JP2014530001A5 - - Google Patents

Info

Publication number

JP2014530001A5

JP2014530001A5 JP2014531755A JP2014531755A JP2014530001A5 JP 2014530001 A5 JP2014530001 A5 JP 2014530001A5 JP 2014531755 A JP2014531755 A JP 2014531755A JP 2014531755 A JP2014531755 A JP 2014531755A JP 2014530001 A5 JP2014530001 A5 JP 2014530001A5

Authority

JP

Japan

Prior art keywords

seq

polypeptide

tnf

light chain

chain variable

Prior art date

2012-09-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 37
• 229920001184 polypeptide Polymers 0.000 claims 35
• 102000004196 processed proteins & peptides Human genes 0.000 claims 35
• 102100027211 Albumin Human genes 0.000 claims 28
• 108010088751 Albumins Proteins 0.000 claims 28
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 24
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 24
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 22
• 125000003275 alpha amino acid group Chemical group 0.000 claims 17
• 239000012634 fragment Substances 0.000 claims 16
• 238000006467 substitution reaction Methods 0.000 claims 10
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
• 241000124008 Mammalia Species 0.000 claims 8
• 239000003814 drug Substances 0.000 claims 6
• 230000004927 fusion Effects 0.000 claims 6
• 102220563880 Glucagon receptor_V15P_mutation Human genes 0.000 claims 4
• 241000283984 Rodentia Species 0.000 claims 4
• 102220359436 c.238T>A Human genes 0.000 claims 4
• 102200074797 rs111033564 Human genes 0.000 claims 4
• 102200150982 rs28939717 Human genes 0.000 claims 4
• 239000000427 antigen Substances 0.000 claims 3
• 102000036639 antigens Human genes 0.000 claims 3
• 108091007433 antigens Proteins 0.000 claims 3
• 239000000539 dimer Substances 0.000 claims 3
• 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims 2
• 241000288906 Primates Species 0.000 claims 2
• 241000120569 Streptococcus equi subsp. zooepidemicus Species 0.000 claims 2
• 102220536557 Transcription factor NF-E4_A45D_mutation Human genes 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 102000057041 human TNF Human genes 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 102000005962 receptors Human genes 0.000 claims 2
• 102200082944 rs1135071 Human genes 0.000 claims 2
• 102220075538 rs796053378 Human genes 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 1
• 208000027866 inflammatory disease Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1