JP2012515540A5 - - Google Patents
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- Publication number
- JP2012515540A5 JP2012515540A5 JP2011546813A JP2011546813A JP2012515540A5 JP 2012515540 A5 JP2012515540 A5 JP 2012515540A5 JP 2011546813 A JP2011546813 A JP 2011546813A JP 2011546813 A JP2011546813 A JP 2011546813A JP 2012515540 A5 JP2012515540 A5 JP 2012515540A5
- Authority
- JP
- Japan
- Prior art keywords
- replaced
- region
- nucleic acid
- heavy chain
- encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200900118 | 2009-01-26 | ||
| DKPA200900118 | 2009-01-26 | ||
| PCT/EP2010/050822 WO2010084197A1 (en) | 2009-01-26 | 2010-01-26 | Methods for producing mixtures of antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016052035A Division JP2016165285A (ja) | 2009-01-26 | 2016-03-16 | 抗体混合物を産生するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012515540A JP2012515540A (ja) | 2012-07-12 |
| JP2012515540A5 true JP2012515540A5 (OSRAM) | 2013-03-14 |
Family
ID=42060888
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011546813A Ceased JP2012515540A (ja) | 2009-01-26 | 2010-01-26 | 抗体混合物を産生するための方法 |
| JP2016052035A Pending JP2016165285A (ja) | 2009-01-26 | 2016-03-16 | 抗体混合物を産生するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016052035A Pending JP2016165285A (ja) | 2009-01-26 | 2016-03-16 | 抗体混合物を産生するための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20120020952A1 (OSRAM) |
| EP (1) | EP2389392A1 (OSRAM) |
| JP (2) | JP2012515540A (OSRAM) |
| CN (2) | CN104262483A (OSRAM) |
| SG (1) | SG172977A1 (OSRAM) |
| WO (1) | WO2010084197A1 (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003250074B2 (en) | 2002-07-18 | 2010-09-09 | Merus N.V. | Recombinant production of mixtures of antibodies |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| CA2661848C (en) | 2006-09-01 | 2015-02-03 | Therapeutic Human Polyclonals, Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| AU2009324092A1 (en) * | 2008-12-03 | 2011-06-23 | Genmab A/S | Antibody variants having modifications in the constant region |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| CN101983968B (zh) * | 2010-09-26 | 2013-03-06 | 浙江海洋学院 | 乌贼墨寡肽的酶解制备方法 |
| BR112013019975A2 (pt) | 2011-02-28 | 2017-08-01 | Hoffmann La Roche | proteínas de ligação de antígeno, composição farmacêutica, uso de uma proteína de ligação de antígeno, método para o tratamento de um paciente e método para a preparação de uma proteína de ligação de antígeno, ácido nucleico, vetor e célula hospedeira" |
| CN103403025B (zh) | 2011-02-28 | 2016-10-12 | 弗·哈夫曼-拉罗切有限公司 | 单价抗原结合蛋白 |
| JP6031735B2 (ja) * | 2011-06-13 | 2016-11-24 | ソニー株式会社 | 情報処理装置、情報処理方法およびコンピュータプログラム |
| CN120383672A (zh) * | 2012-04-20 | 2025-07-29 | 美勒斯公司 | 用于产生免疫球蛋白样分子的方法和手段 |
| CN102851338A (zh) * | 2012-07-25 | 2013-01-02 | 苏州康宁杰瑞生物科技有限公司 | 利用电荷排斥作用制备同二聚体蛋白混合物的方法 |
| PT2900694T (pt) | 2012-09-27 | 2018-11-13 | Merus Nv | Anticorpos de igg biespecíficos como ativadores de células t |
| JP6422956B2 (ja) | 2013-10-11 | 2018-11-14 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 多重特異性ドメイン交換共通可変軽鎖抗体 |
| TW201609805A (zh) | 2013-12-23 | 2016-03-16 | 美國禮來大藥廠 | 結合ｅｇｆｒ及ｍｅｔ之多功能抗體 |
| IL301147A (en) | 2014-02-28 | 2023-05-01 | Merus Nv | An antibody that binds to ErbB-2 and ErbB-3 |
| EP3110846B1 (en) | 2014-02-28 | 2020-08-19 | Merus N.V. | Antibodies that bind egfr and erbb3 |
| ES2833230T3 (es) | 2014-05-13 | 2021-06-14 | Univ Pennsylvania | Composiciones que comprenden AVV que expresan construcciones y usos de doble anticuerpo del mismo |
| CN110658340B (zh) | 2015-01-08 | 2023-10-31 | 苏州康宁杰瑞生物科技有限公司 | 具有共同轻链的双特异性抗体或抗体混合物 |
| HUE042039T2 (hu) | 2015-07-10 | 2019-06-28 | Merus Nv | Humán CD3 kötõ antitest |
| HUE055222T2 (hu) | 2015-10-23 | 2021-11-29 | Merus Nv | Megkötõ molekulák, amelyek gátolják a rák növekedését |
| CN109475627B (zh) * | 2016-05-26 | 2023-01-06 | 齐鲁普吉湾生物治疗公司 | 抗体混合物 |
| CN110650752A (zh) | 2017-03-31 | 2020-01-03 | 美勒斯公司 | 用于治疗具有NRG1融合基因的细胞的ErbB-2和ErbB3结合双特异性抗体 |
| EA201992522A1 (ru) | 2017-05-17 | 2020-04-22 | Мерус Н.В. | КОМБИНАЦИЯ БИСПЕЦИФИЧЕСКОГО АНТИТЕЛА К ErbB-2/ErbB-3 С ЭНДОКРИННОЙ ТЕРАПИЕЙ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ |
| EP3665198B9 (en) | 2017-08-09 | 2025-05-21 | Merus N.V. | Antibodies that bind egfr and cmet |
| WO2025228542A1 (en) | 2024-05-03 | 2025-11-06 | Genmab B.V. | Method for co-expression of a plurality of antibodies |
| EP4644413A1 (en) | 2024-05-03 | 2025-11-05 | Genmab B.V. | Binding agents having altered fc-mediated effector functions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040110226A1 (en) * | 2002-03-01 | 2004-06-10 | Xencor | Antibody optimization |
| AU2003250074B2 (en) * | 2002-07-18 | 2010-09-09 | Merus N.V. | Recombinant production of mixtures of antibodies |
| JP2006501856A (ja) * | 2002-10-09 | 2006-01-19 | インテグリジェン， インコーポレイテッド | 組換え触媒ポリペプチドおよびその使用 |
| EP2395017A3 (en) * | 2003-05-30 | 2012-12-19 | Merus B.V. | Design and use of paired variable regions of specific binding molecules |
| WO2008145137A2 (en) * | 2007-05-31 | 2008-12-04 | Genmab A/S | Recombinant non glycosylated monovalent half-antibodies obtained by molecular engineering |
| ES2563027T3 (es) * | 2008-01-07 | 2016-03-10 | Amgen Inc. | Método para fabricación de moléculas heterodímeras Fc de anticuerpos utilizando efectos de conducción electrostática |
-
2010
- 2010-01-26 EP EP10701360A patent/EP2389392A1/en not_active Withdrawn
- 2010-01-26 US US13/146,297 patent/US20120020952A1/en not_active Abandoned
- 2010-01-26 SG SG2011050903A patent/SG172977A1/en unknown
- 2010-01-26 CN CN201410421605.8A patent/CN104262483A/zh active Pending
- 2010-01-26 CN CN2010800137659A patent/CN102365296A/zh active Pending
- 2010-01-26 JP JP2011546813A patent/JP2012515540A/ja not_active Ceased
- 2010-01-26 WO PCT/EP2010/050822 patent/WO2010084197A1/en not_active Ceased
-
2016
- 2016-03-16 JP JP2016052035A patent/JP2016165285A/ja active Pending
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