KR20100051695A - 양쪽 친매성 폴리머와 ｂｍｐ 패밀리의 골형성 단백질의 복합체 - Google Patents
양쪽 친매성 폴리머와 ｂｍｐ 패밀리의 골형성 단백질의 복합체 Download PDFInfo
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Classifications
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- C08B11/10—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals
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- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
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- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
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- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
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- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
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- C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95240707P | 2007-07-27 | 2007-07-27 | |
| US60/952,407 | 2007-07-27 | ||
| FR0705536A FR2919188B1 (fr) | 2007-07-27 | 2007-07-27 | Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps |
| FR07/05536 | 2007-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20100051695A true KR20100051695A (ko) | 2010-05-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107004494A Withdrawn KR20100051695A (ko) | 2007-07-27 | 2008-07-25 | 양쪽 친매성 폴리머와 ｂｍｐ 패밀리의 골형성 단백질의 복합체 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8389661B2 (https=) |
| EP (1) | EP2178565A1 (https=) |
| JP (1) | JP2010534708A (https=) |
| KR (1) | KR20100051695A (https=) |
| CN (1) | CN101835493A (https=) |
| AU (1) | AU2008281848A1 (https=) |
| BR (1) | BRPI0813025A2 (https=) |
| CA (1) | CA2694600A1 (https=) |
| FR (1) | FR2919188B1 (https=) |
| MX (1) | MX2010001104A (https=) |
| RU (1) | RU2010107203A (https=) |
| WO (1) | WO2009016131A1 (https=) |
| ZA (1) | ZA201001163B (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2914305B1 (fr) * | 2007-03-29 | 2009-07-03 | Proteins & Peptides Man | Dextran fonctionnalise par des amino-acides hydrophobes. |
| US20120041079A1 (en) * | 2006-09-26 | 2012-02-16 | Adocia | Dextran functionalized by hydrophobic amino acids |
| AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
| US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
| CN101801405A (zh) | 2007-08-07 | 2010-08-11 | 先进科技及再生医学有限责任公司 | 包含于酸性水溶液中的gdf-5的蛋白质配方 |
| BRPI0911048A2 (pt) | 2008-04-14 | 2015-12-29 | Atrm Llc | formulações líquidas tamponadas de gdf-5 |
| CN102065882A (zh) * | 2008-04-14 | 2011-05-18 | 阿道恰公司 | 包含生长因子/两亲性聚合物复合物、阳离子的可溶性盐和有机支持物的成骨组合物 |
| US20090291113A1 (en) * | 2008-04-14 | 2009-11-26 | Adocia | Osteogenic composition comprising a growth factor, a soluble cation salt and organic support |
| FR2934999B1 (fr) * | 2008-08-13 | 2011-07-29 | Adocia | Polysaccharides fonctionnalises par des derives du tryptophane |
| CA2738274A1 (fr) | 2008-09-26 | 2010-04-01 | Adocia | Complexe constitue d'un polysaccharide et d'une hpb |
| FR2948573B1 (fr) * | 2009-07-31 | 2011-11-18 | Adocia | Nouvelle forme d'administration de complexes de proteines osteogeniques |
| US8529933B2 (en) | 2009-07-27 | 2013-09-10 | Warsaw Orthopedic, Inc. | Biphasic calcium phosphate cement for drug delivery |
| JP2011030455A (ja) * | 2009-07-30 | 2011-02-17 | Uha Mikakuto Co Ltd | トリプトファン−ヒアルロン酸食品素材及びトリプトファン高含有ペプチド−ヒアルロン酸食品素材並びにそれらの製造方法 |
| FR2952375A1 (fr) * | 2009-11-10 | 2011-05-13 | Adocia | Polysaccharides comportant des groupes fonctionnels carboxyles substitues par esterification par un derive d'alcool hydrophobe |
| FR2956116A1 (fr) * | 2010-02-09 | 2011-08-12 | Adocia | Complexes polysaccharide/bmp-7 solubles a ph physiologique |
| WO2011097342A1 (en) * | 2010-02-04 | 2011-08-11 | University Of Utah Research Foundation | Hydrophobically-modified hyaluronan and methods of making and using thereof |
| FR2958647B1 (fr) | 2010-04-08 | 2013-08-23 | Adocia | Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive hydrophobe porte par un spacer au moins trivalent. |
| WO2011098962A2 (fr) * | 2010-02-09 | 2011-08-18 | Adocia | Polysaccharides anioniques fonctionnalisés par au moins deux groupements hydrophobes portés par un spacer au moins trivalent |
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| CN101942101A (zh) * | 2010-09-02 | 2011-01-12 | 四川大学 | 含疏水烷基侧链的两亲性聚电解质接枝物制备方法 |
| JP2012082180A (ja) * | 2010-10-14 | 2012-04-26 | Nagoya Univ | 骨再生用自己組織化ペプチドハイドロゲル |
| JP5950477B2 (ja) | 2011-08-10 | 2016-07-13 | アドシア | 少なくとも１種の基礎インスリンの注射溶液 |
| WO2013104861A1 (fr) | 2012-01-09 | 2013-07-18 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide substitue |
| US9815912B2 (en) * | 2012-03-19 | 2017-11-14 | University Of Massachusetts | Hydrophilic modification of water insoluble polysaccharide as surface-active agents |
| US20150314003A2 (en) | 2012-08-09 | 2015-11-05 | Adocia | Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer |
| EP2920200A1 (fr) * | 2012-11-13 | 2015-09-23 | Adocia | Composes anioniques substitues constitues d'un squelette forme d'un nombre discret d'unites saccharidiques |
| EP2919804B1 (fr) | 2012-11-13 | 2018-01-31 | Adocia | Formulation à action rapide d'insuline comprenant un composé anionique substitué |
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| JP2009532552A (ja) * | 2006-04-07 | 2009-09-10 | アドシア | 二官能化された多糖類 |
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-
2007
- 2007-07-27 FR FR0705536A patent/FR2919188B1/fr not_active Expired - Fee Related
-
2008
- 2008-07-25 KR KR1020107004494A patent/KR20100051695A/ko not_active Withdrawn
- 2008-07-25 RU RU2010107203/15A patent/RU2010107203A/ru not_active Application Discontinuation
- 2008-07-25 MX MX2010001104A patent/MX2010001104A/es active IP Right Grant
- 2008-07-25 AU AU2008281848A patent/AU2008281848A1/en not_active Abandoned
- 2008-07-25 WO PCT/EP2008/059832 patent/WO2009016131A1/fr not_active Ceased
- 2008-07-25 BR BRPI0813025A patent/BRPI0813025A2/pt not_active IP Right Cessation
- 2008-07-25 CA CA2694600A patent/CA2694600A1/fr not_active Abandoned
- 2008-07-25 EP EP08786481A patent/EP2178565A1/fr not_active Withdrawn
- 2008-07-25 CN CN200880107383A patent/CN101835493A/zh active Pending
- 2008-07-25 JP JP2010518637A patent/JP2010534708A/ja active Pending
- 2008-07-25 US US12/219,679 patent/US8389661B2/en not_active Expired - Fee Related
-
2010
- 2010-02-17 ZA ZA201001163A patent/ZA201001163B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20090048412A1 (en) | 2009-02-19 |
| FR2919188B1 (fr) | 2010-02-26 |
| US8389661B2 (en) | 2013-03-05 |
| JP2010534708A (ja) | 2010-11-11 |
| AU2008281848A1 (en) | 2009-02-05 |
| CN101835493A (zh) | 2010-09-15 |
| RU2010107203A (ru) | 2011-09-10 |
| ZA201001163B (en) | 2010-10-27 |
| EP2178565A1 (fr) | 2010-04-28 |
| MX2010001104A (es) | 2010-04-01 |
| WO2009016131A1 (fr) | 2009-02-05 |
| CA2694600A1 (fr) | 2009-02-05 |
| BRPI0813025A2 (pt) | 2017-08-08 |
| FR2919188A1 (fr) | 2009-01-30 |
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