JP2010523599A5 - - Google Patents
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- Publication number
- JP2010523599A5 JP2010523599A5 JP2010502352A JP2010502352A JP2010523599A5 JP 2010523599 A5 JP2010523599 A5 JP 2010523599A5 JP 2010502352 A JP2010502352 A JP 2010502352A JP 2010502352 A JP2010502352 A JP 2010502352A JP 2010523599 A5 JP2010523599 A5 JP 2010523599A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- group
- heteroaryl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 57
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 10
- 125000001475 halogen functional group Chemical group 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 210000001519 tissue Anatomy 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 206010021143 Hypoxia Diseases 0.000 claims 5
- 230000001146 hypoxic effect Effects 0.000 claims 5
- 108700012439 CA9 Proteins 0.000 claims 4
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 238000002600 positron emission tomography Methods 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000005013 brain tissue Anatomy 0.000 claims 1
- 238000002059 diagnostic imaging Methods 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 210000005228 liver tissue Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 210000005084 renal tissue Anatomy 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92206507P | 2007-04-05 | 2007-04-05 | |
| PCT/US2008/059599 WO2008124703A2 (en) | 2007-04-05 | 2008-04-07 | Development of molecular imaging probes for carbonic anhydrase-ix using click chemistry |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010523599A JP2010523599A (ja) | 2010-07-15 |
| JP2010523599A5 true JP2010523599A5 (https=) | 2010-12-02 |
Family
ID=39743771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010502352A Pending JP2010523599A (ja) | 2007-04-05 | 2008-04-07 | クリックケミストリーを使用した炭酸脱水酵素−ｉｘのための分子イメージングプローブの開発 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7829063B2 (https=) |
| EP (2) | EP2468734A1 (https=) |
| JP (1) | JP2010523599A (https=) |
| KR (2) | KR20090127433A (https=) |
| CN (1) | CN101679318A (https=) |
| CA (1) | CA2683434A1 (https=) |
| WO (1) | WO2008124703A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2703981A1 (en) * | 2007-10-29 | 2009-05-07 | Schering Corporation | Heterocyclic urea and thiourea derivatives and methods of use thereof |
| CA2711678A1 (en) * | 2008-01-09 | 2009-07-16 | Molecular Insight Pharmaceuticals, Inc. | Inhibitors of carbonic anhydrase ix |
| WO2010065899A2 (en) | 2008-12-05 | 2010-06-10 | Molecular Insight Pharmaceuticals, Inc. | Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof |
| ES2467108T3 (es) | 2008-12-09 | 2014-06-11 | Gilead Sciences, Inc. | Moduladores de receptores tipo toll |
| AU2010260195B2 (en) | 2009-06-15 | 2014-11-20 | Molecular Insight Pharmaceuticals, Inc. | Process for production of heterodimers of glutamic acid |
| WO2011018798A2 (en) * | 2009-08-14 | 2011-02-17 | Indian Association For The Cultivation Of Science | Morpholino-based antisense agent |
| US20120263714A1 (en) * | 2009-10-21 | 2012-10-18 | Bayer Intellectual Property Gmbh | Substituted halophenoxybenzamide derivatives |
| WO2011127345A1 (en) | 2010-04-08 | 2011-10-13 | Siemens Medical Solutions Usa, Inc. | Synthesis of 18f-labeled tracers in hydrous organic solvents |
| US10639608B2 (en) | 2010-04-08 | 2020-05-05 | Siemens Medical Solutions Usa, Inc. | System, device and method for preparing tracers and transferring materials during radiosynthesis |
| RU2627694C2 (ru) * | 2010-10-29 | 2017-08-10 | Клино Лтд. | Производные хинолина, визуализирующий белок тау |
| EP3483147A1 (en) | 2010-11-13 | 2019-05-15 | Innocrin Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| WO2012118715A2 (en) * | 2011-02-28 | 2012-09-07 | The Board Of Trustees Of Leland Stanford Junior University | Non-peptidic quenched fluorescent imaging probes |
| CN102219753B (zh) * | 2011-04-21 | 2012-10-31 | 山东大学 | 一种三氮唑类化合物及其制备方法与应用 |
| AU2012253502C1 (en) | 2011-05-09 | 2017-12-14 | Visen Medical, Inc. | Carbonic anhydrase targeting agents and methods of using same |
| JP2014156400A (ja) * | 2011-05-24 | 2014-08-28 | Astellas Pharma Inc | 腫瘍の画像診断用標識誘導体 |
| EP2800471A4 (en) | 2012-01-06 | 2015-11-04 | Molecular Insight Pharm Inc | METAL COMPLEX OF POLY (CARBOXYL) AMINE CONTAINING LIGANDS HAVING AFFINITY FOR CARBON IX ANHYDRASE |
| US9375493B2 (en) | 2012-03-30 | 2016-06-28 | Visen Medical, Inc. | Bacterial imaging agents and methods of using same |
| EP3300746B1 (en) | 2013-01-14 | 2019-05-15 | Molecular Insight Pharmaceuticals, Inc. | Triazine based radiopharmaceuticals and radioimaging agents |
| TW201609674A (zh) | 2013-11-05 | 2016-03-16 | 拜耳作物科學股份有限公司 | 用於控制節肢動物的新穎化合物（二） |
| PT3166607T (pt) | 2014-07-11 | 2022-12-07 | Gilead Sciences Inc | Moduladores de receptores de tipo toll para o tratamento do vih |
| CN104212440B (zh) * | 2014-09-03 | 2016-03-30 | 无锡艾德美特生物科技有限公司 | 一类喹唑啉类荧光探针及其制备和应用 |
| CA2960436C (en) | 2014-09-16 | 2021-01-05 | Gilead Sciences, Inc. | Solid forms of a toll-like receptor modulator |
| BR112017005100A2 (pt) * | 2014-09-16 | 2017-12-05 | Gilead Sciences Inc | métodos de preparação de moduladores de receptores do tipo toll |
| AU2016236239B2 (en) | 2015-03-24 | 2020-06-25 | H. Lundbeck A/S | Manufacture of 4,5,6,7-tetrahydroisozaxolo[5,4-c]pyridin-3-ol |
| LT6401B (lt) | 2015-07-28 | 2017-06-12 | Vilniaus Universitetas | Karboanhidrazės selektyvūs inhibitoriai |
| CN105541825A (zh) * | 2015-12-28 | 2016-05-04 | 中国药科大学 | 三氮唑衍生物制备方法及其作为药物的用途 |
| EP3455222B1 (en) * | 2016-05-13 | 2022-03-02 | The Johns Hopkins University | Nuclear imaging and radiotherapeutics agents targeting carbonic anhydrase ix and uses thereof |
| US10695450B2 (en) | 2016-07-26 | 2020-06-30 | Laboratoires Cyclopharma | Synthesis of a radioactive agent composition |
| BR112019021899A2 (pt) * | 2017-04-20 | 2020-08-18 | The Regents Of The University Of California | moduladores de k-ras |
| DK3668856T3 (da) | 2017-08-17 | 2021-09-20 | Glaxosmithkline Ip Dev Ltd | Hidtil ukendte tetrazolforbindelser og anvendelse deraf til behandling af tuberkulose |
| KR102147971B1 (ko) * | 2019-11-22 | 2020-08-25 | 국방과학연구소 | 반응용매에 대한 혼화성 차이를 이용한 화학선택적 트리아졸의 제조방법 |
| WO2025113696A1 (zh) * | 2023-11-30 | 2025-06-05 | 赣州和美药业股份有限公司 | 一种化合物及其应用 |
| CN117986213A (zh) * | 2024-02-26 | 2024-05-07 | 厦门大学 | 一种5-氯甲基糠醛制备2,5-二（氨基甲基）呋喃的方法 |
| WO2026060272A1 (en) * | 2024-09-16 | 2026-03-19 | Wisconsin Alumni Research Foundation | Long-residence ca9 ligands and radioisotope carriers for inhibition, visualization and irradiation of ca9-expressing tumors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6562319B2 (en) * | 2001-03-12 | 2003-05-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy |
| CA2691447A1 (en) * | 2002-11-26 | 2004-06-10 | Institute Of Virology | Ca ix-specific inhibitors |
| EP1875239B1 (en) * | 2005-04-27 | 2011-10-05 | Siemens Medical Solutions USA, Inc. | A method for the preparation of imaging probes using click chemistry |
| EP1733742A1 (en) | 2005-06-17 | 2006-12-20 | Universiteit Utrecht Holding B.V. | Dendrimers multivalently substituted with active groups |
| CA2617907A1 (en) | 2005-08-05 | 2007-02-15 | Syntarga B.V. | Triazole-containing releasable linkers and conjugates comprising the same |
| US8470587B2 (en) * | 2006-08-28 | 2013-06-25 | The Trustees Of The University Of Pennsylvania | 129Xe biosensors and their use |
| WO2008033557A2 (en) | 2006-09-15 | 2008-03-20 | Siemens Medical Solutions Usa, Inc. | Click chemistry-derived cyclic peptidomimetics as integrin markers |
-
2008
- 2008-04-07 WO PCT/US2008/059599 patent/WO2008124703A2/en not_active Ceased
- 2008-04-07 JP JP2010502352A patent/JP2010523599A/ja active Pending
- 2008-04-07 EP EP12157766A patent/EP2468734A1/en not_active Withdrawn
- 2008-04-07 CA CA002683434A patent/CA2683434A1/en not_active Abandoned
- 2008-04-07 CN CN200880010576A patent/CN101679318A/zh active Pending
- 2008-04-07 KR KR1020097022869A patent/KR20090127433A/ko not_active Ceased
- 2008-04-07 US US12/099,135 patent/US7829063B2/en active Active
- 2008-04-07 EP EP08745260A patent/EP2129666A2/en not_active Withdrawn
- 2008-04-07 KR KR1020117030103A patent/KR20120003499A/ko not_active Withdrawn
-
2010
- 2010-08-25 US US12/862,955 patent/US8354092B2/en active Active
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