JP2010537640A5 - - Google Patents
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- JP2010537640A5 JP2010537640A5 JP2010523121A JP2010523121A JP2010537640A5 JP 2010537640 A5 JP2010537640 A5 JP 2010537640A5 JP 2010523121 A JP2010523121 A JP 2010523121A JP 2010523121 A JP2010523121 A JP 2010523121A JP 2010537640 A5 JP2010537640 A5 JP 2010537640A5
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- Prior art keywords
- item
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- mimetic
- mirna
- overhang
- Prior art date
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96825707P | 2007-08-27 | 2007-08-27 | |
| US2975308P | 2008-02-19 | 2008-02-19 | |
| US3895408P | 2008-03-24 | 2008-03-24 | |
| PCT/US2008/074531 WO2009029690A1 (en) | 2007-08-27 | 2008-08-27 | Composition of asymmetric rna duplex as microrna mimetic or inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010537640A JP2010537640A (ja) | 2010-12-09 |
| JP2010537640A5 true JP2010537640A5 (enExample) | 2011-10-20 |
Family
ID=40387778
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010523120A Pending JP2010537639A (ja) | 2007-08-27 | 2008-08-27 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2010523121A Pending JP2010537640A (ja) | 2007-08-27 | 2008-08-27 | マイクロｒｎａ模倣剤または阻害剤としての非対称性ｒｎａ二重鎖の組成物 |
| JP2014032700A Active JP5986596B2 (ja) | 2007-08-27 | 2014-02-24 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2015085681A Pending JP2015130885A (ja) | 2007-08-27 | 2015-04-20 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2016113256A Active JP6236498B2 (ja) | 2007-08-27 | 2016-06-07 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2016122512A Active JP6453275B2 (ja) | 2007-08-27 | 2016-06-21 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2017091309A Pending JP2017127333A (ja) | 2007-08-27 | 2017-05-01 | 非対称性干渉ｒｎａの組成物およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010523120A Pending JP2010537639A (ja) | 2007-08-27 | 2008-08-27 | 非対称性干渉ｒｎａの組成物およびその使用 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014032700A Active JP5986596B2 (ja) | 2007-08-27 | 2014-02-24 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2015085681A Pending JP2015130885A (ja) | 2007-08-27 | 2015-04-20 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2016113256A Active JP6236498B2 (ja) | 2007-08-27 | 2016-06-07 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2016122512A Active JP6453275B2 (ja) | 2007-08-27 | 2016-06-21 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2017091309A Pending JP2017127333A (ja) | 2007-08-27 | 2017-05-01 | 非対称性干渉ｒｎａの組成物およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US9328345B2 (enExample) |
| EP (4) | EP2193140B1 (enExample) |
| JP (7) | JP2010537639A (enExample) |
| CN (3) | CN101842381A (enExample) |
| CA (2) | CA2735167A1 (enExample) |
| DK (1) | DK2193140T3 (enExample) |
| ES (2) | ES2617877T3 (enExample) |
| WO (2) | WO2009029690A1 (enExample) |
Families Citing this family (147)
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|---|---|---|---|---|
| CN101631454A (zh) | 2006-12-08 | 2010-01-20 | 衣阿华州立大学研究基金公司 | 参与硝酸盐吸收和代谢的植物基因 |
| EP2193140B1 (en) * | 2007-08-27 | 2016-11-02 | 1Globe Health Institute LLC | Compositions of asymmetric interfering rna and uses thereof |
| US8097712B2 (en) | 2007-11-07 | 2012-01-17 | Beelogics Inc. | Compositions for conferring tolerance to viral disease in social insects, and the use thereof |
| KR100949791B1 (ko) * | 2007-12-18 | 2010-03-30 | 이동기 | 오프-타겟 효과를 최소화하고 ＲＮＡｉ 기구를 포화시키지않는 신규한 ｓｉＲＮＡ 구조 및 그 용도 |
| EP2340309A2 (en) | 2008-09-22 | 2011-07-06 | Rxi Pharmaceuticals Corporation | Neutral nanotransporters |
| CN102224254A (zh) | 2008-09-23 | 2011-10-19 | 哈佛大学校长及研究员协会 | Sirt4及其用途 |
| EP2352744B1 (en) * | 2008-10-15 | 2016-09-21 | Somagenics, Inc. | Short hairpin rnas for inhibition of gene expression |
| US9493774B2 (en) | 2009-01-05 | 2016-11-15 | Rxi Pharmaceuticals Corporation | Inhibition of PCSK9 through RNAi |
| WO2010090762A1 (en) | 2009-02-04 | 2010-08-12 | Rxi Pharmaceuticals Corporation | Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
| ES2628144T3 (es) * | 2009-04-03 | 2017-08-01 | Dicerna Pharmaceuticals, Inc. | Métodos y composiciones para la inhibición específica de KRAS por RNA bicatenario asimétrico |
| EP2756845B1 (en) * | 2009-04-03 | 2017-03-15 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA |
| WO2010141933A1 (en) * | 2009-06-05 | 2010-12-09 | Dicerna Pharmaceuticals, Inc. | Specific inhibition of gene expression by nucleic acid containing a dicer substrate |
| US8871730B2 (en) | 2009-07-13 | 2014-10-28 | Somagenics Inc. | Chemical modification of short small hairpin RNAs for inhibition of gene expression |
| US8796238B2 (en) | 2009-09-17 | 2014-08-05 | Sigma-Aldrich Co. Llc | Short RNA mimetics |
| KR20120082906A (ko) | 2009-09-30 | 2012-07-24 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 자가포식현상-향상 유전자 생성물의 조절을 통한 자가포식현상의 조절 방법 |
| US20150025122A1 (en) | 2009-10-12 | 2015-01-22 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
| US8962584B2 (en) | 2009-10-14 | 2015-02-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Compositions for controlling Varroa mites in bees |
| WO2011056005A2 (ko) * | 2009-11-04 | 2011-05-12 | 성균관대학교산학협력단 | 안티센스 가닥에 의한 오프-타겟 효과를 최소화한 신규한 ｓｉＲＮＡ 구조 및 그 용도 |
| WO2011072390A1 (en) * | 2009-12-16 | 2011-06-23 | The University Of Western Ontario | Compositions and methods related to mirna in diabetic conditions |
| PE20130649A1 (es) | 2010-03-08 | 2013-07-13 | Monsanto Technology Llc | Moleculas polinucleotidicas para regulacion genetica en plantas |
| BR112012024049A2 (pt) | 2010-03-24 | 2017-03-01 | Rxi Pharmaceuticals Corp | interferência de rna em indicações dérmicas e fibróticas |
| EP2550000A4 (en) | 2010-03-24 | 2014-03-26 | Advirna Inc | RNAI COMPOUNDS OF REDUCED SIZE ADMINISTERING |
| CN106074591B (zh) | 2010-03-24 | 2020-01-14 | 菲奥医药公司 | 眼部症候中的rna干扰 |
| DK2561078T3 (en) | 2010-04-23 | 2019-01-14 | Cold Spring Harbor Laboratory | NEW STRUCTURALLY DESIGNED SHRNAs |
| GB201006841D0 (en) * | 2010-04-26 | 2010-06-09 | Thomsen Lars | Method, device and system for targetted cell lysis |
| EP2631291B1 (en) * | 2010-10-22 | 2019-05-15 | OliX Pharmaceuticals, Inc. | Nucleic acid molecules inducing rna interference, and uses thereof |
| CN101979558B (zh) * | 2010-10-28 | 2015-09-02 | 百奥迈科生物技术有限公司 | 一种靶向乙型肝炎病毒基因的siRNA分子及其应用 |
| WO2012140234A1 (en) | 2011-04-13 | 2012-10-18 | Vib Vzw | Modulation of mirna in diseases with aberrant angiogenesis |
| WO2012149646A1 (en) * | 2011-05-05 | 2012-11-08 | Sunnybrook Research Institute | Mirna inhibitors and their uses |
| CA2844012C (en) | 2011-08-04 | 2021-03-16 | Yeda Research And Development Co. Ltd. | Micro-rnas and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions |
| US10806146B2 (en) | 2011-09-13 | 2020-10-20 | Monsanto Technology Llc | Methods and compositions for weed control |
| US10829828B2 (en) | 2011-09-13 | 2020-11-10 | Monsanto Technology Llc | Methods and compositions for weed control |
| US10760086B2 (en) | 2011-09-13 | 2020-09-01 | Monsanto Technology Llc | Methods and compositions for weed control |
| EP2755466A4 (en) | 2011-09-13 | 2015-04-15 | Monsanto Technology Llc | METHOD AND COMPOSITIONS FOR WEED CONTROL |
| EP2766482B1 (en) | 2011-10-11 | 2016-12-07 | The Brigham and Women's Hospital, Inc. | Micrornas in neurodegenerative disorders |
| US9593331B2 (en) | 2011-11-02 | 2017-03-14 | Osaka City University | Double-stranded nucleic acid molecule for gene expression control |
| WO2013138280A1 (en) * | 2012-03-12 | 2013-09-19 | Eaker Shannon | IMPROVED ENGRAFTMENT POTENTIAL OF EMBRYONIC STEM CELLS AND PLURIPOTENT STEM CELLS USING MICRO RNAs |
| DK2853597T3 (en) | 2012-05-22 | 2019-04-08 | Olix Pharmaceuticals Inc | RNA INTERFERENCE-INducing NUCLEIC ACID MOLECULES WITH CELL PENETENING EQUIPMENT AND USE THEREOF |
| US10240162B2 (en) | 2012-05-24 | 2019-03-26 | A.B. Seeds Ltd. | Compositions and methods for silencing gene expression |
| CN109810977A (zh) | 2012-05-26 | 2019-05-28 | 株式会社博纳克 | 具有递送功能的基因表达调控用单链核酸分子 |
| EP2703498B1 (en) * | 2012-08-29 | 2015-01-14 | Chanel Parfums Beauté | Inhibitors of micro-RNAs for use for preventing and/or attenuating skin ageing |
| US9096853B2 (en) * | 2012-09-24 | 2015-08-04 | U.S. Department Of Veterans Affairs | Modified siRNA molecules incorporating 5-fluoro-2′-deoxyuridine residues to enhance cytotoxicity |
| WO2014063155A1 (en) | 2012-10-21 | 2014-04-24 | University Of Rochester | Thy1 (cd90) as a novel therapy to control adipose tissue accumulation |
| WO2014089121A2 (en) * | 2012-12-03 | 2014-06-12 | Thomas Ichim | Retrograde delivery of cells and nucleic acids for treatment of cardiovascular diseases |
| WO2014123935A1 (en) * | 2013-02-05 | 2014-08-14 | 1Globe Health Institute Llc | Biodegradable and clinically-compatible nanop articles as drug delivery carriers |
| WO2014164761A1 (en) | 2013-03-13 | 2014-10-09 | Monsanto Technology Llc | Methods and compositions for weed control |
| EP2967082A4 (en) | 2013-03-13 | 2016-11-02 | Monsanto Technology Llc | METHOD AND COMPOSITIONS FOR WEED CONTROL |
| US10568328B2 (en) | 2013-03-15 | 2020-02-25 | Monsanto Technology Llc | Methods and compositions for weed control |
| KR20150139955A (ko) | 2013-04-09 | 2015-12-14 | 보스톤 바이오메디칼, 인크. | 암 치료에 사용하기 위한 2-아세틸나프토[2,3-b]푸란-4,9-디온 |
| JP6668236B2 (ja) | 2013-07-19 | 2020-03-18 | モンサント テクノロジー エルエルシー | Ｌｅｐｔｉｎｏｔａｒｓａ防除用組成物及びその方法 |
| MX390055B (es) | 2013-11-04 | 2025-03-20 | Monsanto Technology Llc | Composiciones y metodos para controlar infestaciones de plagas y parasitos de los artropodos. |
| CN106061488B (zh) | 2013-12-02 | 2021-04-09 | 菲奥医药公司 | 癌症的免疫治疗 |
| UA119253C2 (uk) | 2013-12-10 | 2019-05-27 | Біолоджикс, Інк. | Спосіб боротьби із вірусом у кліща varroa та у бджіл |
| US10612020B2 (en) | 2013-12-26 | 2020-04-07 | Tokyo Medical University | Artificial mimic miRNA for controlling gene expression, and use of same |
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| TW201620525A (zh) | 2014-03-14 | 2016-06-16 | 波士頓生醫公司 | 使ｋ－ｒａｓ靜默之非對稱干擾ｒｎａ組成物及其使用方法 |
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