JP2010536378A5 - - Google Patents
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- JP2010536378A5 JP2010536378A5 JP2010521980A JP2010521980A JP2010536378A5 JP 2010536378 A5 JP2010536378 A5 JP 2010536378A5 JP 2010521980 A JP2010521980 A JP 2010521980A JP 2010521980 A JP2010521980 A JP 2010521980A JP 2010536378 A5 JP2010536378 A5 JP 2010536378A5
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- JP
- Japan
- Prior art keywords
- seq
- group
- binding protein
- antigen binding
- cdrh2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000025171 antigen binding proteins Human genes 0.000 claims description 142
- 108091000831 antigen binding proteins Proteins 0.000 claims description 142
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 92
- 150000001413 amino acids Chemical class 0.000 claims description 61
- 108010058398 Macrophage Colony-Stimulating Factor Receptor Proteins 0.000 claims description 44
- 230000037430 deletion Effects 0.000 claims description 36
- 238000012217 deletion Methods 0.000 claims description 36
- 238000006467 substitution reaction Methods 0.000 claims description 36
- 238000007792 addition Methods 0.000 claims description 22
- 229910052757 nitrogen Inorganic materials 0.000 claims description 22
- 206010028980 Neoplasm Diseases 0.000 claims description 12
- 102000039446 nucleic acids Human genes 0.000 claims description 12
- 108020004707 nucleic acids Proteins 0.000 claims description 12
- 150000007523 nucleic acids Chemical class 0.000 claims description 12
- 230000035772 mutation Effects 0.000 claims description 10
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 8
- 230000002401 inhibitory effect Effects 0.000 claims description 8
- 230000037431 insertion Effects 0.000 claims description 8
- 238000003780 insertion Methods 0.000 claims description 8
- 210000004027 cell Anatomy 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 229910052698 phosphorus Inorganic materials 0.000 claims description 6
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 4
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 4
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims description 4
- 102220523992 Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1_E29R_mutation Human genes 0.000 claims description 4
- 238000009825 accumulation Methods 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 230000005012 migration Effects 0.000 claims description 4
- 238000013508 migration Methods 0.000 claims description 4
- 210000001616 monocyte Anatomy 0.000 claims description 4
- 210000004981 tumor-associated macrophage Anatomy 0.000 claims description 4
- 230000028550 monocyte chemotaxis Effects 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 206010003571 Astrocytoma Diseases 0.000 claims description 2
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 208000020084 Bone disease Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 102100035351 Cadherin-related family member 2 Human genes 0.000 claims description 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
- 206010014733 Endometrial cancer Diseases 0.000 claims description 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims description 2
- 101000737811 Homo sapiens Cadherin-related family member 2 Proteins 0.000 claims description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 230000035578 autophosphorylation Effects 0.000 claims description 2
- 201000010881 cervical cancer Diseases 0.000 claims description 2
- 229940127089 cytotoxic agent Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 201000003908 endometrial adenocarcinoma Diseases 0.000 claims description 2
- 208000029382 endometrium adenocarcinoma Diseases 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 201000010982 kidney cancer Diseases 0.000 claims description 2
- 238000002372 labelling Methods 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 16
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 102000014962 Monocyte Chemoattractant Proteins Human genes 0.000 claims 1
- 108010064136 Monocyte Chemoattractant Proteins Proteins 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 230000003248 secreting effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 12
- 230000006229 amino acid addition Effects 0.000 description 6
- 230000003466 anti-cipated effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95714807P | 2007-08-21 | 2007-08-21 | |
| US60/957,148 | 2007-08-21 | ||
| US8458808P | 2008-07-29 | 2008-07-29 | |
| US61/084,588 | 2008-07-29 | ||
| PCT/US2008/073611 WO2009026303A1 (en) | 2007-08-21 | 2008-08-19 | Human c-fms antigen binding proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014254993A Division JP6189281B2 (ja) | 2007-08-21 | 2014-12-17 | ヒトｃ−ｆｍｓ抗原結合性タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010536378A JP2010536378A (ja) | 2010-12-02 |
| JP2010536378A5 true JP2010536378A5 (enExample) | 2012-08-02 |
| JP5718640B2 JP5718640B2 (ja) | 2015-05-13 |
Family
ID=40019258
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010521980A Active JP5718640B2 (ja) | 2007-08-21 | 2008-08-19 | ヒトｃ−ｆｍｓ抗原結合性タンパク質 |
| JP2014254993A Expired - Fee Related JP6189281B2 (ja) | 2007-08-21 | 2014-12-17 | ヒトｃ−ｆｍｓ抗原結合性タンパク質 |
| JP2017148838A Withdrawn JP2018007683A (ja) | 2007-08-21 | 2017-08-01 | ヒトｃ−ｆｍｓ抗原結合性タンパク質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014254993A Expired - Fee Related JP6189281B2 (ja) | 2007-08-21 | 2014-12-17 | ヒトｃ−ｆｍｓ抗原結合性タンパク質 |
| JP2017148838A Withdrawn JP2018007683A (ja) | 2007-08-21 | 2017-08-01 | ヒトｃ−ｆｍｓ抗原結合性タンパク質 |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US8182813B2 (enExample) |
| EP (4) | EP3330292A1 (enExample) |
| JP (3) | JP5718640B2 (enExample) |
| KR (1) | KR101770429B1 (enExample) |
| CN (1) | CN101802008B (enExample) |
| AR (1) | AR068347A1 (enExample) |
| AU (1) | AU2008288974B2 (enExample) |
| BR (1) | BRPI0815368A2 (enExample) |
| CA (1) | CA2696761C (enExample) |
| CL (1) | CL2008002444A1 (enExample) |
| CR (1) | CR11282A (enExample) |
| CY (1) | CY1119755T1 (enExample) |
| DK (1) | DK2188313T3 (enExample) |
| EA (2) | EA023555B1 (enExample) |
| ES (1) | ES2650224T3 (enExample) |
| HR (1) | HRP20171741T1 (enExample) |
| HU (1) | HUE037265T2 (enExample) |
| LT (1) | LT2188313T (enExample) |
| MX (1) | MX2010001918A (enExample) |
| NO (1) | NO2188313T3 (enExample) |
| NZ (1) | NZ583282A (enExample) |
| PE (1) | PE20091004A1 (enExample) |
| PL (1) | PL2188313T3 (enExample) |
| PT (1) | PT2188313T (enExample) |
| RS (1) | RS56743B1 (enExample) |
| SG (1) | SG10201500328QA (enExample) |
| SI (1) | SI2188313T1 (enExample) |
| TW (1) | TWI595005B (enExample) |
| WO (1) | WO2009026303A1 (enExample) |
| ZA (1) | ZA201001541B (enExample) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8470977B2 (en) | 2008-03-14 | 2013-06-25 | Transgene S.A. | Antibody against the CSF-1R |
| WO2009112245A1 (en) | 2008-03-14 | 2009-09-17 | Transgene S.A. | Antibody against the csf-1 r |
| US8080246B2 (en) | 2008-11-26 | 2011-12-20 | Five Prime Therapeutics, Inc. | Colony stimulating factor 1 receptor (CSF1R) extracellular domain fusion molecules |
| US8183207B2 (en) | 2008-11-26 | 2012-05-22 | Five Prime Therapeutics, Inc. | Treatment of osteolytic disorders and cancer using CSF1R extracellular domain fusion molecules |
| IT1394281B1 (it) * | 2009-01-19 | 2012-06-06 | Zardi | Processo per la produzione di proteine di fusione polivalenti e polispecifiche utilizzando come struttura portante l'uteroglobina e prodotti cosi' ottenuti. |
| WO2011002494A1 (en) * | 2009-07-01 | 2011-01-06 | University Of Tenessee Research Foundation | Use of immunoglobulin heavy and light chains or fragments therof to bind to aggregated amyloidogenic proteins |
| CN105218672A (zh) * | 2009-12-10 | 2016-01-06 | 霍夫曼-拉罗奇有限公司 | 优先结合人csf1r胞外域4的抗体及其用途 |
| KR101656548B1 (ko) | 2010-03-05 | 2016-09-09 | 에프. 호프만-라 로슈 아게 | 인간 ｃｓｆ-1ｒ에 대한 항체 및 이의 용도 |
| RU2617966C2 (ru) | 2010-03-05 | 2017-04-28 | Ф.Хоффманн-Ля Рош Аг | Антитела против csf-1r человека и их применение |
| AR080698A1 (es) | 2010-04-01 | 2012-05-02 | Imclone Llc | Anticuerpo o fragmento del mismo que especificamente enlaza la variante de csf -1r humano, composicion farmaceutica que lo comprende, su uso para la manufactura de un medicamento util para el tratamiento de cancer y metodo para determinar si un sujeto es candidato para tratamiento de cancer basado e |
| KR20200044999A (ko) * | 2010-05-04 | 2020-04-29 | 파이브 프라임 테라퓨틱스, 인크. | Ｃｓｆ1ｒ에 결합하는 항체들 |
| PH12013500703A1 (en) * | 2010-10-13 | 2013-05-20 | Janssen Biotech Inc | Human oncostatin m antibodies and methods of use |
| US9527905B2 (en) * | 2011-02-08 | 2016-12-27 | Medimmune, Llc | Antibodies that specifically bind Staphylococcus aureus alpha toxin and methods of use |
| CN102719404B (zh) * | 2011-03-30 | 2015-02-18 | 中国人民解放军军事医学科学院毒物药物研究所 | 用于筛选c-Fms激酶抑制剂的细胞模型及筛选方法 |
| HUE053545T2 (hu) | 2011-05-17 | 2021-07-28 | Univ Rockefeller | Humán immundeficiencia vírus semlegesítõ antitestek és eljárások alkalmazásukra |
| WO2013011021A1 (en) * | 2011-07-18 | 2013-01-24 | The University Of Melbourne | Use of c-fms antagonists |
| US9139652B2 (en) | 2011-10-21 | 2015-09-22 | Transgene Sa | Method for increasing M1 macrophages in a patient |
| MX356337B (es) | 2011-12-15 | 2018-05-23 | Hoffmann La Roche | Anticuerpos contra csf-1r humano y sus usos. |
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| TWI713436B (zh) | 2012-08-31 | 2020-12-21 | 美商戊瑞治療有限公司 | 用結合群落刺激因子１受體（ｃｓｆ１ｒ）之抗體治療病狀之方法 |
| US9708375B2 (en) | 2013-03-15 | 2017-07-18 | Amgen Inc. | Inhibitory polypeptides specific to WNT inhibitors |
| JP2016516092A (ja) | 2013-04-12 | 2016-06-02 | モルフォシス・アー・ゲー | Ｍ−ｃｓｆを標的とする抗体 |
| AR095882A1 (es) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
| GB201315487D0 (en) | 2013-08-30 | 2013-10-16 | Ucb Pharma Sa | Antibodies |
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| PL3212670T3 (pl) | 2014-10-29 | 2021-06-14 | Five Prime Therapeutics, Inc. | Leczenie skojarzone nowotworów |
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