JP2010535012A5 - - Google Patents
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- JP2010535012A5 JP2010535012A5 JP2009551102A JP2009551102A JP2010535012A5 JP 2010535012 A5 JP2010535012 A5 JP 2010535012A5 JP 2009551102 A JP2009551102 A JP 2009551102A JP 2009551102 A JP2009551102 A JP 2009551102A JP 2010535012 A5 JP2010535012 A5 JP 2010535012A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- egfr
- composition
- separate
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 10
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 8
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 8
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 8
- 150000001413 amino acids Chemical class 0.000 claims 4
- 210000003527 eukaryotic cell Anatomy 0.000 claims 3
- 101000851181 Homo sapiens Epidermal growth factor receptor Proteins 0.000 claims 2
- 102000045108 human EGFR Human genes 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000011275 oncology therapy Methods 0.000 claims 1
- 238000005580 one pot reaction Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200700317 | 2007-03-01 | ||
| DKPA200700317 | 2007-03-01 | ||
| US90477307P | 2007-03-05 | 2007-03-05 | |
| US60/904,773 | 2007-03-05 | ||
| DKPA200701016 | 2007-07-10 | ||
| DKPA200701016 | 2007-07-10 | ||
| US92972707P | 2007-07-11 | 2007-07-11 | |
| US60/929,727 | 2007-07-11 | ||
| PCT/DK2008/050047 WO2008104183A2 (en) | 2007-03-01 | 2008-02-27 | Recombinant anti-epidermal growth factor receptor antibody compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010535012A JP2010535012A (ja) | 2010-11-18 |
| JP2010535012A5 true JP2010535012A5 (OSRAM) | 2011-04-14 |
| JP5726417B2 JP5726417B2 (ja) | 2015-06-03 |
Family
ID=39495833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009551102A Active JP5726417B2 (ja) | 2007-03-01 | 2008-02-27 | 組み換え抗上皮成長因子受容体抗体組成物 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US7887805B2 (OSRAM) |
| EP (2) | EP2132229B1 (OSRAM) |
| JP (1) | JP5726417B2 (OSRAM) |
| KR (2) | KR101805140B1 (OSRAM) |
| CN (2) | CN104151430A (OSRAM) |
| AU (1) | AU2008221118B2 (OSRAM) |
| BR (1) | BRPI0808551B1 (OSRAM) |
| CA (1) | CA2676049C (OSRAM) |
| DK (1) | DK2132229T3 (OSRAM) |
| ES (1) | ES2582386T3 (OSRAM) |
| HK (1) | HK1197252A1 (OSRAM) |
| IL (2) | IL199725A (OSRAM) |
| MX (2) | MX2009008909A (OSRAM) |
| NZ (2) | NZ597466A (OSRAM) |
| PL (1) | PL2132229T3 (OSRAM) |
| RU (1) | RU2013119724A (OSRAM) |
| TW (1) | TWI426083B (OSRAM) |
| WO (1) | WO2008104183A2 (OSRAM) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| ATE521704T1 (de) * | 2007-03-01 | 2011-09-15 | Symphogen As | Verfahren zur klonierung verwandter antikörper |
| AU2008221118B2 (en) | 2007-03-01 | 2013-10-03 | Les Laboratoires Servier | Recombinant anti-epidermal growth factor receptor antibody compositions |
| JP2008289483A (ja) * | 2007-05-25 | 2008-12-04 | Symphogen As | 真核生物系において発現可能な形質転換体のスクリーニング |
| US20110256142A1 (en) * | 2007-09-06 | 2011-10-20 | Genmab A/S | Novel methods and antibodies for treating cancer |
| US20090203038A1 (en) * | 2007-12-27 | 2009-08-13 | Abbott Laboratories | Negative Mimic Antibody For Use as a Blocking Reagent In BNP Immunoassays |
| KR20110058861A (ko) * | 2008-08-29 | 2011-06-01 | 심포젠 에이/에스 | 조류 유래 항체의 클로닝 방법 |
| JP5719298B2 (ja) | 2008-08-29 | 2015-05-13 | シムフォゲン・アクティーゼルスカブSymphogen A/S | 組換え抗上皮増殖因子受容体抗体組成物 |
| US20110224094A1 (en) * | 2008-10-06 | 2011-09-15 | Symphogen A/S | Method for identifying and selecting drug candidates for combinatorial drug products |
| FR2942928B1 (fr) | 2009-03-03 | 2011-04-01 | Alcatel Lucent | Procede et systeme de gestion multicriteres de notifications de presence |
| FR2945538B1 (fr) * | 2009-05-12 | 2014-12-26 | Sanofi Aventis | Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide. |
| WO2011028961A2 (en) | 2009-09-04 | 2011-03-10 | Xoma Technology Ltd. | Anti-botulism antibody coformulations |
| AU2010305150A1 (en) * | 2009-10-09 | 2012-04-05 | Symphogen A/S | Multiplex quantitation of individual recombinant proteins in a mixture by signature peptides and mass spectrometry |
| WO2011106707A2 (en) * | 2010-02-26 | 2011-09-01 | Human Genome Sciences, Inc. | Antibodies that specifically bind to dr3 |
| US8609095B2 (en) | 2010-03-04 | 2013-12-17 | Symphogen A/S | Anti-HER2 antibodies and compositions |
| EP2563393B1 (en) * | 2010-04-26 | 2016-06-08 | Abraxis BioScience, LLC | Sparc binding antibodies and uses thereof |
| WO2011140151A1 (en) * | 2010-05-04 | 2011-11-10 | Dyax Corp. | Antibodies against epidermal growth factor receptor (egfr) |
| MX2012012441A (es) * | 2010-05-04 | 2013-02-26 | Merrimack Pharmaceuticals Inc | Anticuerpos contra el receptor del factor de crecimiento epidermico (egfr) y usos de los mismos. |
| WO2012018260A1 (en) * | 2010-08-05 | 2012-02-09 | Universiteit Utrecht Holding B.V. | Epidermal growth factor receptor targeted immune therapy |
| EP2632490A4 (en) | 2010-10-29 | 2014-10-22 | Immunogen Inc | NOVEL MOLECULES BINDING TO THE EGF RECEPTOR AND IMMUNOCONJUGATES THEREOF |
| CN103328505B (zh) | 2010-10-29 | 2015-12-02 | 伊缪诺金公司 | 非拮抗性egfr结合分子及其免疫偶联物 |
| US9217039B2 (en) * | 2010-11-01 | 2015-12-22 | Symphogen A/S | Anti-HER3 antibodies and compositions |
| US9155802B2 (en) | 2010-11-01 | 2015-10-13 | Symphogen A/S | Pan-HER antibody composition |
| DK2663579T3 (en) | 2011-01-14 | 2017-07-31 | Univ California | THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND PROCEDURES FOR USE THEREOF |
| US10570211B2 (en) | 2011-01-24 | 2020-02-25 | Gilead Sciences, Inc. | Antibodies selective for cells presenting EGFR at high density |
| WO2012122484A1 (en) | 2011-03-09 | 2012-09-13 | Roberto Polakiewicz | Methods and reagents for creating monoclonal antibodies |
| CA2828075A1 (en) | 2011-03-11 | 2012-09-20 | Merrimack Pharmaceuticals, Inc. | Use of inhibitors of egfr-family receptors in the treatment of hormone refractory breast cancers |
| MX2013010444A (es) | 2011-03-15 | 2014-03-21 | Merrimack Pharmaceuticals Inc | Superar la resistencia a inhibidores de la via erbb. |
| US20120258502A1 (en) * | 2011-04-08 | 2012-10-11 | Vinod Pandiripally | Method of producing recombinant plasmid dna using substantially solid growth medium |
| US8691231B2 (en) * | 2011-06-03 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies |
| AU2012340686A1 (en) | 2011-11-21 | 2014-06-19 | Immunogen, Inc. | Method of treatment of tumors that are resistant to EGFR therapies by EGFR antibody cytotoxic agent conjugate |
| CA2862979A1 (en) * | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Humanized antibodies with ultralong cdr3s |
| US9527913B2 (en) | 2012-05-02 | 2016-12-27 | Symphogen A/S | Humanized pan-HER antibody compositions |
| EP2894472A4 (en) * | 2012-09-05 | 2016-03-30 | Jsr Corp | METHOD OF SCREENING MATERIAL FOR EPITHELIAL CONSERVATION OF CELLS |
| EP2912467A4 (en) * | 2012-10-26 | 2016-04-20 | Univ Queensland | METHOD FOR CLASSIFYING TUMORS AND USE THEREOF |
| CN102993305B (zh) * | 2012-11-16 | 2015-05-13 | 上海赛伦生物技术有限公司 | 人源抗人表皮生长因子受体抗体及其编码基因与应用 |
| US9856319B2 (en) * | 2012-12-28 | 2018-01-02 | Abbvie Inc. | Monovalent binding proteins |
| CN104059148B (zh) * | 2013-03-18 | 2016-09-07 | 回而生医药科技(北京)有限公司 | 人源化抗人表皮生长因子受体抗体及其应用 |
| KR20160055253A (ko) * | 2013-09-12 | 2016-05-17 | 할로자임, 아이엔씨 | 변형된 항-상피세포 성장인자 수용체 항체 및 이의 사용 방법 |
| WO2015112749A2 (en) * | 2014-01-22 | 2015-07-30 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for antibody and antibody-loaded dendritic cell mediated therapy |
| GB201402591D0 (en) | 2014-02-14 | 2014-04-02 | Memo Therapeutics Ag | Method for recovering two or more genes, or gene products, encoding an immunoreceptor |
| DK3483593T3 (da) * | 2014-03-26 | 2021-07-19 | Siemens Healthcare Diagnostics Inc | Luminescent-oxygen-channeling-immunoassay ved anvendelse af tre antistoffer og fremgangsmåder til fremstilling og anvendelse deraf |
| MA39599A (fr) | 2014-05-14 | 2016-10-05 | Merrimack Pharmaceuticals Inc | Dosage et administration d'agents thérapeutiques anti-egfr |
| EP3223857A4 (en) * | 2014-10-31 | 2018-06-27 | Formation Biologics Inc. | Egfr antibody-based combination therapy |
| SG11201706236SA (en) | 2015-02-06 | 2017-08-30 | Nat Univ Singapore | Methods for enhancing efficacy of therapeutic immune cells |
| CA2983890A1 (en) | 2015-04-24 | 2016-10-27 | Merrimack Pharmaceuticals, Inc. | Methods of treating patients having mutations in the extracellular domain of epidermal growth factor receptor (egfr) with a combination of three fully human monoclonal anti-egfr antibodies |
| BR112018068512A2 (pt) | 2016-03-15 | 2019-01-22 | Merrimack Pharmaceuticals Inc | métodos para tratar câncer de mama er+, her2-, hrg+ com o uso de terapias de combinação que compreendem um anticorpo anti-erbb3 |
| CN109475627B (zh) * | 2016-05-26 | 2023-01-06 | 齐鲁普吉湾生物治疗公司 | 抗体混合物 |
| CA3029902A1 (en) | 2016-07-07 | 2018-01-11 | The Board Of Trustees Of The Leland Stanford Junior University | Antibody adjuvant conjugates |
| AU2017363278B2 (en) | 2016-11-22 | 2022-10-27 | National University Of Singapore | Blockade of CD7 expression and chimeric antigen receptors for immunotherapy of T-cell malignancies |
| WO2018119402A1 (en) * | 2016-12-23 | 2018-06-28 | Visterra, Inc. | Binding polypeptides and methods of making the same |
| WO2018152634A1 (en) * | 2017-02-22 | 2018-08-30 | University Of Saskatchewan | Egfr-binding agents and uses thereof |
| WO2018166119A1 (zh) * | 2017-03-14 | 2018-09-20 | 北京伟峰益民科技有限公司 | 一种多肽或其衍生物及其在制备治疗肿瘤的药物中的应用 |
| AU2018313939A1 (en) | 2017-08-10 | 2020-02-06 | National University Of Singapore | T cell receptor-deficient chimeric antigen receptor T-cells and methods of use thereof |
| CN111278992A (zh) | 2017-08-30 | 2020-06-12 | 西福根有限公司 | 用抗egfr抗体治疗癌症的组合物和方法 |
| CN109912716B (zh) * | 2017-12-13 | 2022-08-23 | 凯惠科技发展(上海)有限公司 | 一种egfr抗体及其制备方法和应用 |
| MX2020007880A (es) * | 2018-01-25 | 2021-05-14 | Cullinan Mica Corp | Anticuerpos de mica/b y metodos de uso. |
| AU2019275076B2 (en) | 2018-05-23 | 2024-12-19 | National University Of Singapore | Blockade of CD2 surface expression and expression of chimeric antigen receptors for immunotherapy of T-cell malignancies |
| US11274035B2 (en) | 2019-04-24 | 2022-03-15 | X-Celeprint Limited | Overhanging device structures and related methods of manufacture |
| US12162747B2 (en) | 2018-12-03 | 2024-12-10 | X-Celeprint Limited | Enclosed cavity structures |
| US10456776B1 (en) | 2019-02-21 | 2019-10-29 | King Saud University | Method of fabricating a photocatalyst for water splitting |
| CA3130794A1 (en) | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| CN111018990A (zh) * | 2020-02-10 | 2020-04-17 | 张喜田 | 一种新型的重组抗表皮生长因子受体单克隆抗体及其应用 |
| MX2024004145A (es) | 2021-10-04 | 2024-04-22 | Servier Lab | Terapia del cancer dirigida a nkg2a. |
| AR127893A1 (es) | 2021-12-10 | 2024-03-06 | Servier Lab | Terapia del cáncer dirigida a egfr |
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| ATE521704T1 (de) | 2007-03-01 | 2011-09-15 | Symphogen As | Verfahren zur klonierung verwandter antikörper |
| JP2008289483A (ja) * | 2007-05-25 | 2008-12-04 | Symphogen As | 真核生物系において発現可能な形質転換体のスクリーニング |
| JP5719298B2 (ja) * | 2008-08-29 | 2015-05-13 | シムフォゲン・アクティーゼルスカブSymphogen A/S | 組換え抗上皮増殖因子受容体抗体組成物 |
| US9155802B2 (en) * | 2010-11-01 | 2015-10-13 | Symphogen A/S | Pan-HER antibody composition |
-
2008
- 2008-02-27 AU AU2008221118A patent/AU2008221118B2/en active Active
- 2008-02-27 JP JP2009551102A patent/JP5726417B2/ja active Active
- 2008-02-27 KR KR1020167031076A patent/KR101805140B1/ko not_active Expired - Fee Related
- 2008-02-27 ES ES08706941.5T patent/ES2582386T3/es active Active
- 2008-02-27 BR BRPI0808551-0A patent/BRPI0808551B1/pt active IP Right Grant
- 2008-02-27 PL PL08706941.5T patent/PL2132229T3/pl unknown
- 2008-02-27 KR KR1020097020519A patent/KR101676622B1/ko active Active
- 2008-02-27 DK DK08706941.5T patent/DK2132229T3/en active
- 2008-02-27 NZ NZ597466A patent/NZ597466A/xx not_active IP Right Cessation
- 2008-02-27 CA CA2676049A patent/CA2676049C/en active Active
- 2008-02-27 WO PCT/DK2008/050047 patent/WO2008104183A2/en not_active Ceased
- 2008-02-27 CN CN201410211600.2A patent/CN104151430A/zh active Pending
- 2008-02-27 EP EP08706941.5A patent/EP2132229B1/en active Active
- 2008-02-27 CN CN200880006835.0A patent/CN101675075B/zh active Active
- 2008-02-27 EP EP13187455.4A patent/EP2725036B1/en not_active Not-in-force
- 2008-02-27 NZ NZ578943A patent/NZ578943A/xx unknown
- 2008-02-27 MX MX2009008909A patent/MX2009008909A/es active IP Right Grant
- 2008-02-27 MX MX2011011163A patent/MX338151B/es unknown
- 2008-02-29 TW TW097107005A patent/TWI426083B/zh active
- 2008-02-29 US US12/074,056 patent/US7887805B2/en active Active
-
2009
- 2009-07-07 IL IL199725A patent/IL199725A/en active IP Right Grant
-
2010
- 2010-11-12 US US12/945,495 patent/US20110129855A1/en not_active Abandoned
- 2010-11-12 US US12/945,527 patent/US8414896B2/en active Active
-
2011
- 2011-12-08 IL IL216850A patent/IL216850A/en active IP Right Grant
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2013
- 2013-04-26 RU RU2013119724/10A patent/RU2013119724A/ru not_active Application Discontinuation
-
2014
- 2014-10-29 HK HK14110853.9A patent/HK1197252A1/en unknown
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