JP2010534708A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010534708A5 JP2010534708A5 JP2010518637A JP2010518637A JP2010534708A5 JP 2010534708 A5 JP2010534708 A5 JP 2010534708A5 JP 2010518637 A JP2010518637 A JP 2010518637A JP 2010518637 A JP2010518637 A JP 2010518637A JP 2010534708 A5 JP2010534708 A5 JP 2010534708A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- bmp
- complex
- complex according
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims description 9
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims 8
- 150000004804 polysaccharides Polymers 0.000 claims 8
- 229920001282 polysaccharide Polymers 0.000 claims 7
- 239000005017 polysaccharide Substances 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 239000002131 composite material Substances 0.000 claims 5
- 229920002307 Dextran Polymers 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001913 cellulose Substances 0.000 claims 3
- 229920002678 cellulose Polymers 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 230000002209 hydrophobic effect Effects 0.000 claims 3
- 125000001165 hydrophobic group Chemical group 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 2
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 102100035379 Growth/differentiation factor 5 Human genes 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- 239000000783 alginic acid Substances 0.000 claims 2
- 229920000615 alginic acid Polymers 0.000 claims 2
- 235000010443 alginic acid Nutrition 0.000 claims 2
- 229960001126 alginic acid Drugs 0.000 claims 2
- 150000004781 alginic acids Chemical class 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 claims 2
- 229940112869 bone morphogenetic protein Drugs 0.000 claims 2
- 150000007942 carboxylates Chemical class 0.000 claims 2
- 229940045110 chitosan Drugs 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims 1
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 claims 1
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 1
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 claims 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 1
- 108010090254 Growth Differentiation Factor 5 Proteins 0.000 claims 1
- 101710204282 Growth/differentiation factor 5 Proteins 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- -1 amide derivative of tryptophan Chemical class 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 229940059329 chondroitin sulfate Drugs 0.000 claims 1
- 229960001843 dibotermin alfa Drugs 0.000 claims 1
- 150000004676 glycans Polymers 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 230000011164 ossification Effects 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 125000003367 polycyclic group Chemical group 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002441 reversible effect Effects 0.000 claims 1
- 150000007970 thio esters Chemical class 0.000 claims 1
- 150000003568 thioethers Chemical class 0.000 claims 1
- 125000000430 tryptophan group Chemical class [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 239000000872 buffer Substances 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95240707P | 2007-07-27 | 2007-07-27 | |
| FR0705536A FR2919188B1 (fr) | 2007-07-27 | 2007-07-27 | Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps |
| PCT/EP2008/059832 WO2009016131A1 (fr) | 2007-07-27 | 2008-07-25 | COMPLEXES ENTRE UN POLYMÈRE AMPHIPHILE ET UNE PROTÉINE OSTÉOGÉNIQUE APPARTENANT À LA FAMILLE DES BMPs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010534708A JP2010534708A (ja) | 2010-11-11 |
| JP2010534708A5 true JP2010534708A5 (https=) | 2010-12-24 |
Family
ID=38990010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010518637A Pending JP2010534708A (ja) | 2007-07-27 | 2008-07-25 | 両親媒性ポリマーとｂｍｐファミリーに属する骨形成タンパク質との複合体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8389661B2 (https=) |
| EP (1) | EP2178565A1 (https=) |
| JP (1) | JP2010534708A (https=) |
| KR (1) | KR20100051695A (https=) |
| CN (1) | CN101835493A (https=) |
| AU (1) | AU2008281848A1 (https=) |
| BR (1) | BRPI0813025A2 (https=) |
| CA (1) | CA2694600A1 (https=) |
| FR (1) | FR2919188B1 (https=) |
| MX (1) | MX2010001104A (https=) |
| RU (1) | RU2010107203A (https=) |
| WO (1) | WO2009016131A1 (https=) |
| ZA (1) | ZA201001163B (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2914305B1 (fr) * | 2007-03-29 | 2009-07-03 | Proteins & Peptides Man | Dextran fonctionnalise par des amino-acides hydrophobes. |
| US20120041079A1 (en) * | 2006-09-26 | 2012-02-16 | Adocia | Dextran functionalized by hydrophobic amino acids |
| AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
| US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
| CN101801405A (zh) | 2007-08-07 | 2010-08-11 | 先进科技及再生医学有限责任公司 | 包含于酸性水溶液中的gdf-5的蛋白质配方 |
| BRPI0911048A2 (pt) | 2008-04-14 | 2015-12-29 | Atrm Llc | formulações líquidas tamponadas de gdf-5 |
| CN102065882A (zh) * | 2008-04-14 | 2011-05-18 | 阿道恰公司 | 包含生长因子/两亲性聚合物复合物、阳离子的可溶性盐和有机支持物的成骨组合物 |
| US20090291113A1 (en) * | 2008-04-14 | 2009-11-26 | Adocia | Osteogenic composition comprising a growth factor, a soluble cation salt and organic support |
| FR2934999B1 (fr) * | 2008-08-13 | 2011-07-29 | Adocia | Polysaccharides fonctionnalises par des derives du tryptophane |
| CA2738274A1 (fr) | 2008-09-26 | 2010-04-01 | Adocia | Complexe constitue d'un polysaccharide et d'une hpb |
| FR2948573B1 (fr) * | 2009-07-31 | 2011-11-18 | Adocia | Nouvelle forme d'administration de complexes de proteines osteogeniques |
| US8529933B2 (en) | 2009-07-27 | 2013-09-10 | Warsaw Orthopedic, Inc. | Biphasic calcium phosphate cement for drug delivery |
| JP2011030455A (ja) * | 2009-07-30 | 2011-02-17 | Uha Mikakuto Co Ltd | トリプトファン−ヒアルロン酸食品素材及びトリプトファン高含有ペプチド−ヒアルロン酸食品素材並びにそれらの製造方法 |
| FR2952375A1 (fr) * | 2009-11-10 | 2011-05-13 | Adocia | Polysaccharides comportant des groupes fonctionnels carboxyles substitues par esterification par un derive d'alcool hydrophobe |
| FR2956116A1 (fr) * | 2010-02-09 | 2011-08-12 | Adocia | Complexes polysaccharide/bmp-7 solubles a ph physiologique |
| WO2011097342A1 (en) * | 2010-02-04 | 2011-08-11 | University Of Utah Research Foundation | Hydrophobically-modified hyaluronan and methods of making and using thereof |
| FR2958647B1 (fr) | 2010-04-08 | 2013-08-23 | Adocia | Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive hydrophobe porte par un spacer au moins trivalent. |
| WO2011098962A2 (fr) * | 2010-02-09 | 2011-08-18 | Adocia | Polysaccharides anioniques fonctionnalisés par au moins deux groupements hydrophobes portés par un spacer au moins trivalent |
| CA2806143A1 (en) * | 2010-07-30 | 2012-02-02 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mb H | Drug delivery devices and growth factor formulations for accelerated wound healing |
| CN101942101A (zh) * | 2010-09-02 | 2011-01-12 | 四川大学 | 含疏水烷基侧链的两亲性聚电解质接枝物制备方法 |
| JP2012082180A (ja) * | 2010-10-14 | 2012-04-26 | Nagoya Univ | 骨再生用自己組織化ペプチドハイドロゲル |
| JP5950477B2 (ja) | 2011-08-10 | 2016-07-13 | アドシア | 少なくとも１種の基礎インスリンの注射溶液 |
| WO2013104861A1 (fr) | 2012-01-09 | 2013-07-18 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide substitue |
| US9815912B2 (en) * | 2012-03-19 | 2017-11-14 | University Of Massachusetts | Hydrophilic modification of water insoluble polysaccharide as surface-active agents |
| US20150314003A2 (en) | 2012-08-09 | 2015-11-05 | Adocia | Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer |
| EP2920200A1 (fr) * | 2012-11-13 | 2015-09-23 | Adocia | Composes anioniques substitues constitues d'un squelette forme d'un nombre discret d'unites saccharidiques |
| EP2919804B1 (fr) | 2012-11-13 | 2018-01-31 | Adocia | Formulation à action rapide d'insuline comprenant un composé anionique substitué |
| FR3020947B1 (fr) | 2014-05-14 | 2018-08-31 | Adocia | Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations |
| US9795678B2 (en) | 2014-05-14 | 2017-10-24 | Adocia | Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound |
| FR3043557B1 (fr) | 2015-11-16 | 2019-05-31 | Adocia | Composition a action rapide d'insuline comprenant un citrate substitue |
| CN105820270A (zh) * | 2016-03-30 | 2016-08-03 | 中国药科大学 | 硫酸化透明质酰脂肪烃胺 |
| CN119112883B (zh) * | 2024-09-12 | 2025-06-06 | 华南农业大学 | L-色氨酰胺盐酸盐的应用和抗菌组合物 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2808405A (en) * | 1955-03-11 | 1957-10-01 | Ohio Commw Eng Co | Acylated amino acid esters of dextran products and method of making same |
| DE4136324A1 (de) | 1991-11-05 | 1993-05-13 | Hoechst Ag | Dextranderivate als adsorptionsmittel fuer gallensaeuren, mit gallensaeuren beladene dextranderivate und verfahren zu deren herstellung sowie deren anwendung als arzneimittel |
| US6573251B2 (en) * | 1994-03-30 | 2003-06-03 | Denis Barritault | Drug and pharmaceutical composition for the treatment of lesions of the nervous system and fractions enriched in heparan sulfate |
| DE4433101A1 (de) * | 1994-09-16 | 1996-03-21 | Bauer Kurt Heinz Prof Dr | Wasserlösliche Dextranfettsäureester und ihre Verwendung als Solubilisatoren |
| CA2192725C (en) * | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
| US20040132653A1 (en) * | 1997-01-30 | 2004-07-08 | Biopharm Gmbh | Lyophilized composition of bone morphogenetic factor human MP52 |
| WO1998046248A1 (en) * | 1997-04-14 | 1998-10-22 | Anderson Byron E | Method and material for inhibiting complement |
| CA2305621C (en) * | 1997-10-03 | 2009-01-20 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| FR2772382B1 (fr) * | 1997-12-11 | 2000-03-03 | Solutions | Derives de dextrane, leur procede de preparation et leurs applications comme medicaments a action biologique specifique |
| US6423345B2 (en) * | 1998-04-30 | 2002-07-23 | Acusphere, Inc. | Matrices formed of polymer and hydrophobic compounds for use in drug delivery |
| FR2781485B1 (fr) * | 1998-07-21 | 2003-08-08 | Denis Barritault | Polymeres biocompatibles leur procede de preparation et les compositions les contenant |
| JP4548623B2 (ja) * | 1999-02-24 | 2010-09-22 | 多木化学株式会社 | 生体材料 |
| PL351948A1 (en) * | 1999-06-04 | 2003-07-14 | Alza Corp | Implantable gel compositions and method of making thereof |
| FR2794649B1 (fr) * | 1999-06-11 | 2003-04-11 | Solutions | Biomateriau a base d'un derive de dextrane insolubilise et d'un facteur de croissance, son procede de preparation et ses applications |
| EP1481695A1 (en) * | 1999-10-15 | 2004-12-01 | Genetics Institute, LLC | Formulations of hyaluronic acid for delivery of osteogenic proteins |
| PT1223990E (pt) * | 1999-10-15 | 2004-12-31 | Fidia Advanced Biopolymers Srl | Formulacoes de acido hialuronico para administracao de proteinas osteogenicas |
| EP1355965B1 (en) * | 2000-10-19 | 2012-09-19 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Method of synthesizing block copolymers for multifunctional self-assembled systems |
| WO2003011226A2 (en) * | 2001-08-01 | 2003-02-13 | Smithkline Beecham Corporation | Products and drug delivery vehicles |
| BR0310087A (pt) * | 2002-05-17 | 2005-08-16 | Wyeth Corp | Veìculos sólidos injetáveis para ácido hialurÈnico para aplicação de proteìnas osteogênicas |
| ES2380340T3 (es) * | 2003-12-05 | 2012-05-10 | Northwestern University | Anfífilos peptídicos auto-ensamblantes y métodos relacionados para la administración de factores de crecimiento |
| FR2891149B1 (fr) * | 2005-09-26 | 2007-11-30 | Biodex Sarl | Composition pharmaceutique a action cicatrisante comprenant un derive de dextrane soluble et un facteur de croissance derive des plaquettes. |
| FR2914305B1 (fr) * | 2007-03-29 | 2009-07-03 | Proteins & Peptides Man | Dextran fonctionnalise par des amino-acides hydrophobes. |
| JP2009532552A (ja) * | 2006-04-07 | 2009-09-10 | アドシア | 二官能化された多糖類 |
| US20080102128A1 (en) * | 2006-07-28 | 2008-05-01 | Flamel Technologies, Inc. | Modified-release microparticles based on amphiphilic copolymer and on active principles(s) and pharmaceutical formulations comprising them |
-
2007
- 2007-07-27 FR FR0705536A patent/FR2919188B1/fr not_active Expired - Fee Related
-
2008
- 2008-07-25 KR KR1020107004494A patent/KR20100051695A/ko not_active Withdrawn
- 2008-07-25 RU RU2010107203/15A patent/RU2010107203A/ru not_active Application Discontinuation
- 2008-07-25 MX MX2010001104A patent/MX2010001104A/es active IP Right Grant
- 2008-07-25 AU AU2008281848A patent/AU2008281848A1/en not_active Abandoned
- 2008-07-25 WO PCT/EP2008/059832 patent/WO2009016131A1/fr not_active Ceased
- 2008-07-25 BR BRPI0813025A patent/BRPI0813025A2/pt not_active IP Right Cessation
- 2008-07-25 CA CA2694600A patent/CA2694600A1/fr not_active Abandoned
- 2008-07-25 EP EP08786481A patent/EP2178565A1/fr not_active Withdrawn
- 2008-07-25 CN CN200880107383A patent/CN101835493A/zh active Pending
- 2008-07-25 JP JP2010518637A patent/JP2010534708A/ja active Pending
- 2008-07-25 US US12/219,679 patent/US8389661B2/en not_active Expired - Fee Related
-
2010
- 2010-02-17 ZA ZA201001163A patent/ZA201001163B/xx unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010534708A5 (https=) | ||
| RU2010107203A (ru) | Комплексы между амфифильным полимером и остеогенным белком, принадлежащим к семейству вмр | |
| JP5695568B2 (ja) | 疎水性アルコール誘導体により置換されたカルボキシル官能基を含有する多糖類 | |
| JP5945504B2 (ja) | ヒアルロン酸の酸化誘導体，その調製方法及びその修飾方法 | |
| JP2012509303A5 (https=) | ||
| JP3425147B2 (ja) | ポリアニオン性多糖の非水溶性誘導体 | |
| CA2549295C (en) | Modified macromolecules and methods of making and using thereof | |
| JP5886754B2 (ja) | ヒアルロン酸の酸化誘導体の調製方法及びその修飾方法 | |
| JP2009509952A5 (https=) | ||
| RU2008116585A (ru) | Комплекс амфифильный полимер-pdgf | |
| ITFI20000020A1 (it) | Gel di acido ialuronico cross-linked con l-amminoacidi o l-amminoesteri bifunzionali | |
| WO2015128787A1 (en) | Hyaluronan conjugates with pharmaceutically active substances, methods and compositions | |
| ES2907987T3 (es) | Método de reticulación de polisacáridos utilizando grupos protectores fotoremovibles | |
| KR102665664B1 (ko) | 황산화 다당류의 유도체 및 이의 제조 방법, 변형 방법 및 용도 | |
| ES2874075T3 (es) | Nuevos hidrogeles de estructura sililada y procedimiento de obtención |