JP2010537640A5 - - Google Patents
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- JP2010537640A5 JP2010537640A5 JP2010523121A JP2010523121A JP2010537640A5 JP 2010537640 A5 JP2010537640 A5 JP 2010537640A5 JP 2010523121 A JP2010523121 A JP 2010523121A JP 2010523121 A JP2010523121 A JP 2010523121A JP 2010537640 A5 JP2010537640 A5 JP 2010537640A5
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- Prior art keywords
- item
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- mimetic
- mirna
- overhang
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96825707P | 2007-08-27 | 2007-08-27 | |
| US2975308P | 2008-02-19 | 2008-02-19 | |
| US3895408P | 2008-03-24 | 2008-03-24 | |
| PCT/US2008/074531 WO2009029690A1 (en) | 2007-08-27 | 2008-08-27 | Composition of asymmetric rna duplex as microrna mimetic or inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010537640A JP2010537640A (ja) | 2010-12-09 |
| JP2010537640A5 true JP2010537640A5 (enExample) | 2011-10-20 |
Family
ID=40387778
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010523120A Pending JP2010537639A (ja) | 2007-08-27 | 2008-08-27 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2010523121A Pending JP2010537640A (ja) | 2007-08-27 | 2008-08-27 | マイクロｒｎａ模倣剤または阻害剤としての非対称性ｒｎａ二重鎖の組成物 |
| JP2014032700A Active JP5986596B2 (ja) | 2007-08-27 | 2014-02-24 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2015085681A Pending JP2015130885A (ja) | 2007-08-27 | 2015-04-20 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2016113256A Active JP6236498B2 (ja) | 2007-08-27 | 2016-06-07 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2016122512A Active JP6453275B2 (ja) | 2007-08-27 | 2016-06-21 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2017091309A Pending JP2017127333A (ja) | 2007-08-27 | 2017-05-01 | 非対称性干渉ｒｎａの組成物およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010523120A Pending JP2010537639A (ja) | 2007-08-27 | 2008-08-27 | 非対称性干渉ｒｎａの組成物およびその使用 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014032700A Active JP5986596B2 (ja) | 2007-08-27 | 2014-02-24 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2015085681A Pending JP2015130885A (ja) | 2007-08-27 | 2015-04-20 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2016113256A Active JP6236498B2 (ja) | 2007-08-27 | 2016-06-07 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2016122512A Active JP6453275B2 (ja) | 2007-08-27 | 2016-06-21 | 非対称性干渉ｒｎａの組成物およびその使用 |
| JP2017091309A Pending JP2017127333A (ja) | 2007-08-27 | 2017-05-01 | 非対称性干渉ｒｎａの組成物およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US9328345B2 (enExample) |
| EP (4) | EP3121281B1 (enExample) |
| JP (7) | JP2010537639A (enExample) |
| CN (3) | CN105018492B (enExample) |
| CA (2) | CA2735166C (enExample) |
| DK (1) | DK2193140T3 (enExample) |
| ES (2) | ES2617877T3 (enExample) |
| WO (2) | WO2009029688A2 (enExample) |
Families Citing this family (148)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008073578A2 (en) | 2006-12-08 | 2008-06-19 | Iowa State University Research Foundation, Inc. | Plant genes involved in nitrate uptake and metabolism |
| EP3121281B1 (en) | 2007-08-27 | 2021-03-31 | 1Globe Health Institute LLC | Compositions of asymmetric interfering rna and uses thereof |
| US8097712B2 (en) | 2007-11-07 | 2012-01-17 | Beelogics Inc. | Compositions for conferring tolerance to viral disease in social insects, and the use thereof |
| KR100949791B1 (ko) * | 2007-12-18 | 2010-03-30 | 이동기 | 오프-타겟 효과를 최소화하고 ＲＮＡｉ 기구를 포화시키지않는 신규한 ｓｉＲＮＡ 구조 및 그 용도 |
| EP2342340A1 (en) | 2008-09-22 | 2011-07-13 | Rxi Pharmaceuticals Corporation | Rna interference in skin indications |
| US20110287026A1 (en) | 2008-09-23 | 2011-11-24 | President And Fellows Of Harvard College | Sirt4 and uses thereof |
| WO2010045384A2 (en) | 2008-10-15 | 2010-04-22 | Somagenics Inc. | Short hairpin rnas for inhibition of gene expression |
| US9493774B2 (en) | 2009-01-05 | 2016-11-15 | Rxi Pharmaceuticals Corporation | Inhibition of PCSK9 through RNAi |
| WO2010090762A1 (en) | 2009-02-04 | 2010-08-12 | Rxi Pharmaceuticals Corporation | Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
| EP2756845B1 (en) * | 2009-04-03 | 2017-03-15 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA |
| JP6010458B2 (ja) * | 2009-04-03 | 2016-10-19 | ダイセルナ ファーマシューティカルズ， インコーポレイテッドＤｉｃｅｒｎａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 非対称二本鎖ｒｎａによる特異的阻害のための、方法および組成物 |
| WO2010141933A1 (en) * | 2009-06-05 | 2010-12-09 | Dicerna Pharmaceuticals, Inc. | Specific inhibition of gene expression by nucleic acid containing a dicer substrate |
| US8871730B2 (en) | 2009-07-13 | 2014-10-28 | Somagenics Inc. | Chemical modification of short small hairpin RNAs for inhibition of gene expression |
| US8796238B2 (en) | 2009-09-17 | 2014-08-05 | Sigma-Aldrich Co. Llc | Short RNA mimetics |
| CN102639700A (zh) | 2009-09-30 | 2012-08-15 | 哈佛大学校长及研究员协会 | 通过调节自噬增强基因产物调节自噬的方法 |
| US20150025122A1 (en) | 2009-10-12 | 2015-01-22 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
| US8962584B2 (en) | 2009-10-14 | 2015-02-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Compositions for controlling Varroa mites in bees |
| KR101237036B1 (ko) * | 2009-11-04 | 2013-02-25 | 성균관대학교산학협력단 | 안티센스 가닥에 의한 오프-타겟 효과를 최소화한 신규한 ｓｉＲＮＡ 구조 및 그 용도 |
| JP2013514277A (ja) * | 2009-12-16 | 2013-04-25 | ザ ユニバーシティ オブ ウェスタン オンタリオ | 糖尿病におけるｍｉＲＮＡに関連する組成物と方法 |
| KR101982126B1 (ko) | 2010-03-08 | 2019-05-27 | 몬산토 테크놀로지 엘엘씨 | 식물에서 유전자 조절을 위한 폴리뉴클레오타이드 분자 |
| US9095504B2 (en) | 2010-03-24 | 2015-08-04 | Rxi Pharmaceuticals Corporation | RNA interference in ocular indications |
| WO2011119852A1 (en) | 2010-03-24 | 2011-09-29 | Rxi Pharmaceuticals Corporation | Reduced size self-delivering rnai compounds |
| CA2794189C (en) | 2010-03-24 | 2022-01-11 | Rxi Pharmaceuticals Corporation | Rna interference in dermal and fibrotic indications |
| PT2561078T (pt) | 2010-04-23 | 2018-12-03 | Cold Spring Harbor Laboratory | Sharn com uma conceção estrutural inovadora |
| GB201006841D0 (en) * | 2010-04-26 | 2010-06-09 | Thomsen Lars | Method, device and system for targetted cell lysis |
| CN103328633B (zh) * | 2010-10-22 | 2018-07-10 | 成均馆大学校产学协力团 | 诱导rna干扰的核酸分子及其用途 |
| CN101979558B (zh) * | 2010-10-28 | 2015-09-02 | 百奥迈科生物技术有限公司 | 一种靶向乙型肝炎病毒基因的siRNA分子及其应用 |
| WO2012140234A1 (en) | 2011-04-13 | 2012-10-18 | Vib Vzw | Modulation of mirna in diseases with aberrant angiogenesis |
| WO2012149646A1 (en) * | 2011-05-05 | 2012-11-08 | Sunnybrook Research Institute | Mirna inhibitors and their uses |
| ES2632212T3 (es) | 2011-08-04 | 2017-09-11 | Yeda Research And Development Co. Ltd. | miR-135 y composiciones que lo comprenden para el tratamiento de afecciones médicas asociadas con la serotonina |
| US10806146B2 (en) | 2011-09-13 | 2020-10-20 | Monsanto Technology Llc | Methods and compositions for weed control |
| US10760086B2 (en) | 2011-09-13 | 2020-09-01 | Monsanto Technology Llc | Methods and compositions for weed control |
| US10829828B2 (en) | 2011-09-13 | 2020-11-10 | Monsanto Technology Llc | Methods and compositions for weed control |
| BR112014005975A8 (pt) | 2011-09-13 | 2017-09-12 | Monsanto Technology Llc | Método de controle de planta, método de redução de expressão de um gene pds em uma planta, cassete de expressão microbiana, método de fazer um polinucleotídeo, método de identificação de polinucleotídeos, e composições para controle de erva daninha |
| EP2766482B1 (en) * | 2011-10-11 | 2016-12-07 | The Brigham and Women's Hospital, Inc. | Micrornas in neurodegenerative disorders |
| JP6137484B2 (ja) * | 2011-11-02 | 2017-05-31 | 公立大学法人大阪市立大学 | 遺伝子発現抑制用二本鎖核酸分子 |
| WO2013138280A1 (en) * | 2012-03-12 | 2013-09-19 | Eaker Shannon | IMPROVED ENGRAFTMENT POTENTIAL OF EMBRYONIC STEM CELLS AND PLURIPOTENT STEM CELLS USING MICRO RNAs |
| CN108148838B (zh) | 2012-05-22 | 2026-07-31 | 奥利克斯医药有限公司 | 具有细胞内穿透能力的诱导rna干扰的核酸分子及用途 |
| CN104619843B (zh) | 2012-05-24 | 2020-03-06 | A.B.种子有限公司 | 用于使基因表达沉默的组合物和方法 |
| US9663784B2 (en) | 2012-05-26 | 2017-05-30 | Bonac Corporation | Single-stranded nucleic acid molecule for regulating expression of gene having delivering function |
| EP2703498B1 (en) * | 2012-08-29 | 2015-01-14 | Chanel Parfums Beauté | Inhibitors of micro-RNAs for use for preventing and/or attenuating skin ageing |
| US9096853B2 (en) * | 2012-09-24 | 2015-08-04 | U.S. Department Of Veterans Affairs | Modified siRNA molecules incorporating 5-fluoro-2′-deoxyuridine residues to enhance cytotoxicity |
| US9694050B2 (en) | 2012-10-21 | 2017-07-04 | University Of Rochester | THY1 (CD90) as a novel therapy to control adipose tissue accumulation |
| WO2014089121A2 (en) * | 2012-12-03 | 2014-06-12 | Thomas Ichim | Retrograde delivery of cells and nucleic acids for treatment of cardiovascular diseases |
| ES2873600T3 (es) * | 2013-02-05 | 2021-11-03 | 1Globe Health Inst Llc | Nanopartículas biodegradables y clínicamente compatibles como vehículos de suministro de fármacos. |
| AU2014248958A1 (en) | 2013-03-13 | 2015-10-01 | Monsanto Technology Llc | Methods and compositions for weed control |
| CA2905027A1 (en) | 2013-03-13 | 2014-10-09 | Monsanto Technology Llc | Methods and compositions for weed control |
| US10568328B2 (en) | 2013-03-15 | 2020-02-25 | Monsanto Technology Llc | Methods and compositions for weed control |
| US20160030384A1 (en) | 2013-04-09 | 2016-02-04 | Boston Biomedical, Inc. | 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer |
| MX359191B (es) | 2013-07-19 | 2018-09-18 | Monsanto Technology Llc | Composiciones y métodos para controlar leptinotarsa. |
| AR098295A1 (es) | 2013-11-04 | 2016-05-26 | Monsanto Technology Llc | Composiciones y métodos para controlar infestaciones de plagas y parásitos de los artrópodos |
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