proteins 0.000 claims 2
- 108091026375 miR-135b stem-loop Proteins 0.000 claims 2
- 108091086065 miR-135b-2 stem-loop Proteins 0.000 claims 2
- 108091044046 miR-17-1 stem-loop Proteins 0.000 claims 2
- 108091065423 miR-17-3 stem-loop Proteins 0.000 claims 2
- 108091041042 miR-18 stem-loop Proteins 0.000 claims 2
- 108091055042 miR-181 stem-loop Proteins 0.000 claims 2
- 108091043222 miR-181b stem-loop Proteins 0.000 claims 2
- 108091074194 miR-181b-1 stem-loop Proteins 0.000 claims 2
- 108091029500 miR-183 stem-loop Proteins 0.000 claims 2
- 108091062221 miR-18a stem-loop Proteins 0.000 claims 2
- 108091081505 miR-190 stem-loop Proteins 0.000 claims 2
- 108091086834 miR-190-2 stem-loop Proteins 0.000 claims 2
- 108091088515 miR-197 stem-loop Proteins 0.000 claims 2
- 108091046261 miR-198 stem-loop Proteins 0.000 claims 2
- 108091047177 miR-199 stem-loop Proteins 0.000 claims 2
- 108091031898 miR-199-5 stem-loop Proteins 0.000 claims 2
- 108091059199 miR-200a stem-loop Proteins 0.000 claims 2
- 108091031479 miR-204 stem-loop Proteins 0.000 claims 2
- 108091032382 miR-204-1 stem-loop Proteins 0.000 claims 2
- 108091085803 miR-204-2 stem-loop Proteins 0.000 claims 2
- 108091089766 miR-204-3 stem-loop Proteins 0.000 claims 2
- 108091073500 miR-204-4 stem-loop Proteins 0.000 claims 2
- 108091053626 miR-204-5 stem-loop Proteins 0.000 claims 2
- 108091049679 miR-20a stem-loop Proteins 0.000 claims 2
- 108091059105 miR-216-1 stem-loop Proteins 0.000 claims 2
- 108091045470 miR-216-2 stem-loop Proteins 0.000 claims 2
- 108091035328 miR-217 stem-loop Proteins 0.000 claims 2
- 108091039135 miR-217-1 stem-loop Proteins 0.000 claims 2
- 108091029206 miR-217-2 stem-loop Proteins 0.000 claims 2
- 108091040176 miR-218 stem-loop Proteins 0.000 claims 2
- 108091053008 miR-23 stem-loop Proteins 0.000 claims 2
- 108091092825 miR-24 stem-loop Proteins 0.000 claims 2
- 108091048857 miR-24-1 stem-loop Proteins 0.000 claims 2
- 108091032978 miR-24-3 stem-loop Proteins 0.000 claims 2
- 108091064025 miR-24-4 stem-loop Proteins 0.000 claims 2
- 108091046553 miR-26 stem-loop Proteins 0.000 claims 2
- 108091023821 miR-26-1 stem-loop Proteins 0.000 claims 2
- 108091045094 miR-26-2 stem-loop Proteins 0.000 claims 2
- 108091083275 miR-26b stem-loop Proteins 0.000 claims 2
- 108091007431 miR-29 Proteins 0.000 claims 2
- 108091047189 miR-29c stem-loop Proteins 0.000 claims 2
- 108091054490 miR-29c-2 stem-loop Proteins 0.000 claims 2
- 108091055059 miR-30c stem-loop Proteins 0.000 claims 2
- 108091046551 miR-324 stem-loop Proteins 0.000 claims 2
- 108091042879 miR-326 stem-loop Proteins 0.000 claims 2
- 108091055145 miR-342 stem-loop Proteins 0.000 claims 2
- 108091027983 miR-378-1 stem-loop Proteins 0.000 claims 2
- 108091089716 miR-378-2 stem-loop Proteins 0.000 claims 2
- 108091032985 miR-382 Proteins 0.000 claims 2
- 108091050135 miR-382 stem-loop Proteins 0.000 claims 2
- 108091080700 miR-484 stem-loop Proteins 0.000 claims 2
- 108091047084 miR-9 stem-loop Proteins 0.000 claims 2
- 108091032902 miR-93 stem-loop Proteins 0.000 claims 2
- 108091023525 miR-95 stem-loop Proteins 0.000 claims 2
- 108091086713 miR-96 stem-loop Proteins 0.000 claims 2
- 108091070961 miR-96-3 stem-loop Proteins 0.000 claims 2
- 108091007420 miR‐142 Proteins 0.000 claims 2
- 238000004393 prognosis Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 108091008065 MIR21 Proteins 0.000 claims 1
- 108091028066 Mir-126 Proteins 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000012830 cancer therapeutic Substances 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 108091053410 let-7 family Proteins 0.000 claims 1
- 108091023663 let-7 stem-loop Proteins 0.000 claims 1
- 108091063478 let-7-1 stem-loop Proteins 0.000 claims 1
- 108091049777 let-7-2 stem-loop Proteins 0.000 claims 1
- 108091050539 miR-107 stem-loop Proteins 0.000 claims 1
- 108091032320 miR-146 stem-loop Proteins 0.000 claims 1
- 108091024530 miR-146a stem-loop Proteins 0.000 claims 1
- 108091043612 miR-146b stem-loop Proteins 0.000 claims 1
- 108091069239 miR-17-2 stem-loop Proteins 0.000 claims 1
- 108091080321 miR-222 stem-loop Proteins 0.000 claims 1
- 108091035591 miR-23a stem-loop Proteins 0.000 claims 1
- 108091061970 miR-26a stem-loop Proteins 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
- 208000010579 uterine corpus leiomyoma Diseases 0.000 claims 1
- 201000007954 uterine fibroid Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99380907P | 2007-09-14 | 2007-09-14 | |
| US60/993,809 | 2007-09-14 | ||
| US5517808P | 2008-05-22 | 2008-05-22 | |
| US61/055,178 | 2008-05-22 | ||
| PCT/US2008/076109 WO2009036236A1 (en) | 2007-09-14 | 2008-09-12 | Mirna expression in human peripheral blood microvesicles and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010538653A JP2010538653A (ja) | 2010-12-16 |
| JP2010538653A5 true JP2010538653A5 (https=) | 2011-10-27 |
| JP5624470B2 JP5624470B2 (ja) | 2014-11-12 |
Family
ID=40452488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010525014A Active JP5624470B2 (ja) | 2007-09-14 | 2008-09-12 | ヒト末梢血微小胞におけるｍｉＲＮＡの発現およびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8455199B2 (https=) |
| EP (3) | EP2190992B1 (https=) |
| JP (1) | JP5624470B2 (https=) |
| CN (2) | CN104975089A (https=) |
| AU (1) | AU2008298744B8 (https=) |
| BR (1) | BRPI0816852A2 (https=) |
| CA (1) | CA2699646A1 (https=) |
| ES (2) | ES2575868T3 (https=) |
| IL (2) | IL204484A (https=) |
| WO (1) | WO2009036236A1 (https=) |
Families Citing this family (156)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2487258B1 (en) | 2006-01-05 | 2014-10-01 | The Ohio State University Research Foundation | MicroRNA-based methods for the diagnosis of colon, pancreas and stomach cancer |
| ES2446362T3 (es) | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
| CN103424541B (zh) | 2006-05-18 | 2018-01-30 | 分子压型学会股份有限公司 | 确定针对病状的个性化医疗介入的系统和方法 |
| US8768629B2 (en) | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| US8455188B2 (en) | 2007-01-26 | 2013-06-04 | University Of Louisville Research Foundation, Inc. | Modification of exosomal components for use as a vaccine |
| EP2719773A3 (en) * | 2007-06-15 | 2014-07-30 | The Ohio State University Research Foundation | miRNA as marker for acute lamphomic leucemia |
| WO2009015357A1 (en) | 2007-07-25 | 2009-01-29 | University Of Louisville Research Foundation, Inc. | Exosome-associated microrna as a diagnostic marker |
| JP2010535473A (ja) | 2007-08-03 | 2010-11-25 | ズィ、オハイオウ、ステイト、ユーニヴァーサティ、リサーチ、ファウンデイシャン | ｎｃＲＮＡをコードする超保存領域 |
| US20100255514A1 (en) | 2007-08-16 | 2010-10-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Tumor cell-derived microvesicles |
| JP5769417B2 (ja) | 2007-08-16 | 2015-08-26 | ザ ロイヤル インスティチューション フォー ザ アドバンスメント オブ ラーニング／マギル ユニバーシティ | 腫瘍細胞由来微小胞 |
| ES2575868T3 (es) | 2007-09-14 | 2016-07-01 | The Ohio State University Research Foundation | Expresión de miARN en microvesículas de sangre periférica humana y sus usos |
| CN101424640B (zh) * | 2007-11-02 | 2012-07-25 | 江苏命码生物科技有限公司 | 血清中微小核糖核酸的检测方法和用于检测的试剂盒、生物芯片及其制作和应用方法 |
| EP2245199B1 (en) * | 2008-02-01 | 2013-11-13 | The General Hospital Corporation | Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions |
| WO2010018564A1 (en) * | 2008-08-13 | 2010-02-18 | Rosetta Genomics Ltd. | Compositions and methods for determining the prognosis of bladder urothelial cancer |
| EP2358912B1 (en) | 2008-10-30 | 2016-10-12 | Caris Life Sciences Switzerland Holdings GmbH | Methods for assessing rna patterns |
| US20130178383A1 (en) * | 2008-11-12 | 2013-07-11 | David Spetzler | Vesicle isolation methods |
| GB2463401B (en) | 2008-11-12 | 2014-01-29 | Caris Life Sciences Luxembourg Holdings S A R L | Characterizing prostate disorders by analysis of microvesicles |
| WO2011109440A1 (en) * | 2010-03-01 | 2011-09-09 | Caris Life Sciences Luxembourg Holdings | Biomarkers for theranostics |
| RU2400203C1 (ru) * | 2009-04-17 | 2010-09-27 | Илья Николаевич Медведев | Способ уменьшения содержания микровезикул в крови при артериальной гипертонии, дислипидемии и абдоминальном ожирении |
| RU2400209C1 (ru) * | 2009-04-17 | 2010-09-27 | Илья Николаевич Медведев | Способ коррекции уровня микровезикул в крови при артериальной гипертонии, дислипидемии и сахарном диабете ii типа |
| CN102421917B (zh) * | 2009-04-29 | 2014-07-09 | 阿姆斯特丹大学学术医学中心 | 对抗、预防和/或测定心力衰竭或心力衰竭的风险的工具和方法 |
| EP2336353A1 (en) * | 2009-12-17 | 2011-06-22 | febit holding GmbH | miRNA fingerprints in the diagnosis of diseases |
| BR112012001077A2 (pt) * | 2009-07-16 | 2020-08-11 | The General Hospital Corporation | extração de ácido nucleico, métodos para avaliar a qualidade de uma extração de ácido nucleico e de uma amostra biológica, para ober ácido nucleico a partir de uma amostra biológica, para analisar rna de microvesículas e para diagnosticar e monitorar um indivíduo, e, kit |
| WO2011031877A1 (en) | 2009-09-09 | 2011-03-17 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
| EP2475989A4 (en) | 2009-09-09 | 2013-02-27 | Gen Hospital Corp | USE OF MICROVESICLES IN THE ANALYSIS OF KRAS MUTATIONS |
| WO2011040525A1 (ja) * | 2009-09-30 | 2011-04-07 | 財団法人ヒューマンサイエンス振興財団 | 大腸がん検査マーカーおよび大腸がんの検査方法 |
| WO2011039757A2 (en) * | 2009-10-04 | 2011-04-07 | Rosetta Genomics Ltd. | Compositions and methods for prognosis of renal cancer |
| EP2496714B1 (en) | 2009-11-04 | 2016-08-31 | DiamiR, LLC | Methods of using micro-rna from bodily fluids for diagnosis and monitoring of mild cognitive impairment |
| US8916533B2 (en) | 2009-11-23 | 2014-12-23 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
| EP2327783A1 (en) * | 2009-11-27 | 2011-06-01 | Universitätsklinikum Freiburg | Pharmaceutical composition comprising miRNA-100 and its use in the modulation of blood vessel growth |
| CN102080086B (zh) * | 2009-12-01 | 2012-12-26 | 中国科学院上海药物研究所 | 人miR-133a反义核酸及其应用 |
| CN102080083B (zh) * | 2009-12-01 | 2013-02-27 | 中国科学院上海药物研究所 | 人miR-149反义核酸及其应用 |
| WO2011069100A2 (en) * | 2009-12-04 | 2011-06-09 | Duke University | Microrna and use thereof in identification of b cell malignancies |
| WO2011076147A1 (en) * | 2009-12-24 | 2011-06-30 | Fudan University | Plasma-based micro-rna biomarkers and methods for early detection of colorectal cancer |
| WO2011076141A1 (en) * | 2009-12-24 | 2011-06-30 | Fudan University | Diagnostic kits comprising microrna biomarkers and methods for diagnosis of hepatocellular cancer |
| CN102892897B (zh) * | 2009-12-24 | 2016-08-03 | 复旦大学 | 用于肺癌的微rna表达谱分析的组合物和方法 |
| CN102892898B (zh) * | 2009-12-24 | 2016-03-09 | 复旦大学 | 用于肝细胞癌诊断的含微rna生物标记的诊断试剂盒和方法 |
| CN102770560B (zh) * | 2009-12-24 | 2015-11-25 | 复旦大学 | 用于早期检测结直肠癌的基于血浆的微rna生物标记及方法 |
| EP2341145A1 (en) * | 2009-12-30 | 2011-07-06 | febit holding GmbH | miRNA fingerprint in the diagnosis of diseases |
| EP2354246A1 (en) | 2010-02-05 | 2011-08-10 | febit holding GmbH | miRNA in the diagnosis of ovarian cancer |
| EP2363136A1 (en) * | 2010-03-02 | 2011-09-07 | Fresenius Medical Care Deutschland GmbH | Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease |
| JP2011211955A (ja) * | 2010-03-31 | 2011-10-27 | Toray Ind Inc | 肝ガン患者予後予測用組成物及び方法 |
| WO2011127219A1 (en) * | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings | Circulating biomarkers for disease |
| WO2011127625A1 (zh) * | 2010-04-13 | 2011-10-20 | 江苏命码生物科技有限公司 | 一种调节生物体内微小核糖核酸含量的方法及其用途 |
| EP2796563A1 (en) * | 2010-05-04 | 2014-10-29 | MedImmune, LLC | Optimized degenerative muscle disease diagnostics and treatments |
| RU2585491C2 (ru) | 2010-06-04 | 2016-05-27 | Борд Оф Риджентс, Зе Юниверсити Оф Техас Систем | Регуляция метаболизма с помощью mir-378 |
| WO2011160585A1 (en) * | 2010-06-23 | 2011-12-29 | The Chinese University Of Hong Kong | Micro-rna markers for colorectal cancer |
| US20130139273A1 (en) * | 2010-06-24 | 2013-05-30 | The Ohio State University | Chronic Lymphocytic Leukemia Modeled in Mouse by Targeted miR-29 Expression |
| US20140045915A1 (en) | 2010-08-31 | 2014-02-13 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| CN103221542A (zh) * | 2010-09-27 | 2013-07-24 | 萨班哲大学 | miRNA用于诊断、预防、治疗和追踪涉及巨自噬异常的疾病的用途 |
| JP6219721B2 (ja) | 2010-11-10 | 2017-10-25 | エキソソーム ダイアグノスティックス インコーポレイテッド | 核酸含有粒子の単離および該粒子からの核酸の抽出のための方法 |
| JP5931897B2 (ja) | 2010-11-12 | 2016-06-08 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションＴｈｅ Ｏｈｉｏ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | マイクロｒｎａ−２１、ミスマッチ修復および結腸直腸癌に関連する物質および方法 |
| WO2012063894A1 (ja) * | 2010-11-12 | 2012-05-18 | 国立大学法人愛媛大学 | マイクロｒｎａのアンチセンスオリゴヌクレオチドを含む組成物 |
| CA2817982C (en) | 2010-11-15 | 2020-06-30 | The Regents Of The University Of Michigan | Controlled release mucoadhesive systems |
| EA201370139A1 (ru) | 2010-12-15 | 2013-10-30 | Мираген Терапеутикс | Ингибиторы микро-рнк, содержащие закрытые нуклеотиды |
| CN102140465B (zh) * | 2010-12-30 | 2013-06-12 | 苏州吉玛基因股份有限公司 | 人miR-1249反义核酸及其应用 |
| CN102146412B (zh) * | 2011-01-11 | 2012-10-03 | 中山大学 | 一种小分子非编码RNA 基因hsa-miR-29b 及其应用 |
| EP2663323B1 (en) * | 2011-01-14 | 2017-08-16 | The General Hospital Corporation | Methods targeting mir-128 for regulating cholesterol/lipid metabolism |
| CA2833389C (en) | 2011-04-18 | 2022-01-11 | Diamir, Llc | Mirna-based universal screening test (ust) |
| EP2596136B1 (en) * | 2011-05-06 | 2014-07-16 | Zhongshan Hospital Fudan University | Marker consisting of plasma microrna and new method for diagnosis of hepatocellular carcinoma |
| BR112013033488B8 (pt) * | 2011-06-27 | 2022-11-22 | Eisai R&D Man Co Ltd | Métodos para facilitar o diagnóstico do comprometimento cognitivo devido a doença de alzheimer ou comprometimento cognitivo leve (mci)e kit |
| CN102250904B (zh) * | 2011-07-13 | 2013-11-13 | 中国科学技术大学 | 一种预防和/或治疗黑色素瘤的药物 |
| CN103842522A (zh) * | 2011-08-05 | 2014-06-04 | 路易斯维尔大学研究基金会 | 微rna生物标记物 |
| CN103857796A (zh) * | 2011-09-16 | 2014-06-11 | Lsip基金运营联合公司 | 膀胱癌细胞的检测方法、用于膀胱癌细胞的检测方法的引物及膀胱癌标记物 |
| CN102433339B (zh) * | 2011-09-16 | 2012-10-03 | 山东莱博生物科技有限公司 | 一种HCV核酸适配体及其在制备HCV-cAg检测试剂盒中的应用 |
| WO2013052965A2 (en) | 2011-10-06 | 2013-04-11 | Miragen Therapeutics | Control of whole body energy homeostasis by microrna regulation |
| AU2012323924A1 (en) | 2011-10-14 | 2014-05-29 | The Ohio State University | Methods and materials related to ovarian cancer |
| EP2584040A1 (en) * | 2011-10-17 | 2013-04-24 | Pharmahungary 2000 Kft. | Compounds for treatment of ischemic injury |
| CA2859430A1 (en) * | 2011-12-13 | 2013-06-20 | Ohio State Innovation Foundation | Methods and compositions related to mir-21 and mir-29a, exosome inhibition, and cancer metastasis |
| CN102533979A (zh) * | 2011-12-15 | 2012-07-04 | 苏州福英基因科技有限公司 | 各种癌症病理演变前期microrna-520水平原位杂交检测试剂盒及检测方法和应用 |
| ES2432853B1 (es) | 2011-12-15 | 2015-03-09 | Fundación Para La Investigación Biomédica Del Hospital Universitario Ramón Y Cajal | Metodo para el diagnostico y/o pronostico de dano renal agudo |
| US8859202B2 (en) | 2012-01-20 | 2014-10-14 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| CN103372218B (zh) * | 2012-04-19 | 2016-05-04 | 中国科学院上海生命科学研究院 | 自身免疫性疾病相关的microRNA及其应用 |
| WO2013165320A1 (en) * | 2012-05-04 | 2013-11-07 | Agency For Science, Technology And Research | Treating cancer by increasing expression of socs6 |
| CN102676522B (zh) * | 2012-05-16 | 2013-04-10 | 北京旷博生物技术有限公司 | 乳腺癌分子标志物miR-195-5p |
| CN102676524B (zh) * | 2012-05-16 | 2013-04-03 | 北京旷博生物技术有限公司 | 乳腺癌分子标志物miR-147a |
| US9388408B2 (en) | 2012-06-21 | 2016-07-12 | MiRagen Therapeutics, Inc. | Oligonucleotide-based inhibitors comprising locked nucleic acid motif |
| CN102839173B (zh) * | 2012-08-24 | 2013-09-04 | 中国医科大学附属第一医院 | HIV感染疾病进展分子标志物miR-200c |
| CN102839172B (zh) * | 2012-08-24 | 2013-09-25 | 中国医科大学附属第一医院 | HIV感染疾病进展分子标志物miR-503 |
| AU2013340414B2 (en) | 2012-10-23 | 2019-05-02 | Caris Science, Inc. | Aptamers and uses thereof |
| US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
| EP2733219B1 (en) | 2012-11-16 | 2017-09-20 | Siemens Aktiengesellschaft | Diagnostic miRNA markers for Alzheimer |
| CN104903468B (zh) | 2012-11-16 | 2019-04-23 | 萨尔大学 | 用于帕金森氏病的新诊断MiRNA标志物 |
| EP2733220B1 (en) | 2012-11-16 | 2017-10-18 | Siemens Aktiengesellschaft | Novel miRNA as a diagnostic marker for Alzheimer's Disease |
| EP2746406B1 (en) | 2012-12-18 | 2017-08-23 | Samsung Electronics Co., Ltd. | Composition and kit for diagnosing breast cancer including miRNAs within vesicle, and method of diagnosing breast cancer using the same |
| JP6441567B2 (ja) * | 2012-12-18 | 2018-12-19 | 三星電子株式会社Ｓａｍｓｕｎｇ Ｅｌｅｃｔｒｏｎｉｃｓ Ｃｏ．，Ｌｔｄ． | 小胞内のポリヌクレオチドを含む乳がん診断用組成物及びキット、並びにそれを利用した乳がん診断方法 |
| EP2935628B1 (en) | 2012-12-19 | 2018-03-21 | Caris Life Sciences Switzerland Holdings GmbH | Compositions and methods for aptamer screening |
| US9193970B1 (en) * | 2013-03-14 | 2015-11-24 | Raadysan Biotech, Inc. | Replication factor C-40 (RFC40/RFC2) as a prognostic marker and target in estrogen positive and negative and triple negative breast cancer |
| US9546366B2 (en) | 2013-03-14 | 2017-01-17 | Raadysan Biotech, Inc. | Replication factor C-40 (RFC40/RFC2) as a prognostic marker and target in estrogen positive and negative and triple negative breast cancer |
| US9970012B2 (en) | 2013-03-14 | 2018-05-15 | Raadysan Biotech, Inc. | Replication factor C-40 (RFC40/RFC2) as a prognostic marker and target in estrogen positive and negative and triple negative breast cancer |
| CN105264092B (zh) | 2013-03-15 | 2019-02-22 | 得克萨斯州大学系统董事会 | 用于诊断和疗法的外来体中的miRNA生物发生 |
| WO2015020122A1 (ja) * | 2013-08-08 | 2015-02-12 | 国立大学法人 大阪大学 | 尿路上皮癌の診断または治療剤 |
| JP6930832B2 (ja) | 2013-11-18 | 2021-09-01 | ディアミール, エルエルシーDiamir, Llc | パーキンソン病（ＰＤ）の検出およびモニタリングのための、体液からのｍｉＲＮＡを使用する方法 |
| CN103602747B (zh) * | 2013-11-28 | 2014-11-05 | 山东大学齐鲁医院 | 一种用于膀胱癌血清miRNA检测的内参及其检测引物与应用 |
| EP3083987B1 (en) * | 2013-12-19 | 2020-08-05 | Hummingbird Diagnostics GmbH | Determination of platelet-mirnas in alzheimer's disease |
| US9758773B2 (en) | 2014-02-14 | 2017-09-12 | Agilent Technologies, Inc. | Thermostable type-A DNA polymerase mutant with increased resistance to inhibitors in blood |
| JP6415829B2 (ja) * | 2014-02-28 | 2018-10-31 | キヤノンメディカルシステムズ株式会社 | 検体に含まれるエキソソームの特性を判定する方法、診断方法および装置 |
| CN112592980A (zh) * | 2014-08-15 | 2021-04-02 | 深圳市晋百慧生物有限公司 | 用于检测肠癌的标记物及其应用 |
| US9885042B2 (en) | 2015-01-20 | 2018-02-06 | MiRagen Therapeutics, Inc. | miR-92 inhibitors and uses thereof |
| ES2749651T3 (es) | 2015-02-11 | 2020-03-23 | Region Midtjylland | Método basado en microARN para la detección temprana de cáncer de próstata en muestras de orina |
| ES2724404T3 (es) | 2015-02-27 | 2019-09-10 | Qiagen Gmbh | Un procedimiento basado en microARN para evaluar el pronóstico de un paciente de cáncer de próstata |
| ES2741591T3 (es) * | 2015-03-13 | 2020-02-11 | Univ Hiroshima | Método para ayudar a la detección de la enfermedad de Alzheimer o una discapacidad cognitiva moderada |
| CA2991045A1 (en) | 2015-06-29 | 2017-01-05 | Caris Science, Inc. | Therapeutic oligonucleotides binding c1q |
| AU2016298317B2 (en) | 2015-07-28 | 2021-02-18 | Caris Science, Inc. | Targeted oligonucleotides |
| KR102601499B1 (ko) * | 2015-11-06 | 2023-11-13 | 연세대학교 산학협력단 | miRNA 발현 수준으로부터 UQCRB 관련 질병을 진단하는 방법 |
| CN106729750A (zh) * | 2015-11-20 | 2017-05-31 | 昆山彭济凯丰生物科技有限公司 | 通过miR-183治疗高血脂、脂肪肝、二型糖尿病和降低体重的方法和药物及它们的应用 |
| ITUB20155765A1 (it) | 2015-11-20 | 2017-05-20 | Braindtech S R L | Metodi per diagnosi, prognosi e monitoraggio terapeutico di patologie neurologiche, neurodegenerative e infiammatorie basati su microRNA contenuto in microvescicole microglia |
| CN105400785A (zh) * | 2015-12-01 | 2016-03-16 | 中国人民解放军第四军医大学 | 一种与他莫昔芬耐药性相关的microRNA分子MiR-200a及其应用 |
| CN105586401A (zh) * | 2015-12-14 | 2016-05-18 | 常州杰傲医学检验所有限公司 | 一种用于乳腺癌诊断的miRNA标志物、其应用及诊断试剂盒 |
| US10975436B2 (en) | 2016-01-05 | 2021-04-13 | Diamir, Llc | Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders |
| CN105567826A (zh) * | 2016-01-25 | 2016-05-11 | 苏州大学附属第二医院 | has-miR-29b-3p的检测 |
| EP4339288A3 (en) | 2016-03-18 | 2024-06-05 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
| CN105755123A (zh) * | 2016-03-21 | 2016-07-13 | 河北医科大学第医院 | 一种结直肠癌相关的标志物、其引物及应用 |
| US11149313B2 (en) | 2016-03-21 | 2021-10-19 | Diamir, Llc | Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases |
| CN105603113B (zh) * | 2016-03-30 | 2019-02-05 | 江苏省疾病预防控制中心 | HIV-1早期感染相关的血清miRNA在制备试剂盒中的应用 |
| CA3025486A1 (en) | 2016-05-25 | 2017-11-30 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
| CN106282360B (zh) * | 2016-08-31 | 2019-11-08 | 武汉博杰生物医学科技有限公司 | 一种用于结肠癌预测转移的血浆miRNA组合、其探针组合物及应用 |
| US11236337B2 (en) | 2016-11-01 | 2022-02-01 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| US11584932B2 (en) * | 2016-11-01 | 2023-02-21 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| CN108938659A (zh) * | 2017-05-19 | 2018-12-07 | 昆山彭济凯丰生物科技有限公司 | 一种调节食欲和体重的方法和药物及它们的应用 |
| WO2019008415A1 (en) * | 2017-07-05 | 2019-01-10 | Datar Rajan | EXOSOMED AND PBMC GENE EXPRESSION ANALYSIS FOR CANCER CARE |
| US10781487B2 (en) | 2017-07-24 | 2020-09-22 | Diamir, Llc | miRNA-based methods for detecting and monitoring aging |
| CN107557467B (zh) * | 2017-08-10 | 2021-05-11 | 李永东 | 一种与脑动脉瘤相关的临床标志物及其应用 |
| JP2019050772A (ja) * | 2017-09-15 | 2019-04-04 | 国立大学法人 熊本大学 | ワクチン接種後副反応を予測する検査方法 |
| US11395832B2 (en) | 2017-12-14 | 2022-07-26 | Unicyte Ev Ag | Pharmaceutical carriers containing miRNAs for use in the treatment of renal cancer |
| WO2019144183A1 (en) * | 2018-01-23 | 2019-08-01 | La Trobe University | Biomarkers of colorectal cancer |
| CN108295268A (zh) * | 2018-02-05 | 2018-07-20 | 苏州吉玛基因股份有限公司 | 与肝癌诊疗相关的血清外泌体hsa-miR-93及其应用 |
| KR20200120627A (ko) | 2018-02-13 | 2020-10-21 | 도레이 카부시키가이샤 | 인지증 검출을 위한 키트 또는 디바이스 및 방법 |
| CN108103202A (zh) * | 2018-03-06 | 2018-06-01 | 苏州吉玛基因股份有限公司 | 与肝癌诊疗相关的7种血清外泌体miRNAs及其应用 |
| CN108546752B (zh) * | 2018-04-20 | 2021-08-31 | 南京医科大学 | 检测和/或预测人类巨大儿的miRNA标志物或其组合及其应用 |
| CN108676880B (zh) * | 2018-05-24 | 2021-01-01 | 武汉大学 | 一种人血清afp阴性肝细胞癌检测试剂盒 |
| CN109022587B (zh) * | 2018-09-13 | 2022-02-22 | 南京求臻基因科技有限公司 | 一种急性髓系白血病的miRNA标志物及其应用 |
| KR102256747B1 (ko) * | 2018-10-30 | 2021-05-25 | 가톨릭대학교 산학협력단 | 엑소좀 miR-125b를 포함하는 간암 전이 진단 또는 예측용 바이오마커 및 이의 용도 |
| KR102131519B1 (ko) * | 2018-10-30 | 2020-07-07 | 가톨릭대학교 산학협력단 | 간암 전이 진단 또는 예후 예측용 바이오마커 및 이의 용도 |
| CN109295213A (zh) * | 2018-11-01 | 2019-02-01 | 中国人民解放军第00医院 | 免疫性血小板减少症的miRNA标志物及试剂盒和应用 |
| CN109295001A (zh) * | 2018-11-14 | 2019-02-01 | 姜大奎 | 一种脐带间充质干细胞复合外泌体及其制备方法 |
| SG11202106638UA (en) * | 2018-12-19 | 2021-07-29 | Agency Science Tech & Res | Method of diagnosing gastric cancers using micrornas |
| CN109971851A (zh) * | 2019-01-22 | 2019-07-05 | 宁波大学 | MiR-125b-2-3p作为鉴别诊断肾癌亚型的分子标志物及其在肿瘤转移中的用途 |
| CN109777874B (zh) * | 2019-01-29 | 2022-11-11 | 上海长海医院 | 一种适用于胰腺导管腺癌诊断及预后判断的血浆外泌体miRNA标志物及应用 |
| CN109837343B (zh) * | 2019-02-22 | 2024-03-01 | 中国科学院北京基因组研究所 | 早期肺腺癌特异性外泌体miRNA及其应用 |
| US10900091B2 (en) * | 2019-03-15 | 2021-01-26 | The Chinese University Of Hong Kong | miR-133a as a marker for colorectal cancer |
| CN110699450A (zh) * | 2019-05-22 | 2020-01-17 | 璞晞（广州）生物免疫技术有限公司 | miRNA生物标志物在肝脏疾病诊断和预后判断中的应用 |
| CN110791560B (zh) * | 2019-11-06 | 2021-09-14 | 中国医学科学院医药生物技术研究所 | 一种用于阿尔茨海默病诊断和/或治疗的miRNA标志物 |
| US12091716B2 (en) | 2020-01-15 | 2024-09-17 | Mayo Foundation For Medical Education And Research | Methods and materials for identifying and treating traumatic brain injury |
| ES2856232B2 (es) * | 2020-03-25 | 2023-11-24 | Fundacion Para La Investig Biomedica Del Hospital 12 De Octubre | Biomarcadores para predecir la respuesta de un sujeto a una terapia con bcg, metodos y usos basados en los mismos |
| US20230407401A1 (en) * | 2020-05-29 | 2023-12-21 | National Institute Of Immunology | Dna damage dependent microrna signature for cancers, methods and uses related thereto |
| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
| US20220017971A1 (en) * | 2020-07-15 | 2022-01-20 | Kookmin University Industry Academy Cooperation Foundation | Composition for predicting chemotherapy resistance of ovarian cancer and use thereof |
| CN112494654B (zh) * | 2020-12-10 | 2021-12-17 | 暨南大学附属第一医院（广州华侨医院） | 包含LncRNA HCG18抑制剂的药物组合物及其应用 |
| CN114469996B (zh) * | 2021-12-23 | 2023-10-20 | 中国医学科学院医学生物学研究所 | 一种包含miR-135b-5p的外泌体及在抗轮状病毒感染中的应用 |
| CN115192710A (zh) * | 2022-05-27 | 2022-10-18 | 华南理工大学 | 一种miRNA-200s保护剂在制备神经系统疾病类药物中的应用和药物及模型构建方法 |
| CN117802232B (zh) * | 2022-09-30 | 2025-08-19 | 上海思路迪生物医学科技有限公司 | 血液小型胞外囊泡miRNA在卵巢癌诊断中的应用 |
| CN115944646B (zh) * | 2022-12-30 | 2025-12-30 | 南华大学附属第一医院 | MicroRNA-32-5p在制备抗骨质疏松症药物中的应用 |
| ES2981248A1 (es) * | 2023-03-09 | 2024-10-07 | Servicio Andaluz De Salud | Panel de microARNs como biomarcadores de alopecia areata severa |
| CN117821577B (zh) * | 2023-10-19 | 2024-08-23 | 长沙干细胞与再生医学工业技术研究院有限公司 | 一种有效治疗卵巢功能减退的羊膜间充质干细胞的筛选方法 |
| CN119524005B (zh) * | 2024-11-14 | 2025-07-25 | 广东医科大学附属医院 | 干预B细胞miR-330-5p在制备治疗SLE药物中的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089181A (en) * | 1987-02-24 | 1992-02-18 | Vestar, Inc. | Method of dehydrating vesicle preparations for long term storage |
| US6812023B1 (en) * | 2000-04-27 | 2004-11-02 | Anosys, Inc. | Methods of producing membrane vesicles |
| US20050159378A1 (en) * | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA) |
| US20030036077A1 (en) * | 2001-05-31 | 2003-02-20 | Chronix Biomedical | Methods for generating an mRNA expression profile from an ecellular mRNA containing blood sample and using the same to identify functional state markers |
| AU2002314957A1 (en) * | 2001-06-06 | 2002-12-16 | Proteologics, Inc. | Methods and compositions related to tagging of membrane surface proteins |
| US20070077553A1 (en) * | 2003-10-30 | 2007-04-05 | Rosetta Genomics | Bioinformatically detectable group of novel vaccinia regulatory genes and uses thereof |
| US20050064470A1 (en) * | 2003-07-17 | 2005-03-24 | Rana Tariq M. | High throughput screening methods for identifying RNA binding compounds |
| EP1756572B1 (en) * | 2004-05-13 | 2016-02-24 | Centre National De La Recherche Scientifique (Cnrs) | A device for binding a target entity to a bait entity and detection methods using the same |
| EP2290071B1 (en) * | 2004-05-28 | 2014-12-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| US8021847B2 (en) * | 2004-06-02 | 2011-09-20 | Proxy Life Science Holdings, Inc. | Microvesicle-based compositions and methods |
| WO2005121369A2 (en) * | 2004-06-02 | 2005-12-22 | Sourcepharm, Inc. | Rna-containing microvesicles and methods therefor |
| WO2006102687A1 (en) * | 2005-03-22 | 2006-09-28 | The Trustees Of Columbia University In The City Of New York | A liposome-based microarray and methods of use thereof |
| EP2487258B1 (en) * | 2006-01-05 | 2014-10-01 | The Ohio State University Research Foundation | MicroRNA-based methods for the diagnosis of colon, pancreas and stomach cancer |
| WO2007084962A2 (en) * | 2006-01-18 | 2007-07-26 | The Regents Of The University Of California | A fluid membrane-based ligand display system for live cell assays and disease diagnosis applications |
| WO2009015357A1 (en) * | 2007-07-25 | 2009-01-29 | University Of Louisville Research Foundation, Inc. | Exosome-associated microrna as a diagnostic marker |
| ES2575868T3 (es) | 2007-09-14 | 2016-07-01 | The Ohio State University Research Foundation | Expresión de miARN en microvesículas de sangre periférica humana y sus usos |
| GB2463401B (en) * | 2008-11-12 | 2014-01-29 | Caris Life Sciences Luxembourg Holdings S A R L | Characterizing prostate disorders by analysis of microvesicles |
-
2008
- 2008-09-12 ES ES13161709.4T patent/ES2575868T3/es active Active
- 2008-09-12 ES ES08830849T patent/ES2419129T3/es active Active
- 2008-09-12 CA CA2699646A patent/CA2699646A1/en not_active Abandoned
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- 2008-09-12 BR BRPI0816852A patent/BRPI0816852A2/pt not_active Application Discontinuation
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- 2008-09-12 JP JP2010525014A patent/JP5624470B2/ja active Active
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2013
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2015
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2016
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