JP2018504105A5 - - Google Patents

Info

Publication number

JP2018504105A5

JP2018504105A5 JP2017533597A JP2017533597A JP2018504105A5 JP 2018504105 A5 JP2018504105 A5 JP 2018504105A5 JP 2017533597 A JP2017533597 A JP 2017533597A JP 2017533597 A JP2017533597 A JP 2017533597A JP 2018504105 A5 JP2018504105 A5 JP 2018504105A5

Authority

JP

Japan

Prior art keywords

seq

cdr2

cdr3

cdr1

antibody

Prior art date

2015-12-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000427 antigen Substances 0.000 claims 17
• 102000036639 antigens Human genes 0.000 claims 17
• 108091007433 antigens Proteins 0.000 claims 17
• 239000012634 fragment Substances 0.000 claims 17
• 102000040430 polynucleotide Human genes 0.000 claims 7
• 108091033319 polynucleotide Proteins 0.000 claims 7
• 239000002157 polynucleotide Substances 0.000 claims 7
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 5
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 150000007523 nucleic acids Chemical class 0.000 claims 3
• 230000000295 complement effect Effects 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 101000973901 Homo sapiens Tyrosine-protein kinase Mer Proteins 0.000 claims 1
• 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 1
• 210000003445 biliary tract Anatomy 0.000 claims 1
• 210000000988 bone and bone Anatomy 0.000 claims 1
• 210000000481 breast Anatomy 0.000 claims 1
• 210000001072 colon Anatomy 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 210000004696 endometrium Anatomy 0.000 claims 1
• 210000003238 esophagus Anatomy 0.000 claims 1
• 102000045684 human MERTK Human genes 0.000 claims 1
• 210000003734 kidney Anatomy 0.000 claims 1
• 210000000867 larynx Anatomy 0.000 claims 1
• 210000004185 liver Anatomy 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
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• 210000001685 thyroid gland Anatomy 0.000 claims 1
• 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 1
• 210000003932 urinary bladder Anatomy 0.000 claims 1
• 210000004291 uterus Anatomy 0.000 claims 1