FR2948573B1 - Nouvelle forme d'administration de complexes de proteines osteogeniques - Google Patents
Nouvelle forme d'administration de complexes de proteines osteogeniquesInfo
- Publication number
- FR2948573B1 FR2948573B1 FR0903803A FR0903803A FR2948573B1 FR 2948573 B1 FR2948573 B1 FR 2948573B1 FR 0903803 A FR0903803 A FR 0903803A FR 0903803 A FR0903803 A FR 0903803A FR 2948573 B1 FR2948573 B1 FR 2948573B1
- Authority
- FR
- France
- Prior art keywords
- osteogenic protein
- administration
- protein complexes
- new form
- coprecipitate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/721—Dextrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
- A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0903803A FR2948573B1 (fr) | 2009-07-31 | 2009-07-31 | Nouvelle forme d'administration de complexes de proteines osteogeniques |
JP2011536920A JP2012509303A (ja) | 2008-11-19 | 2009-11-19 | 骨形成タンパク質複合体の新規投与形態 |
PCT/FR2009/001332 WO2010058106A1 (fr) | 2008-11-19 | 2009-11-19 | Nouvelle forme d'administration de complexes de protéines ostéogéniques |
AU2009317083A AU2009317083A1 (en) | 2008-11-19 | 2009-11-19 | Novel form of administering osteogenic protein complexes |
SG2011037108A SG171388A1 (en) | 2008-11-19 | 2009-11-19 | Novel form of administering osteogenic protein complexes |
EP09809027A EP2376063A1 (fr) | 2008-11-19 | 2009-11-19 | Nouvelle forme d'administration de complexes de protéines ostéogéniques |
BRPI0916110A BRPI0916110A2 (pt) | 2008-11-19 | 2009-11-19 | "processo para preparação do co-precipitado, co-precipitado e kit para preparar um implante osteogênico" |
CA2744150A CA2744150A1 (fr) | 2008-11-19 | 2009-11-19 | Nouvelle forme d'administration de complexes de proteines osteogeniques |
CN2009801546015A CN102281868A (zh) | 2008-11-19 | 2009-11-19 | 成骨蛋白复合物的新型施用形式 |
US12/591,442 US8546356B2 (en) | 2008-11-19 | 2009-11-19 | Administration form of osteogenic protein complexes |
RU2011124917/15A RU2011124917A (ru) | 2008-11-19 | 2009-11-19 | Новая форма введения остеогенных белковых комплексов |
MX2011005275A MX2011005275A (es) | 2008-11-19 | 2009-11-19 | Nueva forma de administración de complejos de proteína osteogénica. |
KR1020117014109A KR20110086752A (ko) | 2008-11-19 | 2009-11-19 | 골형성 단백질 복합체 투여의 신규한 형태 |
IL213001A IL213001A0 (en) | 2008-11-19 | 2011-05-19 | Novel form of administering osteogenic protein complexes |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0903803A FR2948573B1 (fr) | 2009-07-31 | 2009-07-31 | Nouvelle forme d'administration de complexes de proteines osteogeniques |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2948573A1 FR2948573A1 (fr) | 2011-02-04 |
FR2948573B1 true FR2948573B1 (fr) | 2011-11-18 |
Family
ID=41719051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0903803A Expired - Fee Related FR2948573B1 (fr) | 2008-11-19 | 2009-07-31 | Nouvelle forme d'administration de complexes de proteines osteogeniques |
Country Status (14)
Country | Link |
---|---|
US (1) | US8546356B2 (fr) |
EP (1) | EP2376063A1 (fr) |
JP (1) | JP2012509303A (fr) |
KR (1) | KR20110086752A (fr) |
CN (1) | CN102281868A (fr) |
AU (1) | AU2009317083A1 (fr) |
BR (1) | BRPI0916110A2 (fr) |
CA (1) | CA2744150A1 (fr) |
FR (1) | FR2948573B1 (fr) |
IL (1) | IL213001A0 (fr) |
MX (1) | MX2011005275A (fr) |
RU (1) | RU2011124917A (fr) |
SG (1) | SG171388A1 (fr) |
WO (1) | WO2010058106A1 (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150079145A1 (en) * | 2006-12-14 | 2015-03-19 | DePuy Synthes Products, LLC | Protein stabilization formulations |
FR2948573B1 (fr) | 2009-07-31 | 2011-11-18 | Adocia | Nouvelle forme d'administration de complexes de proteines osteogeniques |
US9018190B2 (en) | 2009-03-27 | 2015-04-28 | Adocia | Functionalized oligosaccharides |
FR2980796B1 (fr) * | 2011-09-30 | 2014-07-04 | Adocia | Oligosaccharides fonctionnalises |
FR2943538B1 (fr) | 2009-03-27 | 2011-05-20 | Adocia | Formulation a action rapide d'insuline recombinante humaine |
FR2956116A1 (fr) | 2010-02-09 | 2011-08-12 | Adocia | Complexes polysaccharide/bmp-7 solubles a ph physiologique |
FR2958647B1 (fr) * | 2010-04-08 | 2013-08-23 | Adocia | Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive hydrophobe porte par un spacer au moins trivalent. |
JP5950458B2 (ja) * | 2010-02-09 | 2016-07-13 | アドシア | 少なくとも3価のスペーサーにより保有される少なくとも2つの疎水性基により官能化されたアニオン性多糖類 |
EP2612674A4 (fr) * | 2010-09-01 | 2014-03-26 | Osteopharma Inc | Préparation cryodesséchée de protéine morphogénétique osseuse humaine recombinante 2 |
WO2012153070A1 (fr) * | 2011-05-10 | 2012-11-15 | Adocia | Oligosaccharides fonctionnalisés |
KR101810055B1 (ko) * | 2011-08-10 | 2017-12-18 | 아도시아 | 하나 이상의 유형의 기저 인슐린의 주사액 |
US20130231281A1 (en) | 2011-11-02 | 2013-09-05 | Adocia | Rapid acting insulin formulation comprising an oligosaccharide |
DK2919804T3 (en) | 2012-11-13 | 2018-05-14 | Adocia | Rapidly acting insulin formulation comprising a substituted anionic compound |
US9359417B2 (en) | 2013-01-25 | 2016-06-07 | Warsaw Orthopedic, Inc. | Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5) |
US8945872B2 (en) | 2013-01-25 | 2015-02-03 | Warsaw Orthopedic, Inc. | Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein |
US9169308B2 (en) | 2013-01-25 | 2015-10-27 | Warsaw Orthopedic, Inc. | Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies |
US8956829B2 (en) | 2013-01-25 | 2015-02-17 | Warsaw Orthopedic, Inc. | Human recombinant growth and differentiaton factor-5 (rhGDF-5) |
US9051389B2 (en) | 2013-01-25 | 2015-06-09 | Warsaw Orthopedic, Inc. | Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5) |
KR102016745B1 (ko) * | 2013-02-01 | 2019-09-02 | 아이진 주식회사 | Bmp―7 및 부형제를 포함하는 흉터 형성의 감소 또는 억제용 조성물 |
CN103919733A (zh) * | 2014-04-11 | 2014-07-16 | 聂和民 | 一种包裹双生长因子的核壳结构微球及其用途 |
FR3020947B1 (fr) | 2014-05-14 | 2018-08-31 | Adocia | Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations |
US9795678B2 (en) | 2014-05-14 | 2017-10-24 | Adocia | Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound |
EP3190089A4 (fr) * | 2014-09-01 | 2018-06-20 | Kyushu University, National University Corporation | Procédé de fabrication d'un composé inorganique et composé inorganique produit |
FR3025428A1 (fr) | 2014-09-08 | 2016-03-11 | Adocia | Composition pharmaceutique stable comprenant du pdgf |
EP3040118A1 (fr) * | 2014-12-29 | 2016-07-06 | Galderma S.A. | Hydrogels de chondroïtine réticulée d'éther et leur utilisation pour des applications de tissu mou |
FR3043557B1 (fr) | 2015-11-16 | 2019-05-31 | Adocia | Composition a action rapide d'insuline comprenant un citrate substitue |
CA3015400A1 (fr) | 2016-02-23 | 2017-08-31 | Matripharm International Inc. | Composition a double vitesse de liberation et a forte charge medicamenteuse |
CN107596451B (zh) * | 2017-08-22 | 2020-11-20 | 东南大学 | 一种基于HA/CS/P(MVE-alt-MA)复合骨修复材料及其制备方法 |
CN113069591A (zh) * | 2021-03-29 | 2021-07-06 | 黄河三角洲京博化工研究院有限公司 | 一种壳聚糖-聚谷氨酸钙生物敷料及其制备方法 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
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US563461A (en) | 1896-07-07 | Water elevator and carrier | ||
FR702316A (fr) | 1929-10-04 | 1931-04-04 | Bosch Robert | Cercle de commande destiné à être fixé sur le volant de direction de voitures |
FR805506A (fr) | 1936-04-27 | 1936-11-21 | Est Aciers Fins | Procédé de fabrication d'aciers fins |
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JP2005508217A (ja) * | 2001-09-21 | 2005-03-31 | ストライカー コーポレイション | 整形外科セメントのための孔形成剤 |
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FR2948573B1 (fr) | 2009-07-31 | 2011-11-18 | Adocia | Nouvelle forme d'administration de complexes de proteines osteogeniques |
-
2009
- 2009-07-31 FR FR0903803A patent/FR2948573B1/fr not_active Expired - Fee Related
- 2009-11-19 BR BRPI0916110A patent/BRPI0916110A2/pt not_active Application Discontinuation
- 2009-11-19 KR KR1020117014109A patent/KR20110086752A/ko not_active Application Discontinuation
- 2009-11-19 CA CA2744150A patent/CA2744150A1/fr not_active Abandoned
- 2009-11-19 JP JP2011536920A patent/JP2012509303A/ja not_active Withdrawn
- 2009-11-19 EP EP09809027A patent/EP2376063A1/fr not_active Withdrawn
- 2009-11-19 MX MX2011005275A patent/MX2011005275A/es not_active Application Discontinuation
- 2009-11-19 RU RU2011124917/15A patent/RU2011124917A/ru not_active Application Discontinuation
- 2009-11-19 US US12/591,442 patent/US8546356B2/en not_active Expired - Fee Related
- 2009-11-19 WO PCT/FR2009/001332 patent/WO2010058106A1/fr active Application Filing
- 2009-11-19 SG SG2011037108A patent/SG171388A1/en unknown
- 2009-11-19 AU AU2009317083A patent/AU2009317083A1/en not_active Abandoned
- 2009-11-19 CN CN2009801546015A patent/CN102281868A/zh active Pending
-
2011
- 2011-05-19 IL IL213001A patent/IL213001A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20110086752A (ko) | 2011-07-29 |
RU2011124917A (ru) | 2012-12-27 |
SG171388A1 (en) | 2011-07-28 |
JP2012509303A (ja) | 2012-04-19 |
EP2376063A1 (fr) | 2011-10-19 |
CA2744150A1 (fr) | 2010-05-27 |
CN102281868A (zh) | 2011-12-14 |
AU2009317083A1 (en) | 2010-05-27 |
BRPI0916110A2 (pt) | 2015-11-03 |
WO2010058106A1 (fr) | 2010-05-27 |
FR2948573A1 (fr) | 2011-02-04 |
IL213001A0 (en) | 2011-07-31 |
US8546356B2 (en) | 2013-10-01 |
US20100166867A1 (en) | 2010-07-01 |
MX2011005275A (es) | 2011-06-24 |
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